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Protein

Solute carrier organic anion transporter family member 1C1

Gene

SLCO1C1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Mediates the Na+-independent high affinity transport of organic anions such as the thyroid hormones thyroxine (T4) and rT3. Other potential substrates, such as triiodothyronine (T3), 17-beta-glucuronosyl estradiol, estrone-3-sulfate and sulfobromophthalein (BSP) are transported with much lower efficiency. May play a signifiant role in regulating T4 flux into and out of the brain (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Ion transport, Transport

Enzyme and pathway databases

ReactomeiR-HSA-879518. Transport of organic anions.

Protein family/group databases

TCDBi2.A.60.1.15. the organo anion transporter (oat) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier organic anion transporter family member 1C1
Alternative name(s):
Organic anion transporter F
Short name:
OATP-F
Organic anion transporter polypeptide-related protein 5
Short name:
OAT-RP-5
Short name:
OATPRP5
Organic anion-transporting polypeptide 14
Short name:
OATP-14
Solute carrier family 21 member 14
Thyroxine transporter
Gene namesi
Name:SLCO1C1
Synonyms:OATP14, OATP1C1, OATPF, SLC21A14
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:13819. SLCO1C1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 4343CytoplasmicSequence analysisAdd
BLAST
Transmembranei44 – 6320Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini64 – 8219ExtracellularSequence analysisAdd
BLAST
Transmembranei83 – 10321Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini104 – 1096CytoplasmicSequence analysis
Transmembranei110 – 13425Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini135 – 18450ExtracellularSequence analysisAdd
BLAST
Transmembranei185 – 21329Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini214 – 23219CytoplasmicSequence analysisAdd
BLAST
Transmembranei233 – 25321Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini254 – 27118ExtracellularSequence analysisAdd
BLAST
Transmembranei272 – 29625Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini297 – 34852CytoplasmicSequence analysisAdd
BLAST
Transmembranei349 – 37022Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini371 – 39020ExtracellularSequence analysisAdd
BLAST
Transmembranei391 – 41424Helical; Name=8Sequence analysisAdd
BLAST
Topological domaini415 – 4184CytoplasmicSequence analysis
Transmembranei419 – 44224Helical; Name=9Sequence analysisAdd
BLAST
Topological domaini443 – 554112ExtracellularSequence analysisAdd
BLAST
Transmembranei555 – 57723Helical; Name=10Sequence analysisAdd
BLAST
Topological domaini578 – 5869CytoplasmicSequence analysis
Transmembranei587 – 61226Helical; Name=11Sequence analysisAdd
BLAST
Topological domaini613 – 64634ExtracellularSequence analysisAdd
BLAST
Transmembranei647 – 66418Helical; Name=12Sequence analysisAdd
BLAST
Topological domaini665 – 71248CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA37815.

Chemistry

ChEMBLiCHEMBL2073697.
DrugBankiDB00286. Conjugated Estrogens.
DB00509. Dextrothyroxine.
DB00586. Diclofenac.
DB00390. Digoxin.
DB00917. Dinoprostone.
DB00783. Estradiol.
DB00451. Levothyroxine.
DB00279. Liothyronine.
DB01583. Liotrix.
DB00939. Meclofenamic acid.
DB00563. Methotrexate.
DB01092. Ouabain.
DB00252. Phenytoin.
DB01032. Probenecid.

Polymorphism and mutation databases

BioMutaiSLCO1C1.
DMDMi27734564.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 712712Solute carrier organic anion transporter family member 1C1PRO_0000191054Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi146 – 1461N-linked (GlcNAc...)Sequence analysis
Disulfide bondi476 ↔ 502PROSITE-ProRule annotation
Disulfide bondi480 ↔ 491PROSITE-ProRule annotation
Disulfide bondi482 ↔ 506PROSITE-ProRule annotation
Glycosylationi510 – 5101N-linked (GlcNAc...)Sequence analysis
Glycosylationi520 – 5201N-linked (GlcNAc...)Sequence analysis
Glycosylationi533 – 5331N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9NYB5.
PeptideAtlasiQ9NYB5.
PRIDEiQ9NYB5.

PTM databases

iPTMnetiQ9NYB5.
PhosphoSiteiQ9NYB5.

Expressioni

Tissue specificityi

Highly expressed in brain and in Leydig cells in testis. Detected in many brain regions with the exception of pons and cerebellum. Not strongly enriched in cerebral microvessels.1 Publication

Gene expression databases

BgeeiENSG00000139155.
CleanExiHS_SLCO1C1.
ExpressionAtlasiQ9NYB5. baseline and differential.
GenevisibleiQ9NYB5. HS.

Organism-specific databases

HPAiCAB022193.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000370964.

Structurei

3D structure databases

ProteinModelPortaliQ9NYB5.
SMRiQ9NYB5. Positions 474-505.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini470 – 52556Kazal-likePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 Kazal-like domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3626. Eukaryota.
ENOG410XRSF. LUCA.
GeneTreeiENSGT00760000119014.
HOGENOMiHOG000231269.
HOVERGENiHBG063896.
InParanoidiQ9NYB5.
KOiK08747.
OMAiYWPGKET.
OrthoDBiEOG091G08QD.
PhylomeDBiQ9NYB5.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR002350. Kazal_dom.
IPR020846. MFS_dom.
IPR004156. OA_transporter.
IPR030764. OATP1C1.
[Graphical view]
PANTHERiPTHR11388. PTHR11388. 1 hit.
PTHR11388:SF99. PTHR11388:SF99. 1 hit.
PfamiPF07648. Kazal_2. 1 hit.
PF03137. OATP. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 4 hits.
TIGRFAMsiTIGR00805. oat. 1 hit.
PROSITEiPS51465. KAZAL_2. 1 hit.
PS50850. MFS. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9NYB5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDTSSKENIQ LFCKTSVQPV GRPSFKTEYP SSEEKQPCCG ELKVFLCALS
60 70 80 90 100
FVYFAKALAE GYLKSTITQI ERRFDIPSSL VGVIDGSFEI GNLLVITFVS
110 120 130 140 150
YFGAKLHRPK IIGAGCVIMG VGTLLIAMPQ FFMEQYKYER YSPSSNSTLS
160 170 180 190 200
ISPCLLESSS QLPVSVMEKS KSKISNECEV DTSSSMWIYV FLGNLLRGIG
210 220 230 240 250
ETPIQPLGIA YLDDFASEDN AAFYIGCVQT VAIIGPIFGF LLGSLCAKLY
260 270 280 290 300
VDIGFVNLDH ITITPKDPQW VGAWWLGYLI AGIISLLAAV PFWYLPKSLP
310 320 330 340 350
RSQSREDSNS SSEKSKFIID DHTDYQTPQG ENAKIMEMAR DFLPSLKNLF
360 370 380 390 400
GNPVYFLYLC TSTVQFNSLF GMVTYKPKYI EQQYGQSSSR ANFVIGLINI
410 420 430 440 450
PAVALGIFSG GIVMKKFRIS VCGAAKLYLG SSVFGYLLFL SLFALGCENS
460 470 480 490 500
DVAGLTVSYQ GTKPVSYHER ALFSDCNSRC KCSETKWEPM CGENGITYVS
510 520 530 540 550
ACLAGCQTSN RSGKNIIFYN CTCVGIAASK SGNSSGIVGR CQKDNGCPQM
560 570 580 590 600
FLYFLVISVI TSYTLSLGGI PGYILLLRCI KPQLKSFALG IYTLAIRVLA
610 620 630 640 650
GIPAPVYFGV LIDTSCLKWG FKRCGSRGSC RLYDSNVFRH IYLGLTVILG
660 670 680 690 700
TVSILLSIAV LFILKKNYVS KHRSFITKRE RTMVSTRFQK ENYTTSDHLL
710
QPNYWPGKET QL
Length:712
Mass (Da):78,696
Last modified:October 1, 2000 - v1
Checksum:iCB6D37AAAA8FA7CD
GO
Isoform 2 (identifier: Q9NYB5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     177-225: Missing.

Note: No experimental confirmation available.
Show »
Length:663
Mass (Da):73,268
Checksum:i2F53E8BAB882A069
GO
Isoform 3 (identifier: Q9NYB5-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     640-712: HIYLGLTVIL...NYWPGKETQL → YQIKSIPASH...KIPKGKLHYK

Show »
Length:730
Mass (Da):80,665
Checksum:iC847E62D6D03E2E8
GO
Isoform 4 (identifier: Q9NYB5-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-118: Missing.
     640-712: HIYLGLTVIL...NYWPGKETQL → YQIKSIPASH...KIPKGKLHYK

Note: No experimental confirmation available.Curated
Show »
Length:612
Mass (Da):67,677
Checksum:iE8A59A7530E0B475
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti444 – 4441A → T in BAH14027 (PubMed:14702039).Curated
Isoform 4 (identifier: Q9NYB5-4)
Sequence conflicti559 – 5591S → F in BAH11737 (PubMed:14702039).Curated
Isoform 3 (identifier: Q9NYB5-3)
Sequence conflicti660 – 6601T → S in BAH14027 (PubMed:14702039).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 118118Missing in isoform 4. 1 PublicationVSP_045278Add
BLAST
Alternative sequencei177 – 22549Missing in isoform 2. 1 PublicationVSP_042882Add
BLAST
Alternative sequencei640 – 71273HIYLG…KETQL → YQIKSIPASHCYSIPDLHNA TDTNKFSCHFTACKTYISGT NCDTGHSVNSPKHCSTFHFK EKLCFKTQKFYNQERKNNGV YKIPKGKLHYK in isoform 3 and isoform 4. 2 PublicationsVSP_045279Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF260704 mRNA. Translation: AAF70338.1.
AF205076 mRNA. Translation: AAG42208.1.
AK294333 mRNA. Translation: BAH11737.1.
AK296236 mRNA. Translation: BAH12289.1.
AK303713 mRNA. Translation: BAH14027.1.
AL834209 mRNA. Translation: CAI46209.1.
AC092491 Genomic DNA. No translation available.
BC022461 mRNA. Translation: AAH22461.1.
CCDSiCCDS53757.1. [Q9NYB5-3]
CCDS53758.1. [Q9NYB5-2]
CCDS53759.1. [Q9NYB5-4]
CCDS8683.1. [Q9NYB5-1]
RefSeqiNP_001139416.1. NM_001145944.1. [Q9NYB5-4]
NP_001139417.1. NM_001145945.1. [Q9NYB5-2]
NP_001139418.1. NM_001145946.1. [Q9NYB5-3]
NP_059131.1. NM_017435.4. [Q9NYB5-1]
XP_005253451.1. XM_005253394.2. [Q9NYB5-1]
XP_005253453.1. XM_005253396.2. [Q9NYB5-4]
XP_011519011.1. XM_011520709.2. [Q9NYB5-4]
UniGeneiHs.47261.

Genome annotation databases

EnsembliENST00000266509; ENSP00000266509; ENSG00000139155. [Q9NYB5-1]
ENST00000540354; ENSP00000438665; ENSG00000139155. [Q9NYB5-2]
ENST00000545102; ENSP00000444527; ENSG00000139155. [Q9NYB5-4]
ENST00000545604; ENSP00000444149; ENSG00000139155. [Q9NYB5-3]
GeneIDi53919.
KEGGihsa:53919.
UCSCiuc001rei.3. human. [Q9NYB5-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF260704 mRNA. Translation: AAF70338.1.
AF205076 mRNA. Translation: AAG42208.1.
AK294333 mRNA. Translation: BAH11737.1.
AK296236 mRNA. Translation: BAH12289.1.
AK303713 mRNA. Translation: BAH14027.1.
AL834209 mRNA. Translation: CAI46209.1.
AC092491 Genomic DNA. No translation available.
BC022461 mRNA. Translation: AAH22461.1.
CCDSiCCDS53757.1. [Q9NYB5-3]
CCDS53758.1. [Q9NYB5-2]
CCDS53759.1. [Q9NYB5-4]
CCDS8683.1. [Q9NYB5-1]
RefSeqiNP_001139416.1. NM_001145944.1. [Q9NYB5-4]
NP_001139417.1. NM_001145945.1. [Q9NYB5-2]
NP_001139418.1. NM_001145946.1. [Q9NYB5-3]
NP_059131.1. NM_017435.4. [Q9NYB5-1]
XP_005253451.1. XM_005253394.2. [Q9NYB5-1]
XP_005253453.1. XM_005253396.2. [Q9NYB5-4]
XP_011519011.1. XM_011520709.2. [Q9NYB5-4]
UniGeneiHs.47261.

3D structure databases

ProteinModelPortaliQ9NYB5.
SMRiQ9NYB5. Positions 474-505.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000370964.

Chemistry

ChEMBLiCHEMBL2073697.
DrugBankiDB00286. Conjugated Estrogens.
DB00509. Dextrothyroxine.
DB00586. Diclofenac.
DB00390. Digoxin.
DB00917. Dinoprostone.
DB00783. Estradiol.
DB00451. Levothyroxine.
DB00279. Liothyronine.
DB01583. Liotrix.
DB00939. Meclofenamic acid.
DB00563. Methotrexate.
DB01092. Ouabain.
DB00252. Phenytoin.
DB01032. Probenecid.

Protein family/group databases

TCDBi2.A.60.1.15. the organo anion transporter (oat) family.

PTM databases

iPTMnetiQ9NYB5.
PhosphoSiteiQ9NYB5.

Polymorphism and mutation databases

BioMutaiSLCO1C1.
DMDMi27734564.

Proteomic databases

PaxDbiQ9NYB5.
PeptideAtlasiQ9NYB5.
PRIDEiQ9NYB5.

Protocols and materials databases

DNASUi53919.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000266509; ENSP00000266509; ENSG00000139155. [Q9NYB5-1]
ENST00000540354; ENSP00000438665; ENSG00000139155. [Q9NYB5-2]
ENST00000545102; ENSP00000444527; ENSG00000139155. [Q9NYB5-4]
ENST00000545604; ENSP00000444149; ENSG00000139155. [Q9NYB5-3]
GeneIDi53919.
KEGGihsa:53919.
UCSCiuc001rei.3. human. [Q9NYB5-1]

Organism-specific databases

CTDi53919.
GeneCardsiSLCO1C1.
HGNCiHGNC:13819. SLCO1C1.
HPAiCAB022193.
MIMi613389. gene.
neXtProtiNX_Q9NYB5.
PharmGKBiPA37815.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3626. Eukaryota.
ENOG410XRSF. LUCA.
GeneTreeiENSGT00760000119014.
HOGENOMiHOG000231269.
HOVERGENiHBG063896.
InParanoidiQ9NYB5.
KOiK08747.
OMAiYWPGKET.
OrthoDBiEOG091G08QD.
PhylomeDBiQ9NYB5.

Enzyme and pathway databases

ReactomeiR-HSA-879518. Transport of organic anions.

Miscellaneous databases

GenomeRNAii53919.
PROiQ9NYB5.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000139155.
CleanExiHS_SLCO1C1.
ExpressionAtlasiQ9NYB5. baseline and differential.
GenevisibleiQ9NYB5. HS.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR002350. Kazal_dom.
IPR020846. MFS_dom.
IPR004156. OA_transporter.
IPR030764. OATP1C1.
[Graphical view]
PANTHERiPTHR11388. PTHR11388. 1 hit.
PTHR11388:SF99. PTHR11388:SF99. 1 hit.
PfamiPF07648. Kazal_2. 1 hit.
PF03137. OATP. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 4 hits.
TIGRFAMsiTIGR00805. oat. 1 hit.
PROSITEiPS51465. KAZAL_2. 1 hit.
PS50850. MFS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSO1C1_HUMAN
AccessioniPrimary (citable) accession number: Q9NYB5
Secondary accession number(s): B7Z251
, B7Z3Q3, B7Z8P1, F5GZD6, Q5JPA4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 10, 2003
Last sequence update: October 1, 2000
Last modified: September 7, 2016
This is version 133 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.