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Q9NYA4

- MTMR4_HUMAN

UniProt

Q9NYA4 - MTMR4_HUMAN

Protein

Myotubularin-related protein 4

Gene

MTMR4

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 101 (01 Oct 2014)
      Sequence version 2 (18 May 2010)
      Previous versions | rss
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    Functioni

    Dephosphorylates proteins phosphorylated on Ser, Thr, and Tyr residues and low molecular weight phosphatase substrate para-nitrophenylphosphate. Phosphorylates phosphatidylinositol 3,4,5-trisphosphate (PIP3).1 Publication

    Catalytic activityi

    Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.PROSITE-ProRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei407 – 4071Phosphocysteine intermediatePROSITE-ProRule annotation
    Binding sitei453 – 4531SubstrateBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri1114 – 117461FYVE-typePROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. protein binding Source: IntAct
    3. protein serine/threonine phosphatase activity Source: Reactome
    4. protein tyrosine phosphatase activity Source: ProtInc

    GO - Biological processi

    1. negative regulation of transforming growth factor beta receptor signaling pathway Source: Reactome
    2. peptidyl-tyrosine dephosphorylation Source: GOC
    3. phosphatidylinositol biosynthetic process Source: Reactome
    4. phospholipid metabolic process Source: Reactome
    5. protein dephosphorylation Source: ProtInc
    6. response to denervation involved in regulation of muscle adaptation Source: Ensembl
    7. small molecule metabolic process Source: Reactome
    8. transforming growth factor beta receptor signaling pathway Source: Reactome

    Keywords - Molecular functioni

    Hydrolase, Protein phosphatase

    Keywords - Ligandi

    Metal-binding, Zinc

    Enzyme and pathway databases

    ReactomeiREACT_120727. Downregulation of TGF-beta receptor signaling.
    REACT_120756. Synthesis of PIPs at the early endosome membrane.
    REACT_120918. Synthesis of PIPs at the late endosome membrane.
    SignaLinkiQ9NYA4.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Myotubularin-related protein 4 (EC:3.1.3.48)
    Alternative name(s):
    FYVE domain-containing dual specificity protein phosphatase 2
    Short name:
    FYVE-DSP2
    Zinc finger FYVE domain-containing protein 11
    Gene namesi
    Name:MTMR4
    Synonyms:KIAA0647, ZFYVE11
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 17

    Organism-specific databases

    HGNCiHGNC:7452. MTMR4.

    Subcellular locationi

    Cytoplasm 1 Publication. Membrane 1 Publication; Peripheral membrane protein 1 Publication
    Note: Localized to perinuclear region.

    GO - Cellular componenti

    1. cytosol Source: Reactome
    2. early endosome membrane Source: Reactome
    3. extracellular space Source: UniProt

    Keywords - Cellular componenti

    Cytoplasm, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA31255.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 11951195Myotubularin-related protein 4PRO_0000304809Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei610 – 6101PhosphoserineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ9NYA4.
    PaxDbiQ9NYA4.
    PRIDEiQ9NYA4.

    PTM databases

    PhosphoSiteiQ9NYA4.

    Expressioni

    Tissue specificityi

    Expressed in brain, heart, kidney, spleen, liver, colon, testis, muscle, placenta, thyroid gland, pancreas, ovary, prostate, skin, peripheral blood, and bone marrow.1 Publication

    Developmental stagei

    Expressed in fetal brain and fetal liver.1 Publication

    Gene expression databases

    ArrayExpressiQ9NYA4.
    BgeeiQ9NYA4.
    CleanExiHS_MTMR4.
    GenevestigatoriQ9NYA4.

    Organism-specific databases

    HPAiHPA043852.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    SMAD2Q157963EBI-1052346,EBI-1040141
    SMAD3P840224EBI-1052346,EBI-347161

    Protein-protein interaction databases

    BioGridi114560. 4 interactions.
    IntActiQ9NYA4. 3 interactions.
    MINTiMINT-1193708.
    STRINGi9606.ENSP00000325285.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9NYA4.
    SMRiQ9NYA4. Positions 48-571, 1111-1173.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini153 – 570418Myotubularin phosphatasePROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni320 – 3234Substrate bindingBy similarity
    Regioni345 – 3462Substrate bindingBy similarity
    Regioni407 – 4137Substrate bindingBy similarity

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili1023 – 105533Sequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Contains 1 FYVE-type zinc finger.PROSITE-ProRule annotation
    Contains 1 myotubularin phosphatase domain.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri1114 – 117461FYVE-typePROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Coiled coil, Zinc-finger

    Phylogenomic databases

    eggNOGiNOG322789.
    HOGENOMiHOG000004861.
    HOVERGENiHBG052526.
    InParanoidiQ9NYA4.
    KOiK18082.
    OMAiGHCTGPG.
    OrthoDBiEOG7PVWNJ.
    PhylomeDBiQ9NYA4.
    TreeFamiTF315197.

    Family and domain databases

    Gene3Di3.30.40.10. 1 hit.
    InterProiIPR010569. Myotubularin-like_Pase_dom.
    IPR029021. Prot-tyrosine_phosphatase-like.
    IPR000387. Tyr/Dual-sp_Pase.
    IPR016130. Tyr_Pase_AS.
    IPR000306. Znf_FYVE.
    IPR017455. Znf_FYVE-rel.
    IPR011011. Znf_FYVE_PHD.
    IPR013083. Znf_RING/FYVE/PHD.
    [Graphical view]
    PfamiPF01363. FYVE. 1 hit.
    PF06602. Myotub-related. 1 hit.
    [Graphical view]
    SMARTiSM00064. FYVE. 1 hit.
    [Graphical view]
    SUPFAMiSSF52799. SSF52799. 2 hits.
    SSF57903. SSF57903. 1 hit.
    PROSITEiPS51339. PPASE_MYOTUBULARIN. 1 hit.
    PS00383. TYR_PHOSPHATASE_1. 1 hit.
    PS50056. TYR_PHOSPHATASE_2. 1 hit.
    PS50178. ZF_FYVE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9NYA4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGEEGPPSLE YIQAKDLFPP KELVKEEENL QVPFTVLQGE GVEFLGRAAD     50
    ALIAISNYRL HIKFKDSVIN VPLRMIDSVE SRDMFQLHIS CKDSKVVRCH 100
    FSTFKQCQEW LSRLSRATAR PAKPEDLFAF AYHAWCLGLT EEDQHTHLCQ 150
    PGEHIRCRQE AELARMGFDL QNVWRVSHIN SNYKLCPSYP QKLLVPVWIT 200
    DKELENVASF RSWKRIPVVV YRHLRNGAAI ARCSQPEISW WGWRNADDEY 250
    LVTSIAKACA LDPGTRATGG SLSTGNNDTS EACDADFDSS LTACSGVEST 300
    AAPQKLLILD ARSYTAAVAN RAKGGGCECE EYYPNCEVVF MGMANIHAIR 350
    NSFQYLRAVC SQMPDPSNWL SALESTKWLQ HLSVMLKAAV LVANTVDREG 400
    RPVLVHCSDG WDRTPQIVAL AKILLDPYYR TLEGFQVLVE SDWLDFGHKF 450
    GDRCGHQENV EDQNEQCPVF LQWLDSVHQL LKQFPCLFEF NEAFLVKLVQ 500
    HTYSCLYGTF LANNPCEREK RNIYKRTCSV WALLRAGNKN FHNFLYTPSS 550
    DMVLHPVCHV RALHLWTAVY LPASSPCTLG EENMDLYLSP VAQSQEFSGR 600
    SLDRLPKTRS MDDLLSACDT SSPLTRTSSD PNLNNHCQEV RVGLEPWHSN 650
    PEGSETSFVD SGVGGPQQTV GEVGLPPPLP SSQKDYLSNK PFKSHKSCSP 700
    SYKLLNTAVP REMKSNTSDP EIKVLEETKG PAPDPSAQDE LGRTLDGIGE 750
    PPEHCPETEA VSALSKVISN KCDGVCNFPE SSQNSPTGTP QQAQPDSMLG 800
    VPSKCVLDHS LSTVCNPPSA ACQTPLDPST DFLNQDPSGS VASISHQEQL 850
    SSVPDLTHGE EDIGKRGNNR NGQLLENPRF GKMPLELVRK PISQSQISEF 900
    SFLGSNWDSF QGMVTSFPSG EATPRRLLSY GCCSKRPNSK QMRATGPCFG 950
    GQWAQREGVK SPVCSSHSNG HCTGPGGKNQ MWLSSHPKQV SSTKPVPLNC 1000
    PSPVPPLYLD DDGLPFPTDV IQHRLRQIEA GYKQEVEQLR RQVRELQMRL 1050
    DIRHCCAPPA EPPMDYEDDF TCLKESDGSD TEDFGSDHSE DCLSEASWEP 1100
    VDKKETEVTR WVPDHMASHC YNCDCEFWLA KRRHHCRNCG NVFCAGCCHL 1150
    KLPIPDQQLY DPVLVCNSCY EHIQVSRARE LMSQQLKKPI ATASS 1195
    Length:1,195
    Mass (Da):133,353
    Last modified:May 18, 2010 - v2
    Checksum:i936EC3F69335CEB4
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti170 – 1701L → V.2 Publications
    Corresponds to variant rs3744108 [ dbSNP | Ensembl ].
    VAR_035110
    Natural varianti280 – 2801S → G.1 Publication
    Corresponds to variant rs2302190 [ dbSNP | Ensembl ].
    VAR_035111
    Natural varianti297 – 2971V → G.
    Corresponds to variant rs2302189 [ dbSNP | Ensembl ].
    VAR_035112

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF264717 mRNA. Translation: AAF72539.1.
    AB014547 mRNA. Translation: BAA31622.2.
    AC005666 Genomic DNA. No translation available.
    CH471109 Genomic DNA. Translation: EAW94454.1.
    CH471109 Genomic DNA. Translation: EAW94455.1.
    BC035609 mRNA. Translation: AAH35609.1.
    CCDSiCCDS11608.1.
    PIRiT00375.
    RefSeqiNP_004678.3. NM_004687.4.
    XP_005257843.1. XM_005257786.2.
    XP_006722231.1. XM_006722168.1.
    UniGeneiHs.514373.

    Genome annotation databases

    EnsembliENST00000323456; ENSP00000325285; ENSG00000108389.
    GeneIDi9110.
    KEGGihsa:9110.
    UCSCiuc002iwj.2. human.

    Polymorphism databases

    DMDMi296438298.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF264717 mRNA. Translation: AAF72539.1 .
    AB014547 mRNA. Translation: BAA31622.2 .
    AC005666 Genomic DNA. No translation available.
    CH471109 Genomic DNA. Translation: EAW94454.1 .
    CH471109 Genomic DNA. Translation: EAW94455.1 .
    BC035609 mRNA. Translation: AAH35609.1 .
    CCDSi CCDS11608.1.
    PIRi T00375.
    RefSeqi NP_004678.3. NM_004687.4.
    XP_005257843.1. XM_005257786.2.
    XP_006722231.1. XM_006722168.1.
    UniGenei Hs.514373.

    3D structure databases

    ProteinModelPortali Q9NYA4.
    SMRi Q9NYA4. Positions 48-571, 1111-1173.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 114560. 4 interactions.
    IntActi Q9NYA4. 3 interactions.
    MINTi MINT-1193708.
    STRINGi 9606.ENSP00000325285.

    PTM databases

    PhosphoSitei Q9NYA4.

    Polymorphism databases

    DMDMi 296438298.

    Proteomic databases

    MaxQBi Q9NYA4.
    PaxDbi Q9NYA4.
    PRIDEi Q9NYA4.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000323456 ; ENSP00000325285 ; ENSG00000108389 .
    GeneIDi 9110.
    KEGGi hsa:9110.
    UCSCi uc002iwj.2. human.

    Organism-specific databases

    CTDi 9110.
    GeneCardsi GC17M056566.
    H-InvDB HIX0202387.
    HGNCi HGNC:7452. MTMR4.
    HPAi HPA043852.
    MIMi 603559. gene.
    neXtProti NX_Q9NYA4.
    PharmGKBi PA31255.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG322789.
    HOGENOMi HOG000004861.
    HOVERGENi HBG052526.
    InParanoidi Q9NYA4.
    KOi K18082.
    OMAi GHCTGPG.
    OrthoDBi EOG7PVWNJ.
    PhylomeDBi Q9NYA4.
    TreeFami TF315197.

    Enzyme and pathway databases

    Reactomei REACT_120727. Downregulation of TGF-beta receptor signaling.
    REACT_120756. Synthesis of PIPs at the early endosome membrane.
    REACT_120918. Synthesis of PIPs at the late endosome membrane.
    SignaLinki Q9NYA4.

    Miscellaneous databases

    ChiTaRSi MTMR4. human.
    GenomeRNAii 9110.
    NextBioi 34145.
    PROi Q9NYA4.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9NYA4.
    Bgeei Q9NYA4.
    CleanExi HS_MTMR4.
    Genevestigatori Q9NYA4.

    Family and domain databases

    Gene3Di 3.30.40.10. 1 hit.
    InterProi IPR010569. Myotubularin-like_Pase_dom.
    IPR029021. Prot-tyrosine_phosphatase-like.
    IPR000387. Tyr/Dual-sp_Pase.
    IPR016130. Tyr_Pase_AS.
    IPR000306. Znf_FYVE.
    IPR017455. Znf_FYVE-rel.
    IPR011011. Znf_FYVE_PHD.
    IPR013083. Znf_RING/FYVE/PHD.
    [Graphical view ]
    Pfami PF01363. FYVE. 1 hit.
    PF06602. Myotub-related. 1 hit.
    [Graphical view ]
    SMARTi SM00064. FYVE. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52799. SSF52799. 2 hits.
    SSF57903. SSF57903. 1 hit.
    PROSITEi PS51339. PPASE_MYOTUBULARIN. 1 hit.
    PS00383. TYR_PHOSPHATASE_1. 1 hit.
    PS50056. TYR_PHOSPHATASE_2. 1 hit.
    PS50178. ZF_FYVE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "FYVE-DSP2, a FYVE domain-containing dual specificity protein phosphatase that dephosphorylates phosphatidylinositol 3-phosphate."
      Zhao R., Qi Y., Chen J., Zhao Z.J.
      Exp. Cell Res. 265:329-338(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, VARIANT VAL-170.
    2. "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro."
      Ishikawa K., Nagase T., Suyama M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
      DNA Res. 5:169-176(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT VAL-170.
      Tissue: Brain.
    3. "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."
      Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T.
      DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: SEQUENCE REVISION.
    4. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
      Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L.
      , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
      Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT GLY-280.
      Tissue: Lung.

    Entry informationi

    Entry nameiMTMR4_HUMAN
    AccessioniPrimary (citable) accession number: Q9NYA4
    Secondary accession number(s): D3DTZ6, Q8IV27, Q9Y4D5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 11, 2007
    Last sequence update: May 18, 2010
    Last modified: October 1, 2014
    This is version 101 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 17
      Human chromosome 17: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3