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Protein

Myotubularin-related protein 4

Gene

MTMR4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Dephosphorylates proteins phosphorylated on Ser, Thr, and Tyr residues and low molecular weight phosphatase substrate para-nitrophenylphosphate. Phosphorylates phosphatidylinositol 3,4,5-trisphosphate (PIP3).1 Publication

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei407Phosphocysteine intermediatePROSITE-ProRule annotation1
Binding sitei453SubstrateBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri1114 – 1174FYVE-typePROSITE-ProRule annotationAdd BLAST61

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protein phosphatase
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-1660516 Synthesis of PIPs at the early endosome membrane
R-HSA-1660517 Synthesis of PIPs at the late endosome membrane
R-HSA-2173788 Downregulation of TGF-beta receptor signaling
SignaLinkiQ9NYA4
SIGNORiQ9NYA4

Names & Taxonomyi

Protein namesi
Recommended name:
Myotubularin-related protein 4 (EC:3.1.3.48)
Alternative name(s):
FYVE domain-containing dual specificity protein phosphatase 2
Short name:
FYVE-DSP2
Zinc finger FYVE domain-containing protein 11
Gene namesi
Name:MTMR4
Synonyms:KIAA0647, ZFYVE11
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000108389.9
HGNCiHGNC:7452 MTMR4
MIMi603559 gene
neXtProtiNX_Q9NYA4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi9110
OpenTargetsiENSG00000108389
PharmGKBiPA31255

Polymorphism and mutation databases

BioMutaiMTMR4
DMDMi296438298

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003048091 – 1195Myotubularin-related protein 4Add BLAST1195

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei8PhosphoserineCombined sources1
Modified residuei610PhosphoserineCombined sources1
Modified residuei629PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9NYA4
MaxQBiQ9NYA4
PaxDbiQ9NYA4
PeptideAtlasiQ9NYA4
PRIDEiQ9NYA4

PTM databases

DEPODiQ9NYA4
iPTMnetiQ9NYA4
PhosphoSitePlusiQ9NYA4

Expressioni

Tissue specificityi

Expressed in brain, heart, kidney, spleen, liver, colon, testis, muscle, placenta, thyroid gland, pancreas, ovary, prostate, skin, peripheral blood, and bone marrow.1 Publication

Developmental stagei

Expressed in fetal brain and fetal liver.1 Publication

Gene expression databases

BgeeiENSG00000108389
CleanExiHS_MTMR4
ExpressionAtlasiQ9NYA4 baseline and differential
GenevisibleiQ9NYA4 HS

Interactioni

Binary interactionsi

Show more details

GO - Molecular functioni

  • protein phosphatase binding Source: UniProtKB

Protein-protein interaction databases

BioGridi114560, 45 interactors
IntActiQ9NYA4, 4 interactors
MINTiQ9NYA4
STRINGi9606.ENSP00000325285

Structurei

3D structure databases

ProteinModelPortaliQ9NYA4
SMRiQ9NYA4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini153 – 570Myotubularin phosphatasePROSITE-ProRule annotationAdd BLAST418

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni320 – 323Substrate bindingBy similarity4
Regioni345 – 346Substrate bindingBy similarity2
Regioni407 – 413Substrate bindingBy similarity7

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili1023 – 1055Sequence analysisAdd BLAST33

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri1114 – 1174FYVE-typePROSITE-ProRule annotationAdd BLAST61

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

eggNOGiENOG410INM5 Eukaryota
ENOG410XPYG LUCA
GeneTreeiENSGT00760000118832
HOGENOMiHOG000004861
HOVERGENiHBG052526
InParanoidiQ9NYA4
KOiK18082
OMAiSNGHCTG
OrthoDBiEOG091G0TBM
PhylomeDBiQ9NYA4
TreeFamiTF315197

Family and domain databases

CDDicd13342 PH-GRAM_MTMR4, 1 hit
Gene3Di3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR030590 MTMR4
IPR035997 MTMR4_PH-GRAM
IPR010569 Myotubularin-like_Pase_dom
IPR030564 Myotubularin_fam
IPR029021 Prot-tyrosine_phosphatase-like
IPR016130 Tyr_Pase_AS
IPR000387 TYR_PHOSPHATASE_dom
IPR000306 Znf_FYVE
IPR017455 Znf_FYVE-rel
IPR011011 Znf_FYVE_PHD
IPR013083 Znf_RING/FYVE/PHD
PANTHERiPTHR10807 PTHR10807, 1 hit
PTHR10807:SF64 PTHR10807:SF64, 1 hit
PfamiView protein in Pfam
PF01363 FYVE, 1 hit
PF06602 Myotub-related, 1 hit
SMARTiView protein in SMART
SM00064 FYVE, 1 hit
SUPFAMiSSF52799 SSF52799, 2 hits
SSF57903 SSF57903, 1 hit
PROSITEiView protein in PROSITE
PS51339 PPASE_MYOTUBULARIN, 1 hit
PS00383 TYR_PHOSPHATASE_1, 1 hit
PS50056 TYR_PHOSPHATASE_2, 1 hit
PS50178 ZF_FYVE, 1 hit

Sequencei

Sequence statusi: Complete.

Q9NYA4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGEEGPPSLE YIQAKDLFPP KELVKEEENL QVPFTVLQGE GVEFLGRAAD
60 70 80 90 100
ALIAISNYRL HIKFKDSVIN VPLRMIDSVE SRDMFQLHIS CKDSKVVRCH
110 120 130 140 150
FSTFKQCQEW LSRLSRATAR PAKPEDLFAF AYHAWCLGLT EEDQHTHLCQ
160 170 180 190 200
PGEHIRCRQE AELARMGFDL QNVWRVSHIN SNYKLCPSYP QKLLVPVWIT
210 220 230 240 250
DKELENVASF RSWKRIPVVV YRHLRNGAAI ARCSQPEISW WGWRNADDEY
260 270 280 290 300
LVTSIAKACA LDPGTRATGG SLSTGNNDTS EACDADFDSS LTACSGVEST
310 320 330 340 350
AAPQKLLILD ARSYTAAVAN RAKGGGCECE EYYPNCEVVF MGMANIHAIR
360 370 380 390 400
NSFQYLRAVC SQMPDPSNWL SALESTKWLQ HLSVMLKAAV LVANTVDREG
410 420 430 440 450
RPVLVHCSDG WDRTPQIVAL AKILLDPYYR TLEGFQVLVE SDWLDFGHKF
460 470 480 490 500
GDRCGHQENV EDQNEQCPVF LQWLDSVHQL LKQFPCLFEF NEAFLVKLVQ
510 520 530 540 550
HTYSCLYGTF LANNPCEREK RNIYKRTCSV WALLRAGNKN FHNFLYTPSS
560 570 580 590 600
DMVLHPVCHV RALHLWTAVY LPASSPCTLG EENMDLYLSP VAQSQEFSGR
610 620 630 640 650
SLDRLPKTRS MDDLLSACDT SSPLTRTSSD PNLNNHCQEV RVGLEPWHSN
660 670 680 690 700
PEGSETSFVD SGVGGPQQTV GEVGLPPPLP SSQKDYLSNK PFKSHKSCSP
710 720 730 740 750
SYKLLNTAVP REMKSNTSDP EIKVLEETKG PAPDPSAQDE LGRTLDGIGE
760 770 780 790 800
PPEHCPETEA VSALSKVISN KCDGVCNFPE SSQNSPTGTP QQAQPDSMLG
810 820 830 840 850
VPSKCVLDHS LSTVCNPPSA ACQTPLDPST DFLNQDPSGS VASISHQEQL
860 870 880 890 900
SSVPDLTHGE EDIGKRGNNR NGQLLENPRF GKMPLELVRK PISQSQISEF
910 920 930 940 950
SFLGSNWDSF QGMVTSFPSG EATPRRLLSY GCCSKRPNSK QMRATGPCFG
960 970 980 990 1000
GQWAQREGVK SPVCSSHSNG HCTGPGGKNQ MWLSSHPKQV SSTKPVPLNC
1010 1020 1030 1040 1050
PSPVPPLYLD DDGLPFPTDV IQHRLRQIEA GYKQEVEQLR RQVRELQMRL
1060 1070 1080 1090 1100
DIRHCCAPPA EPPMDYEDDF TCLKESDGSD TEDFGSDHSE DCLSEASWEP
1110 1120 1130 1140 1150
VDKKETEVTR WVPDHMASHC YNCDCEFWLA KRRHHCRNCG NVFCAGCCHL
1160 1170 1180 1190
KLPIPDQQLY DPVLVCNSCY EHIQVSRARE LMSQQLKKPI ATASS
Length:1,195
Mass (Da):133,353
Last modified:May 18, 2010 - v2
Checksum:i936EC3F69335CEB4
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_035110170L → V2 PublicationsCorresponds to variant dbSNP:rs3744108Ensembl.1
Natural variantiVAR_035111280S → G1 PublicationCorresponds to variant dbSNP:rs2302190Ensembl.1
Natural variantiVAR_035112297V → G. Corresponds to variant dbSNP:rs2302189Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF264717 mRNA Translation: AAF72539.1
AB014547 mRNA Translation: BAA31622.2
AC005666 Genomic DNA No translation available.
CH471109 Genomic DNA Translation: EAW94454.1
CH471109 Genomic DNA Translation: EAW94455.1
BC035609 mRNA Translation: AAH35609.1
CCDSiCCDS11608.1
PIRiT00375
RefSeqiNP_004678.3, NM_004687.4
XP_005257843.1, XM_005257786.4
XP_006722231.1, XM_006722168.3
UniGeneiHs.514373

Genome annotation databases

EnsembliENST00000323456; ENSP00000325285; ENSG00000108389
GeneIDi9110
KEGGihsa:9110
UCSCiuc002iwj.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiMTMR4_HUMAN
AccessioniPrimary (citable) accession number: Q9NYA4
Secondary accession number(s): D3DTZ6, Q8IV27, Q9Y4D5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: May 18, 2010
Last modified: May 23, 2018
This is version 131 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

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