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Q9NYA4 (MTMR4_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 99. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Myotubularin-related protein 4

EC=3.1.3.48
Alternative name(s):
FYVE domain-containing dual specificity protein phosphatase 2
Short name=FYVE-DSP2
Zinc finger FYVE domain-containing protein 11
Gene names
Name:MTMR4
Synonyms:KIAA0647, ZFYVE11
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length1195 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Dephosphorylates proteins phosphorylated on Ser, Thr, and Tyr residues and low molecular weight phosphatase substrate para-nitrophenylphosphate. Phosphorylates phosphatidylinositol 3,4,5-trisphosphate (PIP3). Ref.1

Catalytic activity

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

Subcellular location

Cytoplasm. Membrane; Peripheral membrane protein. Note: Localized to perinuclear region. Ref.1

Tissue specificity

Expressed in brain, heart, kidney, spleen, liver, colon, testis, muscle, placenta, thyroid gland, pancreas, ovary, prostate, skin, peripheral blood, and bone marrow. Ref.1

Developmental stage

Expressed in fetal brain and fetal liver. Ref.1

Sequence similarities

Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.

Contains 1 FYVE-type zinc finger.

Contains 1 myotubularin phosphatase domain.

Ontologies

Keywords
   Cellular componentCytoplasm
Membrane
   Coding sequence diversityPolymorphism
   DomainCoiled coil
Zinc-finger
   LigandMetal-binding
Zinc
   Molecular functionHydrolase
Protein phosphatase
   PTMPhosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processnegative regulation of transforming growth factor beta receptor signaling pathway

Traceable author statement. Source: Reactome

peptidyl-tyrosine dephosphorylation

Traceable author statement PubMed 9736772. Source: GOC

phosphatidylinositol biosynthetic process

Traceable author statement. Source: Reactome

phospholipid metabolic process

Traceable author statement. Source: Reactome

protein dephosphorylation

Traceable author statement PubMed 9736772. Source: ProtInc

response to denervation involved in regulation of muscle adaptation

Inferred from electronic annotation. Source: Ensembl

small molecule metabolic process

Traceable author statement. Source: Reactome

transforming growth factor beta receptor signaling pathway

Traceable author statement. Source: Reactome

   Cellular_componentcytosol

Traceable author statement. Source: Reactome

early endosome membrane

Traceable author statement. Source: Reactome

extracellular space

Inferred from direct assay PubMed 22664934. Source: UniProt

   Molecular_functionmetal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

protein binding

Inferred from physical interaction PubMed 20061380. Source: IntAct

protein serine/threonine phosphatase activity

Traceable author statement. Source: Reactome

protein tyrosine phosphatase activity

Traceable author statement PubMed 9736772. Source: ProtInc

Complete GO annotation...

Binary interactions

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 11951195Myotubularin-related protein 4
PRO_0000304809

Regions

Domain153 – 570418Myotubularin phosphatase
Zinc finger1114 – 117461FYVE-type
Region320 – 3234Substrate binding By similarity
Region345 – 3462Substrate binding By similarity
Region407 – 4137Substrate binding By similarity
Coiled coil1023 – 105533 Potential

Sites

Active site4071Phosphocysteine intermediate By similarity
Binding site4531Substrate By similarity

Amino acid modifications

Modified residue6101Phosphoserine By similarity

Natural variations

Natural variant1701L → V. Ref.1 Ref.2
Corresponds to variant rs3744108 [ dbSNP | Ensembl ].
VAR_035110
Natural variant2801S → G. Ref.6
Corresponds to variant rs2302190 [ dbSNP | Ensembl ].
VAR_035111
Natural variant2971V → G.
Corresponds to variant rs2302189 [ dbSNP | Ensembl ].
VAR_035112

Sequences

Sequence LengthMass (Da)Tools
Q9NYA4 [UniParc].

Last modified May 18, 2010. Version 2.
Checksum: 936EC3F69335CEB4

FASTA1,195133,353
        10         20         30         40         50         60 
MGEEGPPSLE YIQAKDLFPP KELVKEEENL QVPFTVLQGE GVEFLGRAAD ALIAISNYRL 

        70         80         90        100        110        120 
HIKFKDSVIN VPLRMIDSVE SRDMFQLHIS CKDSKVVRCH FSTFKQCQEW LSRLSRATAR 

       130        140        150        160        170        180 
PAKPEDLFAF AYHAWCLGLT EEDQHTHLCQ PGEHIRCRQE AELARMGFDL QNVWRVSHIN 

       190        200        210        220        230        240 
SNYKLCPSYP QKLLVPVWIT DKELENVASF RSWKRIPVVV YRHLRNGAAI ARCSQPEISW 

       250        260        270        280        290        300 
WGWRNADDEY LVTSIAKACA LDPGTRATGG SLSTGNNDTS EACDADFDSS LTACSGVEST 

       310        320        330        340        350        360 
AAPQKLLILD ARSYTAAVAN RAKGGGCECE EYYPNCEVVF MGMANIHAIR NSFQYLRAVC 

       370        380        390        400        410        420 
SQMPDPSNWL SALESTKWLQ HLSVMLKAAV LVANTVDREG RPVLVHCSDG WDRTPQIVAL 

       430        440        450        460        470        480 
AKILLDPYYR TLEGFQVLVE SDWLDFGHKF GDRCGHQENV EDQNEQCPVF LQWLDSVHQL 

       490        500        510        520        530        540 
LKQFPCLFEF NEAFLVKLVQ HTYSCLYGTF LANNPCEREK RNIYKRTCSV WALLRAGNKN 

       550        560        570        580        590        600 
FHNFLYTPSS DMVLHPVCHV RALHLWTAVY LPASSPCTLG EENMDLYLSP VAQSQEFSGR 

       610        620        630        640        650        660 
SLDRLPKTRS MDDLLSACDT SSPLTRTSSD PNLNNHCQEV RVGLEPWHSN PEGSETSFVD 

       670        680        690        700        710        720 
SGVGGPQQTV GEVGLPPPLP SSQKDYLSNK PFKSHKSCSP SYKLLNTAVP REMKSNTSDP 

       730        740        750        760        770        780 
EIKVLEETKG PAPDPSAQDE LGRTLDGIGE PPEHCPETEA VSALSKVISN KCDGVCNFPE 

       790        800        810        820        830        840 
SSQNSPTGTP QQAQPDSMLG VPSKCVLDHS LSTVCNPPSA ACQTPLDPST DFLNQDPSGS 

       850        860        870        880        890        900 
VASISHQEQL SSVPDLTHGE EDIGKRGNNR NGQLLENPRF GKMPLELVRK PISQSQISEF 

       910        920        930        940        950        960 
SFLGSNWDSF QGMVTSFPSG EATPRRLLSY GCCSKRPNSK QMRATGPCFG GQWAQREGVK 

       970        980        990       1000       1010       1020 
SPVCSSHSNG HCTGPGGKNQ MWLSSHPKQV SSTKPVPLNC PSPVPPLYLD DDGLPFPTDV 

      1030       1040       1050       1060       1070       1080 
IQHRLRQIEA GYKQEVEQLR RQVRELQMRL DIRHCCAPPA EPPMDYEDDF TCLKESDGSD 

      1090       1100       1110       1120       1130       1140 
TEDFGSDHSE DCLSEASWEP VDKKETEVTR WVPDHMASHC YNCDCEFWLA KRRHHCRNCG 

      1150       1160       1170       1180       1190 
NVFCAGCCHL KLPIPDQQLY DPVLVCNSCY EHIQVSRARE LMSQQLKKPI ATASS 

« Hide

References

« Hide 'large scale' references
[1]"FYVE-DSP2, a FYVE domain-containing dual specificity protein phosphatase that dephosphorylates phosphatidylinositol 3-phosphate."
Zhao R., Qi Y., Chen J., Zhao Z.J.
Exp. Cell Res. 265:329-338(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, VARIANT VAL-170.
[2]"Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro."
Ishikawa K., Nagase T., Suyama M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
DNA Res. 5:169-176(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT VAL-170.
Tissue: Brain.
[3]"Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."
Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T.
DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: SEQUENCE REVISION.
[4]"DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L. expand/collapse author list , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT GLY-280.
Tissue: Lung.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF264717 mRNA. Translation: AAF72539.1.
AB014547 mRNA. Translation: BAA31622.2.
AC005666 Genomic DNA. No translation available.
CH471109 Genomic DNA. Translation: EAW94454.1.
CH471109 Genomic DNA. Translation: EAW94455.1.
BC035609 mRNA. Translation: AAH35609.1.
CCDSCCDS11608.1.
PIRT00375.
RefSeqNP_004678.3. NM_004687.4.
XP_005257843.1. XM_005257786.2.
XP_006722231.1. XM_006722168.1.
UniGeneHs.514373.

3D structure databases

ProteinModelPortalQ9NYA4.
SMRQ9NYA4. Positions 48-571, 1111-1173.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid114560. 4 interactions.
IntActQ9NYA4. 3 interactions.
MINTMINT-1193708.
STRING9606.ENSP00000325285.

PTM databases

PhosphoSiteQ9NYA4.

Polymorphism databases

DMDM296438298.

Proteomic databases

MaxQBQ9NYA4.
PaxDbQ9NYA4.
PRIDEQ9NYA4.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000323456; ENSP00000325285; ENSG00000108389.
GeneID9110.
KEGGhsa:9110.
UCSCuc002iwj.2. human.

Organism-specific databases

CTD9110.
GeneCardsGC17M056566.
H-InvDBHIX0202387.
HGNCHGNC:7452. MTMR4.
HPAHPA043852.
MIM603559. gene.
neXtProtNX_Q9NYA4.
PharmGKBPA31255.
HUGESearch...
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG322789.
HOGENOMHOG000004861.
HOVERGENHBG052526.
InParanoidQ9NYA4.
KOK18082.
OMAGHCTGPG.
OrthoDBEOG7PVWNJ.
PhylomeDBQ9NYA4.
TreeFamTF315197.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.
REACT_111217. Metabolism.
REACT_116125. Disease.
SignaLinkQ9NYA4.

Gene expression databases

ArrayExpressQ9NYA4.
BgeeQ9NYA4.
CleanExHS_MTMR4.
GenevestigatorQ9NYA4.

Family and domain databases

Gene3D3.30.40.10. 1 hit.
InterProIPR010569. Myotubularin-like_Pase_dom.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
IPR000306. Znf_FYVE.
IPR017455. Znf_FYVE-rel.
IPR011011. Znf_FYVE_PHD.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamPF01363. FYVE. 1 hit.
PF06602. Myotub-related. 1 hit.
[Graphical view]
SMARTSM00064. FYVE. 1 hit.
[Graphical view]
SUPFAMSSF52799. SSF52799. 2 hits.
SSF57903. SSF57903. 1 hit.
PROSITEPS51339. PPASE_MYOTUBULARIN. 1 hit.
PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50178. ZF_FYVE. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSMTMR4. human.
GenomeRNAi9110.
NextBio34145.
PROQ9NYA4.
SOURCESearch...

Entry information

Entry nameMTMR4_HUMAN
AccessionPrimary (citable) accession number: Q9NYA4
Secondary accession number(s): D3DTZ6, Q8IV27, Q9Y4D5
Entry history
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: May 18, 2010
Last modified: July 9, 2014
This is version 99 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 17

Human chromosome 17: entries, gene names and cross-references to MIM