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Q9NYA4

- MTMR4_HUMAN

UniProt

Q9NYA4 - MTMR4_HUMAN

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Protein

Myotubularin-related protein 4

Gene

MTMR4

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Dephosphorylates proteins phosphorylated on Ser, Thr, and Tyr residues and low molecular weight phosphatase substrate para-nitrophenylphosphate. Phosphorylates phosphatidylinositol 3,4,5-trisphosphate (PIP3).1 Publication

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei407 – 4071Phosphocysteine intermediatePROSITE-ProRule annotation
Binding sitei453 – 4531SubstrateBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri1114 – 117461FYVE-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. protein serine/threonine phosphatase activity Source: Reactome
  3. protein tyrosine phosphatase activity Source: ProtInc

GO - Biological processi

  1. negative regulation of transforming growth factor beta receptor signaling pathway Source: Reactome
  2. peptidyl-tyrosine dephosphorylation Source: GOC
  3. phosphatidylinositol biosynthetic process Source: Reactome
  4. phospholipid metabolic process Source: Reactome
  5. protein dephosphorylation Source: ProtInc
  6. response to denervation involved in regulation of muscle adaptation Source: Ensembl
  7. small molecule metabolic process Source: Reactome
  8. transforming growth factor beta receptor signaling pathway Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiREACT_120727. Downregulation of TGF-beta receptor signaling.
REACT_120756. Synthesis of PIPs at the early endosome membrane.
REACT_120918. Synthesis of PIPs at the late endosome membrane.
SignaLinkiQ9NYA4.

Names & Taxonomyi

Protein namesi
Recommended name:
Myotubularin-related protein 4 (EC:3.1.3.48)
Alternative name(s):
FYVE domain-containing dual specificity protein phosphatase 2
Short name:
FYVE-DSP2
Zinc finger FYVE domain-containing protein 11
Gene namesi
Name:MTMR4
Synonyms:KIAA0647, ZFYVE11
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 17

Organism-specific databases

HGNCiHGNC:7452. MTMR4.

Subcellular locationi

Cytoplasm 1 Publication. Membrane 1 Publication; Peripheral membrane protein 1 Publication
Note: Localized to perinuclear region.

GO - Cellular componenti

  1. cytosol Source: Reactome
  2. early endosome membrane Source: Reactome
  3. extracellular space Source: UniProt
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA31255.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 11951195Myotubularin-related protein 4PRO_0000304809Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei610 – 6101PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9NYA4.
PaxDbiQ9NYA4.
PRIDEiQ9NYA4.

PTM databases

PhosphoSiteiQ9NYA4.

Expressioni

Tissue specificityi

Expressed in brain, heart, kidney, spleen, liver, colon, testis, muscle, placenta, thyroid gland, pancreas, ovary, prostate, skin, peripheral blood, and bone marrow.1 Publication

Developmental stagei

Expressed in fetal brain and fetal liver.1 Publication

Gene expression databases

BgeeiQ9NYA4.
CleanExiHS_MTMR4.
ExpressionAtlasiQ9NYA4. baseline and differential.
GenevestigatoriQ9NYA4.

Organism-specific databases

HPAiHPA043852.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
SMAD2Q157963EBI-1052346,EBI-1040141
SMAD3P840224EBI-1052346,EBI-347161

Protein-protein interaction databases

BioGridi114560. 5 interactions.
IntActiQ9NYA4. 3 interactions.
MINTiMINT-1193708.
STRINGi9606.ENSP00000325285.

Structurei

3D structure databases

ProteinModelPortaliQ9NYA4.
SMRiQ9NYA4. Positions 48-571, 1111-1173.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini153 – 570418Myotubularin phosphatasePROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni320 – 3234Substrate bindingBy similarity
Regioni345 – 3462Substrate bindingBy similarity
Regioni407 – 4137Substrate bindingBy similarity

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili1023 – 105533Sequence AnalysisAdd
BLAST

Sequence similaritiesi

Contains 1 FYVE-type zinc finger.PROSITE-ProRule annotation
Contains 1 myotubularin phosphatase domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri1114 – 117461FYVE-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

eggNOGiNOG322789.
GeneTreeiENSGT00760000118832.
HOGENOMiHOG000004861.
HOVERGENiHBG052526.
InParanoidiQ9NYA4.
KOiK18082.
OMAiGHCTGPG.
OrthoDBiEOG7PVWNJ.
PhylomeDBiQ9NYA4.
TreeFamiTF315197.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiIPR010569. Myotubularin-like_Pase_dom.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
IPR000306. Znf_FYVE.
IPR017455. Znf_FYVE-rel.
IPR011011. Znf_FYVE_PHD.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamiPF01363. FYVE. 1 hit.
PF06602. Myotub-related. 1 hit.
[Graphical view]
SMARTiSM00064. FYVE. 1 hit.
[Graphical view]
SUPFAMiSSF52799. SSF52799. 2 hits.
SSF57903. SSF57903. 1 hit.
PROSITEiPS51339. PPASE_MYOTUBULARIN. 1 hit.
PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50178. ZF_FYVE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9NYA4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGEEGPPSLE YIQAKDLFPP KELVKEEENL QVPFTVLQGE GVEFLGRAAD
60 70 80 90 100
ALIAISNYRL HIKFKDSVIN VPLRMIDSVE SRDMFQLHIS CKDSKVVRCH
110 120 130 140 150
FSTFKQCQEW LSRLSRATAR PAKPEDLFAF AYHAWCLGLT EEDQHTHLCQ
160 170 180 190 200
PGEHIRCRQE AELARMGFDL QNVWRVSHIN SNYKLCPSYP QKLLVPVWIT
210 220 230 240 250
DKELENVASF RSWKRIPVVV YRHLRNGAAI ARCSQPEISW WGWRNADDEY
260 270 280 290 300
LVTSIAKACA LDPGTRATGG SLSTGNNDTS EACDADFDSS LTACSGVEST
310 320 330 340 350
AAPQKLLILD ARSYTAAVAN RAKGGGCECE EYYPNCEVVF MGMANIHAIR
360 370 380 390 400
NSFQYLRAVC SQMPDPSNWL SALESTKWLQ HLSVMLKAAV LVANTVDREG
410 420 430 440 450
RPVLVHCSDG WDRTPQIVAL AKILLDPYYR TLEGFQVLVE SDWLDFGHKF
460 470 480 490 500
GDRCGHQENV EDQNEQCPVF LQWLDSVHQL LKQFPCLFEF NEAFLVKLVQ
510 520 530 540 550
HTYSCLYGTF LANNPCEREK RNIYKRTCSV WALLRAGNKN FHNFLYTPSS
560 570 580 590 600
DMVLHPVCHV RALHLWTAVY LPASSPCTLG EENMDLYLSP VAQSQEFSGR
610 620 630 640 650
SLDRLPKTRS MDDLLSACDT SSPLTRTSSD PNLNNHCQEV RVGLEPWHSN
660 670 680 690 700
PEGSETSFVD SGVGGPQQTV GEVGLPPPLP SSQKDYLSNK PFKSHKSCSP
710 720 730 740 750
SYKLLNTAVP REMKSNTSDP EIKVLEETKG PAPDPSAQDE LGRTLDGIGE
760 770 780 790 800
PPEHCPETEA VSALSKVISN KCDGVCNFPE SSQNSPTGTP QQAQPDSMLG
810 820 830 840 850
VPSKCVLDHS LSTVCNPPSA ACQTPLDPST DFLNQDPSGS VASISHQEQL
860 870 880 890 900
SSVPDLTHGE EDIGKRGNNR NGQLLENPRF GKMPLELVRK PISQSQISEF
910 920 930 940 950
SFLGSNWDSF QGMVTSFPSG EATPRRLLSY GCCSKRPNSK QMRATGPCFG
960 970 980 990 1000
GQWAQREGVK SPVCSSHSNG HCTGPGGKNQ MWLSSHPKQV SSTKPVPLNC
1010 1020 1030 1040 1050
PSPVPPLYLD DDGLPFPTDV IQHRLRQIEA GYKQEVEQLR RQVRELQMRL
1060 1070 1080 1090 1100
DIRHCCAPPA EPPMDYEDDF TCLKESDGSD TEDFGSDHSE DCLSEASWEP
1110 1120 1130 1140 1150
VDKKETEVTR WVPDHMASHC YNCDCEFWLA KRRHHCRNCG NVFCAGCCHL
1160 1170 1180 1190
KLPIPDQQLY DPVLVCNSCY EHIQVSRARE LMSQQLKKPI ATASS
Length:1,195
Mass (Da):133,353
Last modified:May 18, 2010 - v2
Checksum:i936EC3F69335CEB4
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti170 – 1701L → V.2 Publications
Corresponds to variant rs3744108 [ dbSNP | Ensembl ].
VAR_035110
Natural varianti280 – 2801S → G.1 Publication
Corresponds to variant rs2302190 [ dbSNP | Ensembl ].
VAR_035111
Natural varianti297 – 2971V → G.
Corresponds to variant rs2302189 [ dbSNP | Ensembl ].
VAR_035112

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF264717 mRNA. Translation: AAF72539.1.
AB014547 mRNA. Translation: BAA31622.2.
AC005666 Genomic DNA. No translation available.
CH471109 Genomic DNA. Translation: EAW94454.1.
CH471109 Genomic DNA. Translation: EAW94455.1.
BC035609 mRNA. Translation: AAH35609.1.
CCDSiCCDS11608.1.
PIRiT00375.
RefSeqiNP_004678.3. NM_004687.4.
XP_005257843.1. XM_005257786.2.
XP_006722231.1. XM_006722168.1.
UniGeneiHs.514373.

Genome annotation databases

EnsembliENST00000323456; ENSP00000325285; ENSG00000108389.
GeneIDi9110.
KEGGihsa:9110.
UCSCiuc002iwj.2. human.

Polymorphism databases

DMDMi296438298.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF264717 mRNA. Translation: AAF72539.1 .
AB014547 mRNA. Translation: BAA31622.2 .
AC005666 Genomic DNA. No translation available.
CH471109 Genomic DNA. Translation: EAW94454.1 .
CH471109 Genomic DNA. Translation: EAW94455.1 .
BC035609 mRNA. Translation: AAH35609.1 .
CCDSi CCDS11608.1.
PIRi T00375.
RefSeqi NP_004678.3. NM_004687.4.
XP_005257843.1. XM_005257786.2.
XP_006722231.1. XM_006722168.1.
UniGenei Hs.514373.

3D structure databases

ProteinModelPortali Q9NYA4.
SMRi Q9NYA4. Positions 48-571, 1111-1173.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 114560. 5 interactions.
IntActi Q9NYA4. 3 interactions.
MINTi MINT-1193708.
STRINGi 9606.ENSP00000325285.

PTM databases

PhosphoSitei Q9NYA4.

Polymorphism databases

DMDMi 296438298.

Proteomic databases

MaxQBi Q9NYA4.
PaxDbi Q9NYA4.
PRIDEi Q9NYA4.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000323456 ; ENSP00000325285 ; ENSG00000108389 .
GeneIDi 9110.
KEGGi hsa:9110.
UCSCi uc002iwj.2. human.

Organism-specific databases

CTDi 9110.
GeneCardsi GC17M056566.
H-InvDB HIX0202387.
HGNCi HGNC:7452. MTMR4.
HPAi HPA043852.
MIMi 603559. gene.
neXtProti NX_Q9NYA4.
PharmGKBi PA31255.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG322789.
GeneTreei ENSGT00760000118832.
HOGENOMi HOG000004861.
HOVERGENi HBG052526.
InParanoidi Q9NYA4.
KOi K18082.
OMAi GHCTGPG.
OrthoDBi EOG7PVWNJ.
PhylomeDBi Q9NYA4.
TreeFami TF315197.

Enzyme and pathway databases

Reactomei REACT_120727. Downregulation of TGF-beta receptor signaling.
REACT_120756. Synthesis of PIPs at the early endosome membrane.
REACT_120918. Synthesis of PIPs at the late endosome membrane.
SignaLinki Q9NYA4.

Miscellaneous databases

ChiTaRSi MTMR4. human.
GenomeRNAii 9110.
NextBioi 34145.
PROi Q9NYA4.
SOURCEi Search...

Gene expression databases

Bgeei Q9NYA4.
CleanExi HS_MTMR4.
ExpressionAtlasi Q9NYA4. baseline and differential.
Genevestigatori Q9NYA4.

Family and domain databases

Gene3Di 3.30.40.10. 1 hit.
InterProi IPR010569. Myotubularin-like_Pase_dom.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
IPR000306. Znf_FYVE.
IPR017455. Znf_FYVE-rel.
IPR011011. Znf_FYVE_PHD.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view ]
Pfami PF01363. FYVE. 1 hit.
PF06602. Myotub-related. 1 hit.
[Graphical view ]
SMARTi SM00064. FYVE. 1 hit.
[Graphical view ]
SUPFAMi SSF52799. SSF52799. 2 hits.
SSF57903. SSF57903. 1 hit.
PROSITEi PS51339. PPASE_MYOTUBULARIN. 1 hit.
PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50178. ZF_FYVE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "FYVE-DSP2, a FYVE domain-containing dual specificity protein phosphatase that dephosphorylates phosphatidylinositol 3-phosphate."
    Zhao R., Qi Y., Chen J., Zhao Z.J.
    Exp. Cell Res. 265:329-338(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, VARIANT VAL-170.
  2. "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro."
    Ishikawa K., Nagase T., Suyama M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
    DNA Res. 5:169-176(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT VAL-170.
    Tissue: Brain.
  3. "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."
    Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T.
    DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: SEQUENCE REVISION.
  4. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
    Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L.
    , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
    Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT GLY-280.
    Tissue: Lung.

Entry informationi

Entry nameiMTMR4_HUMAN
AccessioniPrimary (citable) accession number: Q9NYA4
Secondary accession number(s): D3DTZ6, Q8IV27, Q9Y4D5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: May 18, 2010
Last modified: October 29, 2014
This is version 102 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3