ID GOG6A_HUMAN Reviewed; 693 AA. AC Q9NYA3; A8K959; Q9NYA7; DT 03-JUL-2003, integrated into UniProtKB/Swiss-Prot. DT 25-NOV-2008, sequence version 3. DT 24-JAN-2024, entry version 151. DE RecName: Full=Golgin subfamily A member 6A; DE AltName: Full=Golgin linked to PML; DE AltName: Full=Golgin-like protein; GN Name=GOLGA6A; Synonyms=GLP, GOLGA6; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], AND VARIANT ARG-200. RC TISSUE=Testis; RX PubMed=11161787; DOI=10.1006/geno.2000.6388; RA Gilles F., Goy A., Remache Y., Manova K., Zelenetz A.D.; RT "Cloning and characterization of a golgin-related gene from the large-scale RT polymorphism linked to the PML gene."; RL Genomics 70:364-374(2000). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=Testis; RX PubMed=14702039; DOI=10.1038/ng1285; RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., RA Isogai T., Sugano S.; RT "Complete sequencing and characterization of 21,243 full-length human RT cDNAs."; RL Nat. Genet. 36:40-45(2004). RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=16572171; DOI=10.1038/nature04601; RA Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K., RA Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K., RA FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N., RA Abouelleil A., Arachchi H.M., Baradarani L., Birditt B., Bloom S., RA Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K., RA DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R., Fahey J., RA Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G., Johnson E., RA Jones C., Kamat A., Kaur A., Locke D.P., Madan A., Munson G., Jaffe D.B., RA Lui A., Macdonald P., Mauceli E., Naylor J.W., Nesbitt R., Nicol R., RA O'Leary S.B., Ratcliffe A., Rounsley S., She X., Sneddon K.M.B., RA Stewart S., Sougnez C., Stone S.M., Topham K., Vincent D., Wang S., RA Zimmer A.R., Birren B.W., Hood L., Lander E.S., Nusbaum C.; RT "Analysis of the DNA sequence and duplication history of human chromosome RT 15."; RL Nature 440:671-675(2006). CC -!- INTERACTION: CC Q9NYA3; Q9NX04: AIRIM; NbExp=3; IntAct=EBI-11163335, EBI-8643161; CC Q9NYA3; Q9BRR9: ARHGAP9; NbExp=3; IntAct=EBI-11163335, EBI-750254; CC Q9NYA3; Q9UL15: BAG5; NbExp=3; IntAct=EBI-11163335, EBI-356517; CC Q9NYA3; Q8NA61-2: CBY2; NbExp=3; IntAct=EBI-11163335, EBI-11524851; CC Q9NYA3; O00311: CDC7; NbExp=3; IntAct=EBI-11163335, EBI-374980; CC Q9NYA3; Q9H4E7: DEF6; NbExp=3; IntAct=EBI-11163335, EBI-745369; CC Q9NYA3; Q68J44: DUSP29; NbExp=3; IntAct=EBI-11163335, EBI-1054321; CC Q9NYA3; Q14241: ELOA; NbExp=3; IntAct=EBI-11163335, EBI-742350; CC Q9NYA3; Q9H0I2: ENKD1; NbExp=3; IntAct=EBI-11163335, EBI-744099; CC Q9NYA3; Q96MY7: FAM161B; NbExp=3; IntAct=EBI-11163335, EBI-7225287; CC Q9NYA3; Q14192: FHL2; NbExp=3; IntAct=EBI-11163335, EBI-701903; CC Q9NYA3; Q8TAE8: GADD45GIP1; NbExp=3; IntAct=EBI-11163335, EBI-372506; CC Q9NYA3; P09067: HOXB5; NbExp=3; IntAct=EBI-11163335, EBI-3893317; CC Q9NYA3; Q9UKT9: IKZF3; NbExp=3; IntAct=EBI-11163335, EBI-747204; CC Q9NYA3; Q63ZY3: KANK2; NbExp=3; IntAct=EBI-11163335, EBI-2556193; CC Q9NYA3; Q7L273: KCTD9; NbExp=3; IntAct=EBI-11163335, EBI-4397613; CC Q9NYA3; O60341: KDM1A; NbExp=3; IntAct=EBI-11163335, EBI-710124; CC Q9NYA3; Q9HAQ2: KIF9; NbExp=5; IntAct=EBI-11163335, EBI-8472129; CC Q9NYA3; Q2WGJ6: KLHL38; NbExp=3; IntAct=EBI-11163335, EBI-6426443; CC Q9NYA3; P45984: MAPK9; NbExp=3; IntAct=EBI-11163335, EBI-713568; CC Q9NYA3; Q8IVT4: MGC50722; NbExp=3; IntAct=EBI-11163335, EBI-14086479; CC Q9NYA3; Q13064: MKRN3; NbExp=3; IntAct=EBI-11163335, EBI-2340269; CC Q9NYA3; Q9UBU8-2: MORF4L1; NbExp=3; IntAct=EBI-11163335, EBI-10288852; CC Q9NYA3; P00540: MOS; NbExp=3; IntAct=EBI-11163335, EBI-1757866; CC Q9NYA3; Q96DV4: MRPL38; NbExp=3; IntAct=EBI-11163335, EBI-720441; CC Q9NYA3; Q9NP98: MYOZ1; NbExp=3; IntAct=EBI-11163335, EBI-744402; CC Q9NYA3; Q8TDC0: MYOZ3; NbExp=3; IntAct=EBI-11163335, EBI-5662487; CC Q9NYA3; O76041: NEBL; NbExp=3; IntAct=EBI-11163335, EBI-2880203; CC Q9NYA3; O15160: POLR1C; NbExp=3; IntAct=EBI-11163335, EBI-1055079; CC Q9NYA3; P30153: PPP2R1A; NbExp=3; IntAct=EBI-11163335, EBI-302388; CC Q9NYA3; P54646: PRKAA2; NbExp=3; IntAct=EBI-11163335, EBI-1383852; CC Q9NYA3; P25786: PSMA1; NbExp=3; IntAct=EBI-11163335, EBI-359352; CC Q9NYA3; Q9H0A9-2: SPATC1L; NbExp=5; IntAct=EBI-11163335, EBI-11995806; CC Q9NYA3; Q9BSW7: SYT17; NbExp=5; IntAct=EBI-11163335, EBI-745392; CC Q9NYA3; Q9BUZ4: TRAF4; NbExp=3; IntAct=EBI-11163335, EBI-3650647; CC Q9NYA3; O75865-2: TRAPPC6A; NbExp=3; IntAct=EBI-11163335, EBI-8451480; CC Q9NYA3; Q3SY00: TSGA10IP; NbExp=3; IntAct=EBI-11163335, EBI-10241197; CC Q9NYA3; Q8N0Z6: TTC5; NbExp=3; IntAct=EBI-11163335, EBI-9526213; CC Q9NYA3; P40222: TXLNA; NbExp=3; IntAct=EBI-11163335, EBI-359793; CC Q9NYA3; Q9Y4E8-2: USP15; NbExp=3; IntAct=EBI-11163335, EBI-12041225; CC Q9NYA3; O75604: USP2; NbExp=3; IntAct=EBI-11163335, EBI-743272; CC Q9NYA3; Q5TAP6: UTP14C; NbExp=3; IntAct=EBI-11163335, EBI-11737646; CC Q9NYA3; Q9BW85: YJU2; NbExp=3; IntAct=EBI-11163335, EBI-10300345; CC Q9NYA3; Q53FD0-2: ZC2HC1C; NbExp=3; IntAct=EBI-11163335, EBI-14104088; CC -!- TISSUE SPECIFICITY: Highly expressed in seminiferous tubes in testis. CC Highly expressed in spermatids, barely detectable in late pachytene CC spermatocytes, and not detectable in spermatogonia. Detected at CC intermediate levels in pancreas and lymph nodes, and at much lower CC levels in spleen, peripheral blood leukocytes, skeletal muscle, liver, CC lung, placenta, brain and heart. CC -!- SIMILARITY: Belongs to the GOLGA6 family. {ECO:0000305}. CC -!- CAUTION: Maps to a duplicated region on chromosome 15; the gene is CC present in at least 4 almost identical copies. {ECO:0000305}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AF263742; AAF72196.1; -; mRNA. DR EMBL; AF266285; AAF72535.1; -; Genomic_DNA. DR EMBL; AK292574; BAF85263.1; -; mRNA. DR EMBL; AC013486; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR CCDS; CCDS32290.1; -. DR RefSeq; NP_001033729.2; NM_001038640.2. DR AlphaFoldDB; Q9NYA3; -. DR SMR; Q9NYA3; -. DR BioGRID; 131163; 59. DR IntAct; Q9NYA3; 46. DR STRING; 9606.ENSP00000290438; -. DR iPTMnet; Q9NYA3; -. DR PhosphoSitePlus; Q9NYA3; -. DR BioMuta; GOLGA6A; -. DR DMDM; 215274151; -. DR MassIVE; Q9NYA3; -. DR PaxDb; 9606-ENSP00000290438; -. DR PeptideAtlas; Q9NYA3; -. DR ProteomicsDB; 83204; -. DR Antibodypedia; 26853; 126 antibodies from 22 providers. DR DNASU; 342096; -. DR Ensembl; ENST00000290438.3; ENSP00000290438.3; ENSG00000159289.6. DR GeneID; 342096; -. DR KEGG; hsa:342096; -. DR MANE-Select; ENST00000290438.3; ENSP00000290438.3; NM_001038640.2; NP_001033729.2. DR UCSC; uc002axa.1; human. DR AGR; HGNC:13567; -. DR CTD; 342096; -. DR DisGeNET; 342096; -. DR GeneCards; GOLGA6A; -. DR HGNC; HGNC:13567; GOLGA6A. DR HPA; ENSG00000159289; Tissue enriched (testis). DR MIM; 610288; gene. DR neXtProt; NX_Q9NYA3; -. DR OpenTargets; ENSG00000159289; -. DR PharmGKB; PA38364; -. DR VEuPathDB; HostDB:ENSG00000159289; -. DR eggNOG; KOG4725; Eukaryota. DR GeneTree; ENSGT00530000062932; -. DR HOGENOM; CLU_012403_1_2_1; -. DR InParanoid; Q9NYA3; -. DR OMA; SVEACTL; -. DR OrthoDB; 4705695at2759; -. DR PhylomeDB; Q9NYA3; -. DR TreeFam; TF316990; -. DR PathwayCommons; Q9NYA3; -. DR SignaLink; Q9NYA3; -. DR BioGRID-ORCS; 342096; 589 hits in 1028 CRISPR screens. DR GenomeRNAi; 342096; -. DR Pharos; Q9NYA3; Tdark. DR PRO; PR:Q9NYA3; -. DR Proteomes; UP000005640; Chromosome 15. DR RNAct; Q9NYA3; Protein. DR Bgee; ENSG00000159289; Expressed in right testis and 99 other cell types or tissues. DR GO; GO:0005801; C:cis-Golgi network; IBA:GO_Central. DR GO; GO:0000137; C:Golgi cis cisterna; IBA:GO_Central. DR GO; GO:0032580; C:Golgi cisterna membrane; IBA:GO_Central. DR GO; GO:0007030; P:Golgi organization; IBA:GO_Central. DR InterPro; IPR043976; GOLGA_cons_dom. DR InterPro; IPR024858; Golgin_A. DR PANTHER; PTHR10881:SF44; GOLGIN SUBFAMILY A MEMBER 6A-RELATED; 1. DR PANTHER; PTHR10881; GOLGIN SUBFAMILY A MEMBER-RELATED; 1. DR Pfam; PF15070; GOLGA2L5; 3. DR Genevisible; Q9NYA3; HS. PE 1: Evidence at protein level; KW Coiled coil; Reference proteome. FT CHAIN 1..693 FT /note="Golgin subfamily A member 6A" FT /id="PRO_0000190069" FT REGION 20..69 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 497..547 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 661..693 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COILED 14..611 FT /evidence="ECO:0000255" FT COMPBIAS 20..34 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 504..547 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 675..693 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT VARIANT 200 FT /note="W -> R (in dbSNP:rs2018461)" FT /evidence="ECO:0000269|PubMed:11161787" FT /id="VAR_047540" FT CONFLICT 86 FT /note="S -> N (in Ref. 1; AAF72196)" FT /evidence="ECO:0000305" FT CONFLICT 123 FT /note="R -> Q (in Ref. 1; AAF72196)" FT /evidence="ECO:0000305" FT CONFLICT 134 FT /note="K -> E (in Ref. 2; BAF85263)" FT /evidence="ECO:0000305" FT CONFLICT 198 FT /note="Q -> H (in Ref. 1; AAF72535)" FT /evidence="ECO:0000305" FT CONFLICT 561..566 FT /note="VTDGMR -> LCPLTG (in Ref. 1; AAF72535)" FT /evidence="ECO:0000305" SQ SEQUENCE 693 AA; 79946 MW; D54FA366168C27B2 CRC64; MWPQPYLPPH PMMLEESRQN KLAAAKKKLK EYQQRKSPGI PAGAKTKKKK TDSSPETTTS GGCHSPGDSQ YQELAVALES SSVTISQLNE NIESLKQQKK QVEHQLEEAK KTNNEIHKAQ MERLETINIL TLEKADLKTT LYHTKRAARH FEEESKDLAG RLQYSLQRIQ ELERALCAVS TQQQEEDRSS SCREAVLQRW LQQTIKERAL LNAHVTQVTE SLKQVQLERD EYAKHIKGER ARWQERMWKM SVEARTLKEE KKRDIHRIQE LERSLSELKN QMAEPPSLAP PAVTSVVEQL QDEAKHLRQE VEGLEGKLQS QVENNQALSL LSKEQKQRLQ EQEEMLREQE AQRVREQERL CEQNERLREQ QKTLQEQGER LRKQEQRLRK QEERLRKEEE RLQKQEKRLW DQEERLWKKE ERLQKQEERL ALSQNHKLDK QLAEPQCSFE DLNNEKKSAL QLEQQVKELQ EKLDEEHLEA ASHQNQQLET QLSLVALPGE GDGGQHLDSE EEEAPRPTPN IPEDLESREA TSSFMDLPKE KADGTEQVER RELGFVQPSG VTDGMRESFT VYESQGAVPN TRHQEMEDVI RLAQKEEEMK VKLLELQELV LPLVGNHEGH GKFLIAAQNP ADEPTPGAPA PQELGAAGEQ DVFYEVSLDN NVEPAPGAAR EGSPHDNPTV QQIVQLSPVM QDT //