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Q9NYA3 (GOG6A_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 89. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Golgin subfamily A member 6A
Alternative name(s):
Golgin linked to PML
Golgin-like protein
Gene names
Name:GOLGA6A
Synonyms:GLP, GOLGA6
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length693 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Tissue specificity

Highly expressed in seminiferous tubes in testis. Highly expressed in spermatids, barely detectable in late pachytene spermatocytes, and not detectable in spermatogonia. Detected at intermediate levels in pancreas and lymph nodes, and at much lower levels in spleen, peripheral blood leukocytes, skeletal muscle, liver, lung, placenta, brain and heart.

Sequence similarities

Belongs to the GOLGA6 family.

Caution

Maps to a duplicated region on chromosome 15; the gene is present in at least 4 almost identical copies.

Ontologies

Keywords
   Coding sequence diversityPolymorphism
   DomainCoiled coil
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentGolgi apparatus

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 693693Golgin subfamily A member 6A
PRO_0000190069

Regions

Coiled coil14 – 611598 Potential

Natural variations

Natural variant2001W → R. Ref.1
Corresponds to variant rs2018461 [ dbSNP | Ensembl ].
VAR_047540

Experimental info

Sequence conflict861S → N in AAF72196. Ref.1
Sequence conflict1231R → Q in AAF72196. Ref.1
Sequence conflict1341K → E in BAF85263. Ref.2
Sequence conflict1981Q → H in AAF72535. Ref.1
Sequence conflict561 – 5666VTDGMR → LCPLTG in AAF72535. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q9NYA3 [UniParc].

Last modified November 25, 2008. Version 3.
Checksum: D54FA366168C27B2

FASTA69379,946
        10         20         30         40         50         60 
MWPQPYLPPH PMMLEESRQN KLAAAKKKLK EYQQRKSPGI PAGAKTKKKK TDSSPETTTS 

        70         80         90        100        110        120 
GGCHSPGDSQ YQELAVALES SSVTISQLNE NIESLKQQKK QVEHQLEEAK KTNNEIHKAQ 

       130        140        150        160        170        180 
MERLETINIL TLEKADLKTT LYHTKRAARH FEEESKDLAG RLQYSLQRIQ ELERALCAVS 

       190        200        210        220        230        240 
TQQQEEDRSS SCREAVLQRW LQQTIKERAL LNAHVTQVTE SLKQVQLERD EYAKHIKGER 

       250        260        270        280        290        300 
ARWQERMWKM SVEARTLKEE KKRDIHRIQE LERSLSELKN QMAEPPSLAP PAVTSVVEQL 

       310        320        330        340        350        360 
QDEAKHLRQE VEGLEGKLQS QVENNQALSL LSKEQKQRLQ EQEEMLREQE AQRVREQERL 

       370        380        390        400        410        420 
CEQNERLREQ QKTLQEQGER LRKQEQRLRK QEERLRKEEE RLQKQEKRLW DQEERLWKKE 

       430        440        450        460        470        480 
ERLQKQEERL ALSQNHKLDK QLAEPQCSFE DLNNEKKSAL QLEQQVKELQ EKLDEEHLEA 

       490        500        510        520        530        540 
ASHQNQQLET QLSLVALPGE GDGGQHLDSE EEEAPRPTPN IPEDLESREA TSSFMDLPKE 

       550        560        570        580        590        600 
KADGTEQVER RELGFVQPSG VTDGMRESFT VYESQGAVPN TRHQEMEDVI RLAQKEEEMK 

       610        620        630        640        650        660 
VKLLELQELV LPLVGNHEGH GKFLIAAQNP ADEPTPGAPA PQELGAAGEQ DVFYEVSLDN 

       670        680        690 
NVEPAPGAAR EGSPHDNPTV QQIVQLSPVM QDT 

« Hide

References

« Hide 'large scale' references
[1]"Cloning and characterization of a golgin-related gene from the large-scale polymorphism linked to the PML gene."
Gilles F., Goy A., Remache Y., Manova K., Zelenetz A.D.
Genomics 70:364-374(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], VARIANT ARG-200.
Tissue: Testis.
[2]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Testis.
[3]"Analysis of the DNA sequence and duplication history of human chromosome 15."
Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K., Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N., Abouelleil A. expand/collapse author list , Arachchi H.M., Baradarani L., Birditt B., Bloom S., Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K., DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R., Fahey J., Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G., Johnson E., Jones C., Kamat A., Kaur A., Locke D.P., Madan A., Munson G., Jaffe D.B., Lui A., Macdonald P., Mauceli E., Naylor J.W., Nesbitt R., Nicol R., O'Leary S.B., Ratcliffe A., Rounsley S., She X., Sneddon K.M.B., Stewart S., Sougnez C., Stone S.M., Topham K., Vincent D., Wang S., Zimmer A.R., Birren B.W., Hood L., Lander E.S., Nusbaum C.
Nature 440:671-675(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF263742 mRNA. Translation: AAF72196.1.
AF266285 Genomic DNA. Translation: AAF72535.1.
AK292574 mRNA. Translation: BAF85263.1.
AC013486 Genomic DNA. No translation available.
RefSeqNP_001033729.2. NM_001038640.2.
UniGeneHs.546408.
Hs.672474.

3D structure databases

ProteinModelPortalQ9NYA3.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteQ9NYA3.

Polymorphism databases

DMDM215274151.

Proteomic databases

PaxDbQ9NYA3.
PRIDEQ9NYA3.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000290438; ENSP00000290438; ENSG00000159289.
GeneID342096.
KEGGhsa:342096.
UCSCuc002axa.1. human.

Organism-specific databases

CTD342096.
GeneCardsGC15M074363.
H-InvDBHIX0038091.
HIX0038450.
HIX0059381.
HIX0059448.
HIX0132594.
HGNCHGNC:13567. GOLGA6A.
HPAHPA044978.
MIM610288. gene.
neXtProtNX_Q9NYA3.
PharmGKBPA38364.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG240684.
HOGENOMHOG000218631.
HOVERGENHBG051752.
InParanoidQ9NYA3.
OMAQNTADEP.
OrthoDBEOG71P29T.
PhylomeDBQ9NYA3.
TreeFamTF316990.

Gene expression databases

BgeeQ9NYA3.
CleanExHS_GOLGA6.
GenevestigatorQ9NYA3.

Family and domain databases

InterProIPR024858. Golgin_A.
[Graphical view]
PANTHERPTHR10881. PTHR10881. 1 hit.
ProtoNetSearch...

Other

GenomeRNAi342096.
NextBio98227.
PROQ9NYA3.
SOURCESearch...

Entry information

Entry nameGOG6A_HUMAN
AccessionPrimary (citable) accession number: Q9NYA3
Secondary accession number(s): A8K959, Q9NYA7
Entry history
Integrated into UniProtKB/Swiss-Prot: July 3, 2003
Last sequence update: November 25, 2008
Last modified: April 16, 2014
This is version 89 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 15

Human chromosome 15: entries, gene names and cross-references to MIM