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Protein

Golgin subfamily A member 6A

Gene

GOLGA6A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Golgin subfamily A member 6A
Alternative name(s):
Golgin linked to PML
Golgin-like protein
Gene namesi
Name:GOLGA6A
Synonyms:GLP, GOLGA6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

EuPathDBiHostDB:ENSG00000159289.6.
HGNCiHGNC:13567. GOLGA6A.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi342096.
OpenTargetsiENSG00000159289.
PharmGKBiPA38364.

Polymorphism and mutation databases

BioMutaiGOLGA6A.
DMDMi215274151.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001900691 – 693Golgin subfamily A member 6AAdd BLAST693

Proteomic databases

PaxDbiQ9NYA3.
PeptideAtlasiQ9NYA3.
PRIDEiQ9NYA3.

PTM databases

iPTMnetiQ9NYA3.
PhosphoSitePlusiQ9NYA3.

Expressioni

Tissue specificityi

Highly expressed in seminiferous tubes in testis. Highly expressed in spermatids, barely detectable in late pachytene spermatocytes, and not detectable in spermatogonia. Detected at intermediate levels in pancreas and lymph nodes, and at much lower levels in spleen, peripheral blood leukocytes, skeletal muscle, liver, lung, placenta, brain and heart.

Gene expression databases

BgeeiENSG00000159289.
CleanExiHS_GOLGA6.
GenevisibleiQ9NYA3. HS.

Organism-specific databases

HPAiHPA044978.
HPA050087.

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi131163. 1 interactor.
IntActiQ9NYA3. 42 interactors.
STRINGi9606.ENSP00000290438.

Structurei

3D structure databases

ProteinModelPortaliQ9NYA3.
SMRiQ9NYA3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili14 – 611IEP:Add BLAST598

Sequence similaritiesi

Belongs to the GOLGA6 family.IKR:

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG4725. Eukaryota.
ENOG410ZIE4. LUCA.
GeneTreeiENSGT00530000062932.
HOGENOMiHOG000218631.
HOVERGENiHBG051752.
InParanoidiQ9NYA3.
OMAiSNESAND.
OrthoDBiEOG091G0DDT.
PhylomeDBiQ9NYA3.
TreeFamiTF316990.

Family and domain databases

InterProiView protein in InterPro
IPR024858. Golgin_A.
PfamiView protein in Pfam
PF15070. GOLGA2L5. 3 hits.

Sequencei

Sequence statusi: Complete.

Q9NYA3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MWPQPYLPPH PMMLEESRQN KLAAAKKKLK EYQQRKSPGI PAGAKTKKKK
60 70 80 90 100
TDSSPETTTS GGCHSPGDSQ YQELAVALES SSVTISQLNE NIESLKQQKK
110 120 130 140 150
QVEHQLEEAK KTNNEIHKAQ MERLETINIL TLEKADLKTT LYHTKRAARH
160 170 180 190 200
FEEESKDLAG RLQYSLQRIQ ELERALCAVS TQQQEEDRSS SCREAVLQRW
210 220 230 240 250
LQQTIKERAL LNAHVTQVTE SLKQVQLERD EYAKHIKGER ARWQERMWKM
260 270 280 290 300
SVEARTLKEE KKRDIHRIQE LERSLSELKN QMAEPPSLAP PAVTSVVEQL
310 320 330 340 350
QDEAKHLRQE VEGLEGKLQS QVENNQALSL LSKEQKQRLQ EQEEMLREQE
360 370 380 390 400
AQRVREQERL CEQNERLREQ QKTLQEQGER LRKQEQRLRK QEERLRKEEE
410 420 430 440 450
RLQKQEKRLW DQEERLWKKE ERLQKQEERL ALSQNHKLDK QLAEPQCSFE
460 470 480 490 500
DLNNEKKSAL QLEQQVKELQ EKLDEEHLEA ASHQNQQLET QLSLVALPGE
510 520 530 540 550
GDGGQHLDSE EEEAPRPTPN IPEDLESREA TSSFMDLPKE KADGTEQVER
560 570 580 590 600
RELGFVQPSG VTDGMRESFT VYESQGAVPN TRHQEMEDVI RLAQKEEEMK
610 620 630 640 650
VKLLELQELV LPLVGNHEGH GKFLIAAQNP ADEPTPGAPA PQELGAAGEQ
660 670 680 690
DVFYEVSLDN NVEPAPGAAR EGSPHDNPTV QQIVQLSPVM QDT
Length:693
Mass (Da):79,946
Last modified:November 25, 2008 - v3
Checksum:iD54FA366168C27B2
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti86S → N in AAF72196 (PubMed:11161787).IKR:1
Sequence conflicti123R → Q in AAF72196 (PubMed:11161787).IKR:1
Sequence conflicti134K → E in BAF85263 (PubMed:14702039).IKR:1
Sequence conflicti198Q → H in AAF72535 (PubMed:11161787).IKR:1
Sequence conflicti561 – 566VTDGMR → LCPLTG in AAF72535 (PubMed:11161787).IKR:6

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_047540200W → R1 PublicationCorresponds to variant dbSNP:rs2018461Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF263742 mRNA. Translation: AAF72196.1.
AF266285 Genomic DNA. Translation: AAF72535.1.
AK292574 mRNA. Translation: BAF85263.1.
AC013486 Genomic DNA. No translation available.
CCDSiCCDS32290.1.
RefSeqiNP_001033729.2. NM_001038640.2.
UniGeneiHs.546408.
Hs.672474.

Genome annotation databases

EnsembliENST00000290438; ENSP00000290438; ENSG00000159289.
GeneIDi342096.
KEGGihsa:342096.
UCSCiuc002axa.1. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiGOG6A_HUMAN
AccessioniPrimary (citable) accession number: Q9NYA3
Secondary accession number(s): A8K959, Q9NYA7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 3, 2003
Last sequence update: November 25, 2008
Last modified: September 27, 2017
This is version 116 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Maps to a duplicated region on chromosome 15; the gene is present in at least 4 almost identical copies.IKR:

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families