Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Gamma-2-syntrophin

Gene

SNTG2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Adapter protein that binds to and probably organizes the subcellular localization of a variety of proteins. May link various receptors to the actin cytoskeleton and the dystrophin glycoprotein complex (By similarity).By similarity

GO - Molecular functioni

  • neuroligin family protein binding Source: BHF-UCL
  • PDZ domain binding Source: UniProtKB
  • structural molecule activity Source: InterPro

GO - Biological processi

  • central nervous system development Source: ProtInc
Complete GO annotation...

Keywords - Ligandi

Actin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Gamma-2-syntrophin
Short name:
G2SYN
Alternative name(s):
Syntrophin-5
Short name:
SYN5
Gene namesi
Name:SNTG2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:13741. SNTG2.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB-KW
  • cytoskeleton Source: UniProtKB-SubCell
  • sarcolemma Source: UniProtKB-SubCell
  • syntrophin complex Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Cytoskeleton, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA37807.

Polymorphism and mutation databases

BioMutaiSNTG2.
DMDMi296452909.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 539539Gamma-2-syntrophinPRO_0000184015Add
BLAST

Proteomic databases

EPDiQ9NY99.
PaxDbiQ9NY99.
PeptideAtlasiQ9NY99.
PRIDEiQ9NY99.

PTM databases

iPTMnetiQ9NY99.
PhosphoSiteiQ9NY99.

Expressioni

Tissue specificityi

Widely expressed. Strong expression in brain and testis. In CNS, it is expressed in the perikaryon and proximal portion of the neuronal processes. Strong expression in the hippocampus, neuron-rich dendate granule cells, and pyramidal cell layers. Highly expressed in neurons of the cerebral cortex. Also expressed in the cerebellar cortex, deep cerebellar nuclei, thalamus, and basal ganglia.1 Publication

Gene expression databases

BgeeiQ9NY99.
CleanExiHS_SNTG2.
ExpressionAtlasiQ9NY99. baseline and differential.
GenevisibleiQ9NY99. HS.

Interactioni

Subunit structurei

Interacts with the dystrophin protein DMD and related proteins DTNA and DTNB.1 Publication

GO - Molecular functioni

  • neuroligin family protein binding Source: BHF-UCL
  • PDZ domain binding Source: UniProtKB

Protein-protein interaction databases

BioGridi119929. 13 interactions.
IntActiQ9NY99. 1 interaction.
MINTiMINT-249909.
STRINGi9606.ENSP00000311837.

Structurei

3D structure databases

ProteinModelPortaliQ9NY99.
SMRiQ9NY99. Positions 40-276.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini73 – 15684PDZPROSITE-ProRule annotationAdd
BLAST
Domaini296 – 421126PHAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi6 – 94Poly-Pro

Domaini

The association with dystrophin or related proteins probably leaves the PDZ domain available to recruit proteins to the membrane.By similarity

Sequence similaritiesi

Belongs to the syntrophin family.Curated
Contains 1 PDZ (DHR) domain.PROSITE-ProRule annotation
Contains 1 PH domain.Curated

Phylogenomic databases

eggNOGiKOG3549. Eukaryota.
ENOG410XQXQ. LUCA.
GeneTreeiENSGT00550000074581.
HOGENOMiHOG000230749.
HOVERGENiHBG060412.
InParanoidiQ9NY99.
OMAiQKQDVVC.
OrthoDBiEOG7J70N7.
PhylomeDBiQ9NY99.
TreeFamiTF317932.

Family and domain databases

Gene3Di2.30.42.10. 1 hit.
InterProiIPR001478. PDZ.
IPR011993. PH_dom-like.
IPR015482. Syntrophin.
[Graphical view]
PANTHERiPTHR10554. PTHR10554. 1 hit.
PfamiPF00595. PDZ. 1 hit.
[Graphical view]
SMARTiSM00228. PDZ. 1 hit.
[Graphical view]
SUPFAMiSSF50156. SSF50156. 1 hit.
SSF50729. SSF50729. 2 hits.
PROSITEiPS50106. PDZ. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9NY99-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGTEGPPPPA ASRGRQGCLL VPARTKTTIA LLYDEESENA YDIRLKLTKE
60 70 80 90 100
VLTIQKQDVV CVGGSHQGRN RRTVTLRRQP VGGLGLSIKG GSEHNVPVVI
110 120 130 140 150
SKIFEDQAAD QTGMLFVGDA VLQVNGIHVE NATHEEVVHL LRNAGDEVTI
160 170 180 190 200
TVEYLREAPA FLKLPLGSPG PSSDHSSGAS SPLFDSGLHL NGNSSTTAPS
210 220 230 240 250
SPSSPIAKDP RYEKRWLDTL SVPLSMARIS RYKAGTEKLR WNAFEVLALD
260 270 280 290 300
GVSSGILRFY TAQDGTDWLR AVSANIRELT LQNMKMANKC CSPSDQVVHM
310 320 330 340 350
GWVNEKLQGA DSSQTFRPKF LALKGPSFYV FSTPPVSTFD WVRAERTYHL
360 370 380 390 400
CEVLFKVHKF WLTEDCWLQA NLYLGLQDFD FEDQRPYCFS IVAGHGKSHV
410 420 430 440 450
FNVELGSELA MWEKSFQRAT FMEVQRTGSR TYMCSWQGEM LCFTVDFALG
460 470 480 490 500
FTCFESKTKN VLWRFKFSQL KGSSDDGKTR VKLLFQNLDT KQIETKELEF
510 520 530
QDLRAVLHCI HSFIAAKVAS VDPGFMDSQS LARKYMYSS
Length:539
Mass (Da):60,217
Last modified:May 18, 2010 - v2
Checksum:i0D3B1E24CC05D365
GO
Isoform 2 (identifier: Q9NY99-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     71-197: Missing.

Note: No experimental confirmation available.
Show »
Length:412
Mass (Da):46,842
Checksum:i79D69164BB5D8678
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti495 – 4951T → M in CAB92969 (PubMed:10747910).Curated
Sequence conflicti495 – 4951T → M in AAI25252 (PubMed:15489334).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti168 – 1681S → Y.
Corresponds to variant rs28505970 [ dbSNP | Ensembl ].
VAR_034501
Natural varianti200 – 2001S → L.
Corresponds to variant rs6751090 [ dbSNP | Ensembl ].
VAR_034502
Natural varianti391 – 3911I → V.
Corresponds to variant rs13023962 [ dbSNP | Ensembl ].
VAR_034503

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei71 – 197127Missing in isoform 2. 1 PublicationVSP_039175Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ003029 mRNA. Translation: CAB92969.1.
AC108462 Genomic DNA. No translation available.
AC114808 Genomic DNA. No translation available.
AC116614 Genomic DNA. No translation available.
AC140476 Genomic DNA. No translation available.
AC144444 Genomic DNA. No translation available.
AC144527 Genomic DNA. No translation available.
AC225604 Genomic DNA. No translation available.
BC125251 mRNA. Translation: AAI25252.1.
CCDSiCCDS46220.1. [Q9NY99-1]
RefSeqiNP_061841.2. NM_018968.3. [Q9NY99-1]
UniGeneiHs.595069.

Genome annotation databases

EnsembliENST00000308624; ENSP00000311837; ENSG00000172554. [Q9NY99-1]
ENST00000407292; ENSP00000385020; ENSG00000172554. [Q9NY99-2]
GeneIDi54221.
KEGGihsa:54221.
UCSCiuc002qwq.4. human. [Q9NY99-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ003029 mRNA. Translation: CAB92969.1.
AC108462 Genomic DNA. No translation available.
AC114808 Genomic DNA. No translation available.
AC116614 Genomic DNA. No translation available.
AC140476 Genomic DNA. No translation available.
AC144444 Genomic DNA. No translation available.
AC144527 Genomic DNA. No translation available.
AC225604 Genomic DNA. No translation available.
BC125251 mRNA. Translation: AAI25252.1.
CCDSiCCDS46220.1. [Q9NY99-1]
RefSeqiNP_061841.2. NM_018968.3. [Q9NY99-1]
UniGeneiHs.595069.

3D structure databases

ProteinModelPortaliQ9NY99.
SMRiQ9NY99. Positions 40-276.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119929. 13 interactions.
IntActiQ9NY99. 1 interaction.
MINTiMINT-249909.
STRINGi9606.ENSP00000311837.

PTM databases

iPTMnetiQ9NY99.
PhosphoSiteiQ9NY99.

Polymorphism and mutation databases

BioMutaiSNTG2.
DMDMi296452909.

Proteomic databases

EPDiQ9NY99.
PaxDbiQ9NY99.
PeptideAtlasiQ9NY99.
PRIDEiQ9NY99.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000308624; ENSP00000311837; ENSG00000172554. [Q9NY99-1]
ENST00000407292; ENSP00000385020; ENSG00000172554. [Q9NY99-2]
GeneIDi54221.
KEGGihsa:54221.
UCSCiuc002qwq.4. human. [Q9NY99-1]

Organism-specific databases

CTDi54221.
GeneCardsiSNTG2.
H-InvDBHIX0029856.
HGNCiHGNC:13741. SNTG2.
MIMi608715. gene.
neXtProtiNX_Q9NY99.
PharmGKBiPA37807.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3549. Eukaryota.
ENOG410XQXQ. LUCA.
GeneTreeiENSGT00550000074581.
HOGENOMiHOG000230749.
HOVERGENiHBG060412.
InParanoidiQ9NY99.
OMAiQKQDVVC.
OrthoDBiEOG7J70N7.
PhylomeDBiQ9NY99.
TreeFamiTF317932.

Miscellaneous databases

ChiTaRSiSNTG2. human.
GenomeRNAii54221.
PROiQ9NY99.
SOURCEiSearch...

Gene expression databases

BgeeiQ9NY99.
CleanExiHS_SNTG2.
ExpressionAtlasiQ9NY99. baseline and differential.
GenevisibleiQ9NY99. HS.

Family and domain databases

Gene3Di2.30.42.10. 1 hit.
InterProiIPR001478. PDZ.
IPR011993. PH_dom-like.
IPR015482. Syntrophin.
[Graphical view]
PANTHERiPTHR10554. PTHR10554. 1 hit.
PfamiPF00595. PDZ. 1 hit.
[Graphical view]
SMARTiSM00228. PDZ. 1 hit.
[Graphical view]
SUPFAMiSSF50156. SSF50156. 1 hit.
SSF50729. SSF50729. 2 hits.
PROSITEiPS50106. PDZ. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Gamma1- and gamma2-syntrophins, two novel dystrophin-binding proteins localized in neuronal cells."
    Piluso G., Mirabella M., Ricci E., Belsito A., Abbondanza C., Servidei S., Puca A.A., Tonali P., Puca G.A., Nigro V.
    J. Biol. Chem. 275:15851-15860(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, INTERACTION WITH DMD; DTNA AND DTNB.
    Tissue: Fetal brain and Neuron.
  2. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).

Entry informationi

Entry nameiSNTG2_HUMAN
AccessioniPrimary (citable) accession number: Q9NY99
Secondary accession number(s): Q05AH5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2002
Last sequence update: May 18, 2010
Last modified: July 6, 2016
This is version 117 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.