Q9NY91 (SC5A4_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Low affinity sodium-glucose cotransporter

Alternative name(s):
Sodium/glucose cotransporter 3
Short name=Na(+)/glucose cotransporter 3
Solute carrier family 5 member 4

Gene names

Name:	SLC5A4
Synonyms:	SAAT1, SGLT2

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	659 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Sodium-dependent glucose transporter By similarity.
Subcellular location	Membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family. [View classification]

Ontologies

Keywords
Biological process	Ion transport Sodium transport Sugar transport Symport Transport
Cellular component	Membrane
Coding sequence diversity	Polymorphism
Domain	Transmembrane Transmembrane helix
Ligand	Sodium
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	carbohydrate transport Inferred from electronic annotation. Source: UniProtKB-KW sodium ion transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	symporter activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 659	659	Low affinity sodium-glucose cotransporter		PRO_0000105376
Regions
	Topological domain	1 – 28	28	Cytoplasmic Potential
	Transmembrane	29 – 47	19	Helical; Potential
	Topological domain	48 – 64	17	Extracellular Potential
	Transmembrane	65 – 85	21	Helical; Potential
	Topological domain	86 – 105	20	Cytoplasmic Potential
	Transmembrane	106 – 126	21	Helical; Potential
	Topological domain	127 – 171	45	Extracellular Potential
	Transmembrane	172 – 191	20	Helical; Potential
	Topological domain	192 – 208	17	Cytoplasmic Potential
	Transmembrane	209 – 229	21	Helical; Potential
	Topological domain	230 – 270	41	Extracellular Potential
	Transmembrane	271 – 291	21	Helical; Potential
	Topological domain	292 – 314	23	Cytoplasmic Potential
	Transmembrane	315 – 334	20	Helical; Potential
	Topological domain	335 – 423	89	Extracellular Potential
	Transmembrane	424 – 443	20	Helical; Potential
	Topological domain	444 – 455	12	Cytoplasmic Potential
	Transmembrane	456 – 476	21	Helical; Potential
	Topological domain	477 – 526	50	Extracellular Potential
	Transmembrane	527 – 547	21	Helical; Potential
	Topological domain	548 – 637	90	Cytoplasmic Potential
	Transmembrane	638 – 658	21	Helical; Potential
Amino acid modifications
	Glycosylation	248	1	N-linked (GlcNAc...) Potential
Natural variations
	Natural variant	4	1	T → M. Corresponds to variant rs16990065 [ dbSNP | Ensembl ].		VAR_052489
	Natural variant	46	1	A → T. Corresponds to variant rs2235171 [ dbSNP | Ensembl ].		VAR_021997
Experimental info
	Sequence conflict	76	1	A → V in AAB61732. Ref.3
	Sequence conflict	106	1	S → P in AAB61732. Ref.3
	Sequence conflict	243	1	V → I in AAB61732. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	Q9NY91 [UniParc]. Last modified October 1, 2000. Version 1. Checksum: F8A34AED648B523A	FASTA	659	72,456
	10 20 30 40 50 60 MASTVSPSTI AETPEPPPLS DHIRNAADIS VIVIYFLVVM AVGLWAMLKT NRGTIGGFFL 70 80 90 100 110 120 AGRDMAWWPM GASLFASNIG SNHYVGLAGT GAASGVATVT FEWTSSVMLL ILGWIFVPIY 130 140 150 160 170 180 IKSGVMTMPE YLKKRFGGER LQVYLSILSL FICVVLLISA DIFAGAIFIK LALGLDLYLA 190 200 210 220 230 240 IFILLAMTAV YTTTGGLASV IYTDTLQTII MLIGSFILMG FAFNEVGGYE SFTEKYVNAT 250 260 270 280 290 300 PSVVEGDNLT ISASCYTPRA DSFHIFRDAV TGDIPWPGII FGMPITALWY WCTNQVIVQR 310 320 330 340 350 360 CLCGKDMSHV KAACIMCAYL KLLPMFLMVM PGMISRILYT DMVACVVPSE CVKHCGVDVG 370 380 390 400 410 420 CTNYAYPTMV LELMPQGLRG LMLSVMLASL MSSLTSIFNS ASTLFTIDLY TKMRKQASEK 430 440 450 460 470 480 ELLIAGRIFV LLLTVVSIVW VPLVQVSQNG QLIHYTESIS SYLGPPIAAV FVLAIFCKRV 490 500 510 520 530 540 NEQGAFWGLM VGLAMGLIRM ITEFAYGTGS CLAPSNCPKI ICGVHYLYFS IVLFFGSMLV 550 560 570 580 590 600 TLGISLLTKP IPDVHLYRLC WVLRNSTEER IDIDAEEKSQ EETDDGVEED YPEKSRGCLK 610 620 630 640 650 KAYDLFCGLQ KGPKLTKEEE EALSKKLTDT SERPSWRTIV NINAILLLAV VVFIHGYYA

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The molecular cloning and functional characterization of the human SGLT2 transporter." Gorboulev V., Baumgarten K., Veyhl M., Koepsell H. Submitted (FEB-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Small intestine.
[2]	"The DNA sequence of human chromosome 22." Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M., Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C., Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E., Bridgeman A.M. , Buck D., Burgess J., Burrill W.D., Burton J., Carder C., Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G., Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V., Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M., Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A., Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C., Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E., Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F., Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M., Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A., Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D., Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y., Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S., Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E., Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L., Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L., Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N., Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A., Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L., Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P., Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P., Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q., Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J., Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J., Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D., Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T., Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P., Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K., Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R., Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L., McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J., Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E., Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P., Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y., Wright H. Nature 402:489-495(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	Poppe R., Koepsell H. Submitted (DEC-1995) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 73-247. Tissue: Brain.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ133127 mRNA. Translation: CAB81772.1. AL008723 Genomic DNA. Translation: CAB51758.1. U41897 mRNA. Translation: AAB61732.1.
IPI	IPI00218248.
RefSeq	NP_055042.1. NM_014227.2.
UniGene	Hs.130101.
3D structure databases
ProteinModelPortal	Q9NY91.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000266086.
PTM databases
PhosphoSite	Q9NY91.
Polymorphism databases
DMDM	17433306.
Proteomic databases
PaxDb	Q9NY91.
PRIDE	Q9NY91.
Protocols and materials databases
DNASU	6527.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000266086; ENSP00000266086; ENSG00000100191.
GeneID	6527.
KEGG	hsa:6527.
UCSC	uc003ami.3. human.
Organism-specific databases
CTD	6527.
GeneCards	GC22M032614.
HGNC	HGNC:11039. SLC5A4.
HPA	HPA026840.
neXtProt	NX_Q9NY91.
PharmGKB	PA35904.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG4146.
HOGENOM	HOG000025422.
HOVERGEN	HBG052859.
InParanoid	Q9NY91.
KO	K14384.
OMA	LEHRFHD.
OrthoDB	EOG4B5P4V.
PhylomeDB	Q9NY91.
Gene expression databases
ArrayExpress	Q9NY91.
Bgee	Q9NY91.
CleanEx	HS_SLC5A4.
Genevestigator	Q9NY91.
GermOnline	ENSG00000100191. Homo sapiens.
Family and domain databases
InterPro	IPR001734. Na/solute_symporter. IPR018212. Na/solute_symporter_CS. IPR019900. Na/solute_symporter_subgr. [Graphical view]
PANTHER	PTHR11819. PTHR11819. 1 hit.
Pfam	PF00474. SSF. 1 hit. [Graphical view]
TIGRFAMs	TIGR00813. sss. 1 hit.
PROSITE	PS00456. NA_SOLUT_SYMP_1. 1 hit. PS00457. NA_SOLUT_SYMP_2. 1 hit. PS50283. NA_SOLUT_SYMP_3. 1 hit. [Graphical view]
ProtoNet	Search...
Other
BindingDB	Q9NY91.
ChEMBL	CHEMBL1770047.
GenomeRNAi	6527.
NextBio	25395.

Entry information

Entry name

SC5A4_HUMAN

Accession

Primary (citable) accession number: Q9NY91
Secondary accession number(s): O15279

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 26, 2001
Last sequence update:	October 1, 2000
Last modified:	May 1, 2013
This is version 95 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.