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Q9NY91

- SC5A4_HUMAN

UniProt

Q9NY91 - SC5A4_HUMAN

Protein

Low affinity sodium-glucose cotransporter

Gene

SLC5A4

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 110 (01 Oct 2014)
      Sequence version 1 (01 Oct 2000)
      Previous versions | rss
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    Functioni

    Sodium-dependent glucose transporter.By similarity

    GO - Molecular functioni

    1. symporter activity Source: UniProtKB-KW

    GO - Biological processi

    1. carbohydrate transport Source: UniProtKB-KW
    2. sodium ion transport Source: UniProtKB-KW

    Keywords - Biological processi

    Ion transport, Sodium transport, Sugar transport, Symport, Transport

    Keywords - Ligandi

    Sodium

    Enzyme and pathway databases

    ReactomeiREACT_19165. Na+-dependent glucose transporters.
    REACT_19188. Inositol transporters.
    REACT_9441. Hexose transport.

    Protein family/group databases

    TCDBi2.A.21.3.18. the solute:sodium symporter (sss) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Low affinity sodium-glucose cotransporter
    Alternative name(s):
    Sodium/glucose cotransporter 3
    Short name:
    Na(+)/glucose cotransporter 3
    Solute carrier family 5 member 4
    Gene namesi
    Name:SLC5A4
    Synonyms:SAAT1, SGLT2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 22

    Organism-specific databases

    HGNCiHGNC:11039. SLC5A4.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA35904.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 659659Low affinity sodium-glucose cotransporterPRO_0000105376Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi248 – 2481N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiQ9NY91.
    PRIDEiQ9NY91.

    PTM databases

    PhosphoSiteiQ9NY91.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9NY91.
    BgeeiQ9NY91.
    CleanExiHS_SLC5A4.
    GenevestigatoriQ9NY91.

    Organism-specific databases

    HPAiHPA026840.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000266086.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9NY91.
    SMRiQ9NY91. Positions 28-497.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 2828CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini48 – 6417ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini86 – 10520CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini127 – 17145ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini192 – 20817CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini230 – 27041ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini292 – 31423CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini335 – 42389ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini444 – 45512CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini477 – 52650ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini548 – 63790CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei29 – 4719HelicalSequence AnalysisAdd
    BLAST
    Transmembranei65 – 8521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei106 – 12621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei172 – 19120HelicalSequence AnalysisAdd
    BLAST
    Transmembranei209 – 22921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei271 – 29121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei315 – 33420HelicalSequence AnalysisAdd
    BLAST
    Transmembranei424 – 44320HelicalSequence AnalysisAdd
    BLAST
    Transmembranei456 – 47621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei527 – 54721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei638 – 65821HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG4146.
    HOGENOMiHOG000025422.
    HOVERGENiHBG052859.
    InParanoidiQ9NY91.
    KOiK14384.
    OMAiLTPVMVV.
    OrthoDBiEOG77126J.
    PhylomeDBiQ9NY91.
    TreeFamiTF352855.

    Family and domain databases

    InterProiIPR001734. Na/solute_symporter.
    IPR018212. Na/solute_symporter_CS.
    IPR019900. Na/solute_symporter_subgr.
    [Graphical view]
    PANTHERiPTHR11819. PTHR11819. 1 hit.
    PfamiPF00474. SSF. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00813. sss. 1 hit.
    PROSITEiPS00456. NA_SOLUT_SYMP_1. 1 hit.
    PS00457. NA_SOLUT_SYMP_2. 1 hit.
    PS50283. NA_SOLUT_SYMP_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9NY91-1 [UniParc]FASTAAdd to Basket

    « Hide

    MASTVSPSTI AETPEPPPLS DHIRNAADIS VIVIYFLVVM AVGLWAMLKT    50
    NRGTIGGFFL AGRDMAWWPM GASLFASNIG SNHYVGLAGT GAASGVATVT 100
    FEWTSSVMLL ILGWIFVPIY IKSGVMTMPE YLKKRFGGER LQVYLSILSL 150
    FICVVLLISA DIFAGAIFIK LALGLDLYLA IFILLAMTAV YTTTGGLASV 200
    IYTDTLQTII MLIGSFILMG FAFNEVGGYE SFTEKYVNAT PSVVEGDNLT 250
    ISASCYTPRA DSFHIFRDAV TGDIPWPGII FGMPITALWY WCTNQVIVQR 300
    CLCGKDMSHV KAACIMCAYL KLLPMFLMVM PGMISRILYT DMVACVVPSE 350
    CVKHCGVDVG CTNYAYPTMV LELMPQGLRG LMLSVMLASL MSSLTSIFNS 400
    ASTLFTIDLY TKMRKQASEK ELLIAGRIFV LLLTVVSIVW VPLVQVSQNG 450
    QLIHYTESIS SYLGPPIAAV FVLAIFCKRV NEQGAFWGLM VGLAMGLIRM 500
    ITEFAYGTGS CLAPSNCPKI ICGVHYLYFS IVLFFGSMLV TLGISLLTKP 550
    IPDVHLYRLC WVLRNSTEER IDIDAEEKSQ EETDDGVEED YPEKSRGCLK 600
    KAYDLFCGLQ KGPKLTKEEE EALSKKLTDT SERPSWRTIV NINAILLLAV 650
    VVFIHGYYA 659
    Length:659
    Mass (Da):72,456
    Last modified:October 1, 2000 - v1
    Checksum:iF8A34AED648B523A
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti76 – 761A → V in AAB61732. 1 PublicationCurated
    Sequence conflicti106 – 1061S → P in AAB61732. 1 PublicationCurated
    Sequence conflicti243 – 2431V → I in AAB61732. 1 PublicationCurated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti4 – 41T → M.
    Corresponds to variant rs16990065 [ dbSNP | Ensembl ].
    VAR_052489
    Natural varianti46 – 461A → T.
    Corresponds to variant rs2235171 [ dbSNP | Ensembl ].
    VAR_021997

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ133127 mRNA. Translation: CAB81772.1.
    AL008723 Genomic DNA. Translation: CAB51758.1.
    U41897 mRNA. Translation: AAB61732.1.
    CCDSiCCDS13903.1.
    RefSeqiNP_055042.1. NM_014227.2.
    UniGeneiHs.130101.

    Genome annotation databases

    EnsembliENST00000266086; ENSP00000266086; ENSG00000100191.
    GeneIDi6527.
    KEGGihsa:6527.
    UCSCiuc003ami.3. human.

    Polymorphism databases

    DMDMi17433306.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ133127 mRNA. Translation: CAB81772.1 .
    AL008723 Genomic DNA. Translation: CAB51758.1 .
    U41897 mRNA. Translation: AAB61732.1 .
    CCDSi CCDS13903.1.
    RefSeqi NP_055042.1. NM_014227.2.
    UniGenei Hs.130101.

    3D structure databases

    ProteinModelPortali Q9NY91.
    SMRi Q9NY91. Positions 28-497.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000266086.

    Chemistry

    BindingDBi Q9NY91.
    ChEMBLi CHEMBL1770047.

    Protein family/group databases

    TCDBi 2.A.21.3.18. the solute:sodium symporter (sss) family.

    PTM databases

    PhosphoSitei Q9NY91.

    Polymorphism databases

    DMDMi 17433306.

    Proteomic databases

    PaxDbi Q9NY91.
    PRIDEi Q9NY91.

    Protocols and materials databases

    DNASUi 6527.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000266086 ; ENSP00000266086 ; ENSG00000100191 .
    GeneIDi 6527.
    KEGGi hsa:6527.
    UCSCi uc003ami.3. human.

    Organism-specific databases

    CTDi 6527.
    GeneCardsi GC22M032614.
    HGNCi HGNC:11039. SLC5A4.
    HPAi HPA026840.
    neXtProti NX_Q9NY91.
    PharmGKBi PA35904.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG4146.
    HOGENOMi HOG000025422.
    HOVERGENi HBG052859.
    InParanoidi Q9NY91.
    KOi K14384.
    OMAi LTPVMVV.
    OrthoDBi EOG77126J.
    PhylomeDBi Q9NY91.
    TreeFami TF352855.

    Enzyme and pathway databases

    Reactomei REACT_19165. Na+-dependent glucose transporters.
    REACT_19188. Inositol transporters.
    REACT_9441. Hexose transport.

    Miscellaneous databases

    GeneWikii SLC5A4.
    GenomeRNAii 6527.
    NextBioi 25395.
    PROi Q9NY91.

    Gene expression databases

    ArrayExpressi Q9NY91.
    Bgeei Q9NY91.
    CleanExi HS_SLC5A4.
    Genevestigatori Q9NY91.

    Family and domain databases

    InterProi IPR001734. Na/solute_symporter.
    IPR018212. Na/solute_symporter_CS.
    IPR019900. Na/solute_symporter_subgr.
    [Graphical view ]
    PANTHERi PTHR11819. PTHR11819. 1 hit.
    Pfami PF00474. SSF. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00813. sss. 1 hit.
    PROSITEi PS00456. NA_SOLUT_SYMP_1. 1 hit.
    PS00457. NA_SOLUT_SYMP_2. 1 hit.
    PS50283. NA_SOLUT_SYMP_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The molecular cloning and functional characterization of the human SGLT2 transporter."
      Gorboulev V., Baumgarten K., Veyhl M., Koepsell H.
      Submitted (FEB-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Small intestine.
    2. "The DNA sequence of human chromosome 22."
      Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M., Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C., Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E., Bridgeman A.M.
      , Buck D., Burgess J., Burrill W.D., Burton J., Carder C., Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G., Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V., Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M., Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A., Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C., Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E., Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F., Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M., Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A., Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D., Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y., Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S., Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E., Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L., Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L., Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N., Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A., Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L., Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P., Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P., Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q., Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J., Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J., Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D., Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T., Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P., Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K., Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R., Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L., McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J., Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E., Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P., Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y., Wright H.
      Nature 402:489-495(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. Poppe R., Koepsell H.
      Submitted (DEC-1995) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 73-247.
      Tissue: Brain.

    Entry informationi

    Entry nameiSC5A4_HUMAN
    AccessioniPrimary (citable) accession number: Q9NY91
    Secondary accession number(s): O15279
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 26, 2001
    Last sequence update: October 1, 2000
    Last modified: October 1, 2014
    This is version 110 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 22
      Human chromosome 22: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3