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Q9NY91 (SC5A4_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 105. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Low affinity sodium-glucose cotransporter
Alternative name(s):
Sodium/glucose cotransporter 3
Short name=Na(+)/glucose cotransporter 3
Solute carrier family 5 member 4
Gene names
Name:SLC5A4
Synonyms:SAAT1, SGLT2
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length659 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Sodium-dependent glucose transporter By similarity.

Subcellular location

Membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family. [View classification]

Ontologies

Keywords
   Biological processIon transport
Sodium transport
Sugar transport
Symport
Transport
   Cellular componentMembrane
   Coding sequence diversityPolymorphism
   DomainTransmembrane
Transmembrane helix
   LigandSodium
   PTMGlycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processcarbohydrate transport

Inferred from electronic annotation. Source: UniProtKB-KW

sodium ion transport

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionhydrogen ion transmembrane transporter activity

Inferred from electronic annotation. Source: Ensembl

symporter activity

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 659659Low affinity sodium-glucose cotransporter
PRO_0000105376

Regions

Topological domain1 – 2828Cytoplasmic Potential
Transmembrane29 – 4719Helical; Potential
Topological domain48 – 6417Extracellular Potential
Transmembrane65 – 8521Helical; Potential
Topological domain86 – 10520Cytoplasmic Potential
Transmembrane106 – 12621Helical; Potential
Topological domain127 – 17145Extracellular Potential
Transmembrane172 – 19120Helical; Potential
Topological domain192 – 20817Cytoplasmic Potential
Transmembrane209 – 22921Helical; Potential
Topological domain230 – 27041Extracellular Potential
Transmembrane271 – 29121Helical; Potential
Topological domain292 – 31423Cytoplasmic Potential
Transmembrane315 – 33420Helical; Potential
Topological domain335 – 42389Extracellular Potential
Transmembrane424 – 44320Helical; Potential
Topological domain444 – 45512Cytoplasmic Potential
Transmembrane456 – 47621Helical; Potential
Topological domain477 – 52650Extracellular Potential
Transmembrane527 – 54721Helical; Potential
Topological domain548 – 63790Cytoplasmic Potential
Transmembrane638 – 65821Helical; Potential

Amino acid modifications

Glycosylation2481N-linked (GlcNAc...) Potential

Natural variations

Natural variant41T → M.
Corresponds to variant rs16990065 [ dbSNP | Ensembl ].
VAR_052489
Natural variant461A → T.
Corresponds to variant rs2235171 [ dbSNP | Ensembl ].
VAR_021997

Experimental info

Sequence conflict761A → V in AAB61732. Ref.3
Sequence conflict1061S → P in AAB61732. Ref.3
Sequence conflict2431V → I in AAB61732. Ref.3

Sequences

Sequence LengthMass (Da)Tools
Q9NY91 [UniParc].

Last modified October 1, 2000. Version 1.
Checksum: F8A34AED648B523A

FASTA65972,456
        10         20         30         40         50         60 
MASTVSPSTI AETPEPPPLS DHIRNAADIS VIVIYFLVVM AVGLWAMLKT NRGTIGGFFL 

        70         80         90        100        110        120 
AGRDMAWWPM GASLFASNIG SNHYVGLAGT GAASGVATVT FEWTSSVMLL ILGWIFVPIY 

       130        140        150        160        170        180 
IKSGVMTMPE YLKKRFGGER LQVYLSILSL FICVVLLISA DIFAGAIFIK LALGLDLYLA 

       190        200        210        220        230        240 
IFILLAMTAV YTTTGGLASV IYTDTLQTII MLIGSFILMG FAFNEVGGYE SFTEKYVNAT 

       250        260        270        280        290        300 
PSVVEGDNLT ISASCYTPRA DSFHIFRDAV TGDIPWPGII FGMPITALWY WCTNQVIVQR 

       310        320        330        340        350        360 
CLCGKDMSHV KAACIMCAYL KLLPMFLMVM PGMISRILYT DMVACVVPSE CVKHCGVDVG 

       370        380        390        400        410        420 
CTNYAYPTMV LELMPQGLRG LMLSVMLASL MSSLTSIFNS ASTLFTIDLY TKMRKQASEK 

       430        440        450        460        470        480 
ELLIAGRIFV LLLTVVSIVW VPLVQVSQNG QLIHYTESIS SYLGPPIAAV FVLAIFCKRV 

       490        500        510        520        530        540 
NEQGAFWGLM VGLAMGLIRM ITEFAYGTGS CLAPSNCPKI ICGVHYLYFS IVLFFGSMLV 

       550        560        570        580        590        600 
TLGISLLTKP IPDVHLYRLC WVLRNSTEER IDIDAEEKSQ EETDDGVEED YPEKSRGCLK 

       610        620        630        640        650 
KAYDLFCGLQ KGPKLTKEEE EALSKKLTDT SERPSWRTIV NINAILLLAV VVFIHGYYA 

« Hide

References

« Hide 'large scale' references
[1]"The molecular cloning and functional characterization of the human SGLT2 transporter."
Gorboulev V., Baumgarten K., Veyhl M., Koepsell H.
Submitted (FEB-2000) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Small intestine.
[2]"The DNA sequence of human chromosome 22."
Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M., Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C., Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E., Bridgeman A.M. expand/collapse author list , Buck D., Burgess J., Burrill W.D., Burton J., Carder C., Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G., Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V., Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M., Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A., Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C., Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E., Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F., Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M., Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A., Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D., Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y., Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S., Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E., Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L., Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L., Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N., Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A., Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L., Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P., Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P., Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q., Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J., Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J., Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D., Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T., Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P., Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K., Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R., Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L., McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J., Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E., Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P., Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y., Wright H.
Nature 402:489-495(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]Poppe R., Koepsell H.
Submitted (DEC-1995) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 73-247.
Tissue: Brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ133127 mRNA. Translation: CAB81772.1.
AL008723 Genomic DNA. Translation: CAB51758.1.
U41897 mRNA. Translation: AAB61732.1.
RefSeqNP_055042.1. NM_014227.2.
UniGeneHs.130101.

3D structure databases

ProteinModelPortalQ9NY91.
SMRQ9NY91. Positions 26-553.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000266086.

Chemistry

BindingDBQ9NY91.
ChEMBLCHEMBL1770047.

Protein family/group databases

TCDB2.A.21.3.18. the solute:sodium symporter (sss) family.

PTM databases

PhosphoSiteQ9NY91.

Polymorphism databases

DMDM17433306.

Proteomic databases

PaxDbQ9NY91.
PRIDEQ9NY91.

Protocols and materials databases

DNASU6527.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000266086; ENSP00000266086; ENSG00000100191.
GeneID6527.
KEGGhsa:6527.
UCSCuc003ami.3. human.

Organism-specific databases

CTD6527.
GeneCardsGC22M032614.
HGNCHGNC:11039. SLC5A4.
HPAHPA026840.
neXtProtNX_Q9NY91.
PharmGKBPA35904.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG4146.
HOGENOMHOG000025422.
HOVERGENHBG052859.
InParanoidQ9NY91.
KOK14384.
OMAAIWIAQD.
OrthoDBEOG77126J.
PhylomeDBQ9NY91.
TreeFamTF352855.

Enzyme and pathway databases

ReactomeREACT_111217. Metabolism.
REACT_15518. Transmembrane transport of small molecules.

Gene expression databases

ArrayExpressQ9NY91.
BgeeQ9NY91.
CleanExHS_SLC5A4.
GenevestigatorQ9NY91.

Family and domain databases

InterProIPR001734. Na/solute_symporter.
IPR018212. Na/solute_symporter_CS.
IPR019900. Na/solute_symporter_subgr.
[Graphical view]
PANTHERPTHR11819. PTHR11819. 1 hit.
PfamPF00474. SSF. 1 hit.
[Graphical view]
TIGRFAMsTIGR00813. sss. 1 hit.
PROSITEPS00456. NA_SOLUT_SYMP_1. 1 hit.
PS00457. NA_SOLUT_SYMP_2. 1 hit.
PS50283. NA_SOLUT_SYMP_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiSLC5A4.
GenomeRNAi6527.
NextBio25395.
PROQ9NY91.

Entry information

Entry nameSC5A4_HUMAN
AccessionPrimary (citable) accession number: Q9NY91
Secondary accession number(s): O15279
Entry history
Integrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: October 1, 2000
Last modified: April 16, 2014
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 22

Human chromosome 22: entries, gene names and cross-references to MIM