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Q9NY91

- SC5A4_HUMAN

UniProt

Q9NY91 - SC5A4_HUMAN

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Protein

Low affinity sodium-glucose cotransporter

Gene

SLC5A4

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Sodium-dependent glucose transporter.By similarity

GO - Molecular functioni

  1. symporter activity Source: UniProtKB-KW

GO - Biological processi

  1. carbohydrate transport Source: UniProtKB-KW
  2. sodium ion transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Ion transport, Sodium transport, Sugar transport, Symport, Transport

Keywords - Ligandi

Sodium

Enzyme and pathway databases

ReactomeiREACT_19165. Na+-dependent glucose transporters.
REACT_19188. Inositol transporters.
REACT_9441. Hexose transport.

Protein family/group databases

TCDBi2.A.21.3.18. the solute:sodium symporter (sss) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Low affinity sodium-glucose cotransporter
Alternative name(s):
Sodium/glucose cotransporter 3
Short name:
Na(+)/glucose cotransporter 3
Solute carrier family 5 member 4
Gene namesi
Name:SLC5A4
Synonyms:SAAT1, SGLT2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 22

Organism-specific databases

HGNCiHGNC:11039. SLC5A4.

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA35904.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 659659Low affinity sodium-glucose cotransporterPRO_0000105376Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi248 – 2481N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9NY91.
PRIDEiQ9NY91.

PTM databases

PhosphoSiteiQ9NY91.

Expressioni

Gene expression databases

BgeeiQ9NY91.
CleanExiHS_SLC5A4.
ExpressionAtlasiQ9NY91. baseline.
GenevestigatoriQ9NY91.

Organism-specific databases

HPAiHPA026840.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000266086.

Structurei

3D structure databases

ProteinModelPortaliQ9NY91.
SMRiQ9NY91. Positions 28-497.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2828CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini48 – 6417ExtracellularSequence AnalysisAdd
BLAST
Topological domaini86 – 10520CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini127 – 17145ExtracellularSequence AnalysisAdd
BLAST
Topological domaini192 – 20817CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini230 – 27041ExtracellularSequence AnalysisAdd
BLAST
Topological domaini292 – 31423CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini335 – 42389ExtracellularSequence AnalysisAdd
BLAST
Topological domaini444 – 45512CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini477 – 52650ExtracellularSequence AnalysisAdd
BLAST
Topological domaini548 – 63790CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei29 – 4719HelicalSequence AnalysisAdd
BLAST
Transmembranei65 – 8521HelicalSequence AnalysisAdd
BLAST
Transmembranei106 – 12621HelicalSequence AnalysisAdd
BLAST
Transmembranei172 – 19120HelicalSequence AnalysisAdd
BLAST
Transmembranei209 – 22921HelicalSequence AnalysisAdd
BLAST
Transmembranei271 – 29121HelicalSequence AnalysisAdd
BLAST
Transmembranei315 – 33420HelicalSequence AnalysisAdd
BLAST
Transmembranei424 – 44320HelicalSequence AnalysisAdd
BLAST
Transmembranei456 – 47621HelicalSequence AnalysisAdd
BLAST
Transmembranei527 – 54721HelicalSequence AnalysisAdd
BLAST
Transmembranei638 – 65821HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG4146.
GeneTreeiENSGT00760000118955.
HOGENOMiHOG000025422.
HOVERGENiHBG052859.
InParanoidiQ9NY91.
KOiK14384.
OMAiLTPVMVV.
OrthoDBiEOG77126J.
PhylomeDBiQ9NY91.
TreeFamiTF352855.

Family and domain databases

InterProiIPR001734. Na/solute_symporter.
IPR018212. Na/solute_symporter_CS.
IPR019900. Na/solute_symporter_subgr.
[Graphical view]
PANTHERiPTHR11819. PTHR11819. 1 hit.
PfamiPF00474. SSF. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00813. sss. 1 hit.
PROSITEiPS00456. NA_SOLUT_SYMP_1. 1 hit.
PS00457. NA_SOLUT_SYMP_2. 1 hit.
PS50283. NA_SOLUT_SYMP_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9NY91-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MASTVSPSTI AETPEPPPLS DHIRNAADIS VIVIYFLVVM AVGLWAMLKT
60 70 80 90 100
NRGTIGGFFL AGRDMAWWPM GASLFASNIG SNHYVGLAGT GAASGVATVT
110 120 130 140 150
FEWTSSVMLL ILGWIFVPIY IKSGVMTMPE YLKKRFGGER LQVYLSILSL
160 170 180 190 200
FICVVLLISA DIFAGAIFIK LALGLDLYLA IFILLAMTAV YTTTGGLASV
210 220 230 240 250
IYTDTLQTII MLIGSFILMG FAFNEVGGYE SFTEKYVNAT PSVVEGDNLT
260 270 280 290 300
ISASCYTPRA DSFHIFRDAV TGDIPWPGII FGMPITALWY WCTNQVIVQR
310 320 330 340 350
CLCGKDMSHV KAACIMCAYL KLLPMFLMVM PGMISRILYT DMVACVVPSE
360 370 380 390 400
CVKHCGVDVG CTNYAYPTMV LELMPQGLRG LMLSVMLASL MSSLTSIFNS
410 420 430 440 450
ASTLFTIDLY TKMRKQASEK ELLIAGRIFV LLLTVVSIVW VPLVQVSQNG
460 470 480 490 500
QLIHYTESIS SYLGPPIAAV FVLAIFCKRV NEQGAFWGLM VGLAMGLIRM
510 520 530 540 550
ITEFAYGTGS CLAPSNCPKI ICGVHYLYFS IVLFFGSMLV TLGISLLTKP
560 570 580 590 600
IPDVHLYRLC WVLRNSTEER IDIDAEEKSQ EETDDGVEED YPEKSRGCLK
610 620 630 640 650
KAYDLFCGLQ KGPKLTKEEE EALSKKLTDT SERPSWRTIV NINAILLLAV

VVFIHGYYA
Length:659
Mass (Da):72,456
Last modified:October 1, 2000 - v1
Checksum:iF8A34AED648B523A
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti76 – 761A → V in AAB61732. 1 PublicationCurated
Sequence conflicti106 – 1061S → P in AAB61732. 1 PublicationCurated
Sequence conflicti243 – 2431V → I in AAB61732. 1 PublicationCurated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti4 – 41T → M.
Corresponds to variant rs16990065 [ dbSNP | Ensembl ].
VAR_052489
Natural varianti46 – 461A → T.
Corresponds to variant rs2235171 [ dbSNP | Ensembl ].
VAR_021997

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ133127 mRNA. Translation: CAB81772.1.
AL008723 Genomic DNA. Translation: CAB51758.1.
U41897 mRNA. Translation: AAB61732.1.
CCDSiCCDS13903.1.
RefSeqiNP_055042.1. NM_014227.2.
UniGeneiHs.130101.

Genome annotation databases

EnsembliENST00000266086; ENSP00000266086; ENSG00000100191.
GeneIDi6527.
KEGGihsa:6527.
UCSCiuc003ami.3. human.

Polymorphism databases

DMDMi17433306.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ133127 mRNA. Translation: CAB81772.1 .
AL008723 Genomic DNA. Translation: CAB51758.1 .
U41897 mRNA. Translation: AAB61732.1 .
CCDSi CCDS13903.1.
RefSeqi NP_055042.1. NM_014227.2.
UniGenei Hs.130101.

3D structure databases

ProteinModelPortali Q9NY91.
SMRi Q9NY91. Positions 28-497.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000266086.

Chemistry

BindingDBi Q9NY91.
ChEMBLi CHEMBL1770047.

Protein family/group databases

TCDBi 2.A.21.3.18. the solute:sodium symporter (sss) family.

PTM databases

PhosphoSitei Q9NY91.

Polymorphism databases

DMDMi 17433306.

Proteomic databases

PaxDbi Q9NY91.
PRIDEi Q9NY91.

Protocols and materials databases

DNASUi 6527.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000266086 ; ENSP00000266086 ; ENSG00000100191 .
GeneIDi 6527.
KEGGi hsa:6527.
UCSCi uc003ami.3. human.

Organism-specific databases

CTDi 6527.
GeneCardsi GC22M032614.
HGNCi HGNC:11039. SLC5A4.
HPAi HPA026840.
neXtProti NX_Q9NY91.
PharmGKBi PA35904.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG4146.
GeneTreei ENSGT00760000118955.
HOGENOMi HOG000025422.
HOVERGENi HBG052859.
InParanoidi Q9NY91.
KOi K14384.
OMAi LTPVMVV.
OrthoDBi EOG77126J.
PhylomeDBi Q9NY91.
TreeFami TF352855.

Enzyme and pathway databases

Reactomei REACT_19165. Na+-dependent glucose transporters.
REACT_19188. Inositol transporters.
REACT_9441. Hexose transport.

Miscellaneous databases

GeneWikii SLC5A4.
GenomeRNAii 6527.
NextBioi 25395.
PROi Q9NY91.

Gene expression databases

Bgeei Q9NY91.
CleanExi HS_SLC5A4.
ExpressionAtlasi Q9NY91. baseline.
Genevestigatori Q9NY91.

Family and domain databases

InterProi IPR001734. Na/solute_symporter.
IPR018212. Na/solute_symporter_CS.
IPR019900. Na/solute_symporter_subgr.
[Graphical view ]
PANTHERi PTHR11819. PTHR11819. 1 hit.
Pfami PF00474. SSF. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00813. sss. 1 hit.
PROSITEi PS00456. NA_SOLUT_SYMP_1. 1 hit.
PS00457. NA_SOLUT_SYMP_2. 1 hit.
PS50283. NA_SOLUT_SYMP_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The molecular cloning and functional characterization of the human SGLT2 transporter."
    Gorboulev V., Baumgarten K., Veyhl M., Koepsell H.
    Submitted (FEB-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Small intestine.
  2. "The DNA sequence of human chromosome 22."
    Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M., Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C., Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E., Bridgeman A.M.
    , Buck D., Burgess J., Burrill W.D., Burton J., Carder C., Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G., Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V., Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M., Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A., Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C., Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E., Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F., Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M., Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A., Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D., Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y., Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S., Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E., Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L., Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L., Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N., Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A., Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L., Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P., Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P., Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q., Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J., Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J., Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D., Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T., Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P., Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K., Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R., Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L., McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J., Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E., Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P., Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y., Wright H.
    Nature 402:489-495(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Poppe R., Koepsell H.
    Submitted (DEC-1995) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 73-247.
    Tissue: Brain.

Entry informationi

Entry nameiSC5A4_HUMAN
AccessioniPrimary (citable) accession number: Q9NY91
Secondary accession number(s): O15279
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: October 1, 2000
Last modified: October 29, 2014
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3