ID   SPNXC_HUMAN             Reviewed;          97 AA.
AC   Q9NY87; Q32WL2; Q32WL9; Q32WM0; Q5JX88; Q8TAD1; Q9BS24;
DT   01-FEB-2005, integrated into UniProtKB/Swiss-Prot.
DT   22-JUL-2015, sequence version 2.
DT   24-JAN-2024, entry version 152.
DE   RecName: Full=Sperm protein associated with the nucleus on the X chromosome C {ECO:0000305};
DE   AltName: Full=Cancer/testis antigen 11.3;
DE            Short=CT11.3 {ECO:0000312|HGNC:HGNC:14331};
DE   AltName: Full=Cancer/testis-associated protein CTp11 {ECO:0000312|EMBL:CAB75344.1};
DE   AltName: Full=Nuclear-associated protein SPAN-Xc;
DE            Short=SPANX-C {ECO:0000312|EMBL:AAW47309.1};
DE   AltName: Full=SPANX family member C;
GN   Name=SPANXC;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
RC   TISSUE=Melanoma;
RX   PubMed=10626816;
RA   Zendman A.J.W., Cornelissen I.M.H.A., Weidle U.H., Ruiter D.J.,
RA   Van Muijen G.N.P.;
RT   "CTp11, a novel member of the family of cancer-testis antigens.";
RL   Cancer Res. 59:6223-6229(1999).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], DEVELOPMENTAL STAGE, AND TISSUE
RP   SPECIFICITY.
RX   PubMed=12758128; DOI=10.1016/s0378-1119(03)00497-9;
RA   Zendman A.J., Zschocke J., van Kraats A.A., de Wit N.J.W., Kurpisz M.,
RA   Weidle U.H., Ruiter D.J., Weiss E.H., van Muijen G.N.P.;
RT   "The human SPANX multigene family: genomic organization, alignment and
RT   expression in male germ cells and tumor cell lines.";
RL   Gene 309:125-133(2003).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANT PHE-59.
RX   PubMed=16251457; DOI=10.1101/gr.4212705;
RA   Kouprina N., Pavlicek A., Noskov V.N., Solomon G., Otstot J., Isaacs W.,
RA   Carpten J.D., Trent J.M., Schleutker J., Barrett J.C., Jurka J.,
RA   Larionov V.;
RT   "Dynamic structure of the SPANX gene cluster mapped to the prostate cancer
RT   susceptibility locus HPCX at Xq27.";
RL   Genome Res. 15:1477-1486(2005).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANT PHE-59.
RX   PubMed=17373721; DOI=10.1002/pros.20561;
RA   Kouprina N., Noskov V.N., Solomon G., Otstot J., Isaacs W., Xu J.,
RA   Schleutker J., Larionov V.;
RT   "Mutational analysis of SPANX genes in families with X-linked prostate
RT   cancer.";
RL   Prostate 67:820-828(2007).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15772651; DOI=10.1038/nature03440;
RA   Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D.,
RA   Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L.,
RA   Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.,
RA   Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A.,
RA   Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P.,
RA   Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D.,
RA   Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D.,
RA   Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L.,
RA   Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P.,
RA   Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G.,
RA   Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J.,
RA   Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D.,
RA   Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L.,
RA   Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z.,
RA   Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S.,
RA   Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S.,
RA   Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O.,
RA   Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H.,
RA   Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T.,
RA   Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L.,
RA   Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R.,
RA   Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y.,
RA   Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K.,
RA   Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J.,
RA   Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L.,
RA   Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S.,
RA   Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A.,
RA   Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L.,
RA   Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D.,
RA   Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H.,
RA   McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S.,
RA   Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C.,
RA   Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S.,
RA   Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V.,
RA   Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K.,
RA   Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K.,
RA   Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D.,
RA   Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R.,
RA   Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B.,
RA   Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C.,
RA   d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q.,
RA   Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N.,
RA   Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A.,
RA   Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J.,
RA   Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A.,
RA   Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F.,
RA   Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L.,
RA   Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S.,
RA   Rogers J., Bentley D.R.;
RT   "The DNA sequence of the human X chromosome.";
RL   Nature 434:325-337(2005).
RN   [6]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Bone marrow, and Testis;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- INTERACTION:
CC       Q9NY87; P42858: HTT; NbExp=3; IntAct=EBI-10316585, EBI-466029;
CC       Q9NY87; Q9Y6X0: SETBP1; NbExp=3; IntAct=EBI-10316585, EBI-2548259;
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:10626816}. Nucleus
CC       {ECO:0000269|PubMed:10626816}. Note=Associated with nuclear craters.
CC   -!- TISSUE SPECIFICITY: Detected in testis, melanoma and bladder carcinoma.
CC       {ECO:0000269|PubMed:10626816, ECO:0000269|PubMed:12758128}.
CC   -!- DEVELOPMENTAL STAGE: Detected in round and elongating spermatids.
CC       {ECO:0000269|PubMed:12758128}.
CC   -!- SIMILARITY: Belongs to the SPAN-X family. {ECO:0000305}.
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DR   EMBL; AJ238277; CAB75344.1; -; mRNA.
DR   EMBL; AJ457790; CAD29839.1; -; Genomic_DNA.
DR   EMBL; AJ457792; CAD29841.1; -; Genomic_DNA.
DR   EMBL; AJ457795; CAD29844.1; -; mRNA.
DR   EMBL; AY787084; AAW47309.1; -; Genomic_DNA.
DR   EMBL; AY787086; AAW47310.1; -; Genomic_DNA.
DR   EMBL; AY787088; AAW47312.1; -; Genomic_DNA.
DR   EMBL; AY787089; AAW47313.1; -; Genomic_DNA.
DR   EMBL; AY787091; AAW47314.1; -; Genomic_DNA.
DR   EMBL; AY787093; AAW47315.1; -; Genomic_DNA.
DR   EMBL; AY787095; AAW47317.1; -; Genomic_DNA.
DR   EMBL; AY787096; AAW47318.1; -; Genomic_DNA.
DR   EMBL; AY787097; AAW47319.1; -; Genomic_DNA.
DR   EMBL; AY787098; AAW47320.1; -; Genomic_DNA.
DR   EMBL; AY787099; AAW47321.1; -; Genomic_DNA.
DR   EMBL; AY787100; AAW47322.1; -; Genomic_DNA.
DR   EMBL; AY787102; AAW47324.1; -; Genomic_DNA.
DR   EMBL; AY787103; AAW47325.1; -; Genomic_DNA.
DR   EMBL; AY787104; AAW47326.1; -; Genomic_DNA.
DR   EMBL; AY787105; AAW47327.1; -; Genomic_DNA.
DR   EMBL; AY787106; AAW47328.1; -; Genomic_DNA.
DR   EMBL; AY787107; AAW47329.1; -; Genomic_DNA.
DR   EMBL; AY787108; AAW47330.1; -; Genomic_DNA.
DR   EMBL; AY787109; AAW47331.1; -; Genomic_DNA.
DR   EMBL; AY787110; AAW47332.1; -; Genomic_DNA.
DR   EMBL; AY787111; AAW47333.1; -; Genomic_DNA.
DR   EMBL; AY787112; AAW47334.1; -; Genomic_DNA.
DR   EMBL; AY787113; AAW47335.1; -; Genomic_DNA.
DR   EMBL; AY787114; AAW47336.1; -; Genomic_DNA.
DR   EMBL; AY787116; AAW47338.1; -; Genomic_DNA.
DR   EMBL; AY787117; AAW47339.1; -; Genomic_DNA.
DR   EMBL; AY787119; AAW47341.1; -; Genomic_DNA.
DR   EMBL; AY787121; AAW47343.1; -; Genomic_DNA.
DR   EMBL; AY787122; AAW47344.1; -; Genomic_DNA.
DR   EMBL; AY787124; AAW47346.1; -; Genomic_DNA.
DR   EMBL; DQ994211; ABK19852.1; -; Genomic_DNA.
DR   EMBL; DQ994213; ABK19854.1; -; Genomic_DNA.
DR   EMBL; DQ994214; ABK19855.1; -; Genomic_DNA.
DR   EMBL; DQ994215; ABK19856.1; -; Genomic_DNA.
DR   EMBL; DQ994216; ABK19857.1; -; Genomic_DNA.
DR   EMBL; DQ994217; ABK19858.1; -; Genomic_DNA.
DR   EMBL; DQ994218; ABK19859.1; -; Genomic_DNA.
DR   EMBL; DQ994219; ABK19860.1; -; Genomic_DNA.
DR   EMBL; DQ994220; ABK19861.1; -; Genomic_DNA.
DR   EMBL; DQ994222; ABK19863.1; -; Genomic_DNA.
DR   EMBL; DQ994223; ABK19864.1; -; Genomic_DNA.
DR   EMBL; DQ994225; ABK19866.1; -; Genomic_DNA.
DR   EMBL; DQ994227; ABK19868.1; -; Genomic_DNA.
DR   EMBL; DQ994228; ABK19869.1; -; Genomic_DNA.
DR   EMBL; DQ994229; ABK19870.1; -; Genomic_DNA.
DR   EMBL; DQ994230; ABK19871.1; -; Genomic_DNA.
DR   EMBL; DQ994231; ABK19872.1; -; Genomic_DNA.
DR   EMBL; DQ994232; ABK19873.1; -; Genomic_DNA.
DR   EMBL; DQ994233; ABK19874.1; -; Genomic_DNA.
DR   EMBL; DQ994234; ABK19875.1; -; Genomic_DNA.
DR   EMBL; DQ994235; ABK19876.1; -; Genomic_DNA.
DR   EMBL; DQ994238; ABK19879.1; -; Genomic_DNA.
DR   EMBL; DQ994239; ABK19880.1; -; Genomic_DNA.
DR   EMBL; EF101635; ABK96942.1; -; Genomic_DNA.
DR   EMBL; EF101636; ABK96943.1; -; Genomic_DNA.
DR   EMBL; EF101638; ABK96945.1; -; Genomic_DNA.
DR   EMBL; EF101639; ABK96946.1; -; Genomic_DNA.
DR   EMBL; EF101640; ABK96947.1; -; Genomic_DNA.
DR   EMBL; EF101641; ABK96948.1; -; Genomic_DNA.
DR   EMBL; EF101642; ABK96949.1; -; Genomic_DNA.
DR   EMBL; EF101643; ABK96950.1; -; Genomic_DNA.
DR   EMBL; EF101644; ABK96951.1; -; Genomic_DNA.
DR   EMBL; EF101645; ABK96952.1; -; Genomic_DNA.
DR   EMBL; EF101646; ABK96953.1; -; Genomic_DNA.
DR   EMBL; EF101647; ABK96954.1; -; Genomic_DNA.
DR   EMBL; EF101648; ABK96955.1; -; Genomic_DNA.
DR   EMBL; EF101649; ABK96956.1; -; Genomic_DNA.
DR   EMBL; EF101651; ABK96958.1; -; Genomic_DNA.
DR   EMBL; EF101652; ABK96959.1; -; Genomic_DNA.
DR   EMBL; EF101653; ABK96960.1; -; Genomic_DNA.
DR   EMBL; EF101654; ABK96961.1; -; Genomic_DNA.
DR   EMBL; EF101655; ABK96962.1; -; Genomic_DNA.
DR   EMBL; EF101656; ABK96963.1; -; Genomic_DNA.
DR   EMBL; EF101657; ABK96964.1; -; Genomic_DNA.
DR   EMBL; EF101658; ABK96965.1; -; Genomic_DNA.
DR   EMBL; EF101659; ABK96966.1; -; Genomic_DNA.
DR   EMBL; AL109799; CAI41662.1; -; Genomic_DNA.
DR   EMBL; AC234777; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC005382; AAH05382.1; -; mRNA.
DR   EMBL; BC062672; AAH62672.1; -; mRNA.
DR   EMBL; BC054023; AAH54023.1; -; mRNA.
DR   CCDS; CCDS14673.1; -.
DR   RefSeq; NP_073152.2; NM_022661.3.
DR   RefSeq; XP_016855456.1; XM_016999967.1.
DR   RefSeq; XP_016855457.1; XM_016999968.1.
DR   AlphaFoldDB; Q9NY87; -.
DR   BioGRID; 122228; 8.
DR   IntAct; Q9NY87; 2.
DR   STRING; 9606.ENSP00000351884; -.
DR   iPTMnet; Q9NY87; -.
DR   PhosphoSitePlus; Q9NY87; -.
DR   BioMuta; SPANXC; -.
DR   DMDM; 85700154; -.
DR   MassIVE; Q9NY87; -.
DR   MaxQB; Q9NY87; -.
DR   PaxDb; 9606-ENSP00000351884; -.
DR   PeptideAtlas; Q9NY87; -.
DR   ProteomicsDB; 83195; -.
DR   Pumba; Q9NY87; -.
DR   Antibodypedia; 30548; 141 antibodies from 24 providers.
DR   DNASU; 64663; -.
DR   Ensembl; ENST00000358993.3; ENSP00000351884.2; ENSG00000198573.7.
DR   GeneID; 64663; -.
DR   KEGG; hsa:64663; -.
DR   MANE-Select; ENST00000358993.3; ENSP00000351884.2; NM_022661.4; NP_073152.2.
DR   UCSC; uc033exl.2; human.
DR   AGR; HGNC:14331; -.
DR   CTD; 64663; -.
DR   DisGeNET; 64663; -.
DR   GeneCards; SPANXC; -.
DR   HGNC; HGNC:14331; SPANXC.
DR   HPA; ENSG00000198573; Tissue enriched (testis).
DR   MIM; 300330; gene.
DR   neXtProt; NX_Q9NY87; -.
DR   OpenTargets; ENSG00000198573; -.
DR   PharmGKB; PA37873; -.
DR   VEuPathDB; HostDB:ENSG00000198573; -.
DR   eggNOG; ENOG502TEHU; Eukaryota.
DR   GeneTree; ENSGT00730000111796; -.
DR   HOGENOM; CLU_140435_1_0_1; -.
DR   InParanoid; Q9NY87; -.
DR   OMA; CASNEAG; -.
DR   OrthoDB; 4662796at2759; -.
DR   PhylomeDB; Q9NY87; -.
DR   TreeFam; TF341404; -.
DR   PathwayCommons; Q9NY87; -.
DR   SignaLink; Q9NY87; -.
DR   BioGRID-ORCS; 64663; 17 hits in 612 CRISPR screens.
DR   BioGRID-ORCS; 728712; 59 hits in 602 CRISPR screens.
DR   Pharos; Q9NY87; Tbio.
DR   PRO; PR:Q9NY87; -.
DR   Proteomes; UP000005640; Chromosome X.
DR   RNAct; Q9NY87; Protein.
DR   Bgee; ENSG00000198573; Expressed in male germ line stem cell (sensu Vertebrata) in testis and 30 other cell types or tissues.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; HDA:UniProtKB.
DR   InterPro; IPR010007; SPAN-X_fam.
DR   Pfam; PF07458; SPAN-X; 1.
DR   Genevisible; Q9NY87; HS.
PE   1: Evidence at protein level;
KW   Cytoplasm; Nucleus; Reference proteome.
FT   CHAIN           1..97
FT                   /note="Sperm protein associated with the nucleus on the X
FT                   chromosome C"
FT                   /id="PRO_0000189551"
FT   REGION          1..47
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           37..45
FT                   /note="Nuclear localization signal"
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        22..47
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   VARIANT         59
FT                   /note="V -> F"
FT                   /evidence="ECO:0000269|PubMed:16251457,
FT                   ECO:0000269|PubMed:17373721"
FT                   /id="VAR_032024"
FT   CONFLICT        17..32
FT                   /note="DSNEANEMMPETSSGY -> ESNEVNETMPETPTGD (in Ref. 1;
FT                   CAB75344, 2; CAD29839, 3;
FT                   AAW47309/AAW47312/AAW47313/AAW47314/AAW47315/AAW47317/AAW47319/AAW47320/AAW47321/AAW47322/AAW47325/AAW47327/AAW47328/AAW47329/AAW47330/AAW47331/AAW47333/AAW47334/AAW47335/AAW47336/AAW47338/AAW47339/AAW47343/AAW47344/AAW47346,
FT                   4;
FT                   ABK19854/ABK19856/ABK19857/ABK19864/ABK19866/ABK19868/ABK19869/ABK19870/ABK19871/ABK19872/ABK19873/ABK19879/ABK19880/ABK96948/ABK96950/ABK96951/ABK96952/ABK96953/ABK96958/ABK96961/ABK96963/ABK96966
FT                   and 6; AAH54023)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        42
FT                   /note="L -> M (in Ref. 1; CAB75344, 2; CAD29839, 3;
FT                   AAW47309/AAW47312/AAW47313/AAW47314/AAW47315/AAW47317/AAW47319/AAW47320/AAW47321/AAW47322/AAW47325/AAW47327/AAW47328/AAW47329/AAW47330/AAW47331/AAW47333/AAW47334/AAW47335/AAW47336/AAW47338/AAW47339/AAW47343/AAW47344/AAW47346,
FT                   4;
FT                   ABK19854/ABK19856/ABK19857/ABK19864/ABK19866/ABK19868/ABK19869/ABK19870/ABK19871/ABK19872/ABK19873/ABK19879/ABK19880/ABK96948/ABK96950/ABK96951/ABK96952/ABK96953/ABK96958/ABK96961/ABK96963/ABK96966
FT                   and 6; AAH54023)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        68
FT                   /note="V -> L (in Ref. 1; CAB75344, 2; CAD29839, 3;
FT                   AAW47309/AAW47312/AAW47313/AAW47314/AAW47315/AAW47317/AAW47319/AAW47320/AAW47321/AAW47322/AAW47325/AAW47326/AAW47327/AAW47328/AAW47329/AAW47330/AAW47331/AAW47333/AAW47334/AAW47335/AAW47336/AAW47338/AAW47339/AAW47343/AAW47344/AAW47346,
FT                   4;
FT                   ABK19854/ABK19856/ABK19857/ABK19863/ABK19864/ABK19866/ABK19868/ABK19869/ABK19870/ABK19871/ABK19872/ABK19873/ABK19879/ABK19880/ABK96945/ABK96947/ABK96948/ABK96950/ABK96951/ABK96952/ABK96953/ABK96958/ABK96961/ABK96962/ABK96963/ABK96966
FT                   and 6; AAH05382/AAH54023/AAH62672)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   97 AA;  10982 MW;  D253EC18FF9F8C6A CRC64;
     MDKQSSAGGV KRSVPCDSNE ANEMMPETSS GYSDPQPAPK KLKTSESSTI LVVRYRRNVK
     RTSPEELVND HARENRINPL QMEEEEFMEI MVEIPAK
//