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Q9NY87

- SPNXC_HUMAN

UniProt

Q9NY87 - SPNXC_HUMAN

Protein

Sperm protein associated with the nucleus on the X chromosome C

Gene

SPANXC

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
  1. Names & Taxonomyi

    Protein namesi
    Recommended name:
    Sperm protein associated with the nucleus on the X chromosome C
    Alternative name(s):
    Cancer/testis antigen 11.3
    Short name:
    CT11.3
    Cancer/testis-associated protein CTp11
    Nuclear-associated protein SPAN-Xc
    Short name:
    SPANX-C
    SPANX family member C
    Gene namesi
    Name:SPANXC
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome X

    Organism-specific databases

    HGNCiHGNC:14331. SPANXC.

    Subcellular locationi

    Cytoplasm 1 Publication. Nucleus 1 Publication
    Note: Associated with nuclear craters.

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. nucleus Source: UniProtKB

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA37873.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 9797Sperm protein associated with the nucleus on the X chromosome CPRO_0000189551Add
    BLAST

    Proteomic databases

    MaxQBiQ9NY87.
    PaxDbiQ9NY87.
    PRIDEiQ9NY87.

    Expressioni

    Tissue specificityi

    Detected in testis, melanoma and bladder carcinoma.2 Publications

    Developmental stagei

    Detected in round and elongating spermatids.1 Publication

    Gene expression databases

    BgeeiQ9NY87.
    CleanExiHS_SPANXC.
    GenevestigatoriQ9NY87.

    Organism-specific databases

    HPAiHPA046423.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000351884.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9NY87.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi37 – 459Nuclear localization signalSequence Analysis

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi83 – 864Poly-Glu

    Sequence similaritiesi

    Belongs to the SPAN-X family.Curated

    Phylogenomic databases

    eggNOGiNOG136441.
    HOGENOMiHOG000015252.
    HOVERGENiHBG059401.
    OMAiMELRECA.
    OrthoDBiEOG7N901P.
    PhylomeDBiQ9NY87.
    TreeFamiTF341404.

    Family and domain databases

    InterProiIPR010007. SPANX_prot.
    [Graphical view]
    PANTHERiPTHR23425. PTHR23425. 1 hit.
    PfamiPF07458. SPAN-X. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9NY87-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDKQSSAGGV KRSVPCESNE VNETMPETPT GDSDPQPAPK KMKTSESSTI   50
    LVVRYRRNVK RTSPEELLND HARENRINPL QMEEEEFMEI MVEIPAK 97
    Length:97
    Mass (Da):11,002
    Last modified:October 1, 2000 - v1
    Checksum:i1AAFD5A12FB7CFD5
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti59 – 591V → F.2 Publications
    VAR_032024
    Natural varianti59 – 591V → L.
    Corresponds to variant rs16993705 [ dbSNP | Ensembl ].
    VAR_034515

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ238277 mRNA. Translation: CAB75344.1.
    AJ457790 Genomic DNA. Translation: CAD29839.1.
    AY787084 Genomic DNA. Translation: AAW47309.1.
    AY787088 Genomic DNA. Translation: AAW47312.1.
    AY787089 Genomic DNA. Translation: AAW47313.1.
    AY787091 Genomic DNA. Translation: AAW47314.1.
    AY787093 Genomic DNA. Translation: AAW47315.1.
    AY787095 Genomic DNA. Translation: AAW47317.1.
    AY787097 Genomic DNA. Translation: AAW47319.1.
    AY787098 Genomic DNA. Translation: AAW47320.1.
    AY787099 Genomic DNA. Translation: AAW47321.1.
    AY787100 Genomic DNA. Translation: AAW47322.1.
    AY787103 Genomic DNA. Translation: AAW47325.1.
    AY787105 Genomic DNA. Translation: AAW47327.1.
    AY787106 Genomic DNA. Translation: AAW47328.1.
    AY787107 Genomic DNA. Translation: AAW47329.1.
    AY787108 Genomic DNA. Translation: AAW47330.1.
    AY787109 Genomic DNA. Translation: AAW47331.1.
    AY787111 Genomic DNA. Translation: AAW47333.1.
    AY787112 Genomic DNA. Translation: AAW47334.1.
    AY787113 Genomic DNA. Translation: AAW47335.1.
    AY787114 Genomic DNA. Translation: AAW47336.1.
    AY787116 Genomic DNA. Translation: AAW47338.1.
    AY787117 Genomic DNA. Translation: AAW47339.1.
    AY787121 Genomic DNA. Translation: AAW47343.1.
    AY787122 Genomic DNA. Translation: AAW47344.1.
    AY787124 Genomic DNA. Translation: AAW47346.1.
    DQ994213 Genomic DNA. Translation: ABK19854.1.
    DQ994215 Genomic DNA. Translation: ABK19856.1.
    DQ994216 Genomic DNA. Translation: ABK19857.1.
    DQ994223 Genomic DNA. Translation: ABK19864.1.
    DQ994225 Genomic DNA. Translation: ABK19866.1.
    DQ994227 Genomic DNA. Translation: ABK19868.1.
    DQ994228 Genomic DNA. Translation: ABK19869.1.
    DQ994229 Genomic DNA. Translation: ABK19870.1.
    DQ994230 Genomic DNA. Translation: ABK19871.1.
    DQ994231 Genomic DNA. Translation: ABK19872.1.
    DQ994232 Genomic DNA. Translation: ABK19873.1.
    DQ994238 Genomic DNA. Translation: ABK19879.1.
    DQ994239 Genomic DNA. Translation: ABK19880.1.
    EF101641 Genomic DNA. Translation: ABK96948.1.
    EF101643 Genomic DNA. Translation: ABK96950.1.
    EF101644 Genomic DNA. Translation: ABK96951.1.
    EF101645 Genomic DNA. Translation: ABK96952.1.
    EF101646 Genomic DNA. Translation: ABK96953.1.
    EF101651 Genomic DNA. Translation: ABK96958.1.
    EF101654 Genomic DNA. Translation: ABK96961.1.
    EF101656 Genomic DNA. Translation: ABK96963.1.
    EF101659 Genomic DNA. Translation: ABK96966.1.
    AL109799 Genomic DNA. Translation: CAI41662.1.
    BC054023 mRNA. Translation: AAH54023.1.
    UniGeneiHs.334464.
    Hs.375036.
    Hs.558533.
    Hs.711784.

    Genome annotation databases

    EnsembliENST00000358993; ENSP00000351884; ENSG00000198573.
    KEGGihsa:64663.
    UCSCiuc004fbk.3. human.

    Polymorphism databases

    DMDMi85543354.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ238277 mRNA. Translation: CAB75344.1 .
    AJ457790 Genomic DNA. Translation: CAD29839.1 .
    AY787084 Genomic DNA. Translation: AAW47309.1 .
    AY787088 Genomic DNA. Translation: AAW47312.1 .
    AY787089 Genomic DNA. Translation: AAW47313.1 .
    AY787091 Genomic DNA. Translation: AAW47314.1 .
    AY787093 Genomic DNA. Translation: AAW47315.1 .
    AY787095 Genomic DNA. Translation: AAW47317.1 .
    AY787097 Genomic DNA. Translation: AAW47319.1 .
    AY787098 Genomic DNA. Translation: AAW47320.1 .
    AY787099 Genomic DNA. Translation: AAW47321.1 .
    AY787100 Genomic DNA. Translation: AAW47322.1 .
    AY787103 Genomic DNA. Translation: AAW47325.1 .
    AY787105 Genomic DNA. Translation: AAW47327.1 .
    AY787106 Genomic DNA. Translation: AAW47328.1 .
    AY787107 Genomic DNA. Translation: AAW47329.1 .
    AY787108 Genomic DNA. Translation: AAW47330.1 .
    AY787109 Genomic DNA. Translation: AAW47331.1 .
    AY787111 Genomic DNA. Translation: AAW47333.1 .
    AY787112 Genomic DNA. Translation: AAW47334.1 .
    AY787113 Genomic DNA. Translation: AAW47335.1 .
    AY787114 Genomic DNA. Translation: AAW47336.1 .
    AY787116 Genomic DNA. Translation: AAW47338.1 .
    AY787117 Genomic DNA. Translation: AAW47339.1 .
    AY787121 Genomic DNA. Translation: AAW47343.1 .
    AY787122 Genomic DNA. Translation: AAW47344.1 .
    AY787124 Genomic DNA. Translation: AAW47346.1 .
    DQ994213 Genomic DNA. Translation: ABK19854.1 .
    DQ994215 Genomic DNA. Translation: ABK19856.1 .
    DQ994216 Genomic DNA. Translation: ABK19857.1 .
    DQ994223 Genomic DNA. Translation: ABK19864.1 .
    DQ994225 Genomic DNA. Translation: ABK19866.1 .
    DQ994227 Genomic DNA. Translation: ABK19868.1 .
    DQ994228 Genomic DNA. Translation: ABK19869.1 .
    DQ994229 Genomic DNA. Translation: ABK19870.1 .
    DQ994230 Genomic DNA. Translation: ABK19871.1 .
    DQ994231 Genomic DNA. Translation: ABK19872.1 .
    DQ994232 Genomic DNA. Translation: ABK19873.1 .
    DQ994238 Genomic DNA. Translation: ABK19879.1 .
    DQ994239 Genomic DNA. Translation: ABK19880.1 .
    EF101641 Genomic DNA. Translation: ABK96948.1 .
    EF101643 Genomic DNA. Translation: ABK96950.1 .
    EF101644 Genomic DNA. Translation: ABK96951.1 .
    EF101645 Genomic DNA. Translation: ABK96952.1 .
    EF101646 Genomic DNA. Translation: ABK96953.1 .
    EF101651 Genomic DNA. Translation: ABK96958.1 .
    EF101654 Genomic DNA. Translation: ABK96961.1 .
    EF101656 Genomic DNA. Translation: ABK96963.1 .
    EF101659 Genomic DNA. Translation: ABK96966.1 .
    AL109799 Genomic DNA. Translation: CAI41662.1 .
    BC054023 mRNA. Translation: AAH54023.1 .
    UniGenei Hs.334464.
    Hs.375036.
    Hs.558533.
    Hs.711784.

    3D structure databases

    ProteinModelPortali Q9NY87.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000351884.

    Polymorphism databases

    DMDMi 85543354.

    Proteomic databases

    MaxQBi Q9NY87.
    PaxDbi Q9NY87.
    PRIDEi Q9NY87.

    Protocols and materials databases

    DNASUi 64663.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000358993 ; ENSP00000351884 ; ENSG00000198573 .
    KEGGi hsa:64663.
    UCSCi uc004fbk.3. human.

    Organism-specific databases

    GeneCardsi GC0XM140335.
    HGNCi HGNC:14331. SPANXC.
    HPAi HPA046423.
    MIMi 300330. gene.
    neXtProti NX_Q9NY87.
    PharmGKBi PA37873.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG136441.
    HOGENOMi HOG000015252.
    HOVERGENi HBG059401.
    OMAi MELRECA.
    OrthoDBi EOG7N901P.
    PhylomeDBi Q9NY87.
    TreeFami TF341404.

    Miscellaneous databases

    GenomeRNAii 64663.
    NextBioi 66601.
    PROi Q9NY87.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9NY87.
    CleanExi HS_SPANXC.
    Genevestigatori Q9NY87.

    Family and domain databases

    InterProi IPR010007. SPANX_prot.
    [Graphical view ]
    PANTHERi PTHR23425. PTHR23425. 1 hit.
    Pfami PF07458. SPAN-X. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "CTp11, a novel member of the family of cancer-testis antigens."
      Zendman A.J.W., Cornelissen I.M.H.A., Weidle U.H., Ruiter D.J., Van Muijen G.N.P.
      Cancer Res. 59:6223-6229(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
      Tissue: Melanoma.
    2. "The human SPANX multigene family: genomic organization, alignment and expression in male germ cells and tumor cell lines."
      Zendman A.J., Zschocke J., van Kraats A.A., de Wit N.J.W., Kurpisz M., Weidle U.H., Ruiter D.J., Weiss E.H., van Muijen G.N.P.
      Gene 309:125-133(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], DEVELOPMENTAL STAGE, TISSUE SPECIFICITY.
    3. "Dynamic structure of the SPANX gene cluster mapped to the prostate cancer susceptibility locus HPCX at Xq27."
      Kouprina N., Pavlicek A., Noskov V.N., Solomon G., Otstot J., Isaacs W., Carpten J.D., Trent J.M., Schleutker J., Barrett J.C., Jurka J., Larionov V.
      Genome Res. 15:1477-1486(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT PHE-59.
    4. "Mutational analysis of the SPANX gene cluster in X-linked families with the hereditary prostate cancer."
      Larionov V., Kouprina N.
      Submitted (NOV-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT PHE-59.
    5. "The DNA sequence of the human X chromosome."
      Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
      , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
      Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

    Entry informationi

    Entry nameiSPNXC_HUMAN
    AccessioniPrimary (citable) accession number: Q9NY87
    Secondary accession number(s): Q32WL9, Q5JX88
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 2005
    Last sequence update: October 1, 2000
    Last modified: October 1, 2014
    This is version 91 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome X
      Human chromosome X: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3