Q9NY87 (SPNXC_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Sperm protein associated with the nucleus on the X chromosome C

Alternative name(s):
Cancer/testis antigen 11.3
Short name=CT11.3
Cancer/testis-associated protein CTp11
Nuclear-associated protein SPAN-Xc
Short name=SPANX-C
SPANX family member C

Gene names

Name:

SPANXC

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	97 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Subcellular location	Cytoplasm. Nucleus. Note: Associated with nuclear craters. Ref.1
Tissue specificity	Detected in testis, melanoma and bladder carcinoma. Ref.1 Ref.2
Developmental stage	Detected in round and elongating spermatids. Ref.2
Sequence similarities	Belongs to the SPAN-X family.

Ontologies

Keywords
Cellular component	Cytoplasm Nucleus
Coding sequence diversity	Polymorphism
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell nucleus Traceable author statement Ref.1. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 97	97	Sperm protein associated with the nucleus on the X chromosome C		PRO_0000189551
Regions
	Motif	37 – 45	9	Nuclear localization signal Potential
	Compositional bias	83 – 86	4	Poly-Glu
Natural variations
	Natural variant	59	1	V → F. Ref.3 Ref.4		VAR_032024
	Natural variant	59	1	V → L. Corresponds to variant rs16993705 [ dbSNP | Ensembl ].		VAR_034515

Sequences

	Sequence		Length	Mass (Da)
	Q9NY87 [UniParc]. Last modified October 1, 2000. Version 1. Checksum: 1AAFD5A12FB7CFD5	FASTA	97	11,002
	10 20 30 40 50 60 MDKQSSAGGV KRSVPCESNE VNETMPETPT GDSDPQPAPK KMKTSESSTI LVVRYRRNVK 70 80 90 RTSPEELLND HARENRINPL QMEEEEFMEI MVEIPAK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"CTp11, a novel member of the family of cancer-testis antigens." Zendman A.J.W., Cornelissen I.M.H.A., Weidle U.H., Ruiter D.J., Van Muijen G.N.P. Cancer Res. 59:6223-6229(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, TISSUE SPECIFICITY. Tissue: Melanoma.
[2]	"The human SPANX multigene family: genomic organization, alignment and expression in male germ cells and tumor cell lines." Zendman A.J., Zschocke J., van Kraats A.A., de Wit N.J.W., Kurpisz M., Weidle U.H., Ruiter D.J., Weiss E.H., van Muijen G.N.P. Gene 309:125-133(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], DEVELOPMENTAL STAGE, TISSUE SPECIFICITY.
[3]	"Dynamic structure of the SPANX gene cluster mapped to the prostate cancer susceptibility locus HPCX at Xq27." Kouprina N., Pavlicek A., Noskov V.N., Solomon G., Otstot J., Isaacs W., Carpten J.D., Trent J.M., Schleutker J., Barrett J.C., Jurka J., Larionov V. Genome Res. 15:1477-1486(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT PHE-59.
[4]	"Mutational analysis of the SPANX gene cluster in X-linked families with the hereditary prostate cancer." Larionov V., Kouprina N. Submitted (NOV-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT PHE-59.
[5]	"The DNA sequence of the human X chromosome." Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C. , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R. Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ238277 mRNA. Translation: CAB75344.1. AJ457790 Genomic DNA. Translation: CAD29839.1. AY787084 Genomic DNA. Translation: AAW47309.1. AY787088 Genomic DNA. Translation: AAW47312.1. AY787089 Genomic DNA. Translation: AAW47313.1. AY787091 Genomic DNA. Translation: AAW47314.1. AY787093 Genomic DNA. Translation: AAW47315.1. AY787095 Genomic DNA. Translation: AAW47317.1. AY787097 Genomic DNA. Translation: AAW47319.1. AY787098 Genomic DNA. Translation: AAW47320.1. AY787099 Genomic DNA. Translation: AAW47321.1. AY787100 Genomic DNA. Translation: AAW47322.1. AY787103 Genomic DNA. Translation: AAW47325.1. AY787105 Genomic DNA. Translation: AAW47327.1. AY787106 Genomic DNA. Translation: AAW47328.1. AY787107 Genomic DNA. Translation: AAW47329.1. AY787108 Genomic DNA. Translation: AAW47330.1. AY787109 Genomic DNA. Translation: AAW47331.1. AY787111 Genomic DNA. Translation: AAW47333.1. AY787112 Genomic DNA. Translation: AAW47334.1. AY787113 Genomic DNA. Translation: AAW47335.1. AY787114 Genomic DNA. Translation: AAW47336.1. AY787116 Genomic DNA. Translation: AAW47338.1. AY787117 Genomic DNA. Translation: AAW47339.1. AY787121 Genomic DNA. Translation: AAW47343.1. AY787122 Genomic DNA. Translation: AAW47344.1. AY787124 Genomic DNA. Translation: AAW47346.1. DQ994213 Genomic DNA. Translation: ABK19854.1. DQ994215 Genomic DNA. Translation: ABK19856.1. DQ994216 Genomic DNA. Translation: ABK19857.1. DQ994223 Genomic DNA. Translation: ABK19864.1. DQ994225 Genomic DNA. Translation: ABK19866.1. DQ994227 Genomic DNA. Translation: ABK19868.1. DQ994228 Genomic DNA. Translation: ABK19869.1. DQ994229 Genomic DNA. Translation: ABK19870.1. DQ994230 Genomic DNA. Translation: ABK19871.1. DQ994231 Genomic DNA. Translation: ABK19872.1. DQ994232 Genomic DNA. Translation: ABK19873.1. DQ994238 Genomic DNA. Translation: ABK19879.1. DQ994239 Genomic DNA. Translation: ABK19880.1. EF101641 Genomic DNA. Translation: ABK96948.1. EF101643 Genomic DNA. Translation: ABK96950.1. EF101644 Genomic DNA. Translation: ABK96951.1. EF101645 Genomic DNA. Translation: ABK96952.1. EF101646 Genomic DNA. Translation: ABK96953.1. EF101651 Genomic DNA. Translation: ABK96958.1. EF101654 Genomic DNA. Translation: ABK96961.1. EF101656 Genomic DNA. Translation: ABK96963.1. EF101659 Genomic DNA. Translation: ABK96966.1. AL109799 Genomic DNA. Translation: CAI41662.1. BC054023 mRNA. Translation: AAH54023.1.
IPI	IPI00006961.
RefSeq	NP_073152.1. NM_022661.2.
UniGene	Hs.558533.
3D structure databases
ProteinModelPortal	Q9NY87.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000351884.
Polymorphism databases
DMDM	85543354.
Proteomic databases
PaxDb	Q9NY87.
PRIDE	Q9NY87.
Protocols and materials databases
DNASU	64663.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000358993; ENSP00000351884; ENSG00000198573.
GeneID	64663.
KEGG	hsa:64663.
UCSC	uc004fbk.3. human.
Organism-specific databases
CTD	64663.
GeneCards	GC0XM140335.
HGNC	HGNC:14331. SPANXC.
HPA	HPA046423.
MIM	300330. gene.
neXtProt	NX_Q9NY87.
PharmGKB	PA37873.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG136441.
HOGENOM	HOG000015252.
HOVERGEN	HBG059401.
OMA	NEVNETM.
OrthoDB	EOG4D26S3.
PhylomeDB	Q9NY87.
Gene expression databases
Bgee	Q9NY87.
CleanEx	HS_SPANXC.
Genevestigator	Q9NY87.
GermOnline	ENSG00000198573. Homo sapiens.
Family and domain databases
InterPro	IPR010007. SPANX_prot. [Graphical view]
PANTHER	PTHR23425. PTHR23425. 1 hit.
Pfam	PF07458. SPAN-X. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	64663.
NextBio	66601.
SOURCE	Search...

Entry information

Entry name

SPNXC_HUMAN

Accession

Primary (citable) accession number: Q9NY87
Secondary accession number(s): Q32WL9, Q5JX88

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 2005
Last sequence update:	October 1, 2000
Last modified:	April 3, 2013
This is version 82 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.