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Q9NY87 (SPNXC_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 87. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Sperm protein associated with the nucleus on the X chromosome C
Alternative name(s):
Cancer/testis antigen 11.3
Short name=CT11.3
Cancer/testis-associated protein CTp11
Nuclear-associated protein SPAN-Xc
Short name=SPANX-C
SPANX family member C
Gene names
Name:SPANXC
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length97 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Subcellular location

Cytoplasm. Nucleus. Note: Associated with nuclear craters. Ref.1

Tissue specificity

Detected in testis, melanoma and bladder carcinoma. Ref.1 Ref.2

Developmental stage

Detected in round and elongating spermatids. Ref.2

Sequence similarities

Belongs to the SPAN-X family.

Ontologies

Keywords
   Cellular componentCytoplasm
Nucleus
   Coding sequence diversityPolymorphism
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

nucleus

Traceable author statement Ref.1. Source: UniProtKB

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 9797Sperm protein associated with the nucleus on the X chromosome C
PRO_0000189551

Regions

Motif37 – 459Nuclear localization signal Potential
Compositional bias83 – 864Poly-Glu

Natural variations

Natural variant591V → F. Ref.3 Ref.4
VAR_032024
Natural variant591V → L.
Corresponds to variant rs16993705 [ dbSNP | Ensembl ].
VAR_034515

Sequences

Sequence LengthMass (Da)Tools
Q9NY87 [UniParc].

Last modified October 1, 2000. Version 1.
Checksum: 1AAFD5A12FB7CFD5

FASTA9711,002
        10         20         30         40         50         60 
MDKQSSAGGV KRSVPCESNE VNETMPETPT GDSDPQPAPK KMKTSESSTI LVVRYRRNVK 

        70         80         90 
RTSPEELLND HARENRINPL QMEEEEFMEI MVEIPAK 

« Hide

References

« Hide 'large scale' references
[1]"CTp11, a novel member of the family of cancer-testis antigens."
Zendman A.J.W., Cornelissen I.M.H.A., Weidle U.H., Ruiter D.J., Van Muijen G.N.P.
Cancer Res. 59:6223-6229(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
Tissue: Melanoma.
[2]"The human SPANX multigene family: genomic organization, alignment and expression in male germ cells and tumor cell lines."
Zendman A.J., Zschocke J., van Kraats A.A., de Wit N.J.W., Kurpisz M., Weidle U.H., Ruiter D.J., Weiss E.H., van Muijen G.N.P.
Gene 309:125-133(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], DEVELOPMENTAL STAGE, TISSUE SPECIFICITY.
[3]"Dynamic structure of the SPANX gene cluster mapped to the prostate cancer susceptibility locus HPCX at Xq27."
Kouprina N., Pavlicek A., Noskov V.N., Solomon G., Otstot J., Isaacs W., Carpten J.D., Trent J.M., Schleutker J., Barrett J.C., Jurka J., Larionov V.
Genome Res. 15:1477-1486(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT PHE-59.
[4]"Mutational analysis of the SPANX gene cluster in X-linked families with the hereditary prostate cancer."
Larionov V., Kouprina N.
Submitted (NOV-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT PHE-59.
[5]"The DNA sequence of the human X chromosome."
Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C. expand/collapse author list , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ238277 mRNA. Translation: CAB75344.1.
AJ457790 Genomic DNA. Translation: CAD29839.1.
AY787084 Genomic DNA. Translation: AAW47309.1.
AY787088 Genomic DNA. Translation: AAW47312.1.
AY787089 Genomic DNA. Translation: AAW47313.1.
AY787091 Genomic DNA. Translation: AAW47314.1.
AY787093 Genomic DNA. Translation: AAW47315.1.
AY787095 Genomic DNA. Translation: AAW47317.1.
AY787097 Genomic DNA. Translation: AAW47319.1.
AY787098 Genomic DNA. Translation: AAW47320.1.
AY787099 Genomic DNA. Translation: AAW47321.1.
AY787100 Genomic DNA. Translation: AAW47322.1.
AY787103 Genomic DNA. Translation: AAW47325.1.
AY787105 Genomic DNA. Translation: AAW47327.1.
AY787106 Genomic DNA. Translation: AAW47328.1.
AY787107 Genomic DNA. Translation: AAW47329.1.
AY787108 Genomic DNA. Translation: AAW47330.1.
AY787109 Genomic DNA. Translation: AAW47331.1.
AY787111 Genomic DNA. Translation: AAW47333.1.
AY787112 Genomic DNA. Translation: AAW47334.1.
AY787113 Genomic DNA. Translation: AAW47335.1.
AY787114 Genomic DNA. Translation: AAW47336.1.
AY787116 Genomic DNA. Translation: AAW47338.1.
AY787117 Genomic DNA. Translation: AAW47339.1.
AY787121 Genomic DNA. Translation: AAW47343.1.
AY787122 Genomic DNA. Translation: AAW47344.1.
AY787124 Genomic DNA. Translation: AAW47346.1.
DQ994213 Genomic DNA. Translation: ABK19854.1.
DQ994215 Genomic DNA. Translation: ABK19856.1.
DQ994216 Genomic DNA. Translation: ABK19857.1.
DQ994223 Genomic DNA. Translation: ABK19864.1.
DQ994225 Genomic DNA. Translation: ABK19866.1.
DQ994227 Genomic DNA. Translation: ABK19868.1.
DQ994228 Genomic DNA. Translation: ABK19869.1.
DQ994229 Genomic DNA. Translation: ABK19870.1.
DQ994230 Genomic DNA. Translation: ABK19871.1.
DQ994231 Genomic DNA. Translation: ABK19872.1.
DQ994232 Genomic DNA. Translation: ABK19873.1.
DQ994238 Genomic DNA. Translation: ABK19879.1.
DQ994239 Genomic DNA. Translation: ABK19880.1.
EF101641 Genomic DNA. Translation: ABK96948.1.
EF101643 Genomic DNA. Translation: ABK96950.1.
EF101644 Genomic DNA. Translation: ABK96951.1.
EF101645 Genomic DNA. Translation: ABK96952.1.
EF101646 Genomic DNA. Translation: ABK96953.1.
EF101651 Genomic DNA. Translation: ABK96958.1.
EF101654 Genomic DNA. Translation: ABK96961.1.
EF101656 Genomic DNA. Translation: ABK96963.1.
EF101659 Genomic DNA. Translation: ABK96966.1.
AL109799 Genomic DNA. Translation: CAI41662.1.
BC054023 mRNA. Translation: AAH54023.1.
RefSeqNP_073152.1. NM_022661.2.
UniGeneHs.558533.

3D structure databases

ProteinModelPortalQ9NY87.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000351884.

Polymorphism databases

DMDM85543354.

Proteomic databases

PaxDbQ9NY87.
PRIDEQ9NY87.

Protocols and materials databases

DNASU64663.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000358993; ENSP00000351884; ENSG00000198573.
GeneID64663.
KEGGhsa:64663.
UCSCuc004fbk.3. human.

Organism-specific databases

CTD64663.
GeneCardsGC0XM140335.
HGNCHGNC:14331. SPANXC.
HPAHPA046423.
MIM300330. gene.
neXtProtNX_Q9NY87.
PharmGKBPA37873.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG136441.
HOGENOMHOG000015252.
HOVERGENHBG059401.
OMANEVNETM.
OrthoDBEOG7N901P.
PhylomeDBQ9NY87.
TreeFamTF341404.

Gene expression databases

BgeeQ9NY87.
CleanExHS_SPANXC.
GenevestigatorQ9NY87.

Family and domain databases

InterProIPR010007. SPANX_prot.
[Graphical view]
PANTHERPTHR23425. PTHR23425. 1 hit.
PfamPF07458. SPAN-X. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi64663.
NextBio66601.
PROQ9NY87.
SOURCESearch...

Entry information

Entry nameSPNXC_HUMAN
AccessionPrimary (citable) accession number: Q9NY87
Secondary accession number(s): Q32WL9, Q5JX88
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: October 1, 2000
Last modified: February 19, 2014
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome X

Human chromosome X: entries, gene names and cross-references to MIM