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Protein

Sperm protein associated with the nucleus on the X chromosome C

Gene

SPANXC

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Sperm protein associated with the nucleus on the X chromosome C
Alternative name(s):
Cancer/testis antigen 11.3
Short name:
CT11.3
Cancer/testis-associated protein CTp11
Nuclear-associated protein SPAN-Xc
Short name:
SPANX-C
SPANX family member C
Gene namesi
Name:SPANXC
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome X

Organism-specific databases

HGNCiHGNC:14331. SPANXC.

Subcellular locationi

Cytoplasm 1 Publication. Nucleus 1 Publication
Note: Associated with nuclear craters.

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
  2. nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA37873.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 9797Sperm protein associated with the nucleus on the X chromosome CPRO_0000189551Add
BLAST

Proteomic databases

MaxQBiQ9NY87.
PaxDbiQ9NY87.
PRIDEiQ9NY87.

Expressioni

Tissue specificityi

Detected in testis, melanoma and bladder carcinoma.2 Publications

Developmental stagei

Detected in round and elongating spermatids.1 Publication

Gene expression databases

BgeeiQ9NY87.
CleanExiHS_SPANXC.
ExpressionAtlasiQ9NY87. baseline.
GenevestigatoriQ9NY87.

Organism-specific databases

HPAiHPA046423.

Interactioni

Protein-protein interaction databases

BioGridi122228. 1 interaction.
STRINGi9606.ENSP00000351884.

Structurei

3D structure databases

ProteinModelPortaliQ9NY87.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi37 – 459Nuclear localization signalSequence Analysis

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi83 – 864Poly-Glu

Sequence similaritiesi

Belongs to the SPAN-X family.Curated

Phylogenomic databases

eggNOGiNOG136441.
HOGENOMiHOG000015252.
HOVERGENiHBG059401.
InParanoidiQ9NY87.
OMAiNEVNETM.
OrthoDBiEOG7N901P.
PhylomeDBiQ9NY87.
TreeFamiTF341404.

Family and domain databases

InterProiIPR010007. SPANX_prot.
[Graphical view]
PANTHERiPTHR23425. PTHR23425. 1 hit.
PfamiPF07458. SPAN-X. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9NY87-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDKQSSAGGV KRSVPCESNE VNETMPETPT GDSDPQPAPK KMKTSESSTI
60 70 80 90
LVVRYRRNVK RTSPEELLND HARENRINPL QMEEEEFMEI MVEIPAK
Length:97
Mass (Da):11,002
Last modified:September 30, 2000 - v1
Checksum:i1AAFD5A12FB7CFD5
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti59 – 591V → F.2 Publications
VAR_032024
Natural varianti59 – 591V → L.
Corresponds to variant rs16993705 [ dbSNP | Ensembl ].
VAR_034515

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ238277 mRNA. Translation: CAB75344.1.
AJ457790 Genomic DNA. Translation: CAD29839.1.
AY787084 Genomic DNA. Translation: AAW47309.1.
AY787088 Genomic DNA. Translation: AAW47312.1.
AY787089 Genomic DNA. Translation: AAW47313.1.
AY787091 Genomic DNA. Translation: AAW47314.1.
AY787093 Genomic DNA. Translation: AAW47315.1.
AY787095 Genomic DNA. Translation: AAW47317.1.
AY787097 Genomic DNA. Translation: AAW47319.1.
AY787098 Genomic DNA. Translation: AAW47320.1.
AY787099 Genomic DNA. Translation: AAW47321.1.
AY787100 Genomic DNA. Translation: AAW47322.1.
AY787103 Genomic DNA. Translation: AAW47325.1.
AY787105 Genomic DNA. Translation: AAW47327.1.
AY787106 Genomic DNA. Translation: AAW47328.1.
AY787107 Genomic DNA. Translation: AAW47329.1.
AY787108 Genomic DNA. Translation: AAW47330.1.
AY787109 Genomic DNA. Translation: AAW47331.1.
AY787111 Genomic DNA. Translation: AAW47333.1.
AY787112 Genomic DNA. Translation: AAW47334.1.
AY787113 Genomic DNA. Translation: AAW47335.1.
AY787114 Genomic DNA. Translation: AAW47336.1.
AY787116 Genomic DNA. Translation: AAW47338.1.
AY787117 Genomic DNA. Translation: AAW47339.1.
AY787121 Genomic DNA. Translation: AAW47343.1.
AY787122 Genomic DNA. Translation: AAW47344.1.
AY787124 Genomic DNA. Translation: AAW47346.1.
DQ994213 Genomic DNA. Translation: ABK19854.1.
DQ994215 Genomic DNA. Translation: ABK19856.1.
DQ994216 Genomic DNA. Translation: ABK19857.1.
DQ994223 Genomic DNA. Translation: ABK19864.1.
DQ994225 Genomic DNA. Translation: ABK19866.1.
DQ994227 Genomic DNA. Translation: ABK19868.1.
DQ994228 Genomic DNA. Translation: ABK19869.1.
DQ994229 Genomic DNA. Translation: ABK19870.1.
DQ994230 Genomic DNA. Translation: ABK19871.1.
DQ994231 Genomic DNA. Translation: ABK19872.1.
DQ994232 Genomic DNA. Translation: ABK19873.1.
DQ994238 Genomic DNA. Translation: ABK19879.1.
DQ994239 Genomic DNA. Translation: ABK19880.1.
EF101641 Genomic DNA. Translation: ABK96948.1.
EF101643 Genomic DNA. Translation: ABK96950.1.
EF101644 Genomic DNA. Translation: ABK96951.1.
EF101645 Genomic DNA. Translation: ABK96952.1.
EF101646 Genomic DNA. Translation: ABK96953.1.
EF101651 Genomic DNA. Translation: ABK96958.1.
EF101654 Genomic DNA. Translation: ABK96961.1.
EF101656 Genomic DNA. Translation: ABK96963.1.
EF101659 Genomic DNA. Translation: ABK96966.1.
AL109799 Genomic DNA. Translation: CAI41662.1.
BC054023 mRNA. Translation: AAH54023.1.
UniGeneiHs.334464.
Hs.375036.
Hs.558533.
Hs.711784.

Genome annotation databases

EnsembliENST00000358993; ENSP00000351884; ENSG00000198573.
UCSCiuc004fbk.3. human.

Polymorphism databases

DMDMi85543354.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ238277 mRNA. Translation: CAB75344.1.
AJ457790 Genomic DNA. Translation: CAD29839.1.
AY787084 Genomic DNA. Translation: AAW47309.1.
AY787088 Genomic DNA. Translation: AAW47312.1.
AY787089 Genomic DNA. Translation: AAW47313.1.
AY787091 Genomic DNA. Translation: AAW47314.1.
AY787093 Genomic DNA. Translation: AAW47315.1.
AY787095 Genomic DNA. Translation: AAW47317.1.
AY787097 Genomic DNA. Translation: AAW47319.1.
AY787098 Genomic DNA. Translation: AAW47320.1.
AY787099 Genomic DNA. Translation: AAW47321.1.
AY787100 Genomic DNA. Translation: AAW47322.1.
AY787103 Genomic DNA. Translation: AAW47325.1.
AY787105 Genomic DNA. Translation: AAW47327.1.
AY787106 Genomic DNA. Translation: AAW47328.1.
AY787107 Genomic DNA. Translation: AAW47329.1.
AY787108 Genomic DNA. Translation: AAW47330.1.
AY787109 Genomic DNA. Translation: AAW47331.1.
AY787111 Genomic DNA. Translation: AAW47333.1.
AY787112 Genomic DNA. Translation: AAW47334.1.
AY787113 Genomic DNA. Translation: AAW47335.1.
AY787114 Genomic DNA. Translation: AAW47336.1.
AY787116 Genomic DNA. Translation: AAW47338.1.
AY787117 Genomic DNA. Translation: AAW47339.1.
AY787121 Genomic DNA. Translation: AAW47343.1.
AY787122 Genomic DNA. Translation: AAW47344.1.
AY787124 Genomic DNA. Translation: AAW47346.1.
DQ994213 Genomic DNA. Translation: ABK19854.1.
DQ994215 Genomic DNA. Translation: ABK19856.1.
DQ994216 Genomic DNA. Translation: ABK19857.1.
DQ994223 Genomic DNA. Translation: ABK19864.1.
DQ994225 Genomic DNA. Translation: ABK19866.1.
DQ994227 Genomic DNA. Translation: ABK19868.1.
DQ994228 Genomic DNA. Translation: ABK19869.1.
DQ994229 Genomic DNA. Translation: ABK19870.1.
DQ994230 Genomic DNA. Translation: ABK19871.1.
DQ994231 Genomic DNA. Translation: ABK19872.1.
DQ994232 Genomic DNA. Translation: ABK19873.1.
DQ994238 Genomic DNA. Translation: ABK19879.1.
DQ994239 Genomic DNA. Translation: ABK19880.1.
EF101641 Genomic DNA. Translation: ABK96948.1.
EF101643 Genomic DNA. Translation: ABK96950.1.
EF101644 Genomic DNA. Translation: ABK96951.1.
EF101645 Genomic DNA. Translation: ABK96952.1.
EF101646 Genomic DNA. Translation: ABK96953.1.
EF101651 Genomic DNA. Translation: ABK96958.1.
EF101654 Genomic DNA. Translation: ABK96961.1.
EF101656 Genomic DNA. Translation: ABK96963.1.
EF101659 Genomic DNA. Translation: ABK96966.1.
AL109799 Genomic DNA. Translation: CAI41662.1.
BC054023 mRNA. Translation: AAH54023.1.
UniGeneiHs.334464.
Hs.375036.
Hs.558533.
Hs.711784.

3D structure databases

ProteinModelPortaliQ9NY87.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122228. 1 interaction.
STRINGi9606.ENSP00000351884.

Polymorphism databases

DMDMi85543354.

Proteomic databases

MaxQBiQ9NY87.
PaxDbiQ9NY87.
PRIDEiQ9NY87.

Protocols and materials databases

DNASUi64663.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000358993; ENSP00000351884; ENSG00000198573.
UCSCiuc004fbk.3. human.

Organism-specific databases

GeneCardsiGC0XM140335.
HGNCiHGNC:14331. SPANXC.
HPAiHPA046423.
MIMi300330. gene.
neXtProtiNX_Q9NY87.
PharmGKBiPA37873.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG136441.
HOGENOMiHOG000015252.
HOVERGENiHBG059401.
InParanoidiQ9NY87.
OMAiNEVNETM.
OrthoDBiEOG7N901P.
PhylomeDBiQ9NY87.
TreeFamiTF341404.

Miscellaneous databases

GenomeRNAii64663.
NextBioi66601.
PROiQ9NY87.
SOURCEiSearch...

Gene expression databases

BgeeiQ9NY87.
CleanExiHS_SPANXC.
ExpressionAtlasiQ9NY87. baseline.
GenevestigatoriQ9NY87.

Family and domain databases

InterProiIPR010007. SPANX_prot.
[Graphical view]
PANTHERiPTHR23425. PTHR23425. 1 hit.
PfamiPF07458. SPAN-X. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "CTp11, a novel member of the family of cancer-testis antigens."
    Zendman A.J.W., Cornelissen I.M.H.A., Weidle U.H., Ruiter D.J., Van Muijen G.N.P.
    Cancer Res. 59:6223-6229(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    Tissue: Melanoma.
  2. "The human SPANX multigene family: genomic organization, alignment and expression in male germ cells and tumor cell lines."
    Zendman A.J., Zschocke J., van Kraats A.A., de Wit N.J.W., Kurpisz M., Weidle U.H., Ruiter D.J., Weiss E.H., van Muijen G.N.P.
    Gene 309:125-133(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], DEVELOPMENTAL STAGE, TISSUE SPECIFICITY.
  3. "Dynamic structure of the SPANX gene cluster mapped to the prostate cancer susceptibility locus HPCX at Xq27."
    Kouprina N., Pavlicek A., Noskov V.N., Solomon G., Otstot J., Isaacs W., Carpten J.D., Trent J.M., Schleutker J., Barrett J.C., Jurka J., Larionov V.
    Genome Res. 15:1477-1486(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT PHE-59.
  4. "Mutational analysis of the SPANX gene cluster in X-linked families with the hereditary prostate cancer."
    Larionov V., Kouprina N.
    Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT PHE-59.
  5. "The DNA sequence of the human X chromosome."
    Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
    , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
    Nature 434:325-337(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiSPNXC_HUMAN
AccessioniPrimary (citable) accession number: Q9NY87
Secondary accession number(s): Q32WL9, Q5JX88
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 31, 2005
Last sequence update: September 30, 2000
Last modified: February 3, 2015
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.