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Protein

Ewing's tumor-associated antigen 1

Gene

ETAA1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Ewing's tumor-associated antigen 1
Alternative name(s):
Ewing's tumor-associated antigen 16
Gene namesi
Name:ETAA1
Synonyms:ETAA16
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:24648. ETAA1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162385444.

Polymorphism and mutation databases

BioMutaiETAA1.
DMDMi74734709.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 926926Ewing's tumor-associated antigen 1PRO_0000280099Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki442 – 442Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei833 – 8331PhosphoserineCombined sources

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ9NY74.
MaxQBiQ9NY74.
PaxDbiQ9NY74.
PRIDEiQ9NY74.

PTM databases

iPTMnetiQ9NY74.
PhosphoSiteiQ9NY74.

Expressioni

Tissue specificityi

Expressed at high levels in the brain, liver kidney and Ewing tumor cell lines.1 Publication

Gene expression databases

BgeeiQ9NY74.
CleanExiHS_ETAA1.
GenevisibleiQ9NY74. HS.

Organism-specific databases

HPAiHPA035048.
HPA035049.

Interactioni

Protein-protein interaction databases

BioGridi119971. 5 interactions.
DIPiDIP-47294N.
IntActiQ9NY74. 5 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ9NY74.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili183 – 21432Sequence analysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi885 – 8884Poly-Glu

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IIMC. Eukaryota.
ENOG4111PKA. LUCA.
GeneTreeiENSGT00390000009597.
HOGENOMiHOG000112406.
HOVERGENiHBG081485.
OMAiDIFWDQN.
OrthoDBiEOG7MD4PM.
PhylomeDBiQ9NY74.
TreeFamiTF333863.

Family and domain databases

InterProiIPR029406. ETAA1.
[Graphical view]
PfamiPF15350. ETAA1. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9NY74-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRRRKHDDS PSPKKTPHKT VAAEECGSVV EPGRRRLRSA RGSWPCGARE
60 70 80 90 100
GPPGPVRQRE QPPTAALCSK SNPEERYETP KRALKMDSLS SSFSSPNDPD
110 120 130 140 150
GQNDIFWDQN SPLTKQLGKG RKKQIYTTDS DEISHIVNRI APQDEKPTTN
160 170 180 190 200
SMLDMWIGET AIPCTPSVAK GKSRAKISCT KLKTQSQEEE LMKLAKQFDK
210 220 230 240 250
NMEELDVIQE QNKRNYDFTQ MISETEILSN YKDNIQMWSL HNIVPEIDNA
260 270 280 290 300
TKKPIKGNTK ISVANNQNSS QKPFDQIAEA AFNAIFDGST QKCSGQLSQE
310 320 330 340 350
LPEAFWSTSN TTFVKTNALK EEKIITNETL VIEKLSNKTP RSLSSQVDTP
360 370 380 390 400
IMTKSCVTSC TKEPETSNKY IDAFTTSDFE DDWENLLGSE PFAMQNIDMP
410 420 430 440 450
ELFPSKTAHV TDQKEICTFN SKTVKNTSRA NTSPDARLGD SKVLQDLSSK
460 470 480 490 500
TYDRELIDAE YRFSPNSNKS NKLSTGNKMK FENSSNKIVI QDEIQNCIVT
510 520 530 540 550
SNLTKIKEDI LTNSTEASER KSALNTRYSN EQKNKCILNQ SIKAPVNTDL
560 570 580 590 600
FGSANLGSKT SVSNPNQTSA SKVGSFFDDW NDPSFANEII KACHQLDNTW
610 620 630 640 650
EADDVDDDLL YQACDDIERL TQQQDIRKDS KTSESICEIN NNSEHGAKLT
660 670 680 690 700
QQQDIRKDSK TSESICEINN NSEHGAKNMF AISKQGSNLV QSKHLNPGSI
710 720 730 740 750
SVQTSLTNSS QIDKPMKMEK GEMYGNSPRF LGATNLTMYS KISNCQINNL
760 770 780 790 800
HVSYTNTDVP IQVNSSKLVL PGSSSLNVTS DHMNTEITTY KKKLSTNQPC
810 820 830 840 850
HKTVTDEAQS NLNTTVGFSK FTFTRMKNSQ ILSQFNQNCI TGSMSDTKIT
860 870 880 890 900
QGVEKKKGVN PLLEEAVGQQ SLVKLSESLK QSSKEEEEKN RKCSPEEIQR
910 920
KRQEALVRRM AKARASSVNA APTSFL
Length:926
Mass (Da):103,440
Last modified:March 1, 2004 - v2
Checksum:i4AD88EDD71BADED0
GO

Sequence cautioni

The sequence AAX93100.1 differs from that shown. Reason: Erroneous gene model prediction. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti439 – 4391G → R in AAH33075 (PubMed:15489334).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti50 – 501E → D in a colorectal cancer sample; somatic mutation. 1 Publication
VAR_035916
Natural varianti221 – 2211M → T.1 Publication
Corresponds to variant rs13036061 [ dbSNP | Ensembl ].
VAR_031053
Natural varianti389 – 3891S → N.1 Publication
Corresponds to variant rs3770657 [ dbSNP | Ensembl ].
VAR_031054
Natural varianti715 – 7151P → L.
Corresponds to variant rs3770656 [ dbSNP | Ensembl ].
VAR_031055
Natural varianti771 – 7711P → S.1 Publication
Corresponds to variant rs3770655 [ dbSNP | Ensembl ].
VAR_031056

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ242682 mRNA. Translation: CAB76378.2.
AC023668 Genomic DNA. Translation: AAX93100.1. Sequence problems.
BC033075 mRNA. Translation: AAH33075.1. Different termination.
BC040001 mRNA. Translation: AAH40001.1.
CCDSiCCDS1882.1.
RefSeqiNP_061875.2. NM_019002.3.
UniGeneiHs.353022.

Genome annotation databases

EnsembliENST00000272342; ENSP00000272342; ENSG00000143971.
GeneIDi54465.
KEGGihsa:54465.
UCSCiuc002sdz.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ242682 mRNA. Translation: CAB76378.2.
AC023668 Genomic DNA. Translation: AAX93100.1. Sequence problems.
BC033075 mRNA. Translation: AAH33075.1. Different termination.
BC040001 mRNA. Translation: AAH40001.1.
CCDSiCCDS1882.1.
RefSeqiNP_061875.2. NM_019002.3.
UniGeneiHs.353022.

3D structure databases

ProteinModelPortaliQ9NY74.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119971. 5 interactions.
DIPiDIP-47294N.
IntActiQ9NY74. 5 interactions.

PTM databases

iPTMnetiQ9NY74.
PhosphoSiteiQ9NY74.

Polymorphism and mutation databases

BioMutaiETAA1.
DMDMi74734709.

Proteomic databases

EPDiQ9NY74.
MaxQBiQ9NY74.
PaxDbiQ9NY74.
PRIDEiQ9NY74.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000272342; ENSP00000272342; ENSG00000143971.
GeneIDi54465.
KEGGihsa:54465.
UCSCiuc002sdz.2. human.

Organism-specific databases

CTDi54465.
GeneCardsiETAA1.
HGNCiHGNC:24648. ETAA1.
HPAiHPA035048.
HPA035049.
MIMi613196. gene.
neXtProtiNX_Q9NY74.
PharmGKBiPA162385444.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IIMC. Eukaryota.
ENOG4111PKA. LUCA.
GeneTreeiENSGT00390000009597.
HOGENOMiHOG000112406.
HOVERGENiHBG081485.
OMAiDIFWDQN.
OrthoDBiEOG7MD4PM.
PhylomeDBiQ9NY74.
TreeFamiTF333863.

Miscellaneous databases

GenomeRNAii54465.
NextBioi56737.
PROiQ9NY74.
SOURCEiSearch...

Gene expression databases

BgeeiQ9NY74.
CleanExiHS_ETAA1.
GenevisibleiQ9NY74. HS.

Family and domain databases

InterProiIPR029406. ETAA1.
[Graphical view]
PfamiPF15350. ETAA1. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Structure and function of ETAA16: a novel cell surface antigen in Ewing's tumours."
    Borowski A., Dirksen U., Lixin L., Shi R.L., Goebel U., Schneider E.M.
    Cancer Immunol. Immunother. 55:363-374(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    Tissue: Ewing sarcoma.
  2. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS THR-221; ASN-389 AND SER-771.
    Tissue: Prostate and Uterus.
  4. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-833, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic kidney.
  5. "SUMO-2 orchestrates chromatin modifiers in response to DNA damage."
    Hendriks I.A., Treffers L.W., Verlaan-de Vries M., Olsen J.V., Vertegaal A.C.
    Cell Rep. 10:1778-1791(2015) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUMOYLATION [LARGE SCALE ANALYSIS] AT LYS-442, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  6. Cited for: VARIANT [LARGE SCALE ANALYSIS] ASP-50.

Entry informationi

Entry nameiETAA1_HUMAN
AccessioniPrimary (citable) accession number: Q9NY74
Secondary accession number(s): Q05BT7, Q53SC4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 6, 2007
Last sequence update: March 1, 2004
Last modified: April 13, 2016
This is version 92 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.