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Protein

Sodium channel subunit beta-3

Gene

SCN3B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Modulates channel gating kinetics. Causes unique persistent sodium currents. Inactivates the sodium channel opening more slowly than the subunit beta-1. Its association with neurofascin may target the sodium channels to the nodes of Ranvier of developing axons and retain these channels at the nodes in mature myelinated axons (By similarity).By similarity

GO - Molecular functioni

  • ion channel binding Source: BHF-UCL
  • sodium channel regulator activity Source: BHF-UCL
  • voltage-gated sodium channel activity Source: UniProtKB
  • voltage-gated sodium channel activity involved in cardiac muscle cell action potential Source: BHF-UCL

GO - Biological processi

  • atrial cardiac muscle cell action potential Source: BHF-UCL
  • cardiac muscle cell action potential involved in contraction Source: BHF-UCL
  • cardiac muscle contraction Source: BHF-UCL
  • membrane depolarization Source: BHF-UCL
  • membrane depolarization during action potential Source: BHF-UCL
  • membrane depolarization during cardiac muscle cell action potential Source: BHF-UCL
  • nervous system development Source: Ensembl
  • positive regulation of heart rate Source: BHF-UCL
  • positive regulation of sodium ion transport Source: BHF-UCL
  • protein localization to plasma membrane Source: BHF-UCL
  • regulation of atrial cardiac muscle cell membrane depolarization Source: BHF-UCL
  • regulation of heart rate by cardiac conduction Source: BHF-UCL
  • regulation of sodium ion transmembrane transporter activity Source: BHF-UCL
  • regulation of ventricular cardiac muscle cell membrane depolarization Source: BHF-UCL
  • SA node cell action potential Source: BHF-UCL
  • sensory perception of pain Source: Ensembl
  • sodium ion transmembrane transport Source: BHF-UCL
  • sodium ion transport Source: UniProtKB
  • ventricular cardiac muscle cell action potential Source: BHF-UCL
Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Sodium channel, Voltage-gated channel

Keywords - Biological processi

Ion transport, Sodium transport, Transport

Keywords - Ligandi

Sodium

Enzyme and pathway databases

ReactomeiREACT_22266. Interaction between L1 and Ankyrins.

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium channel subunit beta-3
Gene namesi
Name:SCN3B
Synonyms:KIAA1158
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:20665. SCN3B.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini23 – 159137ExtracellularSequence AnalysisAdd
BLAST
Transmembranei160 – 18021HelicalSequence AnalysisAdd
BLAST
Topological domaini181 – 21535CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB
  • plasma membrane Source: LIFEdb
  • voltage-gated sodium channel complex Source: BHF-UCL
  • Z disc Source: BHF-UCL
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Involvement in diseasei

Brugada syndrome 7 (BRGDA7)1 Publication

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionA tachyarrhythmia characterized by right bundle branch block and ST segment elevation on an electrocardiogram (ECG). It can cause the ventricles to beat so fast that the blood is prevented from circulating efficiently in the body. When this situation occurs, the individual will faint and may die in a few minutes if the heart is not reset.

See also OMIM:613120
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti10 – 101L → P in BRGDA7 AND ATFB16; results in a decrease in peak sodium current density. 2 Publications
VAR_062529
Atrial fibrillation, familial, 16 (ATFB16)2 Publications

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionA familial form of atrial fibrillation, a common sustained cardiac rhythm disturbance. Atrial fibrillation is characterized by disorganized atrial electrical activity and ineffective atrial contraction promoting blood stasis in the atria and reduces ventricular filling. It can result in palpitations, syncope, thromboembolic stroke, and congestive heart failure.

See also OMIM:613120
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti6 – 61R → K in ATFB16; affects steady-state channel inactivation. 1 Publication
VAR_071314
Natural varianti10 – 101L → P in BRGDA7 AND ATFB16; results in a decrease in peak sodium current density. 2 Publications
VAR_062529
Natural varianti130 – 1301A → V in ATFB16; results in decreased sodium current density. 1 Publication
VAR_071315
Natural varianti161 – 1611M → T in ATFB16; results in a decrease in peak sodium current density. 1 Publication
VAR_071316

Keywords - Diseasei

Atrial fibrillation, Brugada syndrome, Disease mutation

Organism-specific databases

MIMi613120. phenotype.
Orphaneti130. Brugada syndrome.
334. Familial atrial fibrillation.
PharmGKBiPA130546912.

Chemistry

DrugBankiDB00313. Valproic Acid.
DB00909. Zonisamide.

Polymorphism and mutation databases

BioMutaiSCN3B.
DMDMi12229762.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222By similarityAdd
BLAST
Chaini23 – 215193Sodium channel subunit beta-3PRO_0000014933Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi26 ↔ 48PROSITE-ProRule annotation
Disulfide bondi45 ↔ 120PROSITE-ProRule annotation
Glycosylationi95 – 951N-linked (GlcNAc...)Sequence Analysis
Glycosylationi109 – 1091N-linked (GlcNAc...)Sequence Analysis
Glycosylationi113 – 1131N-linked (GlcNAc...)Sequence Analysis
Glycosylationi121 – 1211N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiQ9NY72.

PTM databases

PhosphoSiteiQ9NY72.

Miscellaneous databases

PMAP-CutDBQ9NY72.

Expressioni

Tissue specificityi

Expressed in the atrium.1 Publication

Gene expression databases

BgeeiQ9NY72.
CleanExiHS_SCN3B.
ExpressionAtlasiQ9NY72. baseline and differential.
GenevisibleiQ9NY72. HS.

Organism-specific databases

HPAiHPA042518.

Interactioni

Subunit structurei

The voltage-sensitive sodium channel consists of an ion conducting pore forming alpha-subunit regulated by one or more beta-1, beta-2, beta-3 and/or beta-4 subunits. Beta-1 and beta-3 are non-covalently associated with alpha, while beta-2 and beta-4 are covalently linked by disulfide bonds (By similarity).By similarity

Protein-protein interaction databases

BioGridi120912. 81 interactions.
MINTiMINT-4724379.
STRINGi9606.ENSP00000299333.

Structurei

Secondary structure

1
215
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi34 – 363Combined sources
Beta strandi41 – 433Combined sources
Beta strandi57 – 659Combined sources
Beta strandi72 – 8211Combined sources
Turni87 – 904Combined sources
Beta strandi91 – 944Combined sources
Beta strandi100 – 1023Combined sources
Beta strandi105 – 1073Combined sources
Helixi112 – 1143Combined sources
Beta strandi116 – 12510Combined sources
Beta strandi135 – 14511Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4L1DX-ray2.50A/B/C25-145[»]
ProteinModelPortaliQ9NY72.
SMRiQ9NY72. Positions 25-145.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini32 – 154123Ig-like C2-typeAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG40812.
GeneTreeiENSGT00390000018560.
HOGENOMiHOG000276881.
HOVERGENiHBG056582.
InParanoidiQ9NY72.
KOiK04847.
OMAiLLIEMVY.
OrthoDBiEOG7M3J19.
PhylomeDBiQ9NY72.
TreeFamiTF332097.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
IPR027098. Na_channel_b1/b3.
IPR027096. Na_channel_b3.
[Graphical view]
PANTHERiPTHR10546. PTHR10546. 1 hit.
PTHR10546:SF1. PTHR10546:SF1. 1 hit.
PfamiPF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 1 hit.
[Graphical view]
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9NY72-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPAFNRLFPL ASLVLIYWVS VCFPVCVEVP SETEAVQGNP MKLRCISCMK
60 70 80 90 100
REEVEATTVV EWFYRPEGGK DFLIYEYRNG HQEVESPFQG RLQWNGSKDL
110 120 130 140 150
QDVSITVLNV TLNDSGLYTC NVSREFEFEA HRPFVKTTRL IPLRVTEEAG
160 170 180 190 200
EDFTSVVSEI MMYILLVFLT LWLLIEMIYC YRKVSKAEEA AQENASDYLA
210
IPSENKENSA VPVEE
Length:215
Mass (Da):24,702
Last modified:October 1, 2000 - v1
Checksum:i70F6C604E9E26662
GO

Sequence cautioni

The sequence BAA86472.1 differs from that shown. Reason: Erroneous initiation. Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti6 – 61R → K in ATFB16; affects steady-state channel inactivation. 1 Publication
VAR_071314
Natural varianti10 – 101L → P in BRGDA7 AND ATFB16; results in a decrease in peak sodium current density. 2 Publications
VAR_062529
Natural varianti54 – 541V → G Found in a case of idiopathic ventricular fibrillation; unknown pathological significance. 1 Publication
VAR_065232
Natural varianti89 – 891Q → L in a colorectal cancer sample; somatic mutation. 1 Publication
VAR_035521
Natural varianti97 – 971S → N.
Corresponds to variant rs35174956 [ dbSNP | Ensembl ].
VAR_049928
Natural varianti130 – 1301A → V in ATFB16; results in decreased sodium current density. 1 Publication
VAR_071315
Natural varianti161 – 1611M → T in ATFB16; results in a decrease in peak sodium current density. 1 Publication
VAR_071316
Natural varianti195 – 1951A → T in a colorectal cancer sample; somatic mutation. 1 Publication
VAR_035522

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ243396 mRNA. Translation: CAB76825.1.
AL136589 mRNA. Translation: CAB66524.1.
AB032984 mRNA. Translation: BAA86472.1. Different initiation.
AK314513 mRNA. Translation: BAG37113.1.
DQ677666 Genomic DNA. Translation: ABQ01237.1.
BC117282 mRNA. Translation: AAI17283.1.
BC126265 mRNA. Translation: AAI26266.1.
CCDSiCCDS8442.1.
RefSeqiNP_001035241.1. NM_001040151.1.
NP_060870.1. NM_018400.3.
XP_011541199.1. XM_011542897.1.
UniGeneiHs.4865.

Genome annotation databases

EnsembliENST00000299333; ENSP00000299333; ENSG00000166257.
ENST00000392770; ENSP00000376523; ENSG00000166257.
ENST00000530277; ENSP00000432785; ENSG00000166257.
GeneIDi55800.
KEGGihsa:55800.
UCSCiuc001pza.1. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ243396 mRNA. Translation: CAB76825.1.
AL136589 mRNA. Translation: CAB66524.1.
AB032984 mRNA. Translation: BAA86472.1. Different initiation.
AK314513 mRNA. Translation: BAG37113.1.
DQ677666 Genomic DNA. Translation: ABQ01237.1.
BC117282 mRNA. Translation: AAI17283.1.
BC126265 mRNA. Translation: AAI26266.1.
CCDSiCCDS8442.1.
RefSeqiNP_001035241.1. NM_001040151.1.
NP_060870.1. NM_018400.3.
XP_011541199.1. XM_011542897.1.
UniGeneiHs.4865.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4L1DX-ray2.50A/B/C25-145[»]
ProteinModelPortaliQ9NY72.
SMRiQ9NY72. Positions 25-145.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120912. 81 interactions.
MINTiMINT-4724379.
STRINGi9606.ENSP00000299333.

Chemistry

DrugBankiDB00313. Valproic Acid.
DB00909. Zonisamide.

PTM databases

PhosphoSiteiQ9NY72.

Polymorphism and mutation databases

BioMutaiSCN3B.
DMDMi12229762.

Proteomic databases

PRIDEiQ9NY72.

Protocols and materials databases

DNASUi55800.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000299333; ENSP00000299333; ENSG00000166257.
ENST00000392770; ENSP00000376523; ENSG00000166257.
ENST00000530277; ENSP00000432785; ENSG00000166257.
GeneIDi55800.
KEGGihsa:55800.
UCSCiuc001pza.1. human.

Organism-specific databases

CTDi55800.
GeneCardsiGC11M123500.
GeneReviewsiSCN3B.
HGNCiHGNC:20665. SCN3B.
HPAiHPA042518.
MIMi608214. gene.
613120. phenotype.
neXtProtiNX_Q9NY72.
Orphaneti130. Brugada syndrome.
334. Familial atrial fibrillation.
PharmGKBiPA130546912.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG40812.
GeneTreeiENSGT00390000018560.
HOGENOMiHOG000276881.
HOVERGENiHBG056582.
InParanoidiQ9NY72.
KOiK04847.
OMAiLLIEMVY.
OrthoDBiEOG7M3J19.
PhylomeDBiQ9NY72.
TreeFamiTF332097.

Enzyme and pathway databases

ReactomeiREACT_22266. Interaction between L1 and Ankyrins.

Miscellaneous databases

GeneWikiiSCN3B.
GenomeRNAii55800.
NextBioi60937.
PMAP-CutDBQ9NY72.
PROiQ9NY72.
SOURCEiSearch...

Gene expression databases

BgeeiQ9NY72.
CleanExiHS_SCN3B.
ExpressionAtlasiQ9NY72. baseline and differential.
GenevisibleiQ9NY72. HS.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
IPR027098. Na_channel_b1/b3.
IPR027096. Na_channel_b3.
[Graphical view]
PANTHERiPTHR10546. PTHR10546. 1 hit.
PTHR10546:SF1. PTHR10546:SF1. 1 hit.
PfamiPF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 1 hit.
[Graphical view]
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Beta3: an additional auxiliary subunit of the voltage-sensitive sodium channel that modulates channel gating with distinct kinetics."
    Morgan K., Stevens E.B., Shaw B., Cox P., Dixon A.K., Lee K., Pinnock R.D., Highes J., Richardson P.J., Mizuguchi K., Jackson A.P.
    Proc. Natl. Acad. Sci. U.S.A. 97:2308-2313(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Amygdala.
  3. "Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain."
    Hirosawa M., Nagase T., Ishikawa K., Kikuno R., Nomura N., Ohara O.
    DNA Res. 6:329-336(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  5. NHLBI resequencing and genotyping service (RS&G)
    Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  7. Cited for: VARIANTS [LARGE SCALE ANALYSIS] LEU-89 AND THR-195.
  8. "A mutation in the beta-3 subunit of the cardiac sodium channel associated with Brugada ECG phenotype."
    Hu D., Barajas-Martinez H., Burashnikov E., Springer M., Wu Y., Varro A., Pfeiffer R., Koopmann T.T., Cordeiro J.M., Guerchicoff A., Pollevick G.D., Antzelevitch C.
    Circ. Cardiovasc. Genet. 2:270-278(2009)
    Cited for: VARIANT BRGDA7 PRO-10.
  9. "Functional dominant-negative mutation of sodium channel subunit gene SCN3B associated with atrial fibrillation in a Chinese GeneID population."
    Wang P., Yang Q., Wu X., Yang Y., Shi L., Wang C., Wu G., Xia Y., Yang B., Zhang R., Xu C., Cheng X., Li S., Zhao Y., Fu F., Liao Y., Fang F., Chen Q., Tu X., Wang Q.K.
    Biochem. Biophys. Res. Commun. 398:98-104(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: INVOLVEMENT IN ATFB16, VARIANT ATFB16 VAL-130, CHARACTERIZATION OF VARIANT ATFB16 VAL-130.
  10. "Loss-of-function mutation of the SCN3B-encoded sodium channel {beta}3 subunit associated with a case of idiopathic ventricular fibrillation."
    Valdivia C.R., Medeiros-Domingo A., Ye B., Shen W.K., Algiers T.J., Ackerman M.J., Makielski J.C.
    Cardiovasc. Res. 86:392-400(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT GLY-54.
  11. "Mutations in sodium channel beta-subunit SCN3B are associated with early-onset lone atrial fibrillation."
    Olesen M.S., Jespersen T., Nielsen J.B., Liang B., Moller D.V., Hedley P., Christiansen M., Varro A., Olesen S.P., Haunso S., Schmitt N., Svendsen J.H.
    Cardiovasc. Res. 89:786-793(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANTS ATFB16 LYS-6; PRO-10 AND THR-161, TISSUE SPECIFICITY, CHARACTERIZATION OF VARIANTS ATFB16 LYS-6; PRO-10 AND THR-161.

Entry informationi

Entry nameiSCN3B_HUMAN
AccessioniPrimary (citable) accession number: Q9NY72
Secondary accession number(s): A5H1I5, Q17RL3, Q9ULR2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: October 1, 2000
Last modified: July 22, 2015
This is version 141 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.