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Protein

Solute carrier family 2, facilitated glucose transporter member 8

Gene

SLC2A8

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Insulin-regulated facilitative glucose transporter. Binds cytochalasin B in a glucose-inhibitable manner. Seems to be a dual-specific sugar transporter as it is inhibitable by fructose (By similarity).By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei394 – 3941MonosaccharideBy similarity

GO - Molecular functioni

  • glucose binding Source: Ensembl
  • glucose transmembrane transporter activity Source: ProtInc
  • sugar:proton symporter activity Source: GO_Central

GO - Biological processi

  • carbohydrate metabolic process Source: ProtInc
  • glucose import Source: GO_Central
  • glucose transport Source: ProtInc
  • insulin receptor signaling pathway Source: Ensembl
  • male meiosis I Source: Ensembl
  • proton transport Source: GOC
  • response to hypoxia Source: Ensembl
  • transmembrane transport Source: Reactome
Complete GO annotation...

Keywords - Biological processi

Sugar transport, Transport

Enzyme and pathway databases

ReactomeiR-HSA-428790. Facilitative Na+-independent glucose transporters.

Protein family/group databases

TCDBi2.A.1.1.89. the major facilitator superfamily (mfs).

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 2, facilitated glucose transporter member 8
Alternative name(s):
Glucose transporter type 8
Short name:
GLUT-8
Glucose transporter type X1
Gene namesi
Name:SLC2A8
Synonyms:GLUT8, GLUTX1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

HGNCiHGNC:13812. SLC2A8.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2525CytoplasmicSequence analysisAdd
BLAST
Transmembranei26 – 4621Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini47 – 7024ExtracellularSequence analysisAdd
BLAST
Transmembranei71 – 9121Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini92 – 965CytoplasmicSequence analysis
Transmembranei97 – 11721Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini118 – 12710ExtracellularSequence analysis
Transmembranei128 – 14821Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini149 – 1568CytoplasmicSequence analysis
Transmembranei157 – 17721Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini178 – 1825ExtracellularSequence analysis
Transmembranei183 – 20321Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini204 – 25653CytoplasmicSequence analysisAdd
BLAST
Transmembranei257 – 27721Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini278 – 29215ExtracellularSequence analysisAdd
BLAST
Transmembranei293 – 31321Helical; Name=8Sequence analysisAdd
BLAST
Topological domaini314 – 3196CytoplasmicSequence analysis
Transmembranei320 – 34021Helical; Name=9Sequence analysisAdd
BLAST
Topological domaini341 – 36727ExtracellularSequence analysisAdd
BLAST
Transmembranei368 – 38821Helical; Name=10Sequence analysisAdd
BLAST
Topological domaini389 – 40416CytoplasmicSequence analysisAdd
BLAST
Transmembranei405 – 42521Helical; Name=11Sequence analysisAdd
BLAST
Topological domaini426 – 43813ExtracellularSequence analysisAdd
BLAST
Transmembranei439 – 45921Helical; Name=12Sequence analysisAdd
BLAST
Topological domaini460 – 47718CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • cytoplasmic vesicle membrane Source: UniProtKB-SubCell
  • integral component of plasma membrane Source: ProtInc
  • lysosomal membrane Source: UniProtKB
  • plasma membrane Source: Reactome
  • synaptic vesicle Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasmic vesicle, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA37813.

Polymorphism and mutation databases

DMDMi145559479.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 477477Solute carrier family 2, facilitated glucose transporter member 8PRO_0000050375Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi349 – 3491N-linked (GlcNAc...)By similarity

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9NY64.
PRIDEiQ9NY64.

PTM databases

iPTMnetiQ9NY64.
PhosphoSiteiQ9NY64.

Expressioni

Tissue specificityi

Highly expressed in testis, but not in testicular carcinoma. Lower amounts present in most other tissues.

Inductioni

In testis, down-regulated by estrogen.

Gene expression databases

BgeeiQ9NY64.
CleanExiHS_SLC2A8.
ExpressionAtlasiQ9NY64. baseline and differential.
GenevisibleiQ9NY64. HS.

Organism-specific databases

HPAiHPA011935.

Interactioni

Subunit structurei

Interacts with AP2B1.By similarity

Protein-protein interaction databases

BioGridi119013. 9 interactions.
STRINGi9606.ENSP00000362469.

Structurei

3D structure databases

ProteinModelPortaliQ9NY64.
SMRiQ9NY64. Positions 26-477.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni267 – 2737Monosaccharide bindingBy similarity

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi12 – 132Dileucine internalization motifSequence analysis

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0254. Eukaryota.
ENOG410XNQK. LUCA.
GeneTreeiENSGT00720000108754.
HOGENOMiHOG000202868.
HOVERGENiHBG104335.
InParanoidiQ9NY64.
KOiK08145.
OMAiHRHQEAM.
OrthoDBiEOG7N8ZV9.
PhylomeDBiQ9NY64.
TreeFamiTF325324.

Family and domain databases

InterProiIPR020846. MFS_dom.
IPR005828. MFS_sugar_transport_like.
IPR003663. Sugar/inositol_transpt.
IPR005829. Sugar_transporter_CS.
[Graphical view]
PfamiPF00083. Sugar_tr. 1 hit.
[Graphical view]
PRINTSiPR00171. SUGRTRNSPORT.
SUPFAMiSSF103473. SSF103473. 2 hits.
TIGRFAMsiTIGR00879. SP. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
PS00216. SUGAR_TRANSPORT_1. 2 hits.
PS00217. SUGAR_TRANSPORT_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9NY64-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTPEDPEETQ PLLGPPGGSA PRGRRVFLAA FAAALGPLSF GFALGYSSPA
60 70 80 90 100
IPSLQRAAPP APRLDDAAAS WFGAVVTLGA AAGGVLGGWL VDRAGRKLSL
110 120 130 140 150
LLCSVPFVAG FAVITAAQDV WMLLGGRLLT GLACGVASLV APVYISEIAY
160 170 180 190 200
PAVRGLLGSC VQLMVVVGIL LAYLAGWVLE WRWLAVLGCV PPSLMLLLMC
210 220 230 240 250
FMPETPRFLL TQHRRQEAMA ALRFLWGSEQ GWEDPPIGAE QSFHLALLRQ
260 270 280 290 300
PGIYKPFIIG VSLMAFQQLS GVNAVMFYAE TIFEEAKFKD SSLASVVVGV
310 320 330 340 350
IQVLFTAVAA LIMDRAGRRL LLVLSGVVMV FSTSAFGAYF KLTQGGPGNS
360 370 380 390 400
SHVAISAPVS AQPVDASVGL AWLAVGSMCL FIAGFAVGWG PIPWLLMSEI
410 420 430 440 450
FPLHVKGVAT GICVLTNWLM AFLVTKEFSS LMEVLRPYGA FWLASAFCIF
460 470
SVLFTLFCVP ETKGKTLEQI TAHFEGR
Length:477
Mass (Da):50,819
Last modified:April 17, 2007 - v3
Checksum:i0B480F94AF063316
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti377 – 3771S → N in CAB75702 (PubMed:10671487).Curated
Sequence conflicti456 – 4572LF → FS in CAB89809 (PubMed:10821868).Curated
Sequence conflicti462 – 4621T → I in CAB75702 (PubMed:10671487).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti253 – 2531I → T.
Corresponds to variant rs34064803 [ dbSNP | Ensembl ].
VAR_061880

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y17801 mRNA. Translation: CAB89809.1.
AJ245937 mRNA. Translation: CAB75702.1.
AL445222 Genomic DNA. Translation: CAH72918.1.
CH471090 Genomic DNA. Translation: EAW87660.1.
BC019043 mRNA. Translation: AAH19043.1.
CCDSiCCDS6870.1.
RefSeqiNP_001258640.1. NM_001271711.1.
NP_001258641.1. NM_001271712.1.
NP_055395.2. NM_014580.4.
UniGeneiHs.179522.

Genome annotation databases

EnsembliENST00000373371; ENSP00000362469; ENSG00000136856.
GeneIDi29988.
KEGGihsa:29988.
UCSCiuc004bqu.5. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y17801 mRNA. Translation: CAB89809.1.
AJ245937 mRNA. Translation: CAB75702.1.
AL445222 Genomic DNA. Translation: CAH72918.1.
CH471090 Genomic DNA. Translation: EAW87660.1.
BC019043 mRNA. Translation: AAH19043.1.
CCDSiCCDS6870.1.
RefSeqiNP_001258640.1. NM_001271711.1.
NP_001258641.1. NM_001271712.1.
NP_055395.2. NM_014580.4.
UniGeneiHs.179522.

3D structure databases

ProteinModelPortaliQ9NY64.
SMRiQ9NY64. Positions 26-477.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119013. 9 interactions.
STRINGi9606.ENSP00000362469.

Protein family/group databases

TCDBi2.A.1.1.89. the major facilitator superfamily (mfs).

PTM databases

iPTMnetiQ9NY64.
PhosphoSiteiQ9NY64.

Polymorphism and mutation databases

DMDMi145559479.

Proteomic databases

PaxDbiQ9NY64.
PRIDEiQ9NY64.

Protocols and materials databases

DNASUi29988.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000373371; ENSP00000362469; ENSG00000136856.
GeneIDi29988.
KEGGihsa:29988.
UCSCiuc004bqu.5. human.

Organism-specific databases

CTDi29988.
GeneCardsiSLC2A8.
HGNCiHGNC:13812. SLC2A8.
HPAiHPA011935.
MIMi605245. gene.
neXtProtiNX_Q9NY64.
PharmGKBiPA37813.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0254. Eukaryota.
ENOG410XNQK. LUCA.
GeneTreeiENSGT00720000108754.
HOGENOMiHOG000202868.
HOVERGENiHBG104335.
InParanoidiQ9NY64.
KOiK08145.
OMAiHRHQEAM.
OrthoDBiEOG7N8ZV9.
PhylomeDBiQ9NY64.
TreeFamiTF325324.

Enzyme and pathway databases

ReactomeiR-HSA-428790. Facilitative Na+-independent glucose transporters.

Miscellaneous databases

GenomeRNAii29988.
NextBioi52760.
PROiQ9NY64.
SOURCEiSearch...

Gene expression databases

BgeeiQ9NY64.
CleanExiHS_SLC2A8.
ExpressionAtlasiQ9NY64. baseline and differential.
GenevisibleiQ9NY64. HS.

Family and domain databases

InterProiIPR020846. MFS_dom.
IPR005828. MFS_sugar_transport_like.
IPR003663. Sugar/inositol_transpt.
IPR005829. Sugar_transporter_CS.
[Graphical view]
PfamiPF00083. Sugar_tr. 1 hit.
[Graphical view]
PRINTSiPR00171. SUGRTRNSPORT.
SUPFAMiSSF103473. SSF103473. 2 hits.
TIGRFAMsiTIGR00879. SP. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
PS00216. SUGAR_TRANSPORT_1. 2 hits.
PS00217. SUGAR_TRANSPORT_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "GLUT8, a novel member of the sugar transport facilitator family with glucose transport activity."
    Doege H., Schuermann A., Bahrenberg G., Brauers A., Joost H.-G.
    J. Biol. Chem. 275:16275-16280(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Testis.
  2. "GLUTX1, a novel mammalian glucose transporter expressed in the central nervous system and insulin-sensitive tissues."
    Ibberson M.R., Uldry M.A., Thorens B.
    J. Biol. Chem. 275:4607-4612(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "DNA sequence and analysis of human chromosome 9."
    Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
    , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
    Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Skin.
  6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiGTR8_HUMAN
AccessioniPrimary (citable) accession number: Q9NY64
Secondary accession number(s): Q8WUZ9, Q9NSC4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 16, 2001
Last sequence update: April 17, 2007
Last modified: March 16, 2016
This is version 133 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.