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Protein

Solute carrier family 2, facilitated glucose transporter member 8

Gene

SLC2A8

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Insulin-regulated facilitative glucose transporter. Binds cytochalasin B in a glucose-inhibitable manner. Seems to be a dual-specific sugar transporter as it is inhibitable by fructose (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei394MonosaccharideBy similarity1

GO - Molecular functioni

GO - Biological processi

  • carbohydrate metabolic process Source: ProtInc
  • glucose import Source: GO_Central
  • glucose transport Source: ProtInc
  • insulin receptor signaling pathway Source: Ensembl
  • male meiosis I Source: Ensembl
  • membrane organization Source: Reactome
  • response to hypoxia Source: Ensembl

Keywordsi

Biological processSugar transport, Transport

Enzyme and pathway databases

ReactomeiR-HSA-428790. Facilitative Na+-independent glucose transporters.
R-HSA-8856825. Cargo recognition for clathrin-mediated endocytosis.
R-HSA-8856828. Clathrin-mediated endocytosis.

Protein family/group databases

TCDBi2.A.1.1.89. the major facilitator superfamily (mfs).

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 2, facilitated glucose transporter member 8
Alternative name(s):
Glucose transporter type 8
Short name:
GLUT-8
Glucose transporter type X1
Gene namesi
Name:SLC2A8
Synonyms:GLUT8, GLUTX1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

HGNCiHGNC:13812. SLC2A8.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 25CytoplasmicSequence analysisAdd BLAST25
Transmembranei26 – 46Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini47 – 70ExtracellularSequence analysisAdd BLAST24
Transmembranei71 – 91Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini92 – 96CytoplasmicSequence analysis5
Transmembranei97 – 117Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini118 – 127ExtracellularSequence analysis10
Transmembranei128 – 148Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini149 – 156CytoplasmicSequence analysis8
Transmembranei157 – 177Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini178 – 182ExtracellularSequence analysis5
Transmembranei183 – 203Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini204 – 256CytoplasmicSequence analysisAdd BLAST53
Transmembranei257 – 277Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini278 – 292ExtracellularSequence analysisAdd BLAST15
Transmembranei293 – 313Helical; Name=8Sequence analysisAdd BLAST21
Topological domaini314 – 319CytoplasmicSequence analysis6
Transmembranei320 – 340Helical; Name=9Sequence analysisAdd BLAST21
Topological domaini341 – 367ExtracellularSequence analysisAdd BLAST27
Transmembranei368 – 388Helical; Name=10Sequence analysisAdd BLAST21
Topological domaini389 – 404CytoplasmicSequence analysisAdd BLAST16
Transmembranei405 – 425Helical; Name=11Sequence analysisAdd BLAST21
Topological domaini426 – 438ExtracellularSequence analysisAdd BLAST13
Transmembranei439 – 459Helical; Name=12Sequence analysisAdd BLAST21
Topological domaini460 – 477CytoplasmicSequence analysisAdd BLAST18

GO - Cellular componenti

  • clathrin-coated vesicle membrane Source: Reactome
  • integral component of plasma membrane Source: ProtInc
  • lysosomal membrane Source: UniProtKB
  • plasma membrane Source: Reactome
  • synaptic vesicle Source: Ensembl

Keywords - Cellular componenti

Cell membrane, Cytoplasmic vesicle, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi29988.
OpenTargetsiENSG00000136856.
PharmGKBiPA37813.

Chemistry databases

DrugBankiDB09502. Fludeoxyglucose F-18.

Polymorphism and mutation databases

DMDMi145559479.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000503751 – 477Solute carrier family 2, facilitated glucose transporter member 8Add BLAST477

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi349N-linked (GlcNAc...) asparagineBy similarity1

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiQ9NY64.
PaxDbiQ9NY64.
PeptideAtlasiQ9NY64.
PRIDEiQ9NY64.

PTM databases

iPTMnetiQ9NY64.
PhosphoSitePlusiQ9NY64.

Expressioni

Tissue specificityi

Highly expressed in testis, but not in testicular carcinoma. Lower amounts present in most other tissues.

Inductioni

In testis, down-regulated by estrogen.

Gene expression databases

BgeeiENSG00000136856.
CleanExiHS_SLC2A8.
ExpressionAtlasiQ9NY64. baseline and differential.
GenevisibleiQ9NY64. HS.

Organism-specific databases

HPAiHPA011935.

Interactioni

Subunit structurei

Interacts with AP2B1.By similarity

Protein-protein interaction databases

BioGridi119013. 9 interactors.
STRINGi9606.ENSP00000362469.

Structurei

3D structure databases

ProteinModelPortaliQ9NY64.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni267 – 273Monosaccharide bindingBy similarity7

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi12 – 13Dileucine internalization motifSequence analysis2

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0254. Eukaryota.
ENOG410XNQK. LUCA.
GeneTreeiENSGT00880000137949.
HOGENOMiHOG000202868.
HOVERGENiHBG104335.
InParanoidiQ9NY64.
KOiK08145.
OMAiAGWVLEW.
OrthoDBiEOG091G1600.
PhylomeDBiQ9NY64.
TreeFamiTF325324.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiView protein in InterPro
IPR020846. MFS_dom.
IPR005828. MFS_sugar_transport-like.
IPR003663. Sugar/inositol_transpt.
IPR005829. Sugar_transporter_CS.
PfamiView protein in Pfam
PF00083. Sugar_tr. 1 hit.
PRINTSiPR00171. SUGRTRNSPORT.
SUPFAMiSSF103473. SSF103473. 2 hits.
TIGRFAMsiTIGR00879. SP. 1 hit.
PROSITEiView protein in PROSITE
PS50850. MFS. 1 hit.
PS00216. SUGAR_TRANSPORT_1. 2 hits.
PS00217. SUGAR_TRANSPORT_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9NY64-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTPEDPEETQ PLLGPPGGSA PRGRRVFLAA FAAALGPLSF GFALGYSSPA
60 70 80 90 100
IPSLQRAAPP APRLDDAAAS WFGAVVTLGA AAGGVLGGWL VDRAGRKLSL
110 120 130 140 150
LLCSVPFVAG FAVITAAQDV WMLLGGRLLT GLACGVASLV APVYISEIAY
160 170 180 190 200
PAVRGLLGSC VQLMVVVGIL LAYLAGWVLE WRWLAVLGCV PPSLMLLLMC
210 220 230 240 250
FMPETPRFLL TQHRRQEAMA ALRFLWGSEQ GWEDPPIGAE QSFHLALLRQ
260 270 280 290 300
PGIYKPFIIG VSLMAFQQLS GVNAVMFYAE TIFEEAKFKD SSLASVVVGV
310 320 330 340 350
IQVLFTAVAA LIMDRAGRRL LLVLSGVVMV FSTSAFGAYF KLTQGGPGNS
360 370 380 390 400
SHVAISAPVS AQPVDASVGL AWLAVGSMCL FIAGFAVGWG PIPWLLMSEI
410 420 430 440 450
FPLHVKGVAT GICVLTNWLM AFLVTKEFSS LMEVLRPYGA FWLASAFCIF
460 470
SVLFTLFCVP ETKGKTLEQI TAHFEGR
Length:477
Mass (Da):50,819
Last modified:April 17, 2007 - v3
Checksum:i0B480F94AF063316
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti377S → N in CAB75702 (PubMed:10671487).Curated1
Sequence conflicti456 – 457LF → FS in CAB89809 (PubMed:10821868).Curated2
Sequence conflicti462T → I in CAB75702 (PubMed:10671487).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_061880253I → T. Corresponds to variant dbSNP:rs34064803Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y17801 mRNA. Translation: CAB89809.1.
AJ245937 mRNA. Translation: CAB75702.1.
AL445222 Genomic DNA. No translation available.
CH471090 Genomic DNA. Translation: EAW87660.1.
BC019043 mRNA. Translation: AAH19043.1.
CCDSiCCDS6870.1.
RefSeqiNP_001258640.1. NM_001271711.1.
NP_001258641.1. NM_001271712.1.
NP_055395.2. NM_014580.4.
UniGeneiHs.179522.

Genome annotation databases

EnsembliENST00000373371; ENSP00000362469; ENSG00000136856.
GeneIDi29988.
KEGGihsa:29988.
UCSCiuc004bqu.5. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiGTR8_HUMAN
AccessioniPrimary (citable) accession number: Q9NY64
Secondary accession number(s): Q8WUZ9, Q9NSC4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 16, 2001
Last sequence update: April 17, 2007
Last modified: June 7, 2017
This is version 143 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families