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Protein

Protein AATF

Gene

AATF

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May function as a general inhibitor of the histone deacetylase HDAC1. Binding to the pocket region of RB1 may displace HDAC1 from RB1/E2F complexes, leading to activation of E2F target genes and cell cycle progression. Conversely, displacement of HDAC1 from SP1 bound to the CDKN1A promoter leads to increased expression of this CDK inhibitor and blocks cell cycle progression. Also antagonizes PAWR mediated induction of aberrant amyloid peptide production in Alzheimer disease (presenile and senile dementia), although the molecular basis for this phenomenon has not been described to date.4 Publications

GO - Molecular functioni

  • leucine zipper domain binding Source: UniProtKB
  • poly(A) RNA binding Source: UniProtKB
  • transcription factor activity, sequence-specific DNA binding Source: Ensembl

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-HSA-193648. NRAGE signals death through JNK.
SIGNORiQ9NY61.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein AATF
Alternative name(s):
Apoptosis-antagonizing transcription factor
Rb-binding protein Che-1
Gene namesi
Name:AATF
Synonyms:CHE1, DED
ORF Names:HSPC277
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:19235. AATF.

Subcellular locationi

GO - Cellular componenti

  • centrosome Source: HPA
  • cytoplasm Source: UniProtKB
  • focal adhesion Source: HPA
  • Golgi apparatus Source: Ensembl
  • nucleolus Source: HPA
  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi26574.
OpenTargetsiENSG00000275700.
ENSG00000276072.
PharmGKBiPA128395780.

Polymorphism and mutation databases

BioMutaiAATF.
DMDMi71152211.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00000566162 – 560Protein AATFAdd BLAST559

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1
Modified residuei61PhosphoserineCombined sources1
Modified residuei63PhosphoserineCombined sources1
Modified residuei150PhosphoserineCombined sources1
Modified residuei155PhosphoserineCombined sources1
Modified residuei203PhosphoserineCombined sources1
Modified residuei273PhosphoserineCombined sources1
Modified residuei316PhosphoserineCombined sources1
Modified residuei320PhosphoserineCombined sources1
Modified residuei321PhosphoserineCombined sources1

Post-translational modificationi

Hyperphosphorylated during the G1/S phase transition.

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9NY61.
MaxQBiQ9NY61.
PaxDbiQ9NY61.
PeptideAtlasiQ9NY61.
PRIDEiQ9NY61.
TopDownProteomicsiQ9NY61.

2D gel databases

SWISS-2DPAGEQ9NY61.

PTM databases

iPTMnetiQ9NY61.
PhosphoSitePlusiQ9NY61.

Expressioni

Tissue specificityi

Ubiquitously expressed. Expressed at high levels in brain, heart, kidney, placenta and thymus.2 Publications

Gene expression databases

BgeeiENSG00000108270.
CleanExiHS_AATF.
ExpressionAtlasiQ9NY61. baseline and differential.
GenevisibleiQ9NY61. HS.

Organism-specific databases

HPAiHPA004940.

Interactioni

Subunit structurei

Binds PAWR, POLR2J, RB1/RB, RBL1/P107, RBL2/P130, and SP1. May also bind MAPT.

Binary interactionsi

WithEntry#Exp.IntActNotes
ATMQ133153EBI-372428,EBI-495465
CHEK2O960174EBI-372428,EBI-1180783
Myl12aQ6ZWQ93EBI-372428,EBI-8034418From a different organism.
NGDNQ8NEJ93EBI-372428,EBI-9995414
RELAQ042063EBI-372428,EBI-73886
SP1P080472EBI-372428,EBI-298336

GO - Molecular functioni

  • leucine zipper domain binding Source: UniProtKB

Protein-protein interaction databases

BioGridi117743. 67 interactors.
IntActiQ9NY61. 27 interactors.
MINTiMINT-131397.
STRINGi9606.ENSP00000225402.

Structurei

3D structure databases

ProteinModelPortaliQ9NY61.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni273 – 315POLR2J bindingAdd BLAST43
Regioni316 – 372RB1 bindingAdd BLAST57
Regioni373 – 472RB1 and SP1 bindingAdd BLAST100

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi96 – 195Glu-richAdd BLAST100

Sequence similaritiesi

Belongs to the AATF family.Curated

Phylogenomic databases

eggNOGiKOG2773. Eukaryota.
ENOG410XWGK. LUCA.
GeneTreeiENSGT00390000000288.
HOGENOMiHOG000007555.
HOVERGENiHBG080805.
InParanoidiQ9NY61.
KOiK14782.
OMAiQLHPPDE.
OrthoDBiEOG091G0F1H.
PhylomeDBiQ9NY61.
TreeFamiTF324341.

Family and domain databases

InterProiIPR025160. AATF.
IPR012617. AATF_C.
[Graphical view]
PfamiPF13339. AATF-Che1. 1 hit.
PF08164. TRAUB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9NY61-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGPQPLALQ LEQLLNPRPS EADPEADPEE ATAARVIDRF DEGEDGEGDF
60 70 80 90 100
LVVGSIRKLA SASLLDTDKR YCGKTTSRKA WNEDHWEQTL PGSSDEEISD
110 120 130 140 150
EEGSGDEDSE GLGLEEYDED DLGAAEEQEC GDHRESKKSR SHSAKTPGFS
160 170 180 190 200
VQSISDFEKF TKGMDDLGSS EEEEDEESGM EEGDDAEDSQ GESEEDRAGD
210 220 230 240 250
RNSEDDGVVM TFSSVKVSEE VEKGRAVKNQ IALWDQLLEG RIKLQKALLT
260 270 280 290 300
TNQLPQPDVF PLFKDKGGPE FSSALKNSHK ALKALLRSLV GLQEELLFQY
310 320 330 340 350
PDTRYLVDGT KPNAGSEEIS SEDDELVEEK KQQRRRVPAK RKLEMEDYPS
360 370 380 390 400
FMAKRFADFT VYRNRTLQKW HDKTKLASGK LGKGFGAFER SILTQIDHIL
410 420 430 440 450
MDKERLLRRT QTKRSVYRVL GKPEPAAQPV PESLPGEPEI LPQAPANAHL
460 470 480 490 500
KDLDEEIFDD DDFYHQLLRE LIERKTSSLD PNDQVAMGRQ WLAIQKLRSK
510 520 530 540 550
IHKKVDRKAS KGRKLRFHVL SKLLSFMAPI DHTTMNDDAR TELYRSLFGQ
560
LHPPDEGHGD
Length:560
Mass (Da):63,133
Last modified:October 1, 2000 - v1
Checksum:iEC493EF3B4C3A199
GO

Sequence cautioni

The sequence AAD52016 differs from that shown. Reason: Frameshift at positions 355, 365, 487, 498 and 503.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti2 – 3AG → GR in AAD52016 (PubMed:10783144).Curated2
Sequence conflicti4 – 5Missing in AAD52016 (PubMed:10783144).Curated2
Sequence conflicti139S → T in AAD52016 (PubMed:10783144).Curated1
Sequence conflicti262L → V in AAD52016 (PubMed:10783144).Curated1
Sequence conflicti272S → A in AAD52016 (PubMed:10783144).Curated1
Sequence conflicti306L → V in AAD52016 (PubMed:10783144).Curated1
Sequence conflicti402D → C in AAD52016 (PubMed:10783144).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ249940 mRNA. Translation: CAB57451.2.
AF083208 mRNA. Translation: AAD52016.1. Frameshift.
AK057229 mRNA. Translation: BAG51888.1.
AC003103 Genomic DNA. No translation available.
CH471199 Genomic DNA. Translation: EAW57575.1.
BC000591 mRNA. Translation: AAH00591.1.
AF161395 mRNA. Translation: AAF28955.1.
CCDSiCCDS32632.1.
RefSeqiNP_036270.1. NM_012138.3.
UniGeneiHs.195740.

Genome annotation databases

EnsembliENST00000619387; ENSP00000477848; ENSG00000275700.
ENST00000620004; ENSP00000481894; ENSG00000276072.
GeneIDi26574.
KEGGihsa:26574.
UCSCiuc002hni.3. human.

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ249940 mRNA. Translation: CAB57451.2.
AF083208 mRNA. Translation: AAD52016.1. Frameshift.
AK057229 mRNA. Translation: BAG51888.1.
AC003103 Genomic DNA. No translation available.
CH471199 Genomic DNA. Translation: EAW57575.1.
BC000591 mRNA. Translation: AAH00591.1.
AF161395 mRNA. Translation: AAF28955.1.
CCDSiCCDS32632.1.
RefSeqiNP_036270.1. NM_012138.3.
UniGeneiHs.195740.

3D structure databases

ProteinModelPortaliQ9NY61.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117743. 67 interactors.
IntActiQ9NY61. 27 interactors.
MINTiMINT-131397.
STRINGi9606.ENSP00000225402.

PTM databases

iPTMnetiQ9NY61.
PhosphoSitePlusiQ9NY61.

Polymorphism and mutation databases

BioMutaiAATF.
DMDMi71152211.

2D gel databases

SWISS-2DPAGEQ9NY61.

Proteomic databases

EPDiQ9NY61.
MaxQBiQ9NY61.
PaxDbiQ9NY61.
PeptideAtlasiQ9NY61.
PRIDEiQ9NY61.
TopDownProteomicsiQ9NY61.

Protocols and materials databases

DNASUi26574.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000619387; ENSP00000477848; ENSG00000275700.
ENST00000620004; ENSP00000481894; ENSG00000276072.
GeneIDi26574.
KEGGihsa:26574.
UCSCiuc002hni.3. human.

Organism-specific databases

CTDi26574.
DisGeNETi26574.
GeneCardsiAATF.
HGNCiHGNC:19235. AATF.
HPAiHPA004940.
MIMi608463. gene.
neXtProtiNX_Q9NY61.
OpenTargetsiENSG00000275700.
ENSG00000276072.
PharmGKBiPA128395780.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2773. Eukaryota.
ENOG410XWGK. LUCA.
GeneTreeiENSGT00390000000288.
HOGENOMiHOG000007555.
HOVERGENiHBG080805.
InParanoidiQ9NY61.
KOiK14782.
OMAiQLHPPDE.
OrthoDBiEOG091G0F1H.
PhylomeDBiQ9NY61.
TreeFamiTF324341.

Enzyme and pathway databases

ReactomeiR-HSA-193648. NRAGE signals death through JNK.
SIGNORiQ9NY61.

Miscellaneous databases

ChiTaRSiAATF. human.
GeneWikiiApoptosis-antagonizing_transcription_factor.
GenomeRNAii26574.
PROiQ9NY61.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000108270.
CleanExiHS_AATF.
ExpressionAtlasiQ9NY61. baseline and differential.
GenevisibleiQ9NY61. HS.

Family and domain databases

InterProiIPR025160. AATF.
IPR012617. AATF_C.
[Graphical view]
PfamiPF13339. AATF-Che1. 1 hit.
PF08164. TRAUB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiAATF_HUMAN
AccessioniPrimary (citable) accession number: Q9NY61
Secondary accession number(s): A6NCJ6
, B3KQ26, Q9P0A4, Q9UNX5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: October 1, 2000
Last modified: November 2, 2016
This is version 133 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.