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Protein

Serine/threonine-protein kinase 32B

Gene

STK32B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.By similarity

Cofactori

Mg2+By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei52ATPPROSITE-ProRule annotationBy similarity1
Active sitei146Proton acceptorPROSITE-ProRule annotationBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi29 – 37ATPPROSITE-ProRule annotationBy similarity9

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

SignaLinkiQ9NY57

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase 32B (EC:2.7.11.1)
Alternative name(s):
Yet another novel kinase 2
Gene namesi
Name:STK32BImported
Synonyms:YANK2
ORF Names:UNQ3003/PRO9744
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

EuPathDBiHostDB:ENSG00000152953.12
HGNCiHGNC:14217 STK32B
neXtProtiNX_Q9NY57

Subcellular locationi

Pathology & Biotechi

Organism-specific databases

DisGeNETi55351
OpenTargetsiENSG00000152953
PharmGKBiPA128394683

Chemistry databases

ChEMBLiCHEMBL5912
GuidetoPHARMACOLOGYi1538

Polymorphism and mutation databases

BioMutaiSTK32B
DMDMi74761811

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002324131 – 414Serine/threonine-protein kinase 32BAdd BLAST414

Proteomic databases

PaxDbiQ9NY57
PeptideAtlasiQ9NY57
PRIDEiQ9NY57

PTM databases

iPTMnetiQ9NY57
PhosphoSitePlusiQ9NY57

Expressioni

Gene expression databases

BgeeiENSG00000152953
CleanExiHS_STK32B
ExpressionAtlasiQ9NY57 baseline and differential
GenevisibleiQ9NY57 HS

Organism-specific databases

HPAiHPA015820
HPA058536

Interactioni

Protein-protein interaction databases

BioGridi120631, 1 interactor
IntActiQ9NY57, 1 interactor
STRINGi9606.ENSP00000282908

Chemistry databases

BindingDBiQ9NY57

Structurei

3D structure databases

ProteinModelPortaliQ9NY57
SMRiQ9NY57
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini23 – 283Protein kinasePROSITE-ProRule annotationAdd BLAST261

Sequence similaritiesi

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0598 Eukaryota
ENOG410XNPH LUCA
GeneTreeiENSGT00860000133699
HOGENOMiHOG000021314
HOVERGENiHBG106458
InParanoidiQ9NY57
KOiK08793
OMAiHFTEGTV
OrthoDBiEOG091G0XV4
PhylomeDBiQ9NY57
TreeFamiTF313395

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 12 Publications (identifier: Q9NY57-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGGNHSHKPP VFDENEEVNF DHFQILRAIG KGSFGKVCIV QKRDTKKMYA
60 70 80 90 100
MKYMNKQKCI ERDEVRNVFR ELQIMQGLEH PFLVNLWYSF QDEEDMFMVV
110 120 130 140 150
DLLLGGDLRY HLQQNVHFTE GTVKLYICEL ALALEYLQRY HIIHRDIKPD
160 170 180 190 200
NILLDEHGHV HITDFNIATV VKGAERASSM AGTKPYMAPE VFQVYMDRGP
210 220 230 240 250
GYSYPVDWWS LGITAYELLR GWRPYEIHSV TPIDEILNMF KVERVHYSST
260 270 280 290 300
WCKGMVALLR KLLTKDPESR VSSLHDIQSV PYLADMNWDA VFKKALMPGF
310 320 330 340 350
VPNKGRLNCD PTFELEEMIL ESKPLHKKKK RLAKNRSRDG TKDSCPLNGH
360 370 380 390 400
LQHCLETVRE EFIIFNREKL RRQQGQGSQL LDTDSRGGGQ AQSKLQDGCN
410
NNLLTHTCTR GCSS
Length:414
Mass (Da):47,883
Last modified:October 1, 2000 - v1
Checksum:i8FCD58A67EF09B0E
GO
Isoform 21 Publication (identifier: Q9NY57-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-47: Missing.

Note: It is unsure whether Met-1 or Met-3 is the initiator. No experimental confirmation available.
Show »
Length:367
Mass (Da):42,561
Checksum:i9EFB9AA946D8779C
GO

Sequence cautioni

The sequence AAQ88719 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04116635G → E in a metastatic melanoma sample; somatic mutation. 1 Publication1
Natural variantiVAR_025899198R → G2 PublicationsCorresponds to variant dbSNP:rs3733182Ensembl.1
Natural variantiVAR_041167244R → H1 PublicationCorresponds to variant dbSNP:rs35207488Ensembl.1
Natural variantiVAR_041168310D → V1 PublicationCorresponds to variant dbSNP:rs56259884Ensembl.1
Natural variantiVAR_041169342K → T1 PublicationCorresponds to variant dbSNP:rs55961955Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0519971 – 47Missing in isoform 2. 1 PublicationAdd BLAST47

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ250839 mRNA Translation: CAB76471.1
AY358353 mRNA Translation: AAQ88719.1 Different initiation.
BC038238 mRNA Translation: AAH38238.1
CCDSiCCDS3380.1 [Q9NY57-1]
CCDS77895.1 [Q9NY57-2]
RefSeqiNP_001293011.1, NM_001306082.1 [Q9NY57-2]
NP_060871.1, NM_018401.2 [Q9NY57-1]
UniGeneiHs.133062
Hs.694667

Genome annotation databases

EnsembliENST00000282908; ENSP00000282908; ENSG00000152953 [Q9NY57-1]
ENST00000510398; ENSP00000420984; ENSG00000152953 [Q9NY57-2]
GeneIDi55351
KEGGihsa:55351
UCSCiuc003gih.2 human [Q9NY57-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiST32B_HUMAN
AccessioniPrimary (citable) accession number: Q9NY57
Secondary accession number(s): Q6UXH3, Q8IY14
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 18, 2006
Last sequence update: October 1, 2000
Last modified: February 28, 2018
This is version 134 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health