Q9NY56 (OBP2A_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Odorant-binding protein 2a

Alternative name(s):
Odorant-binding protein IIa
Short name=OBPIIa

Gene names

Name:

OBP2A

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	170 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Probably binds and transports small hydrophobic volatile molecules with a higher affinity for aldehydes and large fatty acids. Ref.4
Subunit structure	Monomer. Ref.4
Subcellular location	Secreted Probable.
Tissue specificity	Strongly expressed in the nasal structures, salivary and lachrymal glands, and lung.
Sequence similarities	Belongs to the calycin superfamily. Lipocalin family.

Ontologies

Keywords
Biological process	Olfaction Sensory transduction Transport
Cellular component	Secreted
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Signal
PTM	Disulfide bond
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	response to stimulus Inferred from electronic annotation. Source: UniProtKB-KW sensory perception of smell Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	odorant binding Non-traceable author statement Ref.1. Source: UniProtKB transporter activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]

Isoform Aa (identifier: Q9NY56-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform Ab (identifier: Q9NY56-2)

The sequence of this isoform differs from the canonical sequence as follows:
     131-170: RNPNTNLEALEEFKKLVQHKGLSEEDIFMPLQTGSCVLEH → PCRCPHVGSPGHLTCR

Isoform Ad (identifier: Q9NY56-3)

The sequence of this isoform differs from the canonical sequence as follows:
     25-129: ITGTWYVKAM...GGLRYMGKLV → EGESVHPEEN...TLAHLATSPA

Isoform Ag (identifier: Q9NY56-4)

The sequence of this isoform differs from the canonical sequence as follows:
     130-170: GRNPNTNLEA...LQTGSCVLEH → ASAPCRAVPL...SHDPSLLPPT

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 15	15	Potential
	Chain	16 – 170	155	Odorant-binding protein 2a		PRO_0000017937
Amino acid modifications
	Disulfide bond	74 ↔ 166		Ref.4
Natural variations
	Alternative sequence	25 – 129	105	ITGTW…MGKLV → EGESVHPEENPDAEDGGAWQ IQRLWGQEAHIPAGAARDGR LRLLLQRPAPWGPALHGKAC GICSLQGRAAVPTLAHLATS PA in isoform Ad.		VSP_003135
	Alternative sequence	130 – 170	41	GRNPN…CVLEH → ASAPCRAVPLSPRRLTWPPH LQVGILIPTWRPWKNLRNWC STRDSRRRTFSCPCRREAAF SNTRQPPGLHLQSPPYHQTQ SPDHLDLPSSHDPSLLPPT in isoform Ag.		VSP_003137
	Alternative sequence	131 – 170	40	RNPNT…CVLEH → PCRCPHVGSPGHLTCR in isoform Ab.		VSP_003136
	Natural variant	61	1	N → K. Corresponds to variant rs3180357 [ dbSNP | Ensembl ].		VAR_034354
	Natural variant	130	1	G → A. Corresponds to variant rs55695858 [ dbSNP | Ensembl ].		VAR_061359
	Natural variant	133	1	P → S. Corresponds to variant rs3178137 [ dbSNP | Ensembl ].		VAR_061360
	Natural variant	159	1	M → T. Ref.1 Corresponds to variant rs2853652 [ dbSNP | Ensembl ].		VAR_050176
Experimental info
	Sequence conflict	90	1	F → Y in CAB71326. Ref.1
	Sequence conflict	149	1	H → R in CAB71320. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Isoform Aa [UniParc]. Last modified October 1, 2000. Version 1. Checksum: 391F55E2E3629E75	FASTA	170	19,318
	10 20 30 40 50 60 MKTLFLGVTL GLAAALSFTL EEEDITGTWY VKAMVVDKDF PEDRRPRKVS PVKVTALGGG 70 80 90 100 110 120 NLEATFTFMR EDRCIQKKIL MRKTEEPGKF SAYGGRKLIY LQELPGTDDY VFYCKDQRRG 130 140 150 160 170 GLRYMGKLVG RNPNTNLEAL EEFKKLVQHK GLSEEDIFMP LQTGSCVLEH
	Isoform Ab [UniParc]. Checksum: 7C0774DB7E9E767A	FASTA	146	16,442
	10 20 30 40 50 60 MKTLFLGVTL GLAAALSFTL EEEDITGTWY VKAMVVDKDF PEDRRPRKVS PVKVTALGGG 70 80 90 100 110 120 NLEATFTFMR EDRCIQKKIL MRKTEEPGKF SAYGGRKLIY LQELPGTDDY VFYCKDQRRG 130 140 GLRYMGKLVG PCRCPHVGSP GHLTCR
	Isoform Ad [UniParc]. Checksum: 8D57B038D35F36BA	FASTA	147	15,821
	10 20 30 40 50 60 MKTLFLGVTL GLAAALSFTL EEEDEGESVH PEENPDAEDG GAWQIQRLWG QEAHIPAGAA 70 80 90 100 110 120 RDGRLRLLLQ RPAPWGPALH GKACGICSLQ GRAAVPTLAH LATSPAGRNP NTNLEALEEF 130 140 KKLVQHKGLS EEDIFMPLQT GSCVLEH
	Isoform Ag [UniParc]. Checksum: F77392851D8AB471	FASTA	228	26,014
	10 20 30 40 50 60 MKTLFLGVTL GLAAALSFTL EEEDITGTWY VKAMVVDKDF PEDRRPRKVS PVKVTALGGG 70 80 90 100 110 120 NLEATFTFMR EDRCIQKKIL MRKTEEPGKF SAYGGRKLIY LQELPGTDDY VFYCKDQRRG 130 140 150 160 170 180 GLRYMGKLVA SAPCRAVPLS PRRLTWPPHL QVGILIPTWR PWKNLRNWCS TRDSRRRTFS 190 200 210 220 CPCRREAAFS NTRQPPGLHL QSPPYHQTQS PDHLDLPSSH DPSLLPPT

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A novel human odorant-binding protein gene family resulting from genomic duplicons at 9q34: differential expression in the oral and genital spheres." Lacazette E., Gachon A.-M., Pitiot G. Hum. Mol. Genet. 9:289-301(2000) [PubMed: 10607840] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORMS AA; AB; AD AND AG), VARIANT THR-159.
[2]	"DNA sequence and analysis of human chromosome 9." Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L. , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I. Nature 429:369-374(2004) [PubMed: 15164053] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM AA).
[4]	"Evidence of an odorant-binding protein in the human olfactory mucus: location, structural characterization, and odorant-binding properties." Briand L., Eloit C., Nespoulous C., Bezirard V., Huet J.C., Henry C., Blon F., Trotier D., Pernollet J.C. Biochemistry 41:7241-7252(2002) [PubMed: 12044155] [Abstract] Cited for: FUNCTION, SUBUNIT, DISULFIDE BOND.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ251021 mRNA. Translation: CAB71318.1. AJ251022 mRNA. Translation: CAB71319.1. AJ251023 mRNA. Translation: CAB71320.1. AJ251024 mRNA. Translation: CAB71321.1. AJ251029 Genomic DNA. Translation: CAB71326.1. AL161452 Genomic DNA. Translation: CAI14043.1. BC069563 mRNA. Translation: AAH69563.1.
IPI	IPI00005153. IPI00221280. IPI00221281. IPI00221282.
RefSeq	NP_055397.1. NM_014582.2.
UniGene	Hs.567489.
3D structure databases
ProteinModelPortal	Q9NY56.
SMR	Q9NY56. Positions 25-168.
ModBase	Search...
Protein-protein interaction databases
STRING	Q9NY56.
Polymorphism databases
DMDM	20139237.
Proteomic databases
PRIDE	Q9NY56.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000371776; ENSP00000360841; ENSG00000122136.
GeneID	29991.
KEGG	hsa:29991.
UCSC	uc004cgb.1. human.
Organism-specific databases
CTD	29991.
GeneCards	GC09P138437.
H-InvDB	HIX0034789.
HGNC	HGNC:23380. OBP2A.
MIM	164320. gene.
neXtProt	NX_Q9NY56.
PharmGKB	PA134915019.
GenAtlas	Search...
Phylogenomic databases
GeneTree	ENSGT00440000033563.
HOVERGEN	HBG101411.
Gene expression databases
ArrayExpress	Q9NY56.
Bgee	Q9NY56.
CleanEx	HS_OBP2A.
Genevestigator	Q9NY56.
GermOnline	ENSG00000122136. Homo sapiens.
Family and domain databases
InterPro	IPR012674. Calycin. IPR011038. Calycin-like. IPR000566. Lipocln_cytosolic_FA-bd_dom. IPR002450. vonEbner_gland. [Graphical view]
Gene3D	G3DSA:2.40.128.20. Calycin. 1 hit.
Pfam	PF00061. Lipocalin. 1 hit. [Graphical view]
PRINTS	PR01175. VNEBNERGLAND.
SUPFAM	SSF50814. Calycin. 1 hit.
PROSITE	PS00213. LIPOCALIN. False negative. [Graphical view]
ProtoNet	Search...
Other
NextBio	52776.
SOURCE	Search...

Entry information

Entry name

OBP2A_HUMAN

Accession

Primary (citable) accession number: Q9NY56
Secondary accession number(s): Q5T8A3 , Q9NY50, Q9NY53, Q9NY54, Q9NY55

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 3, 2002
Last sequence update:	October 1, 2000
Last modified:	January 25, 2012
This is version 81 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.