Q9NY47 (CA2D2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Voltage-dependent calcium channel subunit alpha-2/delta-2

Alternative name(s):
Voltage-gated calcium channel subunit alpha-2/delta-2

Cleaved into the following 2 chains:

1. Voltage-dependent calcium channel subunit alpha-2-2
2. Voltage-dependent calcium channel subunit delta-2

Gene names

Name:	CACNA2D2
Synonyms:	KIAA0558

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	1150 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel. Acts as a regulatory subunit for P/Q-type calcium channel (CACNA1A), N-type (CACNA1B), L-type (CACNA1C OR CACNA1D) and possibly T-type (CACNA1G). Overexpression induces apoptosis. Ref.10 Ref.11
Subunit structure	Dimer formed of alpha-2-2 and delta-2 chains; disulfide-linked. Voltage-dependent calcium channels are multisubunit complexes, consisting of alpha-1 (CACNA1), alpha-2 (CACNA2D), beta (CACNB) and delta (CACNA2D) subunits in a 1:1:1:1 ratio By similarity.
Subcellular location	Membrane; Single-pass type I membrane protein Potential. Note: Colocalizes with CACNA1A in lipid raft fractions By similarity.
Tissue specificity	Predominantly present in cerebellar cortex. Present in various lung tumor cell lines, while it is absent in normal lung (at protein level). Highly expressed in heart, lung, testis, pancreas and skeletal muscle. Also expressed in kidney, liver, placenta and brain. Ref.1 Ref.2 Ref.8
Domain	The MIDAS-like motif in the VWFA domain binds divalent metal cations and is required to promote trafficking of the alpha-1 (CACNA1) subunit to the plasma membrane by an integrin-like switch By similarity.
Post-translational modification	May be proteolytically processed into subunits alpha-2-2 and delta-2 that are disulfide-linked. It is however unclear whether such cleavage really takes place in vivo and has a functional role By similarity.
Miscellaneous	Binds gabapentin, an antiepileptic drug.
Sequence similarities	Belongs to the calcium channel subunit alpha-2/delta family. Contains 1 cache domain. Contains 1 VWFA domain.

Ontologies

Keywords
Biological process	Calcium transport Ion transport Transport
Cellular component	Membrane
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Signal Transmembrane Transmembrane helix
Ligand	Calcium Metal-binding
Molecular function	Calcium channel Ion channel Voltage-gated channel
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	energy reserve metabolic process Traceable author statement. Source: Reactome neuromuscular junction development Inferred from electronic annotation. Source: Compara positive regulation of organ growth Inferred from electronic annotation. Source: Compara regulation of insulin secretion Traceable author statement. Source: Reactome regulation of multicellular organism growth Inferred from electronic annotation. Source: Compara rhythmic synaptic transmission Inferred from electronic annotation. Source: Compara small molecule metabolic process Traceable author statement. Source: Reactome
Cellular_component	plasma membrane Traceable author statement. Source: Reactome voltage-gated calcium channel complex Inferred from electronic annotation. Source: Compara
Molecular_function	metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW voltage-gated calcium channel activity Inferred from electronic annotation. Source: Compara
Complete GO annotation...

Alternative products

This entry describes 5 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q9NY47-1)

Also known as: Alpha2delta-2a;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9NY47-2)

Also known as: Alpha2delta-2b;

The sequence of this isoform differs from the canonical sequence as follows:
     662-669: LPISKLKD → Y

Isoform 3 (identifier: Q9NY47-3)

The sequence of this isoform differs from the canonical sequence as follows:
     662-669: LPISKLKD → Y
     1076-1077: HS → HCPA

Isoform 4 (identifier: Q9NY47-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1-69: Missing.
     662-669: LPISKLKD → Y
     1076-1077: HS → HCPA

Isoform 5 (identifier: Q9NY47-5)

Also known as: Alpha2delta-2c;

The sequence of this isoform differs from the canonical sequence as follows:
     1076-1077: HS → HCPA

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 18	18	Potential
	Chain	19 – 1150	1132	Voltage-dependent calcium channel subunit alpha-2/delta-2		PRO_0000304637
	Chain	19 – 1001	983	Voltage-dependent calcium channel subunit alpha-2-2 Potential		PRO_0000304638
	Chain	1002 – 1150	149	Voltage-dependent calcium channel subunit delta-2 Potential		PRO_0000304639
Regions
	Topological domain	19 – 1113	1095	Extracellular Potential
	Transmembrane	1114 – 1134	21	Helical; Potential
	Topological domain	1135 – 1150	16	Cytoplasmic Potential
	Domain	291 – 469	179	VWFA
	Domain	485 – 574	90	Cache
	Motif	297 – 301	5	MIDAS-like motif
Sites
	Metal binding	297	1	Divalent metal cation By similarity
	Metal binding	299	1	Divalent metal cation By similarity
	Metal binding	301	1	Divalent metal cation By similarity
Amino acid modifications
	Glycosylation	386	1	N-linked (GlcNAc...) Ref.12
	Glycosylation	418	1	N-linked (GlcNAc...) Potential
	Glycosylation	507	1	N-linked (GlcNAc...) Potential
	Glycosylation	540	1	N-linked (GlcNAc...) Potential
	Glycosylation	861	1	N-linked (GlcNAc...) Potential
Natural variations
	Alternative sequence	1 – 69	69	Missing in isoform 4.		VSP_028058
	Alternative sequence	662 – 669	8	LPISKLKD → Y in isoform 2, isoform 3 and isoform 4.		VSP_028059
	Alternative sequence	1076 – 1077	2	HS → HCPA in isoform 3, isoform 4 and isoform 5.		VSP_028060
	Natural variant	138	1	A → V. Corresponds to variant rs35497591 [ dbSNP | Ensembl ].		VAR_035048
	Natural variant	334	1	E → K. Corresponds to variant rs743855 [ dbSNP | Ensembl ].		VAR_057782
Experimental info
	Sequence conflict	663	1	P → R in CAB86193. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 (Alpha2delta-2a) [UniParc]. Last modified May 16, 2012. Version 2. Checksum: 502B86A5E6279AA0	FASTA	1,150	129,817
	10 20 30 40 50 60 MAVPARTCGA SRPGPARTAR PWPGCGPHPG PGTRRPTSGP PRPLWLLLPL LPLLAAPGAS 70 80 90 100 110 120 AYSFPQQHTM QHWARRLEQE VDGVMRIFGG VQQLREIYKD NRNLFEVQEN EPQKLVEKVA 130 140 150 160 170 180 GDIESLLDRK VQALKRLADA AENFQKAHRW QDNIKEEDIV YYDAKADAEL DDPESEDVER 190 200 210 220 230 240 GSKASTLRLD FIEDPNFKNK VNYSYAAVQI PTDIYKGSTV ILNELNWTEA LENVFMENRR 250 260 270 280 290 300 QDPTLLWQVF GSATGVTRYY PATPWRAPKK IDLYDVRRRP WYIQGASSPK DMVIIVDVSG 310 320 330 340 350 360 SVSGLTLKLM KTSVCEMLDT LSDDDYVNVA SFNEKAQPVS CFTHLVQANV RNKKVFKEAV 370 380 390 400 410 420 QGMVAKGTTG YKAGFEYAFD QLQNSNITRA NCNKMIMMFT DGGEDRVQDV FEKYNWPNRT 430 440 450 460 470 480 VRVFTFSVGQ HNYDVTPLQW MACANKGYYF EIPSIGAIRI NTQEYLDVLG RPMVLAGKEA 490 500 510 520 530 540 KQVQWTNVYE DALGLGLVVT GTLPVFNLTQ DGPGEKKNQL ILGVMGIDVA LNDIKRLTPN 550 560 570 580 590 600 YTLGANGYVF AIDLNGYVLL HPNLKPQTTN FREPVTLDFL DAELEDENKE EIRRSMIDGN 610 620 630 640 650 660 KGHKQIRTLV KSLDERYIDE VTRNYTWVPI RSTNYSLGLV LPPYSTFYLQ ANLSDQILQV 670 680 690 700 710 720 KLPISKLKDF EFLLPSSFES EGHVFIAPRE YCKDLNASDN NTEFLKNFIE LMEKVTPDSK 730 740 750 760 770 780 QCNNFLLHNL ILDTGITQQL VERVWRDQDL NTYSLLAVFA ATDGGITRVF PNKAAEDWTE 790 800 810 820 830 840 NPEPFNASFY RRSLDNHGYV FKPPHQDALL RPLELENDTV GILVSTAVEL SLGRRTLRPA 850 860 870 880 890 900 VVGVKLDLEA WAEKFKVLAS NRTHQDQPQK CGPNSHCEMD CEVNNEDLLC VLIDDGGFLV 910 920 930 940 950 960 LSNQNHQWDQ VGRFFSEVDA NLMLALYNNS FYTRKESYDY QAACAPQPPG NLGAAPRGVF 970 980 990 1000 1010 1020 VPTVADFLNL AWWTSAAAWS LFQQLLYGLI YHSWFQADPA EAEGSPETRE SSCVMKQTQY 1030 1040 1050 1060 1070 1080 YFGSVNASYN AIIDCGNCSR LFHAQRLTNT NLLFVVAEKP LCSQCEAGRL LQKETHSDGP 1090 1100 1110 1120 1130 1140 EQCELVQRPR YRRGPHICFD YNATEDTSDC GRGASFPPSL GVLVSLQLLL LLGLPPRPQP 1150 QVLVHASRRL
	Isoform 2 (Alpha2delta-2b) [UniParc]. Checksum: 492556C9919A0CE5	FASTA	1,143	129,085
	10 20 30 40 50 60 MAVPARTCGA SRPGPARTAR PWPGCGPHPG PGTRRPTSGP PRPLWLLLPL LPLLAAPGAS 70 80 90 100 110 120 AYSFPQQHTM QHWARRLEQE VDGVMRIFGG VQQLREIYKD NRNLFEVQEN EPQKLVEKVA 130 140 150 160 170 180 GDIESLLDRK VQALKRLADA AENFQKAHRW QDNIKEEDIV YYDAKADAEL DDPESEDVER 190 200 210 220 230 240 GSKASTLRLD FIEDPNFKNK VNYSYAAVQI PTDIYKGSTV ILNELNWTEA LENVFMENRR 250 260 270 280 290 300 QDPTLLWQVF GSATGVTRYY PATPWRAPKK IDLYDVRRRP WYIQGASSPK DMVIIVDVSG 310 320 330 340 350 360 SVSGLTLKLM KTSVCEMLDT LSDDDYVNVA SFNEKAQPVS CFTHLVQANV RNKKVFKEAV 370 380 390 400 410 420 QGMVAKGTTG YKAGFEYAFD QLQNSNITRA NCNKMIMMFT DGGEDRVQDV FEKYNWPNRT 430 440 450 460 470 480 VRVFTFSVGQ HNYDVTPLQW MACANKGYYF EIPSIGAIRI NTQEYLDVLG RPMVLAGKEA 490 500 510 520 530 540 KQVQWTNVYE DALGLGLVVT GTLPVFNLTQ DGPGEKKNQL ILGVMGIDVA LNDIKRLTPN 550 560 570 580 590 600 YTLGANGYVF AIDLNGYVLL HPNLKPQTTN FREPVTLDFL DAELEDENKE EIRRSMIDGN 610 620 630 640 650 660 KGHKQIRTLV KSLDERYIDE VTRNYTWVPI RSTNYSLGLV LPPYSTFYLQ ANLSDQILQV 670 680 690 700 710 720 KYFEFLLPSS FESEGHVFIA PREYCKDLNA SDNNTEFLKN FIELMEKVTP DSKQCNNFLL 730 740 750 760 770 780 HNLILDTGIT QQLVERVWRD QDLNTYSLLA VFAATDGGIT RVFPNKAAED WTENPEPFNA 790 800 810 820 830 840 SFYRRSLDNH GYVFKPPHQD ALLRPLELEN DTVGILVSTA VELSLGRRTL RPAVVGVKLD 850 860 870 880 890 900 LEAWAEKFKV LASNRTHQDQ PQKCGPNSHC EMDCEVNNED LLCVLIDDGG FLVLSNQNHQ 910 920 930 940 950 960 WDQVGRFFSE VDANLMLALY NNSFYTRKES YDYQAACAPQ PPGNLGAAPR GVFVPTVADF 970 980 990 1000 1010 1020 LNLAWWTSAA AWSLFQQLLY GLIYHSWFQA DPAEAEGSPE TRESSCVMKQ TQYYFGSVNA 1030 1040 1050 1060 1070 1080 SYNAIIDCGN CSRLFHAQRL TNTNLLFVVA EKPLCSQCEA GRLLQKETHS DGPEQCELVQ 1090 1100 1110 1120 1130 1140 RPRYRRGPHI CFDYNATEDT SDCGRGASFP PSLGVLVSLQ LLLLLGLPPR PQPQVLVHAS RRL
	Isoform 3 [UniParc]. Checksum: 9ADA4807FC70971B	FASTA	1,145	129,269
	10 20 30 40 50 60 MAVPARTCGA SRPGPARTAR PWPGCGPHPG PGTRRPTSGP PRPLWLLLPL LPLLAAPGAS 70 80 90 100 110 120 AYSFPQQHTM QHWARRLEQE VDGVMRIFGG VQQLREIYKD NRNLFEVQEN EPQKLVEKVA 130 140 150 160 170 180 GDIESLLDRK VQALKRLADA AENFQKAHRW QDNIKEEDIV YYDAKADAEL DDPESEDVER 190 200 210 220 230 240 GSKASTLRLD FIEDPNFKNK VNYSYAAVQI PTDIYKGSTV ILNELNWTEA LENVFMENRR 250 260 270 280 290 300 QDPTLLWQVF GSATGVTRYY PATPWRAPKK IDLYDVRRRP WYIQGASSPK DMVIIVDVSG 310 320 330 340 350 360 SVSGLTLKLM KTSVCEMLDT LSDDDYVNVA SFNEKAQPVS CFTHLVQANV RNKKVFKEAV 370 380 390 400 410 420 QGMVAKGTTG YKAGFEYAFD QLQNSNITRA NCNKMIMMFT DGGEDRVQDV FEKYNWPNRT 430 440 450 460 470 480 VRVFTFSVGQ HNYDVTPLQW MACANKGYYF EIPSIGAIRI NTQEYLDVLG RPMVLAGKEA 490 500 510 520 530 540 KQVQWTNVYE DALGLGLVVT GTLPVFNLTQ DGPGEKKNQL ILGVMGIDVA LNDIKRLTPN 550 560 570 580 590 600 YTLGANGYVF AIDLNGYVLL HPNLKPQTTN FREPVTLDFL DAELEDENKE EIRRSMIDGN 610 620 630 640 650 660 KGHKQIRTLV KSLDERYIDE VTRNYTWVPI RSTNYSLGLV LPPYSTFYLQ ANLSDQILQV 670 680 690 700 710 720 KYFEFLLPSS FESEGHVFIA PREYCKDLNA SDNNTEFLKN FIELMEKVTP DSKQCNNFLL 730 740 750 760 770 780 HNLILDTGIT QQLVERVWRD QDLNTYSLLA VFAATDGGIT RVFPNKAAED WTENPEPFNA 790 800 810 820 830 840 SFYRRSLDNH GYVFKPPHQD ALLRPLELEN DTVGILVSTA VELSLGRRTL RPAVVGVKLD 850 860 870 880 890 900 LEAWAEKFKV LASNRTHQDQ PQKCGPNSHC EMDCEVNNED LLCVLIDDGG FLVLSNQNHQ 910 920 930 940 950 960 WDQVGRFFSE VDANLMLALY NNSFYTRKES YDYQAACAPQ PPGNLGAAPR GVFVPTVADF 970 980 990 1000 1010 1020 LNLAWWTSAA AWSLFQQLLY GLIYHSWFQA DPAEAEGSPE TRESSCVMKQ TQYYFGSVNA 1030 1040 1050 1060 1070 1080 SYNAIIDCGN CSRLFHAQRL TNTNLLFVVA EKPLCSQCEA GRLLQKETHC PADGPEQCEL 1090 1100 1110 1120 1130 1140 VQRPRYRRGP HICFDYNATE DTSDCGRGAS FPPSLGVLVS LQLLLLLGLP PRPQPQVLVH ASRRL
	Isoform 4 [UniParc]. Checksum: EEC474836B7EDA85	FASTA	1,076	122,117
	10 20 30 40 50 60 MQHWARRLEQ EVDGVMRIFG GVQQLREIYK DNRNLFEVQE NEPQKLVEKV AGDIESLLDR 70 80 90 100 110 120 KVQALKRLAD AAENFQKAHR WQDNIKEEDI VYYDAKADAE LDDPESEDVE RGSKASTLRL 130 140 150 160 170 180 DFIEDPNFKN KVNYSYAAVQ IPTDIYKGST VILNELNWTE ALENVFMENR RQDPTLLWQV 190 200 210 220 230 240 FGSATGVTRY YPATPWRAPK KIDLYDVRRR PWYIQGASSP KDMVIIVDVS GSVSGLTLKL 250 260 270 280 290 300 MKTSVCEMLD TLSDDDYVNV ASFNEKAQPV SCFTHLVQAN VRNKKVFKEA VQGMVAKGTT 310 320 330 340 350 360 GYKAGFEYAF DQLQNSNITR ANCNKMIMMF TDGGEDRVQD VFEKYNWPNR TVRVFTFSVG 370 380 390 400 410 420 QHNYDVTPLQ WMACANKGYY FEIPSIGAIR INTQEYLDVL GRPMVLAGKE AKQVQWTNVY 430 440 450 460 470 480 EDALGLGLVV TGTLPVFNLT QDGPGEKKNQ LILGVMGIDV ALNDIKRLTP NYTLGANGYV 490 500 510 520 530 540 FAIDLNGYVL LHPNLKPQTT NFREPVTLDF LDAELEDENK EEIRRSMIDG NKGHKQIRTL 550 560 570 580 590 600 VKSLDERYID EVTRNYTWVP IRSTNYSLGL VLPPYSTFYL QANLSDQILQ VKYFEFLLPS 610 620 630 640 650 660 SFESEGHVFI APREYCKDLN ASDNNTEFLK NFIELMEKVT PDSKQCNNFL LHNLILDTGI 670 680 690 700 710 720 TQQLVERVWR DQDLNTYSLL AVFAATDGGI TRVFPNKAAE DWTENPEPFN ASFYRRSLDN 730 740 750 760 770 780 HGYVFKPPHQ DALLRPLELE NDTVGILVST AVELSLGRRT LRPAVVGVKL DLEAWAEKFK 790 800 810 820 830 840 VLASNRTHQD QPQKCGPNSH CEMDCEVNNE DLLCVLIDDG GFLVLSNQNH QWDQVGRFFS 850 860 870 880 890 900 EVDANLMLAL YNNSFYTRKE SYDYQAACAP QPPGNLGAAP RGVFVPTVAD FLNLAWWTSA 910 920 930 940 950 960 AAWSLFQQLL YGLIYHSWFQ ADPAEAEGSP ETRESSCVMK QTQYYFGSVN ASYNAIIDCG 970 980 990 1000 1010 1020 NCSRLFHAQR LTNTNLLFVV AEKPLCSQCE AGRLLQKETH CPADGPEQCE LVQRPRYRRG 1030 1040 1050 1060 1070 PHICFDYNAT EDTSDCGRGA SFPPSLGVLV SLQLLLLLGL PPRPQPQVLV HASRRL
	Isoform 5 (Alpha2delta-2c) [UniParc]. Checksum: 5C1121092C1CE0A6	FASTA	1,152	130,001
	10 20 30 40 50 60 MAVPARTCGA SRPGPARTAR PWPGCGPHPG PGTRRPTSGP PRPLWLLLPL LPLLAAPGAS 70 80 90 100 110 120 AYSFPQQHTM QHWARRLEQE VDGVMRIFGG VQQLREIYKD NRNLFEVQEN EPQKLVEKVA 130 140 150 160 170 180 GDIESLLDRK VQALKRLADA AENFQKAHRW QDNIKEEDIV YYDAKADAEL DDPESEDVER 190 200 210 220 230 240 GSKASTLRLD FIEDPNFKNK VNYSYAAVQI PTDIYKGSTV ILNELNWTEA LENVFMENRR 250 260 270 280 290 300 QDPTLLWQVF GSATGVTRYY PATPWRAPKK IDLYDVRRRP WYIQGASSPK DMVIIVDVSG 310 320 330 340 350 360 SVSGLTLKLM KTSVCEMLDT LSDDDYVNVA SFNEKAQPVS CFTHLVQANV RNKKVFKEAV 370 380 390 400 410 420 QGMVAKGTTG YKAGFEYAFD QLQNSNITRA NCNKMIMMFT DGGEDRVQDV FEKYNWPNRT 430 440 450 460 470 480 VRVFTFSVGQ HNYDVTPLQW MACANKGYYF EIPSIGAIRI NTQEYLDVLG RPMVLAGKEA 490 500 510 520 530 540 KQVQWTNVYE DALGLGLVVT GTLPVFNLTQ DGPGEKKNQL ILGVMGIDVA LNDIKRLTPN 550 560 570 580 590 600 YTLGANGYVF AIDLNGYVLL HPNLKPQTTN FREPVTLDFL DAELEDENKE EIRRSMIDGN 610 620 630 640 650 660 KGHKQIRTLV KSLDERYIDE VTRNYTWVPI RSTNYSLGLV LPPYSTFYLQ ANLSDQILQV 670 680 690 700 710 720 KLPISKLKDF EFLLPSSFES EGHVFIAPRE YCKDLNASDN NTEFLKNFIE LMEKVTPDSK 730 740 750 760 770 780 QCNNFLLHNL ILDTGITQQL VERVWRDQDL NTYSLLAVFA ATDGGITRVF PNKAAEDWTE 790 800 810 820 830 840 NPEPFNASFY RRSLDNHGYV FKPPHQDALL RPLELENDTV GILVSTAVEL SLGRRTLRPA 850 860 870 880 890 900 VVGVKLDLEA WAEKFKVLAS NRTHQDQPQK CGPNSHCEMD CEVNNEDLLC VLIDDGGFLV 910 920 930 940 950 960 LSNQNHQWDQ VGRFFSEVDA NLMLALYNNS FYTRKESYDY QAACAPQPPG NLGAAPRGVF 970 980 990 1000 1010 1020 VPTVADFLNL AWWTSAAAWS LFQQLLYGLI YHSWFQADPA EAEGSPETRE SSCVMKQTQY 1030 1040 1050 1060 1070 1080 YFGSVNASYN AIIDCGNCSR LFHAQRLTNT NLLFVVAEKP LCSQCEAGRL LQKETHCPAD 1090 1100 1110 1120 1130 1140 GPEQCELVQR PRYRRGPHIC FDYNATEDTS DCGRGASFPP SLGVLVSLQL LLLLGLPPRP 1150 QPQVLVHASR RL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular diversity of the calcium channel alpha2delta subunit." Klugbauer N., Lacinova L., Marais E., Hobom M., Hofmann F. J. Neurosci. 19:684-691(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 3 AND 4), TISSUE SPECIFICITY.
[2]	"Functional properties of a new voltage-dependent calcium channel alpha(2)delta auxiliary subunit gene (CACNA2D2)." Gao B., Sekido Y., Maximov A., Saad M., Forgacs E., Latif F., Wei M.-H., Lerman M., Lee J.-H., Perez-Reyes E., Bezprozvanny I., Minna J.D. J. Biol. Chem. 275:12237-12242(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3), TISSUE SPECIFICITY.
[3]	"Neuronal distribution and functional characterization of the calcium channel alpha2delta-2 subunit." Hobom M., Dai S., Marais E., Lacinova L., Hofmann F., Klugbauer N. Eur. J. Neurosci. 12:1217-1226(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2). Tissue: Thyroid.
[4]	"Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro." Nagase T., Ishikawa K., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O. DNA Res. 5:31-39(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3). Tissue: Brain.
[5]	"The DNA sequence, annotation and analysis of human chromosome 3." Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J. , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A. Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
[8]	"Tissue-specific expression and gabapentin-binding properties of calcium channel alpha2delta subunit subtypes." Gong H.C., Hang J., Kohler W., Li L., Su T.-Z. J. Membr. Biol. 184:35-43(2001) [PubMed] [Europe PMC] [Abstract] Cited for: DISULFIDE BONDS, TISSUE SPECIFICITY, GABAPENTIN-BINDING.
[9]	"Calcium channel alpha2delta subunits: differential expression, function, and drug binding." Klugbauer N., Marais E., Hofmann F. J. Bioenerg. Biomembr. 35:639-647(2003) [PubMed] [Europe PMC] [Abstract] Cited for: ALTERNATIVE SPLICING (ISOFORM 5).
[10]	"CACNA2D2-mediated apoptosis in NSCLC cells is associated with alterations of the intracellular calcium signaling and disruption of mitochondria membrane integrity." Carboni G.L., Gao B., Nishizaki M., Xu K., Minna J.D., Roth J.A., Ji L. Oncogene 22:615-626(2003) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION.
[11]	"Modulation of gating currents of the Ca(v)3.1 calcium channel by alpha 2 delta 2 and gamma 5 subunits." Lacinova L., Klugbauer N. Arch. Biochem. Biophys. 425:207-213(2004) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION.
[12]	"Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins." Wollscheid B., Bausch-Fluck D., Henderson C., O'Brien R., Bibel M., Schiess R., Aebersold R., Watts J.D. Nat. Biotechnol. 27:378-386(2009) [PubMed] [Europe PMC] [Abstract] Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-386, MASS SPECTROMETRY. Tissue: Leukemic T-cell.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF042792 mRNA. Translation: AAB96913.1. AF042793 mRNA. Translation: AAB96914.1. AF040709 mRNA. Translation: AAC70914.1. AJ251367 mRNA. Translation: CAB86192.1. AJ251368 mRNA. Translation: CAB86193.1. AB011130 mRNA. Translation: BAA25484.1. AL450422 Genomic DNA. No translation available. Z75742 Genomic DNA. No translation available. Z75743 Genomic DNA. No translation available. Z84492 Genomic DNA. No translation available. Z84494 Genomic DNA. No translation available. Z84495 Genomic DNA. No translation available. CH471055 Genomic DNA. Translation: EAW65121.1. BC152438 mRNA. Translation: AAI52439.1.
IPI	IPI00410600. IPI00479758. IPI00794469. IPI00796052. IPI00946159.
RefSeq	NP_001005505.1. NM_001005505.1. NP_001167522.1. NM_001174051.1. NP_006021.2. NM_006030.2.
UniGene	Hs.476273. Hs.674666.
3D structure databases
ProteinModelPortal	Q9NY47.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9NY47. 1 interaction.
STRING	9606.ENSP00000390329.
Protein family/group databases
TCDB	8.A.18.2.1. Ca2+ channel auxiliary subunit alpha2delta types 1-4 (CCA-alpha2delta) family.
PTM databases
PhosphoSite	Q9NY47.
Polymorphism databases
DMDM	74725352.
Proteomic databases
PaxDb	Q9NY47.
PRIDE	Q9NY47.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000266039; ENSP00000266039; ENSG00000007402. ENST00000360963; ENSP00000354228; ENSG00000007402. ENST00000424201; ENSP00000390329; ENSG00000007402. ENST00000479441; ENSP00000418081; ENSG00000007402.
GeneID	9254.
KEGG	hsa:9254.
UCSC	uc003dap.3. human. uc003daq.3. human.
Organism-specific databases
CTD	9254.
GeneCards	GC03M050400.
HGNC	HGNC:1400. CACNA2D2.
HPA	HPA034771.
MIM	607082. gene.
neXtProt	NX_Q9NY47.
PharmGKB	PA26012.
HUGE	Search...
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG307080.
HOGENOM	HOG000004860.
HOVERGEN	HBG057779.
InParanoid	Q9NY47.
KO	K04859.
Enzyme and pathway databases
Reactome	REACT_111217. Metabolism. REACT_13685. Neuronal System.
Gene expression databases
ArrayExpress	Q9NY47.
Bgee	Q9NY47.
CleanEx	HS_CACNA2D2.
Genevestigator	Q9NY47.
Family and domain databases
InterPro	IPR004010. Cache_domain. IPR013680. VDCC_a2/dsu. IPR013608. VWA_N. IPR002035. VWF_A. [Graphical view]
Pfam	PF02743. Cache_1. 1 hit. PF08473. VGCC_alpha2. 1 hit. PF00092. VWA. 1 hit. PF08399. VWA_N. 1 hit. [Graphical view]
SMART	SM00327. VWA. 1 hit. [Graphical view]
PROSITE	PS50234. VWFA. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChEMBL	CHEMBL3896.
DrugBank	DB00996. Gabapentin.
GenomeRNAi	9254.
NextBio	34689.
SOURCE	Search...

Entry information

Entry name

CA2D2_HUMAN

Accession

Primary (citable) accession number: Q9NY47
Secondary accession number(s): A7MD15 , Q9NY48, Q9UEW0, Q9Y268

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 11, 2007
Last sequence update:	May 16, 2012
Last modified:	May 1, 2013
This is version 80 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.