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Q9NY47

- CA2D2_HUMAN

UniProt

Q9NY47 - CA2D2_HUMAN

Protein

Voltage-dependent calcium channel subunit alpha-2/delta-2

Gene

CACNA2D2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 96 (01 Oct 2014)
      Sequence version 2 (16 May 2012)
      Previous versions | rss
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    Functioni

    The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel. Acts as a regulatory subunit for P/Q-type calcium channel (CACNA1A), N-type (CACNA1B), L-type (CACNA1C OR CACNA1D) and possibly T-type (CACNA1G). Overexpression induces apoptosis.2 Publications

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi297 – 2971Divalent metal cationBy similarity
    Metal bindingi299 – 2991Divalent metal cationBy similarity
    Metal bindingi301 – 3011Divalent metal cationBy similarity

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. voltage-gated calcium channel activity Source: Ensembl

    GO - Biological processi

    1. energy reserve metabolic process Source: Reactome
    2. muscle fiber development Source: Ensembl
    3. neuromuscular junction development Source: Ensembl
    4. positive regulation of organ growth Source: Ensembl
    5. regulation of insulin secretion Source: Reactome
    6. regulation of multicellular organism growth Source: Ensembl
    7. rhythmic synaptic transmission Source: Ensembl
    8. small molecule metabolic process Source: Reactome

    Keywords - Molecular functioni

    Calcium channel, Ion channel, Voltage-gated channel

    Keywords - Biological processi

    Calcium transport, Ion transport, Transport

    Keywords - Ligandi

    Calcium, Metal-binding

    Enzyme and pathway databases

    ReactomeiREACT_13606. Depolarization of the Presynaptic Terminal Triggers the Opening of Calcium Channels.
    REACT_18325. Regulation of insulin secretion.
    REACT_18339. Adrenaline,noradrenaline inhibits insulin secretion.

    Protein family/group databases

    TCDBi8.A.18.2.1. the ca(2+) channel auxiliary subunit 2 types 1-4 (cca-2) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Voltage-dependent calcium channel subunit alpha-2/delta-2
    Alternative name(s):
    Voltage-gated calcium channel subunit alpha-2/delta-2
    Cleaved into the following 2 chains:
    Gene namesi
    Name:CACNA2D2
    Synonyms:KIAA0558
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 3

    Organism-specific databases

    HGNCiHGNC:1400. CACNA2D2.

    Subcellular locationi

    Membrane Curated; Single-pass type I membrane protein Curated
    Note: Colocalizes with CACNA1A in lipid raft fractions.By similarity

    GO - Cellular componenti

    1. plasma membrane Source: Reactome
    2. voltage-gated calcium channel complex Source: Ensembl

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    Orphaneti1934. Early infantile epileptic encephalopathy.
    PharmGKBiPA26012.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1818Sequence AnalysisAdd
    BLAST
    Chaini19 – 11501132Voltage-dependent calcium channel subunit alpha-2/delta-2PRO_0000304637Add
    BLAST
    Chaini19 – 1001983Voltage-dependent calcium channel subunit alpha-2-2Sequence AnalysisPRO_0000304638Add
    BLAST
    Chaini1002 – 1150149Voltage-dependent calcium channel subunit delta-2Sequence AnalysisPRO_0000304639Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi386 – 3861N-linked (GlcNAc...)1 Publication
    Glycosylationi418 – 4181N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi443 ↔ 1098Interchain (between alpha-2-2 and delta-2 chains)By similarity
    Glycosylationi507 – 5071N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi540 – 5401N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi624 – 6241N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi861 – 8611N-linked (GlcNAc...)Sequence Analysis

    Post-translational modificationi

    May be proteolytically processed into subunits alpha-2-2 and delta-2 that are disulfide-linked. It is however unclear whether such cleavage really takes place in vivo and has a functional role By similarity.By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    MaxQBiQ9NY47.
    PaxDbiQ9NY47.
    PRIDEiQ9NY47.

    PTM databases

    PhosphoSiteiQ9NY47.

    Expressioni

    Tissue specificityi

    Predominantly present in cerebellar cortex. Present in various lung tumor cell lines, while it is absent in normal lung (at protein level). Highly expressed in heart, lung, testis, pancreas and skeletal muscle. Also expressed in kidney, liver, placenta and brain.3 Publications

    Gene expression databases

    ArrayExpressiQ9NY47.
    BgeeiQ9NY47.
    CleanExiHS_CACNA2D2.
    GenevestigatoriQ9NY47.

    Organism-specific databases

    HPAiHPA034771.

    Interactioni

    Subunit structurei

    Dimer formed of alpha-2-2 and delta-2 chains; disulfide-linked. Voltage-dependent calcium channels are multisubunit complexes, consisting of alpha-1 (CACNA1), alpha-2 (CACNA2D), beta (CACNB) and delta (CACNA2D) subunits in a 1:1:1:1 ratio By similarity.By similarity

    Protein-protein interaction databases

    BioGridi114678. 1 interaction.
    IntActiQ9NY47. 1 interaction.
    STRINGi9606.ENSP00000390329.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9NY47.
    SMRiQ9NY47. Positions 287-447.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini19 – 11131095ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini1135 – 115016CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei1114 – 113421HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini291 – 469179VWFAPROSITE-ProRule annotationAdd
    BLAST
    Domaini485 – 57490CacheAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi297 – 3015MIDAS-like motif

    Domaini

    The MIDAS-like motif in the VWFA domain binds divalent metal cations and is required to promote trafficking of the alpha-1 (CACNA1) subunit to the plasma membrane by an integrin-like switch.By similarity

    Sequence similaritiesi

    Contains 1 cache domain.Curated
    Contains 1 VWFA domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG307080.
    HOGENOMiHOG000004860.
    HOVERGENiHBG057779.
    InParanoidiQ9NY47.
    KOiK04859.
    TreeFamiTF315824.

    Family and domain databases

    Gene3Di3.40.50.410. 1 hit.
    InterProiIPR004010. Cache_domain.
    IPR013680. VDCC_a2/dsu.
    IPR013608. VWA_N.
    IPR002035. VWF_A.
    [Graphical view]
    PfamiPF02743. Cache_1. 1 hit.
    PF08473. VGCC_alpha2. 1 hit.
    PF00092. VWA. 1 hit.
    PF08399. VWA_N. 1 hit.
    [Graphical view]
    SMARTiSM00327. VWA. 1 hit.
    [Graphical view]
    SUPFAMiSSF53300. SSF53300. 1 hit.
    PROSITEiPS50234. VWFA. 1 hit.
    [Graphical view]

    Sequences (5)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 5 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9NY47-1) [UniParc]FASTAAdd to Basket

    Also known as: Alpha2delta-2a

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAVPARTCGA SRPGPARTAR PWPGCGPHPG PGTRRPTSGP PRPLWLLLPL     50
    LPLLAAPGAS AYSFPQQHTM QHWARRLEQE VDGVMRIFGG VQQLREIYKD 100
    NRNLFEVQEN EPQKLVEKVA GDIESLLDRK VQALKRLADA AENFQKAHRW 150
    QDNIKEEDIV YYDAKADAEL DDPESEDVER GSKASTLRLD FIEDPNFKNK 200
    VNYSYAAVQI PTDIYKGSTV ILNELNWTEA LENVFMENRR QDPTLLWQVF 250
    GSATGVTRYY PATPWRAPKK IDLYDVRRRP WYIQGASSPK DMVIIVDVSG 300
    SVSGLTLKLM KTSVCEMLDT LSDDDYVNVA SFNEKAQPVS CFTHLVQANV 350
    RNKKVFKEAV QGMVAKGTTG YKAGFEYAFD QLQNSNITRA NCNKMIMMFT 400
    DGGEDRVQDV FEKYNWPNRT VRVFTFSVGQ HNYDVTPLQW MACANKGYYF 450
    EIPSIGAIRI NTQEYLDVLG RPMVLAGKEA KQVQWTNVYE DALGLGLVVT 500
    GTLPVFNLTQ DGPGEKKNQL ILGVMGIDVA LNDIKRLTPN YTLGANGYVF 550
    AIDLNGYVLL HPNLKPQTTN FREPVTLDFL DAELEDENKE EIRRSMIDGN 600
    KGHKQIRTLV KSLDERYIDE VTRNYTWVPI RSTNYSLGLV LPPYSTFYLQ 650
    ANLSDQILQV KLPISKLKDF EFLLPSSFES EGHVFIAPRE YCKDLNASDN 700
    NTEFLKNFIE LMEKVTPDSK QCNNFLLHNL ILDTGITQQL VERVWRDQDL 750
    NTYSLLAVFA ATDGGITRVF PNKAAEDWTE NPEPFNASFY RRSLDNHGYV 800
    FKPPHQDALL RPLELENDTV GILVSTAVEL SLGRRTLRPA VVGVKLDLEA 850
    WAEKFKVLAS NRTHQDQPQK CGPNSHCEMD CEVNNEDLLC VLIDDGGFLV 900
    LSNQNHQWDQ VGRFFSEVDA NLMLALYNNS FYTRKESYDY QAACAPQPPG 950
    NLGAAPRGVF VPTVADFLNL AWWTSAAAWS LFQQLLYGLI YHSWFQADPA 1000
    EAEGSPETRE SSCVMKQTQY YFGSVNASYN AIIDCGNCSR LFHAQRLTNT 1050
    NLLFVVAEKP LCSQCEAGRL LQKETHSDGP EQCELVQRPR YRRGPHICFD 1100
    YNATEDTSDC GRGASFPPSL GVLVSLQLLL LLGLPPRPQP QVLVHASRRL 1150
    Length:1,150
    Mass (Da):129,817
    Last modified:May 16, 2012 - v2
    Checksum:i502B86A5E6279AA0
    GO
    Isoform 2 (identifier: Q9NY47-2) [UniParc]FASTAAdd to Basket

    Also known as: Alpha2delta-2b

    The sequence of this isoform differs from the canonical sequence as follows:
         662-669: LPISKLKD → Y

    Show »
    Length:1,143
    Mass (Da):129,085
    Checksum:i492556C9919A0CE5
    GO
    Isoform 3 (identifier: Q9NY47-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         662-669: LPISKLKD → Y
         1076-1077: HS → HCPA

    Show »
    Length:1,145
    Mass (Da):129,269
    Checksum:i9ADA4807FC70971B
    GO
    Isoform 4 (identifier: Q9NY47-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-69: Missing.
         662-669: LPISKLKD → Y
         1076-1077: HS → HCPA

    Show »
    Length:1,076
    Mass (Da):122,117
    Checksum:iEEC474836B7EDA85
    GO
    Isoform 5 (identifier: Q9NY47-5) [UniParc]FASTAAdd to Basket

    Also known as: Alpha2delta-2c

    The sequence of this isoform differs from the canonical sequence as follows:
         1076-1077: HS → HCPA

    Show »
    Length:1,152
    Mass (Da):130,001
    Checksum:i5C1121092C1CE0A6
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti663 – 6631P → R in CAB86193. (PubMed:10762351)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti138 – 1381A → V.
    Corresponds to variant rs35497591 [ dbSNP | Ensembl ].
    VAR_035048
    Natural varianti334 – 3341E → K.
    Corresponds to variant rs743855 [ dbSNP | Ensembl ].
    VAR_057782

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 6969Missing in isoform 4. 1 PublicationVSP_028058Add
    BLAST
    Alternative sequencei662 – 6698LPISKLKD → Y in isoform 2, isoform 3 and isoform 4. 5 PublicationsVSP_028059
    Alternative sequencei1076 – 10772HS → HCPA in isoform 3, isoform 4 and isoform 5. 4 PublicationsVSP_028060

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF042792 mRNA. Translation: AAB96913.1.
    AF042793 mRNA. Translation: AAB96914.1.
    AF040709 mRNA. Translation: AAC70914.1.
    AJ251367 mRNA. Translation: CAB86192.1.
    AJ251368 mRNA. Translation: CAB86193.1.
    AB011130 mRNA. Translation: BAA25484.1.
    AL450422 Genomic DNA. No translation available.
    Z75742 Genomic DNA. No translation available.
    Z75743 Genomic DNA. No translation available.
    Z84492 Genomic DNA. No translation available.
    Z84494 Genomic DNA. No translation available.
    Z84495 Genomic DNA. No translation available.
    CH471055 Genomic DNA. Translation: EAW65121.1.
    BC152438 mRNA. Translation: AAI52439.1.
    CCDSiCCDS33763.1. [Q9NY47-2]
    CCDS54588.1. [Q9NY47-1]
    CCDS63647.1. [Q9NY47-3]
    RefSeqiNP_001005505.1. NM_001005505.2. [Q9NY47-3]
    NP_001167522.1. NM_001174051.2. [Q9NY47-1]
    NP_001278030.1. NM_001291101.1. [Q9NY47-4]
    NP_006021.2. NM_006030.3. [Q9NY47-2]
    UniGeneiHs.476273.
    Hs.674666.

    Genome annotation databases

    EnsembliENST00000266039; ENSP00000266039; ENSG00000007402. [Q9NY47-3]
    ENST00000360963; ENSP00000354228; ENSG00000007402. [Q9NY47-4]
    ENST00000424201; ENSP00000390329; ENSG00000007402. [Q9NY47-2]
    ENST00000479441; ENSP00000418081; ENSG00000007402. [Q9NY47-1]
    GeneIDi9254.
    KEGGihsa:9254.
    UCSCiuc003dap.3. human. [Q9NY47-2]
    uc003daq.3. human. [Q9NY47-1]

    Polymorphism databases

    DMDMi387912827.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF042792 mRNA. Translation: AAB96913.1 .
    AF042793 mRNA. Translation: AAB96914.1 .
    AF040709 mRNA. Translation: AAC70914.1 .
    AJ251367 mRNA. Translation: CAB86192.1 .
    AJ251368 mRNA. Translation: CAB86193.1 .
    AB011130 mRNA. Translation: BAA25484.1 .
    AL450422 Genomic DNA. No translation available.
    Z75742 Genomic DNA. No translation available.
    Z75743 Genomic DNA. No translation available.
    Z84492 Genomic DNA. No translation available.
    Z84494 Genomic DNA. No translation available.
    Z84495 Genomic DNA. No translation available.
    CH471055 Genomic DNA. Translation: EAW65121.1 .
    BC152438 mRNA. Translation: AAI52439.1 .
    CCDSi CCDS33763.1. [Q9NY47-2 ]
    CCDS54588.1. [Q9NY47-1 ]
    CCDS63647.1. [Q9NY47-3 ]
    RefSeqi NP_001005505.1. NM_001005505.2. [Q9NY47-3 ]
    NP_001167522.1. NM_001174051.2. [Q9NY47-1 ]
    NP_001278030.1. NM_001291101.1. [Q9NY47-4 ]
    NP_006021.2. NM_006030.3. [Q9NY47-2 ]
    UniGenei Hs.476273.
    Hs.674666.

    3D structure databases

    ProteinModelPortali Q9NY47.
    SMRi Q9NY47. Positions 287-447.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 114678. 1 interaction.
    IntActi Q9NY47. 1 interaction.
    STRINGi 9606.ENSP00000390329.

    Chemistry

    ChEMBLi CHEMBL3896.
    DrugBanki DB00996. Gabapentin.

    Protein family/group databases

    TCDBi 8.A.18.2.1. the ca(2+) channel auxiliary subunit 2 types 1-4 (cca-2) family.

    PTM databases

    PhosphoSitei Q9NY47.

    Polymorphism databases

    DMDMi 387912827.

    Proteomic databases

    MaxQBi Q9NY47.
    PaxDbi Q9NY47.
    PRIDEi Q9NY47.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000266039 ; ENSP00000266039 ; ENSG00000007402 . [Q9NY47-3 ]
    ENST00000360963 ; ENSP00000354228 ; ENSG00000007402 . [Q9NY47-4 ]
    ENST00000424201 ; ENSP00000390329 ; ENSG00000007402 . [Q9NY47-2 ]
    ENST00000479441 ; ENSP00000418081 ; ENSG00000007402 . [Q9NY47-1 ]
    GeneIDi 9254.
    KEGGi hsa:9254.
    UCSCi uc003dap.3. human. [Q9NY47-2 ]
    uc003daq.3. human. [Q9NY47-1 ]

    Organism-specific databases

    CTDi 9254.
    GeneCardsi GC03M050400.
    HGNCi HGNC:1400. CACNA2D2.
    HPAi HPA034771.
    MIMi 607082. gene.
    neXtProti NX_Q9NY47.
    Orphaneti 1934. Early infantile epileptic encephalopathy.
    PharmGKBi PA26012.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG307080.
    HOGENOMi HOG000004860.
    HOVERGENi HBG057779.
    InParanoidi Q9NY47.
    KOi K04859.
    TreeFami TF315824.

    Enzyme and pathway databases

    Reactomei REACT_13606. Depolarization of the Presynaptic Terminal Triggers the Opening of Calcium Channels.
    REACT_18325. Regulation of insulin secretion.
    REACT_18339. Adrenaline,noradrenaline inhibits insulin secretion.

    Miscellaneous databases

    GeneWikii CACNA2D2.
    GenomeRNAii 9254.
    NextBioi 34689.
    PROi Q9NY47.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9NY47.
    Bgeei Q9NY47.
    CleanExi HS_CACNA2D2.
    Genevestigatori Q9NY47.

    Family and domain databases

    Gene3Di 3.40.50.410. 1 hit.
    InterProi IPR004010. Cache_domain.
    IPR013680. VDCC_a2/dsu.
    IPR013608. VWA_N.
    IPR002035. VWF_A.
    [Graphical view ]
    Pfami PF02743. Cache_1. 1 hit.
    PF08473. VGCC_alpha2. 1 hit.
    PF00092. VWA. 1 hit.
    PF08399. VWA_N. 1 hit.
    [Graphical view ]
    SMARTi SM00327. VWA. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53300. SSF53300. 1 hit.
    PROSITEi PS50234. VWFA. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular diversity of the calcium channel alpha2delta subunit."
      Klugbauer N., Lacinova L., Marais E., Hobom M., Hofmann F.
      J. Neurosci. 19:684-691(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 3 AND 4), TISSUE SPECIFICITY.
    2. "Functional properties of a new voltage-dependent calcium channel alpha(2)delta auxiliary subunit gene (CACNA2D2)."
      Gao B., Sekido Y., Maximov A., Saad M., Forgacs E., Latif F., Wei M.-H., Lerman M., Lee J.-H., Perez-Reyes E., Bezprozvanny I., Minna J.D.
      J. Biol. Chem. 275:12237-12242(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3), TISSUE SPECIFICITY.
    3. "Neuronal distribution and functional characterization of the calcium channel alpha2delta-2 subunit."
      Hobom M., Dai S., Marais E., Lacinova L., Hofmann F., Klugbauer N.
      Eur. J. Neurosci. 12:1217-1226(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
      Tissue: Thyroid.
    4. "Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro."
      Nagase T., Ishikawa K., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
      DNA Res. 5:31-39(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
      Tissue: Brain.
    5. "The DNA sequence, annotation and analysis of human chromosome 3."
      Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
      , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
      Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    8. "Tissue-specific expression and gabapentin-binding properties of calcium channel alpha2delta subunit subtypes."
      Gong H.C., Hang J., Kohler W., Li L., Su T.-Z.
      J. Membr. Biol. 184:35-43(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: DISULFIDE BONDS, TISSUE SPECIFICITY, GABAPENTIN-BINDING.
    9. "Calcium channel alpha2delta subunits: differential expression, function, and drug binding."
      Klugbauer N., Marais E., Hofmann F.
      J. Bioenerg. Biomembr. 35:639-647(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: ALTERNATIVE SPLICING (ISOFORM 5).
    10. "CACNA2D2-mediated apoptosis in NSCLC cells is associated with alterations of the intracellular calcium signaling and disruption of mitochondria membrane integrity."
      Carboni G.L., Gao B., Nishizaki M., Xu K., Minna J.D., Roth J.A., Ji L.
      Oncogene 22:615-626(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    11. "Modulation of gating currents of the Ca(v)3.1 calcium channel by alpha 2 delta 2 and gamma 5 subunits."
      Lacinova L., Klugbauer N.
      Arch. Biochem. Biophys. 425:207-213(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    12. "Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins."
      Wollscheid B., Bausch-Fluck D., Henderson C., O'Brien R., Bibel M., Schiess R., Aebersold R., Watts J.D.
      Nat. Biotechnol. 27:378-386(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-386.
      Tissue: Leukemic T-cell.

    Entry informationi

    Entry nameiCA2D2_HUMAN
    AccessioniPrimary (citable) accession number: Q9NY47
    Secondary accession number(s): A7MD15
    , Q9NY48, Q9UEW0, Q9Y268
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 11, 2007
    Last sequence update: May 16, 2012
    Last modified: October 1, 2014
    This is version 96 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Miscellaneous

    Binds gabapentin, an antiepileptic drug.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 3
      Human chromosome 3: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3