ID   BARH2_HUMAN             Reviewed;         387 AA.
AC   Q9NY43; A0AVP2; Q7Z4N7;
DT   25-MAR-2003, integrated into UniProtKB/Swiss-Prot.
DT   10-MAY-2004, sequence version 2.
DT   24-JAN-2024, entry version 170.
DE   RecName: Full=BarH-like 2 homeobox protein;
GN   Name=BARHL2;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Shan Y.X., Yu L., Huang C.Q., Guo Z.K.;
RT   "Cloning and characterization of human novel homeodomain box gene BARHL2.";
RL   Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 297-364.
RX   PubMed=10814725; DOI=10.1093/hmg/9.9.1443;
RA   Bulfone A., Menguzzato E., Broccoli V., Marchitiello A., Gattuso C.,
RA   Mariani M., Consalez G.G., Martinez S., Ballabio A., Banfi S.;
RT   "Barhl1, a gene belonging to a new subfamily of mammalian homeobox genes,
RT   is expressed in migrating neurons of the CNS.";
RL   Hum. Mol. Genet. 9:1443-1452(2000).
CC   -!- FUNCTION: Potential regulator of neural basic helix-loop-helix genes.
CC       {ECO:0000250}.
CC   -!- INTERACTION:
CC       Q9NY43; Q9H8W4: PLEKHF2; NbExp=3; IntAct=EBI-10316571, EBI-742388;
CC       Q9NY43; Q04864: REL; NbExp=3; IntAct=EBI-10316571, EBI-307352;
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the BAR homeobox family. {ECO:0000305}.
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DR   EMBL; AY338397; AAQ01189.1; -; mRNA.
DR   EMBL; BC126439; AAI26440.1; -; mRNA.
DR   EMBL; BC126441; AAI26442.1; -; mRNA.
DR   EMBL; AJ251753; CAB92440.1; -; Genomic_DNA.
DR   CCDS; CCDS730.1; -.
DR   RefSeq; NP_064447.1; NM_020063.1.
DR   AlphaFoldDB; Q9NY43; -.
DR   SMR; Q9NY43; -.
DR   BioGRID; 131253; 2.
DR   IntAct; Q9NY43; 2.
DR   STRING; 9606.ENSP00000359474; -.
DR   iPTMnet; Q9NY43; -.
DR   PhosphoSitePlus; Q9NY43; -.
DR   BioMuta; BARHL2; -.
DR   DMDM; 47117915; -.
DR   jPOST; Q9NY43; -.
DR   MassIVE; Q9NY43; -.
DR   PaxDb; 9606-ENSP00000359474; -.
DR   PeptideAtlas; Q9NY43; -.
DR   ProteomicsDB; 83164; -.
DR   Antibodypedia; 19858; 87 antibodies from 24 providers.
DR   DNASU; 343472; -.
DR   Ensembl; ENST00000370445.5; ENSP00000359474.3; ENSG00000143032.8.
DR   GeneID; 343472; -.
DR   KEGG; hsa:343472; -.
DR   MANE-Select; ENST00000370445.5; ENSP00000359474.3; NM_020063.2; NP_064447.1.
DR   UCSC; uc001dns.4; human.
DR   AGR; HGNC:954; -.
DR   CTD; 343472; -.
DR   DisGeNET; 343472; -.
DR   GeneCards; BARHL2; -.
DR   HGNC; HGNC:954; BARHL2.
DR   HPA; ENSG00000143032; Tissue enriched (brain).
DR   MIM; 605212; gene.
DR   neXtProt; NX_Q9NY43; -.
DR   OpenTargets; ENSG00000143032; -.
DR   PharmGKB; PA25258; -.
DR   VEuPathDB; HostDB:ENSG00000143032; -.
DR   eggNOG; KOG0488; Eukaryota.
DR   GeneTree; ENSGT00940000158611; -.
DR   HOGENOM; CLU_074592_0_0_1; -.
DR   InParanoid; Q9NY43; -.
DR   OMA; SVSMEHP; -.
DR   OrthoDB; 4204245at2759; -.
DR   PhylomeDB; Q9NY43; -.
DR   TreeFam; TF316128; -.
DR   PathwayCommons; Q9NY43; -.
DR   SignaLink; Q9NY43; -.
DR   BioGRID-ORCS; 343472; 13 hits in 1169 CRISPR screens.
DR   GenomeRNAi; 343472; -.
DR   Pharos; Q9NY43; Tbio.
DR   PRO; PR:Q9NY43; -.
DR   Proteomes; UP000005640; Chromosome 1.
DR   RNAct; Q9NY43; Protein.
DR   Bgee; ENSG00000143032; Expressed in cerebellum and 20 other cell types or tissues.
DR   GO; GO:0000785; C:chromatin; ISA:NTNU_SB.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IEA:Ensembl.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; ISA:NTNU_SB.
DR   GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:1990837; F:sequence-specific double-stranded DNA binding; IDA:ARUK-UCL.
DR   GO; GO:0035881; P:amacrine cell differentiation; IEA:Ensembl.
DR   GO; GO:0001709; P:cell fate determination; IEA:Ensembl.
DR   GO; GO:0001764; P:neuron migration; IEA:Ensembl.
DR   GO; GO:0045727; P:positive regulation of translation; IEA:Ensembl.
DR   GO; GO:0030516; P:regulation of axon extension; IEA:Ensembl.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   CDD; cd00086; homeodomain; 1.
DR   Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR020479; Homeobox_metazoa.
DR   PANTHER; PTHR24330:SF4; BARH-LIKE 2 HOMEOBOX PROTEIN; 1.
DR   PANTHER; PTHR24330; HOMEOBOX PROTEIN BARH-LIKE; 1.
DR   Pfam; PF00046; Homeodomain; 1.
DR   PRINTS; PR00024; HOMEOBOX.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; Homeodomain-like; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   1: Evidence at protein level;
KW   DNA-binding; Homeobox; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..387
FT                   /note="BarH-like 2 homeobox protein"
FT                   /id="PRO_0000048829"
FT   DNA_BIND        232..291
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          1..145
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          157..240
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          367..387
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..26
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        43..67
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        110..129
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        130..145
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        158..172
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        173..238
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   387 AA;  41981 MW;  F563EA63489D936D CRC64;
     MTMEGASGSS FGIDTILSSA SSGSPGMMNG DFRPLGEART ADFRSQATPS PCSEIDTVGT
     APSSPISVTM EPPEPHLVAD ATQHHHHLHH SQQPPPPAAA PTQSLQPLPQ QQQPLPPQQP
     PPPPPQQLGS AASAPRTSTS SFLIKDILGD SKPLAACAPY STSVSSPHHT PKQESNAVHE
     SFRPKLEQED SKTKLDKRED SQSDIKCHGT KEEGDREITS SRESPPVRAK KPRKARTAFS
     DHQLNQLERS FERQKYLSVQ DRMDLAAALN LTDTQVKTWY QNRRTKWKRQ TAVGLELLAE
     AGNYSALQRM FPSPYFYHPS LLGSMDSTTA AAAAAAMYSS MYRTPPAPHP QLQRPLVPRV
     LIHGLGPGGQ PALNPLSSPI PGTPHPR
//