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Q9NY43

- BARH2_HUMAN

UniProt

Q9NY43 - BARH2_HUMAN

Protein

BarH-like 2 homeobox protein

Gene

BARHL2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 103 (01 Oct 2014)
      Sequence version 2 (10 May 2004)
      Previous versions | rss
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    Functioni

    Potential regulator of neural basic helix-loop-helix genes.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi232 – 29160HomeoboxPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Source: Ensembl
    2. sequence-specific DNA binding Source: InterPro

    GO - Biological processi

    1. cell fate determination Source: Ensembl
    2. neuron differentiation Source: Ensembl
    3. neuron migration Source: Ensembl
    4. positive regulation of translation Source: Ensembl
    5. regulation of axon extension Source: Ensembl

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Enzyme and pathway databases

    BRENDAi3.1.30.1. 7453.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    BarH-like 2 homeobox protein
    Gene namesi
    Name:BARHL2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:954. BARHL2.

    Subcellular locationi

    Nucleus Curated

    GO - Cellular componenti

    1. cytoplasm Source: HPA
    2. nucleus Source: HPA

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA25258.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 387387BarH-like 2 homeobox proteinPRO_0000048829Add
    BLAST

    Proteomic databases

    PaxDbiQ9NY43.
    PRIDEiQ9NY43.

    PTM databases

    PhosphoSiteiQ9NY43.

    Expressioni

    Gene expression databases

    BgeeiQ9NY43.
    CleanExiHS_BARHL2.
    GenevestigatoriQ9NY43.

    Organism-specific databases

    HPAiHPA028176.
    HPA031326.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000359474.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9NY43.
    SMRiQ9NY43. Positions 210-291.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi92 – 12736Gln/Pro-richAdd
    BLAST

    Sequence similaritiesi

    Belongs to the BAR homeobox family.Curated
    Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Homeobox

    Phylogenomic databases

    eggNOGiNOG263484.
    HOGENOMiHOG000231533.
    HOVERGENiHBG050663.
    InParanoidiQ9NY43.
    KOiK09360.
    OMAiISVTMEH.
    OrthoDBiEOG79GT7B.
    PhylomeDBiQ9NY43.
    TreeFamiTF316128.

    Family and domain databases

    Gene3Di1.10.10.60. 1 hit.
    InterProiIPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR020479. Homeobox_metazoa.
    IPR009057. Homeodomain-like.
    [Graphical view]
    PfamiPF00046. Homeobox. 1 hit.
    [Graphical view]
    PRINTSiPR00024. HOMEOBOX.
    SMARTiSM00389. HOX. 1 hit.
    [Graphical view]
    SUPFAMiSSF46689. SSF46689. 1 hit.
    PROSITEiPS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9NY43-1 [UniParc]FASTAAdd to Basket

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    MTMEGASGSS FGIDTILSSA SSGSPGMMNG DFRPLGEART ADFRSQATPS    50
    PCSEIDTVGT APSSPISVTM EPPEPHLVAD ATQHHHHLHH SQQPPPPAAA 100
    PTQSLQPLPQ QQQPLPPQQP PPPPPQQLGS AASAPRTSTS SFLIKDILGD 150
    SKPLAACAPY STSVSSPHHT PKQESNAVHE SFRPKLEQED SKTKLDKRED 200
    SQSDIKCHGT KEEGDREITS SRESPPVRAK KPRKARTAFS DHQLNQLERS 250
    FERQKYLSVQ DRMDLAAALN LTDTQVKTWY QNRRTKWKRQ TAVGLELLAE 300
    AGNYSALQRM FPSPYFYHPS LLGSMDSTTA AAAAAAMYSS MYRTPPAPHP 350
    QLQRPLVPRV LIHGLGPGGQ PALNPLSSPI PGTPHPR 387
    Length:387
    Mass (Da):41,981
    Last modified:May 10, 2004 - v2
    Checksum:iF563EA63489D936D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY338397 mRNA. Translation: AAQ01189.1.
    BC126439 mRNA. Translation: AAI26440.1.
    BC126441 mRNA. Translation: AAI26442.1.
    AJ251753 Genomic DNA. Translation: CAB92440.1.
    CCDSiCCDS730.1.
    RefSeqiNP_064447.1. NM_020063.1.
    UniGeneiHs.451956.

    Genome annotation databases

    EnsembliENST00000370445; ENSP00000359474; ENSG00000143032.
    GeneIDi343472.
    KEGGihsa:343472.
    UCSCiuc001dns.3. human.

    Polymorphism databases

    DMDMi47117915.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY338397 mRNA. Translation: AAQ01189.1 .
    BC126439 mRNA. Translation: AAI26440.1 .
    BC126441 mRNA. Translation: AAI26442.1 .
    AJ251753 Genomic DNA. Translation: CAB92440.1 .
    CCDSi CCDS730.1.
    RefSeqi NP_064447.1. NM_020063.1.
    UniGenei Hs.451956.

    3D structure databases

    ProteinModelPortali Q9NY43.
    SMRi Q9NY43. Positions 210-291.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000359474.

    PTM databases

    PhosphoSitei Q9NY43.

    Polymorphism databases

    DMDMi 47117915.

    Proteomic databases

    PaxDbi Q9NY43.
    PRIDEi Q9NY43.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000370445 ; ENSP00000359474 ; ENSG00000143032 .
    GeneIDi 343472.
    KEGGi hsa:343472.
    UCSCi uc001dns.3. human.

    Organism-specific databases

    CTDi 343472.
    GeneCardsi GC01M091177.
    HGNCi HGNC:954. BARHL2.
    HPAi HPA028176.
    HPA031326.
    MIMi 605212. gene.
    neXtProti NX_Q9NY43.
    PharmGKBi PA25258.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG263484.
    HOGENOMi HOG000231533.
    HOVERGENi HBG050663.
    InParanoidi Q9NY43.
    KOi K09360.
    OMAi ISVTMEH.
    OrthoDBi EOG79GT7B.
    PhylomeDBi Q9NY43.
    TreeFami TF316128.

    Enzyme and pathway databases

    BRENDAi 3.1.30.1. 7453.

    Miscellaneous databases

    GenomeRNAii 343472.
    NextBioi 98538.
    PROi Q9NY43.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9NY43.
    CleanExi HS_BARHL2.
    Genevestigatori Q9NY43.

    Family and domain databases

    Gene3Di 1.10.10.60. 1 hit.
    InterProi IPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR020479. Homeobox_metazoa.
    IPR009057. Homeodomain-like.
    [Graphical view ]
    Pfami PF00046. Homeobox. 1 hit.
    [Graphical view ]
    PRINTSi PR00024. HOMEOBOX.
    SMARTi SM00389. HOX. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46689. SSF46689. 1 hit.
    PROSITEi PS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and characterization of human novel homeodomain box gene BARHL2."
      Shan Y.X., Yu L., Huang C.Q., Guo Z.K.
      Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    3. "Barhl1, a gene belonging to a new subfamily of mammalian homeobox genes, is expressed in migrating neurons of the CNS."
      Bulfone A., Menguzzato E., Broccoli V., Marchitiello A., Gattuso C., Mariani M., Consalez G.G., Martinez S., Ballabio A., Banfi S.
      Hum. Mol. Genet. 9:1443-1452(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 297-364.

    Entry informationi

    Entry nameiBARH2_HUMAN
    AccessioniPrimary (citable) accession number: Q9NY43
    Secondary accession number(s): A0AVP2, Q7Z4N7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 25, 2003
    Last sequence update: May 10, 2004
    Last modified: October 1, 2014
    This is version 103 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3