Q9NY43 (BARH2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
BarH-like 2 homeobox protein

Gene names

Name:

BARHL2

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	387 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Potential regulator of neural basic helix-loop-helix genes By similarity.
Subcellular location	Nucleus Probable.
Sequence similarities	Belongs to the BAR homeobox family. Contains 1 homeobox DNA-binding domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Domain	Homeobox
Ligand	DNA-binding
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cell fate determination Inferred from electronic annotation. Source: Compara neuron differentiation Inferred from electronic annotation. Source: Compara neuron migration Inferred from electronic annotation. Source: Compara positive regulation of translation Inferred from electronic annotation. Source: Compara regulation of axon extension Inferred from electronic annotation. Source: Compara
Cellular_component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Inferred from electronic annotation. Source: Compara sequence-specific DNA binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 387	387	BarH-like 2 homeobox protein		PRO_0000048829
Regions
	DNA binding	232 – 291	60	Homeobox
	Compositional bias	92 – 127	36	Gln/Pro-rich

Sequences

	Sequence		Length	Mass (Da)
	Q9NY43 [UniParc]. Last modified May 10, 2004. Version 2. Checksum: F563EA63489D936D	FASTA	387	41,981
	10 20 30 40 50 60 MTMEGASGSS FGIDTILSSA SSGSPGMMNG DFRPLGEART ADFRSQATPS PCSEIDTVGT 70 80 90 100 110 120 APSSPISVTM EPPEPHLVAD ATQHHHHLHH SQQPPPPAAA PTQSLQPLPQ QQQPLPPQQP 130 140 150 160 170 180 PPPPPQQLGS AASAPRTSTS SFLIKDILGD SKPLAACAPY STSVSSPHHT PKQESNAVHE 190 200 210 220 230 240 SFRPKLEQED SKTKLDKRED SQSDIKCHGT KEEGDREITS SRESPPVRAK KPRKARTAFS 250 260 270 280 290 300 DHQLNQLERS FERQKYLSVQ DRMDLAAALN LTDTQVKTWY QNRRTKWKRQ TAVGLELLAE 310 320 330 340 350 360 AGNYSALQRM FPSPYFYHPS LLGSMDSTTA AAAAAAMYSS MYRTPPAPHP QLQRPLVPRV 370 380 LIHGLGPGGQ PALNPLSSPI PGTPHPR

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning and characterization of human novel homeodomain box gene BARHL2." Shan Y.X., Yu L., Huang C.Q., Guo Z.K. Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[3]	"Barhl1, a gene belonging to a new subfamily of mammalian homeobox genes, is expressed in migrating neurons of the CNS." Bulfone A., Menguzzato E., Broccoli V., Marchitiello A., Gattuso C., Mariani M., Consalez G.G., Martinez S., Ballabio A., Banfi S. Hum. Mol. Genet. 9:1443-1452(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 297-364.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY338397 mRNA. Translation: AAQ01189.1. BC126439 mRNA. Translation: AAI26440.1. BC126441 mRNA. Translation: AAI26442.1. AJ251753 Genomic DNA. Translation: CAB92440.1.
IPI	IPI00059055.
RefSeq	NP_064447.1. NM_020063.1.
UniGene	Hs.451956.
3D structure databases
ProteinModelPortal	Q9NY43.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000359474.
PTM databases
PhosphoSite	Q9NY43.
Polymorphism databases
DMDM	47117915.
Proteomic databases
PaxDb	Q9NY43.
PRIDE	Q9NY43.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000370445; ENSP00000359474; ENSG00000143032.
GeneID	343472.
KEGG	hsa:343472.
UCSC	uc001dns.3. human.
Organism-specific databases
CTD	343472.
GeneCards	GC01M091177.
HGNC	HGNC:954. BARHL2.
HPA	HPA028176.
MIM	605212. gene.
neXtProt	NX_Q9NY43.
PharmGKB	PA25258.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG263484.
HOGENOM	HOG000231533.
HOVERGEN	HBG050663.
InParanoid	Q9NY43.
KO	K09360.
OMA	ISVTMEH.
OrthoDB	EOG4KH2VD.
Enzyme and pathway databases
BRENDA	3.1.30.1. 7453.
Gene expression databases
Bgee	Q9NY43.
CleanEx	HS_BARHL2.
Genevestigator	Q9NY43.
Family and domain databases
Gene3D	1.10.10.60. 1 hit.
InterPro	IPR017970. Homeobox_CS. IPR020479. Homeobox_metazoa. IPR001356. Homeodomain. IPR009057. Homeodomain-like. [Graphical view]
Pfam	PF00046. Homeobox. 1 hit. [Graphical view]
PRINTS	PR00024. HOMEOBOX.
SMART	SM00389. HOX. 1 hit. [Graphical view]
SUPFAM	SSF46689. Homeodomain_like. 1 hit.
PROSITE	PS00027. HOMEOBOX_1. 1 hit. PS50071. HOMEOBOX_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	343472.
NextBio	98538.
SOURCE	Search...

Entry information

Entry name

BARH2_HUMAN

Accession

Primary (citable) accession number: Q9NY43
Secondary accession number(s): A0AVP2, Q7Z4N7

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 25, 2003
Last sequence update:	May 10, 2004
Last modified:	May 1, 2013
This is version 93 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.