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Protein

BarH-like 2 homeobox protein

Gene

BARHL2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Potential regulator of neural basic helix-loop-helix genes.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi232 – 29160HomeoboxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
BarH-like 2 homeobox protein
Gene namesi
Name:BARHL2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:954. BARHL2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA25258.

Polymorphism and mutation databases

BioMutaiBARHL2.
DMDMi47117915.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 387387BarH-like 2 homeobox proteinPRO_0000048829Add
BLAST

Proteomic databases

PaxDbiQ9NY43.
PRIDEiQ9NY43.

PTM databases

PhosphoSiteiQ9NY43.

Expressioni

Gene expression databases

BgeeiQ9NY43.
CleanExiHS_BARHL2.

Organism-specific databases

HPAiHPA028176.
HPA031326.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
RELQ048643EBI-10316571,EBI-307352

Protein-protein interaction databases

BioGridi131253. 1 interaction.
IntActiQ9NY43. 1 interaction.
STRINGi9606.ENSP00000359474.

Structurei

3D structure databases

ProteinModelPortaliQ9NY43.
SMRiQ9NY43. Positions 210-291.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi92 – 12736Gln/Pro-richAdd
BLAST

Sequence similaritiesi

Belongs to the BAR homeobox family.Curated
Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiNOG263484.
GeneTreeiENSGT00790000122955.
HOGENOMiHOG000231533.
HOVERGENiHBG050663.
InParanoidiQ9NY43.
KOiK09360.
OMAiDSRTADF.
OrthoDBiEOG79GT7B.
PhylomeDBiQ9NY43.
TreeFamiTF316128.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00024. HOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9NY43-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTMEGASGSS FGIDTILSSA SSGSPGMMNG DFRPLGEART ADFRSQATPS
60 70 80 90 100
PCSEIDTVGT APSSPISVTM EPPEPHLVAD ATQHHHHLHH SQQPPPPAAA
110 120 130 140 150
PTQSLQPLPQ QQQPLPPQQP PPPPPQQLGS AASAPRTSTS SFLIKDILGD
160 170 180 190 200
SKPLAACAPY STSVSSPHHT PKQESNAVHE SFRPKLEQED SKTKLDKRED
210 220 230 240 250
SQSDIKCHGT KEEGDREITS SRESPPVRAK KPRKARTAFS DHQLNQLERS
260 270 280 290 300
FERQKYLSVQ DRMDLAAALN LTDTQVKTWY QNRRTKWKRQ TAVGLELLAE
310 320 330 340 350
AGNYSALQRM FPSPYFYHPS LLGSMDSTTA AAAAAAMYSS MYRTPPAPHP
360 370 380
QLQRPLVPRV LIHGLGPGGQ PALNPLSSPI PGTPHPR
Length:387
Mass (Da):41,981
Last modified:May 10, 2004 - v2
Checksum:iF563EA63489D936D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY338397 mRNA. Translation: AAQ01189.1.
BC126439 mRNA. Translation: AAI26440.1.
BC126441 mRNA. Translation: AAI26442.1.
AJ251753 Genomic DNA. Translation: CAB92440.1.
CCDSiCCDS730.1.
RefSeqiNP_064447.1. NM_020063.1.
UniGeneiHs.451956.

Genome annotation databases

EnsembliENST00000370445; ENSP00000359474; ENSG00000143032.
GeneIDi343472.
KEGGihsa:343472.
UCSCiuc001dns.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY338397 mRNA. Translation: AAQ01189.1.
BC126439 mRNA. Translation: AAI26440.1.
BC126441 mRNA. Translation: AAI26442.1.
AJ251753 Genomic DNA. Translation: CAB92440.1.
CCDSiCCDS730.1.
RefSeqiNP_064447.1. NM_020063.1.
UniGeneiHs.451956.

3D structure databases

ProteinModelPortaliQ9NY43.
SMRiQ9NY43. Positions 210-291.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi131253. 1 interaction.
IntActiQ9NY43. 1 interaction.
STRINGi9606.ENSP00000359474.

PTM databases

PhosphoSiteiQ9NY43.

Polymorphism and mutation databases

BioMutaiBARHL2.
DMDMi47117915.

Proteomic databases

PaxDbiQ9NY43.
PRIDEiQ9NY43.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000370445; ENSP00000359474; ENSG00000143032.
GeneIDi343472.
KEGGihsa:343472.
UCSCiuc001dns.3. human.

Organism-specific databases

CTDi343472.
GeneCardsiGC01M091177.
HGNCiHGNC:954. BARHL2.
HPAiHPA028176.
HPA031326.
MIMi605212. gene.
neXtProtiNX_Q9NY43.
PharmGKBiPA25258.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG263484.
GeneTreeiENSGT00790000122955.
HOGENOMiHOG000231533.
HOVERGENiHBG050663.
InParanoidiQ9NY43.
KOiK09360.
OMAiDSRTADF.
OrthoDBiEOG79GT7B.
PhylomeDBiQ9NY43.
TreeFamiTF316128.

Miscellaneous databases

GenomeRNAii343472.
NextBioi98538.
PROiQ9NY43.
SOURCEiSearch...

Gene expression databases

BgeeiQ9NY43.
CleanExiHS_BARHL2.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00024. HOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and characterization of human novel homeodomain box gene BARHL2."
    Shan Y.X., Yu L., Huang C.Q., Guo Z.K.
    Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. "Barhl1, a gene belonging to a new subfamily of mammalian homeobox genes, is expressed in migrating neurons of the CNS."
    Bulfone A., Menguzzato E., Broccoli V., Marchitiello A., Gattuso C., Mariani M., Consalez G.G., Martinez S., Ballabio A., Banfi S.
    Hum. Mol. Genet. 9:1443-1452(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 297-364.

Entry informationi

Entry nameiBARH2_HUMAN
AccessioniPrimary (citable) accession number: Q9NY43
Secondary accession number(s): A0AVP2, Q7Z4N7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 25, 2003
Last sequence update: May 10, 2004
Last modified: July 22, 2015
This is version 112 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.