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Q9NY43

- BARH2_HUMAN

UniProt

Q9NY43 - BARH2_HUMAN

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Protein
BarH-like 2 homeobox protein
Gene
BARHL2
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Potential regulator of neural basic helix-loop-helix genes By similarity.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi232 – 29160Homeobox
Add
BLAST

GO - Molecular functioni

  1. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Source: Ensembl
  2. sequence-specific DNA binding Source: InterPro

GO - Biological processi

  1. cell fate determination Source: Ensembl
  2. neuron differentiation Source: Ensembl
  3. neuron migration Source: Ensembl
  4. positive regulation of translation Source: Ensembl
  5. regulation of axon extension Source: Ensembl
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

BRENDAi3.1.30.1. 7453.

Names & Taxonomyi

Protein namesi
Recommended name:
BarH-like 2 homeobox protein
Gene namesi
Name:BARHL2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:954. BARHL2.

Subcellular locationi

Nucleus Inferred

GO - Cellular componenti

  1. cytoplasm Source: HPA
  2. nucleus Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA25258.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 387387BarH-like 2 homeobox protein
PRO_0000048829Add
BLAST

Proteomic databases

PaxDbiQ9NY43.
PRIDEiQ9NY43.

PTM databases

PhosphoSiteiQ9NY43.

Expressioni

Gene expression databases

BgeeiQ9NY43.
CleanExiHS_BARHL2.
GenevestigatoriQ9NY43.

Organism-specific databases

HPAiHPA028176.
HPA031326.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000359474.

Structurei

3D structure databases

ProteinModelPortaliQ9NY43.
SMRiQ9NY43. Positions 210-291.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi92 – 12736Gln/Pro-rich
Add
BLAST

Sequence similaritiesi

Belongs to the BAR homeobox family.

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiNOG263484.
HOGENOMiHOG000231533.
HOVERGENiHBG050663.
InParanoidiQ9NY43.
KOiK09360.
OMAiISVTMEH.
OrthoDBiEOG79GT7B.
PhylomeDBiQ9NY43.
TreeFamiTF316128.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00024. HOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9NY43-1 [UniParc]FASTAAdd to Basket

« Hide

MTMEGASGSS FGIDTILSSA SSGSPGMMNG DFRPLGEART ADFRSQATPS    50
PCSEIDTVGT APSSPISVTM EPPEPHLVAD ATQHHHHLHH SQQPPPPAAA 100
PTQSLQPLPQ QQQPLPPQQP PPPPPQQLGS AASAPRTSTS SFLIKDILGD 150
SKPLAACAPY STSVSSPHHT PKQESNAVHE SFRPKLEQED SKTKLDKRED 200
SQSDIKCHGT KEEGDREITS SRESPPVRAK KPRKARTAFS DHQLNQLERS 250
FERQKYLSVQ DRMDLAAALN LTDTQVKTWY QNRRTKWKRQ TAVGLELLAE 300
AGNYSALQRM FPSPYFYHPS LLGSMDSTTA AAAAAAMYSS MYRTPPAPHP 350
QLQRPLVPRV LIHGLGPGGQ PALNPLSSPI PGTPHPR 387
Length:387
Mass (Da):41,981
Last modified:May 10, 2004 - v2
Checksum:iF563EA63489D936D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY338397 mRNA. Translation: AAQ01189.1.
BC126439 mRNA. Translation: AAI26440.1.
BC126441 mRNA. Translation: AAI26442.1.
AJ251753 Genomic DNA. Translation: CAB92440.1.
CCDSiCCDS730.1.
RefSeqiNP_064447.1. NM_020063.1.
UniGeneiHs.451956.

Genome annotation databases

EnsembliENST00000370445; ENSP00000359474; ENSG00000143032.
GeneIDi343472.
KEGGihsa:343472.
UCSCiuc001dns.3. human.

Polymorphism databases

DMDMi47117915.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY338397 mRNA. Translation: AAQ01189.1 .
BC126439 mRNA. Translation: AAI26440.1 .
BC126441 mRNA. Translation: AAI26442.1 .
AJ251753 Genomic DNA. Translation: CAB92440.1 .
CCDSi CCDS730.1.
RefSeqi NP_064447.1. NM_020063.1.
UniGenei Hs.451956.

3D structure databases

ProteinModelPortali Q9NY43.
SMRi Q9NY43. Positions 210-291.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000359474.

PTM databases

PhosphoSitei Q9NY43.

Polymorphism databases

DMDMi 47117915.

Proteomic databases

PaxDbi Q9NY43.
PRIDEi Q9NY43.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000370445 ; ENSP00000359474 ; ENSG00000143032 .
GeneIDi 343472.
KEGGi hsa:343472.
UCSCi uc001dns.3. human.

Organism-specific databases

CTDi 343472.
GeneCardsi GC01M091177.
HGNCi HGNC:954. BARHL2.
HPAi HPA028176.
HPA031326.
MIMi 605212. gene.
neXtProti NX_Q9NY43.
PharmGKBi PA25258.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG263484.
HOGENOMi HOG000231533.
HOVERGENi HBG050663.
InParanoidi Q9NY43.
KOi K09360.
OMAi ISVTMEH.
OrthoDBi EOG79GT7B.
PhylomeDBi Q9NY43.
TreeFami TF316128.

Enzyme and pathway databases

BRENDAi 3.1.30.1. 7453.

Miscellaneous databases

GenomeRNAii 343472.
NextBioi 98538.
PROi Q9NY43.
SOURCEi Search...

Gene expression databases

Bgeei Q9NY43.
CleanExi HS_BARHL2.
Genevestigatori Q9NY43.

Family and domain databases

Gene3Di 1.10.10.60. 1 hit.
InterProi IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view ]
Pfami PF00046. Homeobox. 1 hit.
[Graphical view ]
PRINTSi PR00024. HOMEOBOX.
SMARTi SM00389. HOX. 1 hit.
[Graphical view ]
SUPFAMi SSF46689. SSF46689. 1 hit.
PROSITEi PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and characterization of human novel homeodomain box gene BARHL2."
    Shan Y.X., Yu L., Huang C.Q., Guo Z.K.
    Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. "Barhl1, a gene belonging to a new subfamily of mammalian homeobox genes, is expressed in migrating neurons of the CNS."
    Bulfone A., Menguzzato E., Broccoli V., Marchitiello A., Gattuso C., Mariani M., Consalez G.G., Martinez S., Ballabio A., Banfi S.
    Hum. Mol. Genet. 9:1443-1452(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 297-364.

Entry informationi

Entry nameiBARH2_HUMAN
AccessioniPrimary (citable) accession number: Q9NY43
Secondary accession number(s): A0AVP2, Q7Z4N7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 25, 2003
Last sequence update: May 10, 2004
Last modified: July 9, 2014
This is version 102 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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