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Q9NY43 (BARH2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 100. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
BarH-like 2 homeobox protein
Gene names
Name:BARHL2
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length387 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Potential regulator of neural basic helix-loop-helix genes By similarity.

Subcellular location

Nucleus Probable.

Sequence similarities

Belongs to the BAR homeobox family.

Contains 1 homeobox DNA-binding domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 387387BarH-like 2 homeobox protein
PRO_0000048829

Regions

DNA binding232 – 29160Homeobox
Compositional bias92 – 12736Gln/Pro-rich

Sequences

Sequence LengthMass (Da)Tools
Q9NY43 [UniParc].

Last modified May 10, 2004. Version 2.
Checksum: F563EA63489D936D

FASTA38741,981
        10         20         30         40         50         60 
MTMEGASGSS FGIDTILSSA SSGSPGMMNG DFRPLGEART ADFRSQATPS PCSEIDTVGT 

        70         80         90        100        110        120 
APSSPISVTM EPPEPHLVAD ATQHHHHLHH SQQPPPPAAA PTQSLQPLPQ QQQPLPPQQP 

       130        140        150        160        170        180 
PPPPPQQLGS AASAPRTSTS SFLIKDILGD SKPLAACAPY STSVSSPHHT PKQESNAVHE 

       190        200        210        220        230        240 
SFRPKLEQED SKTKLDKRED SQSDIKCHGT KEEGDREITS SRESPPVRAK KPRKARTAFS 

       250        260        270        280        290        300 
DHQLNQLERS FERQKYLSVQ DRMDLAAALN LTDTQVKTWY QNRRTKWKRQ TAVGLELLAE 

       310        320        330        340        350        360 
AGNYSALQRM FPSPYFYHPS LLGSMDSTTA AAAAAAMYSS MYRTPPAPHP QLQRPLVPRV 

       370        380 
LIHGLGPGGQ PALNPLSSPI PGTPHPR 

« Hide

References

« Hide 'large scale' references
[1]"Cloning and characterization of human novel homeodomain box gene BARHL2."
Shan Y.X., Yu L., Huang C.Q., Guo Z.K.
Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[3]"Barhl1, a gene belonging to a new subfamily of mammalian homeobox genes, is expressed in migrating neurons of the CNS."
Bulfone A., Menguzzato E., Broccoli V., Marchitiello A., Gattuso C., Mariani M., Consalez G.G., Martinez S., Ballabio A., Banfi S.
Hum. Mol. Genet. 9:1443-1452(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 297-364.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY338397 mRNA. Translation: AAQ01189.1.
BC126439 mRNA. Translation: AAI26440.1.
BC126441 mRNA. Translation: AAI26442.1.
AJ251753 Genomic DNA. Translation: CAB92440.1.
RefSeqNP_064447.1. NM_020063.1.
UniGeneHs.451956.

3D structure databases

ProteinModelPortalQ9NY43.
SMRQ9NY43. Positions 210-291.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000359474.

PTM databases

PhosphoSiteQ9NY43.

Polymorphism databases

DMDM47117915.

Proteomic databases

PaxDbQ9NY43.
PRIDEQ9NY43.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000370445; ENSP00000359474; ENSG00000143032.
GeneID343472.
KEGGhsa:343472.
UCSCuc001dns.3. human.

Organism-specific databases

CTD343472.
GeneCardsGC01M091177.
HGNCHGNC:954. BARHL2.
HPAHPA028176.
HPA031326.
MIM605212. gene.
neXtProtNX_Q9NY43.
PharmGKBPA25258.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG263484.
HOGENOMHOG000231533.
HOVERGENHBG050663.
InParanoidQ9NY43.
KOK09360.
OMAISVTMEH.
OrthoDBEOG79GT7B.
PhylomeDBQ9NY43.
TreeFamTF316128.

Enzyme and pathway databases

BRENDA3.1.30.1. 7453.

Gene expression databases

BgeeQ9NY43.
CleanExHS_BARHL2.
GenevestigatorQ9NY43.

Family and domain databases

Gene3D1.10.10.60. 1 hit.
InterProIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSPR00024. HOMEOBOX.
SMARTSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMSSF46689. SSF46689. 1 hit.
PROSITEPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi343472.
NextBio98538.
PROQ9NY43.
SOURCESearch...

Entry information

Entry nameBARH2_HUMAN
AccessionPrimary (citable) accession number: Q9NY43
Secondary accession number(s): A0AVP2, Q7Z4N7
Entry history
Integrated into UniProtKB/Swiss-Prot: March 25, 2003
Last sequence update: May 10, 2004
Last modified: April 16, 2014
This is version 100 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 1

Human chromosome 1: entries, gene names and cross-references to MIM