Q9NY37 (ASIC5_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Acid-sensing ion channel 5
Short name=ASIC5

Alternative name(s):
Amiloride-sensitive cation channel 5
Human intestine Na(+) channel
Short name=HINaC

Gene names

Name:	ASIC5
Synonyms:	ACCN5, HINAC

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	505 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Cation channel that gives rise to very low constitutive currents in the absence of activation. The activated channel exhibits selectivity for sodium, and is inhibited by amiloride. Ref.1
Subunit structure	Homotrimer or heterotrimer with other ASIC proteins By similarity.
Subcellular location	Cell membrane; Multi-pass membrane protein Ref.1.
Tissue specificity	Detected in small intestine, duodenum and jejunum. Detected at very low levels in testis and rectum. Ref.1
Sequence similarities	Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. ASIC5 subfamily. [View classification]

Ontologies

Keywords
Biological process	Ion transport Sodium transport Transport
Cellular component	Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Ligand	Sodium
Molecular function	Ion channel Sodium channel
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	hydrogen ion channel activity Inferred from electronic annotation. Source: Compara ligand-gated sodium channel activity Inferred from electronic annotation. Source: Compara
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 505	505	Acid-sensing ion channel 5		PRO_0000335597
Regions
	Topological domain	1 – 61	61	Cytoplasmic Potential
	Transmembrane	62 – 82	21	Helical; Potential
	Topological domain	83 – 459	377	Extracellular Potential
	Transmembrane	460 – 480	21	Helical; Potential
	Topological domain	481 – 505	25	Cytoplasmic Potential
Amino acid modifications
	Glycosylation	147	1	N-linked (GlcNAc...) Potential
	Glycosylation	163	1	N-linked (GlcNAc...) Potential
	Disulfide bond	112 ↔ 207		By similarity
	Disulfide bond	185 ↔ 192		By similarity
	Disulfide bond	298 ↔ 377		By similarity
	Disulfide bond	315 ↔ 373		By similarity
	Disulfide bond	319 ↔ 364		By similarity
	Disulfide bond	328 ↔ 350		By similarity
	Disulfide bond	330 ↔ 342		By similarity
Experimental info
	Mutagenesis	443	1	A → C: Slightly activates the channel. Ref.1
	Mutagenesis	443	1	A → F or T: Activates the channel. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q9NY37 [UniParc]. Last modified October 1, 2000. Version 1. Checksum: 3479F297202789D6	FASTA	505	57,464
	10 20 30 40 50 60 MEQTEKSKVY AENGLLEKIK LCLSKKPLPS PTERKKFDHD FAISTSFHGI HNIVQNRSKI 70 80 90 100 110 120 RRVLWLVVVL GSVSLVTWQI YIRLLNYFTW PTTTSIEVQY VEKMEFPAVT FCNLNRFQTD 130 140 150 160 170 180 AVAKFGVIFF LWHIVSKVLH LQEITANSTG SREATDFAAS HQNFSIVEFI RNKGFYLNNS 190 200 210 220 230 240 TLLDCEFFGK PCSPKDFAHV FTEYGNCFTF NHGETLQAKR KVSVSGRGLS LLFNVNQEAF 250 260 270 280 290 300 TDNPALGFVD AGIIFVIHSP KKVPQFDGLG LLSPVGMHAR VTIRQVKTVH QEYPWGECNP 310 320 330 340 350 360 NIKLQNFSSY STSGCLKECK AQHIKKQCGC VPFLLPGYGI ECDLQKYFSC VSPVLDHIEF 370 380 390 400 410 420 KDLCTVGTHN SSCPVSCEEI EYPATISYSS FPSQKALKYL SKKLNQSRKY IRENLVKIEI 430 440 450 460 470 480 NYSDLNYKIT QQQKAVSVSE LLADLGGQLG LFCGASLITI IEIIEYLFTN FYWICIFFLL 490 500 KISEMTQWTP PPQNHLGNKN RIEEC

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular cloning, functional expression and chromosomal localization of an amiloride-sensitive Na(+) channel from human small intestine." Schaefer L., Sakai H., Mattei M.-G., Lazdunski M., Lingueglia E. FEBS Lett. 471:205-210(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, MUTAGENESIS OF ALA-443, SUBCELLULAR LOCATION, TISSUE SPECIFICITY. Tissue: Small intestine.
[2]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ252011 mRNA. Translation: CAB85607.1. CH471056 Genomic DNA. Translation: EAX04887.1.
IPI	IPI00026554.
RefSeq	NP_059115.1. NM_017419.2.
UniGene	Hs.381349.
3D structure databases
ProteinModelPortal	Q9NY37.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000264432.
PTM databases
PhosphoSite	Q9NY37.
Polymorphism databases
DMDM	74753059.
Proteomic databases
PaxDb	Q9NY37.
PRIDE	Q9NY37.
Protocols and materials databases
DNASU	51802.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000537611; ENSP00000442477; ENSG00000256394. ENST00000572394; ENSP00000461559; ENSG00000262505.
GeneID	51802.
KEGG	hsa:51802.
UCSC	uc003ipe.1. human.
Organism-specific databases
CTD	51802.
GeneCards	GC04M156751.
HGNC	HGNC:17537. ASIC5.
HPA	HPA014903. HPA029444.
neXtProt	NX_Q9NY37.
PharmGKB	PA134946702.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG268293.
HOGENOM	HOG000033777.
HOVERGEN	HBG095680.
InParanoid	Q9NY37.
KO	K04832.
OMA	RFQTDAV.
OrthoDB	EOG4J6RQM.
PhylomeDB	Q9NY37.
Gene expression databases
CleanEx	HS_ACCN5.
Genevestigator	Q9NY37.
Family and domain databases
InterPro	IPR001873. Na+channel_ASC. [Graphical view]
PANTHER	PTHR11690. PTHR11690. 1 hit.
Pfam	PF00858. ASC. 1 hit. [Graphical view]
PRINTS	PR01078. AMINACHANNEL.
PROSITE	PS01206. ASC. False negative. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	51802.
NextBio	55916.

Entry information

Entry name

ASIC5_HUMAN

Accession

Primary (citable) accession number: Q9NY37

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 20, 2008
Last sequence update:	October 1, 2000
Last modified:	May 1, 2013
This is version 79 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.