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Protein

Acid-sensing ion channel 5

Gene

ASIC5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Cation channel that gives rise to very low constitutive currents in the absence of activation. The activated channel exhibits selectivity for sodium, and is inhibited by amiloride.1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Sodium channel

Keywords - Biological processi

Ion transport, Sodium transport, Transport

Keywords - Ligandi

Sodium

Enzyme and pathway databases

ReactomeiR-HSA-2672351. Stimuli-sensing channels.

Names & Taxonomyi

Protein namesi
Recommended name:
Acid-sensing ion channel 5
Short name:
ASIC5
Alternative name(s):
Amiloride-sensitive cation channel 5
Human intestine Na(+) channel
Short name:
HINaC
Gene namesi
Name:ASIC5
Synonyms:ACCN5, HINAC
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

HGNCiHGNC:17537. ASIC5.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 6161CytoplasmicSequence analysisAdd
BLAST
Transmembranei62 – 8221HelicalSequence analysisAdd
BLAST
Topological domaini83 – 459377ExtracellularSequence analysisAdd
BLAST
Transmembranei460 – 48021HelicalSequence analysisAdd
BLAST
Topological domaini481 – 50525CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi443 – 4431A → C: Slightly activates the channel. 1 Publication
Mutagenesisi443 – 4431A → F or T: Activates the channel. 1 Publication

Organism-specific databases

PharmGKBiPA134946702.

Polymorphism and mutation databases

BioMutaiASIC5.
DMDMi74753059.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 505505Acid-sensing ion channel 5PRO_0000335597Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi112 ↔ 207By similarity
Glycosylationi147 – 1471N-linked (GlcNAc...)Sequence analysis
Glycosylationi163 – 1631N-linked (GlcNAc...)Sequence analysis
Disulfide bondi185 ↔ 192By similarity
Disulfide bondi298 ↔ 377By similarity
Disulfide bondi315 ↔ 373By similarity
Disulfide bondi319 ↔ 364By similarity
Disulfide bondi328 ↔ 350By similarity
Disulfide bondi330 ↔ 342By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiQ9NY37.
PaxDbiQ9NY37.
PRIDEiQ9NY37.

PTM databases

iPTMnetiQ9NY37.
PhosphoSiteiQ9NY37.

Expressioni

Tissue specificityi

Detected in small intestine, duodenum and jejunum. Detected at very low levels in testis and rectum.1 Publication

Gene expression databases

CleanExiHS_ACCN5.
GenevisibleiQ9NY37. HS.

Organism-specific databases

HPAiHPA014903.
HPA029444.

Interactioni

Subunit structurei

Homotrimer or heterotrimer with other ASIC proteins.By similarity

Protein-protein interaction databases

STRINGi9606.ENSP00000442477.

Structurei

3D structure databases

ProteinModelPortaliQ9NY37.
SMRiQ9NY37. Positions 60-466.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4294. Eukaryota.
ENOG410ZNFK. LUCA.
GeneTreeiENSGT00760000119120.
HOGENOMiHOG000033777.
HOVERGENiHBG095680.
InParanoidiQ9NY37.
KOiK04832.
OMAiTERKKFD.
OrthoDBiEOG72VH5P.
PhylomeDBiQ9NY37.
TreeFamiTF330663.

Family and domain databases

InterProiIPR001873. Na+channel_ASC.
[Graphical view]
PANTHERiPTHR11690. PTHR11690. 1 hit.
PfamiPF00858. ASC. 1 hit.
[Graphical view]
PRINTSiPR01078. AMINACHANNEL.

Sequencei

Sequence statusi: Complete.

Q9NY37-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEQTEKSKVY AENGLLEKIK LCLSKKPLPS PTERKKFDHD FAISTSFHGI
60 70 80 90 100
HNIVQNRSKI RRVLWLVVVL GSVSLVTWQI YIRLLNYFTW PTTTSIEVQY
110 120 130 140 150
VEKMEFPAVT FCNLNRFQTD AVAKFGVIFF LWHIVSKVLH LQEITANSTG
160 170 180 190 200
SREATDFAAS HQNFSIVEFI RNKGFYLNNS TLLDCEFFGK PCSPKDFAHV
210 220 230 240 250
FTEYGNCFTF NHGETLQAKR KVSVSGRGLS LLFNVNQEAF TDNPALGFVD
260 270 280 290 300
AGIIFVIHSP KKVPQFDGLG LLSPVGMHAR VTIRQVKTVH QEYPWGECNP
310 320 330 340 350
NIKLQNFSSY STSGCLKECK AQHIKKQCGC VPFLLPGYGI ECDLQKYFSC
360 370 380 390 400
VSPVLDHIEF KDLCTVGTHN SSCPVSCEEI EYPATISYSS FPSQKALKYL
410 420 430 440 450
SKKLNQSRKY IRENLVKIEI NYSDLNYKIT QQQKAVSVSE LLADLGGQLG
460 470 480 490 500
LFCGASLITI IEIIEYLFTN FYWICIFFLL KISEMTQWTP PPQNHLGNKN

RIEEC
Length:505
Mass (Da):57,464
Last modified:October 1, 2000 - v1
Checksum:i3479F297202789D6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ252011 mRNA. Translation: CAB85607.1.
CH471056 Genomic DNA. Translation: EAX04887.1.
CCDSiCCDS3793.1.
RefSeqiNP_059115.1. NM_017419.2.
UniGeneiHs.381349.

Genome annotation databases

EnsembliENST00000537611; ENSP00000442477; ENSG00000256394.
GeneIDi51802.
KEGGihsa:51802.
UCSCiuc003ipe.1. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ252011 mRNA. Translation: CAB85607.1.
CH471056 Genomic DNA. Translation: EAX04887.1.
CCDSiCCDS3793.1.
RefSeqiNP_059115.1. NM_017419.2.
UniGeneiHs.381349.

3D structure databases

ProteinModelPortaliQ9NY37.
SMRiQ9NY37. Positions 60-466.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000442477.

PTM databases

iPTMnetiQ9NY37.
PhosphoSiteiQ9NY37.

Polymorphism and mutation databases

BioMutaiASIC5.
DMDMi74753059.

Proteomic databases

EPDiQ9NY37.
PaxDbiQ9NY37.
PRIDEiQ9NY37.

Protocols and materials databases

DNASUi51802.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000537611; ENSP00000442477; ENSG00000256394.
GeneIDi51802.
KEGGihsa:51802.
UCSCiuc003ipe.1. human.

Organism-specific databases

CTDi51802.
GeneCardsiASIC5.
HGNCiHGNC:17537. ASIC5.
HPAiHPA014903.
HPA029444.
MIMi616693. gene.
neXtProtiNX_Q9NY37.
PharmGKBiPA134946702.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4294. Eukaryota.
ENOG410ZNFK. LUCA.
GeneTreeiENSGT00760000119120.
HOGENOMiHOG000033777.
HOVERGENiHBG095680.
InParanoidiQ9NY37.
KOiK04832.
OMAiTERKKFD.
OrthoDBiEOG72VH5P.
PhylomeDBiQ9NY37.
TreeFamiTF330663.

Enzyme and pathway databases

ReactomeiR-HSA-2672351. Stimuli-sensing channels.

Miscellaneous databases

GenomeRNAii51802.
NextBioi55916.
PROiQ9NY37.
SOURCEiSearch...

Gene expression databases

CleanExiHS_ACCN5.
GenevisibleiQ9NY37. HS.

Family and domain databases

InterProiIPR001873. Na+channel_ASC.
[Graphical view]
PANTHERiPTHR11690. PTHR11690. 1 hit.
PfamiPF00858. ASC. 1 hit.
[Graphical view]
PRINTSiPR01078. AMINACHANNEL.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning, functional expression and chromosomal localization of an amiloride-sensitive Na(+) channel from human small intestine."
    Schaefer L., Sakai H., Mattei M.-G., Lazdunski M., Lingueglia E.
    FEBS Lett. 471:205-210(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, MUTAGENESIS OF ALA-443, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    Tissue: Small intestine.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiASIC5_HUMAN
AccessioniPrimary (citable) accession number: Q9NY37
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: October 1, 2000
Last modified: March 16, 2016
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.