Reviewed, UniProtKB/Swiss-Prot Q9NY37 (ACCN5_HUMAN)

Names and origin

Protein names

Recommended name:
    Amiloride-sensitive cation channel 5
Alternative name(s):
    Human intestine Na(+) channel
      Short name=HINaC

Gene names

Name:	ACCN5
Synonyms:	HINAC

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	505 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Cation channel that gives rise to very low constitutive currents in the absence of activation. The activated channel exhibits selectivity for sodium, and is inhibited by amiloride. Ref.1
Subunit structure	Homotetramer or heterotetramer By similarity.
Subcellular location	Cell membrane; Multi-pass membrane protein Ref.1.
Tissue specificity	Detected in small intestine, duodenum and jejunum. Detected at very low levels in testis and rectum. Ref.1
Sequence similarities	Belongs to the amiloride-sensitive sodium channel family.

Ontologies

Keywords
Biological process	Ion transport Sodium transport Transport
Cellular component	Cell membrane Membrane
Domain	Transmembrane
Ligand	Sodium
Molecular function	Ionic channel Sodium channel
PTM	Glycoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	sodium ion transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell plasma membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	sodium ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 505	505	Amiloride-sensitive cation channel 5		PRO_0000335597
Regions
	Topological domain	1 – 61	61	Cytoplasmic Potential
	Transmembrane	62 – 82	21	Potential
	Topological domain	83 – 459	377	Extracellular Potential
	Transmembrane	460 – 480	21	Potential
	Topological domain	481 – 505	25	Cytoplasmic Potential
Amino acid modifications
	Glycosylation	147	1	N-linked (GlcNAc...) Potential
	Glycosylation	163	1	N-linked (GlcNAc...) Potential
Experimental info
	Mutagenesis	443	1	A → C: Slightly activates the channel. Ref.1
	Mutagenesis	443	1	A → F or T: Activates the channel. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q9NY37-1 [UniParc]. Last modified October 1, 2000. Version 1. Checksum: 3479F297202789D6	FASTA	505	57,464
	10 20 30 40 50 60 MEQTEKSKVY AENGLLEKIK LCLSKKPLPS PTERKKFDHD FAISTSFHGI HNIVQNRSKI 70 80 90 100 110 120 RRVLWLVVVL GSVSLVTWQI YIRLLNYFTW PTTTSIEVQY VEKMEFPAVT FCNLNRFQTD 130 140 150 160 170 180 AVAKFGVIFF LWHIVSKVLH LQEITANSTG SREATDFAAS HQNFSIVEFI RNKGFYLNNS 190 200 210 220 230 240 TLLDCEFFGK PCSPKDFAHV FTEYGNCFTF NHGETLQAKR KVSVSGRGLS LLFNVNQEAF 250 260 270 280 290 300 TDNPALGFVD AGIIFVIHSP KKVPQFDGLG LLSPVGMHAR VTIRQVKTVH QEYPWGECNP 310 320 330 340 350 360 NIKLQNFSSY STSGCLKECK AQHIKKQCGC VPFLLPGYGI ECDLQKYFSC VSPVLDHIEF 370 380 390 400 410 420 KDLCTVGTHN SSCPVSCEEI EYPATISYSS FPSQKALKYL SKKLNQSRKY IRENLVKIEI 430 440 450 460 470 480 NYSDLNYKIT QQQKAVSVSE LLADLGGQLG LFCGASLITI IEIIEYLFTN FYWICIFFLL 490 500 KISEMTQWTP PPQNHLGNKN RIEEC

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular cloning, functional expression and chromosomal localization of an amiloride-sensitive Na(+) channel from human small intestine." Schaefer L., Sakai H., Mattei M.-G., Lazdunski M., Lingueglia E. FEBS Lett. 471:205-210(2000) [PubMed: 10767424] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, MUTAGENESIS OF ALA-443, SUBCELLULAR LOCATION, TISSUE SPECIFICITY. Tissue: Small intestine.
[2]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	AJ252011 mRNA. Translation: CAB85607.1. CH471056 Genomic DNA. Translation: EAX04887.1.
IPI	IPI00026554.
RefSeq	NP_059115.1.
UniGene	Hs.381349
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q9NY37.
Proteomic databases
PRIDE	Q9NY37.
Genome annotation databases
Ensembl	ENST00000264432; ENSP00000264432; ENSG00000023843; Homo sapiens. [Genome view]
GeneID	51802.
KEGG	hsa:51802.
UCSC	uc003ipe.1. human.
Organism-specific databases
CTD	51802.
GeneCards	GC04M156970.
HGNC	HGNC:17537. ACCN5.
HPA	HPA014903.
PharmGKB	PA134946702.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	HBG279815.
HOVERGEN	Q9NY37.
InParanoid	Q9NY37.
OMA	TIRQVKT.
OrthoDB	EOG9XPT1V.
Gene expression databases
ArrayExpress	Q9NY37.
Bgee	Q9NY37.
CleanEx	HS_ACCN5.
Genevestigator	Q9NY37.
Family and domain databases
InterPro	IPR001873. Na+channel_ASC. [Graphical view]
PANTHER	PTHR11690. Na+channel_ASC. 1 hit.
Pfam	PF00858. ASC. 1 hit. [Graphical view]
PRINTS	PR01078. AMINACHANNEL.
PROSITE	PS01206. ASC. False negative. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	55916.

Entry information

Entry name

ACCN5_HUMAN

Accession

Primary (citable) accession number: Q9NY37

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 20, 2008
Last sequence update:	October 1, 2000
Last modified:	December 15, 2009
This is version 51 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.