Q9NY37 (ASIC5_HUMAN) Reviewed, UniProtKB/Swiss-Prot
Last modified
May 1, 2013.
Version 79.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Acid-sensing ion channel 5 Short name=ASIC5 Alternative name(s): Amiloride-sensitive cation channel 5 Human intestine Na(+) channel Short name=HINaC | ||||
| Gene names |
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| Organism | Homo sapiens (Human) [Reference proteome] | ||||
| Taxonomic identifier | 9606 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo![]() |
Protein attributes
| Sequence length | 505 AA. |
| Sequence status | Complete. |
| Protein existence | Evidence at protein level |
General annotation (Comments)
| Function | Cation channel that gives rise to very low constitutive currents in the absence of activation. The activated channel exhibits selectivity for sodium, and is inhibited by amiloride. Ref.1 |
| Subunit structure | Homotrimer or heterotrimer with other ASIC proteins By similarity. |
| Subcellular location | |
| Tissue specificity | Detected in small intestine, duodenum and jejunum. Detected at very low levels in testis and rectum. Ref.1 |
| Sequence similarities | Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. ASIC5 subfamily. [View classification] |
Ontologies
| Keywords | |
|---|---|
| Biological process | Ion transport Sodium transport Transport |
| Cellular component | Cell membrane Membrane |
| Domain | Transmembrane Transmembrane helix |
| Ligand | Sodium |
| Molecular function | Ion channel Sodium channel |
| PTM | Disulfide bond Glycoprotein |
| Technical term | Complete proteome Reference proteome |
| Gene Ontology (GO) | |
| Cellular_component | integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membraneInferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular_function | hydrogen ion channel activity Inferred from electronic annotation. Source: Compara ligand-gated sodium channel activityInferred from electronic annotation. Source: Compara |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||||
Molecule processing | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 505 | 505 | Acid-sensing ion channel 5 | PRO_0000335597 | |||||||
Regions | |||||||||||
| Topological domain | 1 – 61 | 61 | Cytoplasmic Potential | ||||||||
| Transmembrane | 62 – 82 | 21 | Helical; Potential | ||||||||
| Topological domain | 83 – 459 | 377 | Extracellular Potential | ||||||||
| Transmembrane | 460 – 480 | 21 | Helical; Potential | ||||||||
| Topological domain | 481 – 505 | 25 | Cytoplasmic Potential | ||||||||
Amino acid modifications | |||||||||||
| Glycosylation | 147 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 163 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Disulfide bond | 112 ↔ 207 | By similarity | |||||||||
| Disulfide bond | 185 ↔ 192 | By similarity | |||||||||
| Disulfide bond | 298 ↔ 377 | By similarity | |||||||||
| Disulfide bond | 315 ↔ 373 | By similarity | |||||||||
| Disulfide bond | 319 ↔ 364 | By similarity | |||||||||
| Disulfide bond | 328 ↔ 350 | By similarity | |||||||||
| Disulfide bond | 330 ↔ 342 | By similarity | |||||||||
Experimental info | |||||||||||
| Mutagenesis | 443 | 1 | A → C: Slightly activates the channel. Ref.1 | ||||||||
| Mutagenesis | 443 | 1 | A → F or T: Activates the channel. Ref.1 | ||||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Molecular cloning, functional expression and chromosomal localization of an amiloride-sensitive Na(+) channel from human small intestine." Schaefer L., Sakai H., Mattei M.-G., Lazdunski M., Lingueglia E. FEBS Lett. 471:205-210(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, MUTAGENESIS OF ALA-443, SUBCELLULAR LOCATION, TISSUE SPECIFICITY. Tissue: Small intestine. |
| [2] | Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. Venter J.C.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | AJ252011 mRNA. Translation: CAB85607.1. CH471056 Genomic DNA. Translation: EAX04887.1. |
| IPI | IPI00026554. |
| RefSeq | NP_059115.1. NM_017419.2. |
| UniGene | Hs.381349. |
3D structure databases | |
| ProteinModelPortal | Q9NY37. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | 9606.ENSP00000264432. |
PTM databases | |
| PhosphoSite | Q9NY37. |
Polymorphism databases | |
| DMDM | 74753059. |
Proteomic databases | |
| PaxDb | Q9NY37. |
| PRIDE | Q9NY37. |
Protocols and materials databases | |
| DNASU | 51802. |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| Ensembl | ENST00000537611; ENSP00000442477; ENSG00000256394. ENST00000572394; ENSP00000461559; ENSG00000262505. |
| GeneID | 51802. |
| KEGG | hsa:51802. |
| UCSC | uc003ipe.1. human. |
Organism-specific databases | |
| CTD | 51802. |
| GeneCards | GC04M156751. |
| HGNC | HGNC:17537. ASIC5. |
| HPA | HPA014903. HPA029444. |
| neXtProt | NX_Q9NY37. |
| PharmGKB | PA134946702. |
| GenAtlas | Search... |
Phylogenomic databases | |
| eggNOG | NOG268293. |
| HOGENOM | HOG000033777. |
| HOVERGEN | HBG095680. |
| InParanoid | Q9NY37. |
| KO | K04832. |
| OMA | RFQTDAV. |
| OrthoDB | EOG4J6RQM. |
| PhylomeDB | Q9NY37. |
Gene expression databases | |
| CleanEx | HS_ACCN5. |
| Genevestigator | Q9NY37. |
Family and domain databases | |
| InterPro | IPR001873. Na+channel_ASC. [Graphical view] |
| PANTHER | PTHR11690. PTHR11690. 1 hit. |
| Pfam | PF00858. ASC. 1 hit. [Graphical view] |
| PRINTS | PR01078. AMINACHANNEL. |
| PROSITE | PS01206. ASC. False negative. [Graphical view] |
| ProtoNet | Search... |
Other | |
| GenomeRNAi | 51802. |
| NextBio | 55916. |
Entry information
| Entry name | ASIC5_HUMAN | ||||||||
| Accession | Primary (citable) accession number: Q9NY37 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Chordata Protein Annotation Program | ||||||||
| Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. | ||||||||
Relevant documents
| Human chromosome 4 Human chromosome 4: entries, gene names and cross-references to MIM |
| SIMILARITY comments Index of protein domains and families |

Clusters with
