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Q9NY26

- S39A1_HUMAN

UniProt

Q9NY26 - S39A1_HUMAN

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Protein

Zinc transporter ZIP1

Gene
SLC39A1, IRT1, ZIP1, ZIRTL, CGI-08, CGI-71
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Mediates zinc uptake. May function as a major endogenous zinc uptake transporter in many cells of the body. Responsible for the rapid uptake and accumulation of physiologically effective zinc in prostate cells.1 Publication

GO - Molecular functioni

  1. inorganic cation transmembrane transporter activity Source: ProtInc
  2. zinc ion transmembrane transporter activity Source: Ensembl

GO - Biological processi

  1. cation transport Source: ProtInc
  2. transmembrane transport Source: Reactome
  3. zinc ion transmembrane transport Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Ion transport, Transport, Zinc transport

Keywords - Ligandi

Zinc

Enzyme and pathway databases

ReactomeiREACT_20603. Zinc influx into cells by the SLC39 gene family.

Protein family/group databases

TCDBi2.A.5.3.2. the zinc (zn(2+))-iron (fe(2+)) permease (zip) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc transporter ZIP1
Alternative name(s):
Solute carrier family 39 member 1
Zinc-iron-regulated transporter-like
Zrt- and Irt-like protein 1
Short name:
ZIP-1
Short name:
hZIP1
Gene namesi
Name:SLC39A1
Synonyms:IRT1, ZIP1, ZIRTL
ORF Names:CGI-08, CGI-71
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:12876. SLC39A1.

Subcellular locationi

Cell membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein
Note: Shows a vesicular localization corresponding partially to the endoplasmic reticulum in several epithelial cell lines.1 Publication

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3030Extracellular Reviewed predictionAdd
BLAST
Transmembranei31 – 5121Helical; Reviewed predictionAdd
BLAST
Topological domaini52 – 6817Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei69 – 8921Helical; Reviewed predictionAdd
BLAST
Topological domaini90 – 10415Extracellular Reviewed predictionAdd
BLAST
Transmembranei105 – 12521Helical; Reviewed predictionAdd
BLAST
Topological domaini126 – 17954Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei180 – 20021Helical; Reviewed predictionAdd
BLAST
Topological domaini201 – 2066Extracellular Reviewed prediction
Transmembranei207 – 22721Helical; Reviewed predictionAdd
BLAST
Topological domaini228 – 23710Cytoplasmic Reviewed prediction
Transmembranei238 – 25821Helical; Reviewed predictionAdd
BLAST
Topological domaini259 – 27214Extracellular Reviewed predictionAdd
BLAST
Transmembranei273 – 29321Helical; Reviewed predictionAdd
BLAST
Topological domaini294 – 30310Cytoplasmic Reviewed prediction
Transmembranei304 – 32421Helical; Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
  2. integral component of membrane Source: ProtInc
  3. membrane Source: ProtInc
  4. plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Endoplasmic reticulum, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA37465.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 324324Zinc transporter ZIP1PRO_0000068763Add
BLAST

Proteomic databases

MaxQBiQ9NY26.
PaxDbiQ9NY26.
PRIDEiQ9NY26.

PTM databases

PhosphoSiteiQ9NY26.

Expressioni

Tissue specificityi

Ubiquitous. Expressed in most adult and fetal tissues including the epidermis.1 Publication

Gene expression databases

ArrayExpressiQ9NY26.
BgeeiQ9NY26.
CleanExiHS_SLC39A1.
GenevestigatoriQ9NY26.

Organism-specific databases

HPAiHPA016506.

Interactioni

Protein-protein interaction databases

BioGridi118050. 2 interactions.
IntActiQ9NY26. 3 interactions.
STRINGi9606.ENSP00000309710.

Structurei

3D structure databases

ProteinModelPortaliQ9NY26.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni190 – 1912Heavy metals binding By similarity

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG84653.
HOGENOMiHOG000236331.
HOVERGENiHBG015174.
InParanoidiQ9NY26.
KOiK14709.
OMAiQSHLRVQ.
OrthoDBiEOG74R1RF.
PhylomeDBiQ9NY26.
TreeFamiTF317098.

Family and domain databases

InterProiIPR003689. ZIP.
[Graphical view]
PfamiPF02535. Zip. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9NY26-1 [UniParc]FASTAAdd to Basket

« Hide

MGPWGEPELL VWRPEAVASE PPVPVGLEVK LGALVLLLVL TLLCSLVPIC    50
VLRRPGANHE GSASRQKALS LVSCFAGGVF LATCLLDLLP DYLAAIDEAL 100
AALHVTLQFP LQEFILAMGF FLVLVMEQIT LAYKEQSGPS PLEETRALLG 150
TVNGGPQHWH DGPGVPQASG APATPSALRA CVLVFSLALH SVFEGLAVGL 200
QRDRARAMEL CLALLLHKGI LAVSLSLRLL QSHLRAQVVA GCGILFSCMT 250
PLGIGLGAAL AESAGPLHQL AQSVLEGMAA GTFLYITFLE ILPQELASSE 300
QRILKVILLL AGFALLTGLL FIQI 324
Length:324
Mass (Da):34,250
Last modified:October 1, 2000 - v1
Checksum:i884C168AA8E8C0DF
GO

Sequence cautioni

The sequence AAD27717.1 differs from that shown. Reason: Frameshift at positions 16 and 40.

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti10 – 189LVWRPEAVA → HGVAPRGGT in AAD34066. 1 Publication
Sequence conflicti16 – 161A → S in AAH03152. 1 Publication
Sequence conflicti47 – 504VPIC → GSIG in CAB59979. 1 Publication
Sequence conflicti47 – 504VPIC → GSIG in CAB59980. 1 Publication
Sequence conflicti55 – 551P → T in CAB59979. 1 Publication
Sequence conflicti55 – 551P → T in CAB59980. 1 Publication
Sequence conflicti120 – 1201F → V in AAD27717. 1 Publication
Sequence conflicti120 – 1201F → V in AAD34066. 1 Publication
Sequence conflicti302 – 3021R → G in BAC11502. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ243649 mRNA. Translation: CAB59979.1.
AJ243650 Genomic DNA. Translation: CAB59980.1.
AJ271671 mRNA. Translation: CAB82784.1.
AF132942 mRNA. Translation: AAD27717.1. Frameshift.
AF151829 mRNA. Translation: AAD34066.1.
AK075257 mRNA. Translation: BAC11502.1.
AK074943 mRNA. Translation: BAG52035.1.
AL358472 Genomic DNA. Translation: CAI14019.1.
CH471121 Genomic DNA. Translation: EAW53259.1.
CH471121 Genomic DNA. Translation: EAW53261.1.
CH471121 Genomic DNA. Translation: EAW53264.1.
CH471121 Genomic DNA. Translation: EAW53265.1.
CH471121 Genomic DNA. Translation: EAW53267.1.
BC002563 mRNA. Translation: AAH02563.1.
BC003152 mRNA. Translation: AAH03152.1.
BC007886 mRNA. Translation: AAH07886.1.
BC014303 mRNA. Translation: AAH14303.1.
CCDSiCCDS1055.1.
RefSeqiNP_001258886.1. NM_001271957.1.
NP_001258887.1. NM_001271958.1.
NP_001258888.1. NM_001271959.1.
NP_001258889.1. NM_001271960.1.
NP_055252.2. NM_014437.4.
XP_006711339.1. XM_006711276.1.
UniGeneiHs.743291.
Hs.7854.

Genome annotation databases

EnsembliENST00000310483; ENSP00000309710; ENSG00000143570.
ENST00000356205; ENSP00000348535; ENSG00000143570.
ENST00000368621; ENSP00000357610; ENSG00000143570.
ENST00000368623; ENSP00000357612; ENSG00000143570.
GeneIDi27173.
KEGGihsa:27173.
UCSCiuc001fdi.4. human.

Polymorphism databases

DMDMi37090460.

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ243649 mRNA. Translation: CAB59979.1 .
AJ243650 Genomic DNA. Translation: CAB59980.1 .
AJ271671 mRNA. Translation: CAB82784.1 .
AF132942 mRNA. Translation: AAD27717.1 . Frameshift.
AF151829 mRNA. Translation: AAD34066.1 .
AK075257 mRNA. Translation: BAC11502.1 .
AK074943 mRNA. Translation: BAG52035.1 .
AL358472 Genomic DNA. Translation: CAI14019.1 .
CH471121 Genomic DNA. Translation: EAW53259.1 .
CH471121 Genomic DNA. Translation: EAW53261.1 .
CH471121 Genomic DNA. Translation: EAW53264.1 .
CH471121 Genomic DNA. Translation: EAW53265.1 .
CH471121 Genomic DNA. Translation: EAW53267.1 .
BC002563 mRNA. Translation: AAH02563.1 .
BC003152 mRNA. Translation: AAH03152.1 .
BC007886 mRNA. Translation: AAH07886.1 .
BC014303 mRNA. Translation: AAH14303.1 .
CCDSi CCDS1055.1.
RefSeqi NP_001258886.1. NM_001271957.1.
NP_001258887.1. NM_001271958.1.
NP_001258888.1. NM_001271959.1.
NP_001258889.1. NM_001271960.1.
NP_055252.2. NM_014437.4.
XP_006711339.1. XM_006711276.1.
UniGenei Hs.743291.
Hs.7854.

3D structure databases

ProteinModelPortali Q9NY26.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 118050. 2 interactions.
IntActi Q9NY26. 3 interactions.
STRINGi 9606.ENSP00000309710.

Protein family/group databases

TCDBi 2.A.5.3.2. the zinc (zn(2+))-iron (fe(2+)) permease (zip) family.

PTM databases

PhosphoSitei Q9NY26.

Polymorphism databases

DMDMi 37090460.

Proteomic databases

MaxQBi Q9NY26.
PaxDbi Q9NY26.
PRIDEi Q9NY26.

Protocols and materials databases

DNASUi 27173.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000310483 ; ENSP00000309710 ; ENSG00000143570 .
ENST00000356205 ; ENSP00000348535 ; ENSG00000143570 .
ENST00000368621 ; ENSP00000357610 ; ENSG00000143570 .
ENST00000368623 ; ENSP00000357612 ; ENSG00000143570 .
GeneIDi 27173.
KEGGi hsa:27173.
UCSCi uc001fdi.4. human.

Organism-specific databases

CTDi 27173.
GeneCardsi GC01M153931.
HGNCi HGNC:12876. SLC39A1.
HPAi HPA016506.
MIMi 604740. gene.
neXtProti NX_Q9NY26.
PharmGKBi PA37465.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG84653.
HOGENOMi HOG000236331.
HOVERGENi HBG015174.
InParanoidi Q9NY26.
KOi K14709.
OMAi QSHLRVQ.
OrthoDBi EOG74R1RF.
PhylomeDBi Q9NY26.
TreeFami TF317098.

Enzyme and pathway databases

Reactomei REACT_20603. Zinc influx into cells by the SLC39 gene family.

Miscellaneous databases

ChiTaRSi SLC39A1. human.
GeneWikii SLC39A1.
GenomeRNAii 27173.
NextBioi 49976.
PROi Q9NY26.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q9NY26.
Bgeei Q9NY26.
CleanExi HS_SLC39A1.
Genevestigatori Q9NY26.

Family and domain databases

InterProi IPR003689. ZIP.
[Graphical view ]
Pfami PF02535. Zip. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Isolation and characterization of human and mouse ZIRTL, a member of the IRT1 family of transporters, mapping within the epidermal differentiation complex."
    Lioumi M., Ferguson C.A., Sharpe P.T., Freeman T., Marenholz I., Mischke D., Heizmann C., Ragoussis J.
    Genomics 62:272-280(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], TISSUE SPECIFICITY.
  2. "Differential subcellular localization of hZip1 in adherent and non-adherent cells."
    Milon B., Dhermy D., Pountney D., Bourgeois M., Beaumont C.
    FEBS Lett. 507:241-246(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION.
  3. "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics."
    Lai C.-H., Chou C.-Y., Ch'ang L.-Y., Liu C.-S., Lin W.-C.
    Genome Res. 10:703-713(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Thyroid.
  5. "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries."
    Otsuki T., Ota T., Nishikawa T., Hayashi K., Suzuki Y., Yamamoto J., Wakamatsu A., Kimura K., Sakamoto K., Hatano N., Kawai Y., Ishii S., Saito K., Kojima S., Sugiyama T., Ono T., Okano K., Yoshikawa Y.
    , Aotsuka S., Sasaki N., Hattori A., Okumura K., Nagai K., Sugano S., Isogai T.
    DNA Res. 12:117-126(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  6. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Kidney, Lung, Muscle and Placenta.
  9. "The human ZIP1 transporter mediates zinc uptake in human K562 erythroleukemia cells."
    Gaither L.A., Eide D.J.
    J. Biol. Chem. 276:22258-22264(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: CHARACTERIZATION.
  10. "Human ZIP1 is a major zinc uptake transporter for the accumulation of zinc in prostate cells."
    Franklin R.B., Ma J., Zou J., Guan Z., Kukoyi B.I., Feng P., Costello L.C.
    J. Inorg. Biochem. 96:435-442(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  11. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiS39A1_HUMAN
AccessioniPrimary (citable) accession number: Q9NY26
Secondary accession number(s): Q5T4K1
, Q8N2H7, Q9BTV0, Q9UBI7, Q9Y2Z7, Q9Y380
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 26, 2003
Last sequence update: October 1, 2000
Last modified: September 3, 2014
This is version 116 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Inhibited by Ni2+ ions. Fe2+ ions do not inhibit zinc uptake.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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