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Q9NY26

- S39A1_HUMAN

UniProt

Q9NY26 - S39A1_HUMAN

Protein

Zinc transporter ZIP1

Gene

SLC39A1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 117 (01 Oct 2014)
      Sequence version 1 (01 Oct 2000)
      Previous versions | rss
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    Functioni

    Mediates zinc uptake. May function as a major endogenous zinc uptake transporter in many cells of the body. Responsible for the rapid uptake and accumulation of physiologically effective zinc in prostate cells.1 Publication

    GO - Molecular functioni

    1. inorganic cation transmembrane transporter activity Source: ProtInc
    2. zinc ion transmembrane transporter activity Source: Ensembl

    GO - Biological processi

    1. cation transport Source: ProtInc
    2. transmembrane transport Source: Reactome
    3. zinc ion transmembrane transport Source: UniProtKB

    Keywords - Biological processi

    Ion transport, Transport, Zinc transport

    Keywords - Ligandi

    Zinc

    Enzyme and pathway databases

    ReactomeiREACT_20603. Zinc influx into cells by the SLC39 gene family.

    Protein family/group databases

    TCDBi2.A.5.3.2. the zinc (zn(2+))-iron (fe(2+)) permease (zip) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Zinc transporter ZIP1
    Alternative name(s):
    Solute carrier family 39 member 1
    Zinc-iron-regulated transporter-like
    Zrt- and Irt-like protein 1
    Short name:
    ZIP-1
    Short name:
    hZIP1
    Gene namesi
    Name:SLC39A1
    Synonyms:IRT1, ZIP1, ZIRTL
    ORF Names:CGI-08, CGI-71
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:12876. SLC39A1.

    Subcellular locationi

    Cell membrane 1 Publication; Multi-pass membrane protein 1 Publication. Endoplasmic reticulum membrane 1 Publication; Multi-pass membrane protein 1 Publication
    Note: Shows a vesicular localization corresponding partially to the endoplasmic reticulum in several epithelial cell lines.

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
    2. integral component of membrane Source: ProtInc
    3. membrane Source: ProtInc
    4. plasma membrane Source: UniProtKB

    Keywords - Cellular componenti

    Cell membrane, Endoplasmic reticulum, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA37465.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 324324Zinc transporter ZIP1PRO_0000068763Add
    BLAST

    Proteomic databases

    MaxQBiQ9NY26.
    PaxDbiQ9NY26.
    PRIDEiQ9NY26.

    PTM databases

    PhosphoSiteiQ9NY26.

    Expressioni

    Tissue specificityi

    Ubiquitous. Expressed in most adult and fetal tissues including the epidermis.1 Publication

    Gene expression databases

    ArrayExpressiQ9NY26.
    BgeeiQ9NY26.
    CleanExiHS_SLC39A1.
    GenevestigatoriQ9NY26.

    Organism-specific databases

    HPAiHPA016506.

    Interactioni

    Protein-protein interaction databases

    BioGridi118050. 2 interactions.
    IntActiQ9NY26. 3 interactions.
    STRINGi9606.ENSP00000309710.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9NY26.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 3030ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini52 – 6817CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini90 – 10415ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini126 – 17954CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini201 – 2066ExtracellularSequence Analysis
    Topological domaini228 – 23710CytoplasmicSequence Analysis
    Topological domaini259 – 27214ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini294 – 30310CytoplasmicSequence Analysis

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei31 – 5121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei69 – 8921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei105 – 12521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei180 – 20021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei207 – 22721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei238 – 25821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei273 – 29321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei304 – 32421HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni190 – 1912Heavy metals bindingBy similarity

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG84653.
    HOGENOMiHOG000236331.
    HOVERGENiHBG015174.
    InParanoidiQ9NY26.
    KOiK14709.
    OMAiQSHLRVQ.
    OrthoDBiEOG74R1RF.
    PhylomeDBiQ9NY26.
    TreeFamiTF317098.

    Family and domain databases

    InterProiIPR003689. ZIP.
    [Graphical view]
    PfamiPF02535. Zip. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9NY26-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MGPWGEPELL VWRPEAVASE PPVPVGLEVK LGALVLLLVL TLLCSLVPIC    50
    VLRRPGANHE GSASRQKALS LVSCFAGGVF LATCLLDLLP DYLAAIDEAL 100
    AALHVTLQFP LQEFILAMGF FLVLVMEQIT LAYKEQSGPS PLEETRALLG 150
    TVNGGPQHWH DGPGVPQASG APATPSALRA CVLVFSLALH SVFEGLAVGL 200
    QRDRARAMEL CLALLLHKGI LAVSLSLRLL QSHLRAQVVA GCGILFSCMT 250
    PLGIGLGAAL AESAGPLHQL AQSVLEGMAA GTFLYITFLE ILPQELASSE 300
    QRILKVILLL AGFALLTGLL FIQI 324
    Length:324
    Mass (Da):34,250
    Last modified:October 1, 2000 - v1
    Checksum:i884C168AA8E8C0DF
    GO
    Isoform 2 (identifier: Q9NY26-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-106: MGPWGEPELL...DEALAALHVT → MKAQ

    Note: No experimental confirmation available.

    Show »
    Length:222
    Mass (Da):23,589
    Checksum:i44531D0D0811E7DE
    GO

    Sequence cautioni

    The sequence AAD27717.1 differs from that shown. Reason: Frameshift at positions 16 and 40.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti10 – 189LVWRPEAVA → HGVAPRGGT in AAD34066. (PubMed:10810093)Curated
    Sequence conflicti16 – 161A → S in AAH03152. (PubMed:15489334)Curated
    Sequence conflicti47 – 504VPIC → GSIG in CAB59979. (PubMed:10610721)Curated
    Sequence conflicti47 – 504VPIC → GSIG in CAB59980. (PubMed:10610721)Curated
    Sequence conflicti55 – 551P → T in CAB59979. (PubMed:10610721)Curated
    Sequence conflicti55 – 551P → T in CAB59980. (PubMed:10610721)Curated
    Sequence conflicti120 – 1201F → V in AAD27717. (PubMed:10810093)Curated
    Sequence conflicti120 – 1201F → V in AAD34066. (PubMed:10810093)Curated
    Sequence conflicti302 – 3021R → G in BAC11502. (PubMed:14702039)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 106106MGPWG…ALHVT → MKAQ in isoform 2. 1 PublicationVSP_056522Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ243649 mRNA. Translation: CAB59979.1.
    AJ243650 Genomic DNA. Translation: CAB59980.1.
    AJ271671 mRNA. Translation: CAB82784.1.
    AF132942 mRNA. Translation: AAD27717.1. Frameshift.
    AF151829 mRNA. Translation: AAD34066.1.
    AK075257 mRNA. Translation: BAC11502.1.
    AK074943 mRNA. Translation: BAG52035.1.
    AK293389 mRNA. Translation: BAG56898.1.
    AL358472 Genomic DNA. Translation: CAI14019.1.
    CH471121 Genomic DNA. Translation: EAW53259.1.
    CH471121 Genomic DNA. Translation: EAW53261.1.
    CH471121 Genomic DNA. Translation: EAW53264.1.
    CH471121 Genomic DNA. Translation: EAW53265.1.
    CH471121 Genomic DNA. Translation: EAW53267.1.
    BC002563 mRNA. Translation: AAH02563.1.
    BC003152 mRNA. Translation: AAH03152.1.
    BC007886 mRNA. Translation: AAH07886.1.
    BC014303 mRNA. Translation: AAH14303.1.
    CCDSiCCDS1055.1.
    RefSeqiNP_001258886.1. NM_001271957.1.
    NP_001258887.1. NM_001271958.1.
    NP_001258888.1. NM_001271959.1.
    NP_001258889.1. NM_001271960.1.
    NP_001258890.1. NM_001271961.1.
    NP_055252.2. NM_014437.4.
    XP_006711339.1. XM_006711276.1.
    UniGeneiHs.743291.
    Hs.7854.

    Genome annotation databases

    EnsembliENST00000310483; ENSP00000309710; ENSG00000143570.
    ENST00000356205; ENSP00000348535; ENSG00000143570.
    ENST00000368621; ENSP00000357610; ENSG00000143570.
    ENST00000368623; ENSP00000357612; ENSG00000143570.
    ENST00000537590; ENSP00000443632; ENSG00000143570.
    GeneIDi27173.
    KEGGihsa:27173.
    UCSCiuc001fdi.4. human.

    Polymorphism databases

    DMDMi37090460.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Web resourcesi

    Atlas of Genetics and Cytogenetics in Oncology and Haematology

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ243649 mRNA. Translation: CAB59979.1 .
    AJ243650 Genomic DNA. Translation: CAB59980.1 .
    AJ271671 mRNA. Translation: CAB82784.1 .
    AF132942 mRNA. Translation: AAD27717.1 . Frameshift.
    AF151829 mRNA. Translation: AAD34066.1 .
    AK075257 mRNA. Translation: BAC11502.1 .
    AK074943 mRNA. Translation: BAG52035.1 .
    AK293389 mRNA. Translation: BAG56898.1 .
    AL358472 Genomic DNA. Translation: CAI14019.1 .
    CH471121 Genomic DNA. Translation: EAW53259.1 .
    CH471121 Genomic DNA. Translation: EAW53261.1 .
    CH471121 Genomic DNA. Translation: EAW53264.1 .
    CH471121 Genomic DNA. Translation: EAW53265.1 .
    CH471121 Genomic DNA. Translation: EAW53267.1 .
    BC002563 mRNA. Translation: AAH02563.1 .
    BC003152 mRNA. Translation: AAH03152.1 .
    BC007886 mRNA. Translation: AAH07886.1 .
    BC014303 mRNA. Translation: AAH14303.1 .
    CCDSi CCDS1055.1.
    RefSeqi NP_001258886.1. NM_001271957.1.
    NP_001258887.1. NM_001271958.1.
    NP_001258888.1. NM_001271959.1.
    NP_001258889.1. NM_001271960.1.
    NP_001258890.1. NM_001271961.1.
    NP_055252.2. NM_014437.4.
    XP_006711339.1. XM_006711276.1.
    UniGenei Hs.743291.
    Hs.7854.

    3D structure databases

    ProteinModelPortali Q9NY26.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 118050. 2 interactions.
    IntActi Q9NY26. 3 interactions.
    STRINGi 9606.ENSP00000309710.

    Protein family/group databases

    TCDBi 2.A.5.3.2. the zinc (zn(2+))-iron (fe(2+)) permease (zip) family.

    PTM databases

    PhosphoSitei Q9NY26.

    Polymorphism databases

    DMDMi 37090460.

    Proteomic databases

    MaxQBi Q9NY26.
    PaxDbi Q9NY26.
    PRIDEi Q9NY26.

    Protocols and materials databases

    DNASUi 27173.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000310483 ; ENSP00000309710 ; ENSG00000143570 .
    ENST00000356205 ; ENSP00000348535 ; ENSG00000143570 .
    ENST00000368621 ; ENSP00000357610 ; ENSG00000143570 .
    ENST00000368623 ; ENSP00000357612 ; ENSG00000143570 .
    ENST00000537590 ; ENSP00000443632 ; ENSG00000143570 .
    GeneIDi 27173.
    KEGGi hsa:27173.
    UCSCi uc001fdi.4. human.

    Organism-specific databases

    CTDi 27173.
    GeneCardsi GC01M153931.
    HGNCi HGNC:12876. SLC39A1.
    HPAi HPA016506.
    MIMi 604740. gene.
    neXtProti NX_Q9NY26.
    PharmGKBi PA37465.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG84653.
    HOGENOMi HOG000236331.
    HOVERGENi HBG015174.
    InParanoidi Q9NY26.
    KOi K14709.
    OMAi QSHLRVQ.
    OrthoDBi EOG74R1RF.
    PhylomeDBi Q9NY26.
    TreeFami TF317098.

    Enzyme and pathway databases

    Reactomei REACT_20603. Zinc influx into cells by the SLC39 gene family.

    Miscellaneous databases

    ChiTaRSi SLC39A1. human.
    GeneWikii SLC39A1.
    GenomeRNAii 27173.
    NextBioi 49976.
    PROi Q9NY26.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9NY26.
    Bgeei Q9NY26.
    CleanExi HS_SLC39A1.
    Genevestigatori Q9NY26.

    Family and domain databases

    InterProi IPR003689. ZIP.
    [Graphical view ]
    Pfami PF02535. Zip. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Isolation and characterization of human and mouse ZIRTL, a member of the IRT1 family of transporters, mapping within the epidermal differentiation complex."
      Lioumi M., Ferguson C.A., Sharpe P.T., Freeman T., Marenholz I., Mischke D., Heizmann C., Ragoussis J.
      Genomics 62:272-280(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
    2. "Differential subcellular localization of hZip1 in adherent and non-adherent cells."
      Milon B., Dhermy D., Pountney D., Bourgeois M., Beaumont C.
      FEBS Lett. 507:241-246(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), SUBCELLULAR LOCATION.
    3. "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics."
      Lai C.-H., Chou C.-Y., Ch'ang L.-Y., Liu C.-S., Lin W.-C.
      Genome Res. 10:703-713(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Tissue: Thyroid and Urinary bladder.
    5. "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries."
      Otsuki T., Ota T., Nishikawa T., Hayashi K., Suzuki Y., Yamamoto J., Wakamatsu A., Kimura K., Sakamoto K., Hatano N., Kawai Y., Ishii S., Saito K., Kojima S., Sugiyama T., Ono T., Okano K., Yoshikawa Y.
      , Aotsuka S., Sasaki N., Hattori A., Okumura K., Nagai K., Sugano S., Isogai T.
      DNA Res. 12:117-126(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    6. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Kidney, Lung, Muscle and Placenta.
    9. "The human ZIP1 transporter mediates zinc uptake in human K562 erythroleukemia cells."
      Gaither L.A., Eide D.J.
      J. Biol. Chem. 276:22258-22264(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: CHARACTERIZATION.
    10. "Human ZIP1 is a major zinc uptake transporter for the accumulation of zinc in prostate cells."
      Franklin R.B., Ma J., Zou J., Guan Z., Kukoyi B.I., Feng P., Costello L.C.
      J. Inorg. Biochem. 96:435-442(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    11. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiS39A1_HUMAN
    AccessioniPrimary (citable) accession number: Q9NY26
    Secondary accession number(s): B4DDY7
    , Q5T4K1, Q8N2H7, Q9BTV0, Q9UBI7, Q9Y2Z7, Q9Y380
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 26, 2003
    Last sequence update: October 1, 2000
    Last modified: October 1, 2014
    This is version 117 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Miscellaneous

    Inhibited by Ni2+ ions. Fe2+ ions do not inhibit zinc uptake.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3