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Q9NY26 (S39A1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 115. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Zinc transporter ZIP1
Alternative name(s):
Solute carrier family 39 member 1
Zinc-iron-regulated transporter-like
Zrt- and Irt-like protein 1
Short name=ZIP-1
Short name=hZIP1
Gene names
Name:SLC39A1
Synonyms:IRT1, ZIP1, ZIRTL
ORF Names:CGI-08, CGI-71
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length324 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Mediates zinc uptake. May function as a major endogenous zinc uptake transporter in many cells of the body. Responsible for the rapid uptake and accumulation of physiologically effective zinc in prostate cells. Ref.10

Subcellular location

Cell membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. Note: Shows a vesicular localization corresponding partially to the endoplasmic reticulum in several epithelial cell lines. Ref.2

Tissue specificity

Ubiquitous. Expressed in most adult and fetal tissues including the epidermis. Ref.1

Miscellaneous

Inhibited by Ni2+ ions. Fe2+ ions do not inhibit zinc uptake.

Sequence similarities

Belongs to the ZIP transporter (TC 2.A.5) family. [View classification]

Sequence caution

The sequence AAD27717.1 differs from that shown. Reason: Frameshift at positions 16 and 40.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 324324Zinc transporter ZIP1
PRO_0000068763

Regions

Topological domain1 – 3030Extracellular Potential
Transmembrane31 – 5121Helical; Potential
Topological domain52 – 6817Cytoplasmic Potential
Transmembrane69 – 8921Helical; Potential
Topological domain90 – 10415Extracellular Potential
Transmembrane105 – 12521Helical; Potential
Topological domain126 – 17954Cytoplasmic Potential
Transmembrane180 – 20021Helical; Potential
Topological domain201 – 2066Extracellular Potential
Transmembrane207 – 22721Helical; Potential
Topological domain228 – 23710Cytoplasmic Potential
Transmembrane238 – 25821Helical; Potential
Topological domain259 – 27214Extracellular Potential
Transmembrane273 – 29321Helical; Potential
Topological domain294 – 30310Cytoplasmic Potential
Transmembrane304 – 32421Helical; Potential
Region190 – 1912Heavy metals binding By similarity

Experimental info

Sequence conflict10 – 189LVWRPEAVA → HGVAPRGGT in AAD34066. Ref.3
Sequence conflict161A → S in AAH03152. Ref.8
Sequence conflict47 – 504VPIC → GSIG in CAB59979. Ref.1
Sequence conflict47 – 504VPIC → GSIG in CAB59980. Ref.1
Sequence conflict551P → T in CAB59979. Ref.1
Sequence conflict551P → T in CAB59980. Ref.1
Sequence conflict1201F → V in AAD27717. Ref.3
Sequence conflict1201F → V in AAD34066. Ref.3
Sequence conflict3021R → G in BAC11502. Ref.4

Sequences

Sequence LengthMass (Da)Tools
Q9NY26 [UniParc].

Last modified October 1, 2000. Version 1.
Checksum: 884C168AA8E8C0DF

FASTA32434,250
        10         20         30         40         50         60 
MGPWGEPELL VWRPEAVASE PPVPVGLEVK LGALVLLLVL TLLCSLVPIC VLRRPGANHE 

        70         80         90        100        110        120 
GSASRQKALS LVSCFAGGVF LATCLLDLLP DYLAAIDEAL AALHVTLQFP LQEFILAMGF 

       130        140        150        160        170        180 
FLVLVMEQIT LAYKEQSGPS PLEETRALLG TVNGGPQHWH DGPGVPQASG APATPSALRA 

       190        200        210        220        230        240 
CVLVFSLALH SVFEGLAVGL QRDRARAMEL CLALLLHKGI LAVSLSLRLL QSHLRAQVVA 

       250        260        270        280        290        300 
GCGILFSCMT PLGIGLGAAL AESAGPLHQL AQSVLEGMAA GTFLYITFLE ILPQELASSE 

       310        320 
QRILKVILLL AGFALLTGLL FIQI 

« Hide

References

« Hide 'large scale' references
[1]"Isolation and characterization of human and mouse ZIRTL, a member of the IRT1 family of transporters, mapping within the epidermal differentiation complex."
Lioumi M., Ferguson C.A., Sharpe P.T., Freeman T., Marenholz I., Mischke D., Heizmann C., Ragoussis J.
Genomics 62:272-280(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], TISSUE SPECIFICITY.
[2]"Differential subcellular localization of hZip1 in adherent and non-adherent cells."
Milon B., Dhermy D., Pountney D., Bourgeois M., Beaumont C.
FEBS Lett. 507:241-246(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION.
[3]"Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics."
Lai C.-H., Chou C.-Y., Ch'ang L.-Y., Liu C.-S., Lin W.-C.
Genome Res. 10:703-713(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Thyroid.
[5]"Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries."
Otsuki T., Ota T., Nishikawa T., Hayashi K., Suzuki Y., Yamamoto J., Wakamatsu A., Kimura K., Sakamoto K., Hatano N., Kawai Y., Ishii S., Saito K., Kojima S., Sugiyama T., Ono T., Okano K., Yoshikawa Y. expand/collapse author list , Aotsuka S., Sasaki N., Hattori A., Okumura K., Nagai K., Sugano S., Isogai T.
DNA Res. 12:117-126(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[6]"The DNA sequence and biological annotation of human chromosome 1."
Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. expand/collapse author list , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[8]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Kidney, Lung, Muscle and Placenta.
[9]"The human ZIP1 transporter mediates zinc uptake in human K562 erythroleukemia cells."
Gaither L.A., Eide D.J.
J. Biol. Chem. 276:22258-22264(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: CHARACTERIZATION.
[10]"Human ZIP1 is a major zinc uptake transporter for the accumulation of zinc in prostate cells."
Franklin R.B., Ma J., Zou J., Guan Z., Kukoyi B.I., Feng P., Costello L.C.
J. Inorg. Biochem. 96:435-442(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[11]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ243649 mRNA. Translation: CAB59979.1.
AJ243650 Genomic DNA. Translation: CAB59980.1.
AJ271671 mRNA. Translation: CAB82784.1.
AF132942 mRNA. Translation: AAD27717.1. Frameshift.
AF151829 mRNA. Translation: AAD34066.1.
AK075257 mRNA. Translation: BAC11502.1.
AK074943 mRNA. Translation: BAG52035.1.
AL358472 Genomic DNA. Translation: CAI14019.1.
CH471121 Genomic DNA. Translation: EAW53259.1.
CH471121 Genomic DNA. Translation: EAW53261.1.
CH471121 Genomic DNA. Translation: EAW53264.1.
CH471121 Genomic DNA. Translation: EAW53265.1.
CH471121 Genomic DNA. Translation: EAW53267.1.
BC002563 mRNA. Translation: AAH02563.1.
BC003152 mRNA. Translation: AAH03152.1.
BC007886 mRNA. Translation: AAH07886.1.
BC014303 mRNA. Translation: AAH14303.1.
CCDSCCDS1055.1.
RefSeqNP_001258886.1. NM_001271957.1.
NP_001258887.1. NM_001271958.1.
NP_001258888.1. NM_001271959.1.
NP_001258889.1. NM_001271960.1.
NP_055252.2. NM_014437.4.
XP_006711339.1. XM_006711276.1.
UniGeneHs.743291.
Hs.7854.

3D structure databases

ProteinModelPortalQ9NY26.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid118050. 2 interactions.
IntActQ9NY26. 3 interactions.
STRING9606.ENSP00000309710.

Protein family/group databases

TCDB2.A.5.3.2. the zinc (zn(2+))-iron (fe(2+)) permease (zip) family.

PTM databases

PhosphoSiteQ9NY26.

Polymorphism databases

DMDM37090460.

Proteomic databases

MaxQBQ9NY26.
PaxDbQ9NY26.
PRIDEQ9NY26.

Protocols and materials databases

DNASU27173.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000310483; ENSP00000309710; ENSG00000143570.
ENST00000356205; ENSP00000348535; ENSG00000143570.
ENST00000368621; ENSP00000357610; ENSG00000143570.
ENST00000368623; ENSP00000357612; ENSG00000143570.
GeneID27173.
KEGGhsa:27173.
UCSCuc001fdi.4. human.

Organism-specific databases

CTD27173.
GeneCardsGC01M153931.
HGNCHGNC:12876. SLC39A1.
HPAHPA016506.
MIM604740. gene.
neXtProtNX_Q9NY26.
PharmGKBPA37465.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG84653.
HOGENOMHOG000236331.
HOVERGENHBG015174.
InParanoidQ9NY26.
KOK14709.
OMAQSHLRVQ.
OrthoDBEOG74R1RF.
PhylomeDBQ9NY26.
TreeFamTF317098.

Enzyme and pathway databases

ReactomeREACT_15518. Transmembrane transport of small molecules.

Gene expression databases

ArrayExpressQ9NY26.
BgeeQ9NY26.
CleanExHS_SLC39A1.
GenevestigatorQ9NY26.

Family and domain databases

InterProIPR003689. ZIP.
[Graphical view]
PfamPF02535. Zip. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSSLC39A1. human.
GeneWikiSLC39A1.
GenomeRNAi27173.
NextBio49976.
PROQ9NY26.
SOURCESearch...

Entry information

Entry nameS39A1_HUMAN
AccessionPrimary (citable) accession number: Q9NY26
Secondary accession number(s): Q5T4K1 expand/collapse secondary AC list , Q8N2H7, Q9BTV0, Q9UBI7, Q9Y2Z7, Q9Y380
Entry history
Integrated into UniProtKB/Swiss-Prot: September 26, 2003
Last sequence update: October 1, 2000
Last modified: July 9, 2014
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 1

Human chromosome 1: entries, gene names and cross-references to MIM