Q9NY15 (STAB1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Stabilin-1

Alternative name(s):
Fasciclin, EGF-like, laminin-type EGF-like and link domain-containing scavenger receptor 1
Short name=FEEL-1
MS-1 antigen

Gene names

Name:	STAB1
Synonyms:	FEEL1, KIAA0246

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	2570 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Acts as a scavenger receptor for acetylated low density lipoprotein. Binds to both Gram-positive and Gram-negative bacteria and may play a role in defense against bacterial infection. When inhibited in endothelial tube formation assays, there is a marked decrease in cell-cell interactions, suggesting a role in angiogenesis. Involved in the delivery of newly synthesized CHID1/SI-CLP from the biosynthetic compartment to the endosomal/lysosomal system. Ref.2 Ref.7
Subunit structure	Interacts with CHID1. Ref.7
Subcellular location	Membrane; Single-pass type I membrane protein Potential.
Tissue specificity	High levels found in spleen, lymph node, liver and placenta. Also expressed in endothelial cells. Ref.1 Ref.2
Sequence similarities	Contains 16 EGF-like domains. Contains 7 FAS1 domains. Contains 2 laminin EGF-like domains. Contains 1 Link domain.
Sequence caution	The sequence BAA13377.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Ontologies

Keywords
Biological process	Inflammatory response
Cellular component	Membrane
Coding sequence diversity	Alternative splicing Polymorphism
Domain	EGF-like domain Laminin EGF-like domain Repeat Signal Transmembrane Transmembrane helix
Molecular function	Receptor
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cell adhesion Non-traceable author statement Ref.2. Source: UniProtKB cell-cell signaling Inferred from direct assay Ref.2. Source: UniProtKB defense response to bacterium Inferred from direct assay Ref.2. Source: UniProtKB inflammatory response Inferred from electronic annotation. Source: UniProtKB-KW negative regulation of angiogenesis Inferred from mutant phenotype Ref.2. Source: UniProtKB
Cellular_component	integral to plasma membrane Inferred from direct assay Ref.2. Source: UniProtKB
Molecular_function	bacterial cell surface binding Inferred from direct assay Ref.2. Source: UniProtKB hyaluronic acid binding Inferred from electronic annotation. Source: InterPro low-density lipoprotein particle binding Inferred from direct assay Ref.2. Source: UniProtKB low-density lipoprotein receptor activity Inferred from direct assay Ref.2. Source: UniProtKB protein disulfide oxidoreductase activity Non-traceable author statement Ref.2. Source: UniProtKB scavenger receptor activity Inferred from direct assay Ref.2. Source: UniProtKB
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 Ref.2 (identifier: Q9NY15-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 Ref.2 (identifier: Q9NY15-2)

The sequence of this isoform differs from the canonical sequence as follows:
     746-803: CSDGIQGNGA...RPGSGGVCQQ → VSPILSWGEV...IISHILIKNN
     804-2570: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 25	25	Potential
	Chain	26 – 2570	2545	Stabilin-1		PRO_0000007710
Regions
	Topological domain	26 – 2478	2453	Extracellular Potential
	Transmembrane	2479 – 2499	21	Helical; Potential
	Topological domain	2500 – 2570	71	Cytoplasmic Potential
	Domain	110 – 148	39	EGF-like 1
	Domain	156 – 193	38	EGF-like 2
	Domain	195 – 229	35	EGF-like 3
	Domain	232 – 271	40	EGF-like 4
	Domain	356 – 494	139	FAS1 1
	Domain	506 – 641	136	FAS1 2
	Domain	728 – 768	41	EGF-like 5
	Domain	818 – 858	41	EGF-like 6
	Domain	861 – 903	43	EGF-like 7
	Domain	904 – 946	43	EGF-like 8
	Domain	947 – 986	40	EGF-like 9
	Domain	988 – 1118	131	FAS1 3
	Domain	1128 – 1253	126	FAS1 4
	Domain	1327 – 1392	66	Laminin EGF-like 1
	Domain	1416 – 1454	39	EGF-like 10
	Domain	1455 – 1496	42	EGF-like 11
	Domain	1497 – 1539	43	EGF-like 12
	Domain	1540 – 1582	43	EGF-like 13
	Domain	1582 – 1708	127	FAS1 5
	Domain	1724 – 1864	141	FAS1 6
	Domain	1966 – 2031	66	Laminin EGF-like 2
	Domain	2056 – 2090	35	EGF-like 14
	Domain	2091 – 2131	41	EGF-like 15
	Domain	2132 – 2174	43	EGF-like 16
	Domain	2206 – 2301	96	Link
	Domain	2322 – 2459	138	FAS1 7
Amino acid modifications
	Glycosylation	133	1	N-linked (GlcNAc...) Potential
	Glycosylation	286	1	N-linked (GlcNAc...) Potential
	Glycosylation	312	1	N-linked (GlcNAc...) Potential
	Glycosylation	413	1	N-linked (GlcNAc...) Potential
	Glycosylation	606	1	N-linked (GlcNAc...) Potential
	Glycosylation	673	1	N-linked (GlcNAc...) Potential
	Glycosylation	712	1	N-linked (GlcNAc...) Potential
	Glycosylation	745	1	N-linked (GlcNAc...) Potential
	Glycosylation	816	1	N-linked (GlcNAc...) Potential
	Glycosylation	1087	1	N-linked (GlcNAc...) Potential
	Glycosylation	1096	1	N-linked (GlcNAc...) Ref.8
	Glycosylation	1170	1	N-linked (GlcNAc...) Potential
	Glycosylation	1178	1	N-linked (GlcNAc...) Potential
	Glycosylation	1222	1	N-linked (GlcNAc...) Potential
	Glycosylation	1274	1	N-linked (GlcNAc...) Potential
	Glycosylation	1378	1	N-linked (GlcNAc...) Potential
	Glycosylation	1471	1	N-linked (GlcNAc...) Potential
	Glycosylation	1626	1	N-linked (GlcNAc...) Ref.8
	Glycosylation	1727	1	N-linked (GlcNAc...) Ref.8
	Glycosylation	2107	1	N-linked (GlcNAc...) Potential
	Glycosylation	2222	1	N-linked (GlcNAc...) Potential
	Glycosylation	2261	1	N-linked (GlcNAc...) Potential
	Glycosylation	2290	1	N-linked (GlcNAc...) Potential
	Glycosylation	2334	1	N-linked (GlcNAc...) Potential
	Glycosylation	2347	1	N-linked (GlcNAc...) Ref.8
	Glycosylation	2379	1	N-linked (GlcNAc...) Potential
	Glycosylation	2393	1	N-linked (GlcNAc...) Potential
	Glycosylation	2400	1	N-linked (GlcNAc...) Potential
	Glycosylation	2424	1	N-linked (GlcNAc...) Ref.8
	Disulfide bond	112 ↔ 126		By similarity
	Disulfide bond	120 ↔ 136		By similarity
	Disulfide bond	138 ↔ 147		By similarity
	Disulfide bond	160 ↔ 171		By similarity
	Disulfide bond	164 ↔ 181		By similarity
	Disulfide bond	183 ↔ 192		By similarity
	Disulfide bond	199 ↔ 210		By similarity
	Disulfide bond	204 ↔ 217		By similarity
	Disulfide bond	236 ↔ 247		By similarity
	Disulfide bond	241 ↔ 257		By similarity
	Disulfide bond	259 ↔ 270		By similarity
	Disulfide bond	732 ↔ 746		By similarity
	Disulfide bond	740 ↔ 756		By similarity
	Disulfide bond	758 ↔ 767		By similarity
	Disulfide bond	822 ↔ 837		By similarity
	Disulfide bond	831 ↔ 846		By similarity
	Disulfide bond	865 ↔ 879		By similarity
	Disulfide bond	873 ↔ 889		By similarity
	Disulfide bond	891 ↔ 902		By similarity
	Disulfide bond	908 ↔ 922		By similarity
	Disulfide bond	916 ↔ 932		By similarity
	Disulfide bond	934 ↔ 945		By similarity
	Disulfide bond	951 ↔ 964		By similarity
	Disulfide bond	958 ↔ 974		By similarity
	Disulfide bond	1332 ↔ 1346		By similarity
	Disulfide bond	1340 ↔ 1356		By similarity
	Disulfide bond	1358 ↔ 1367		By similarity
	Disulfide bond	1379 ↔ 1390		By similarity
	Disulfide bond	1383 ↔ 1400		By similarity
	Disulfide bond	1402 ↔ 1411		By similarity
	Disulfide bond	1420 ↔ 1430		By similarity
	Disulfide bond	1424 ↔ 1440		By similarity
	Disulfide bond	1442 ↔ 1453		By similarity
	Disulfide bond	1459 ↔ 1472		By similarity
	Disulfide bond	1466 ↔ 1482		By similarity
	Disulfide bond	1484 ↔ 1495		By similarity
	Disulfide bond	1501 ↔ 1514		By similarity
	Disulfide bond	1508 ↔ 1524		By similarity
	Disulfide bond	1526 ↔ 1538		By similarity
	Disulfide bond	1544 ↔ 1557		By similarity
	Disulfide bond	1551 ↔ 1567		By similarity
	Disulfide bond	1569 ↔ 1581		By similarity
	Disulfide bond	1971 ↔ 1985		By similarity
	Disulfide bond	1979 ↔ 1995		By similarity
	Disulfide bond	1997 ↔ 2006		By similarity
	Disulfide bond	2018 ↔ 2029		By similarity
	Disulfide bond	2023 ↔ 2039		By similarity
	Disulfide bond	2041 ↔ 2050		By similarity
	Disulfide bond	2060 ↔ 2070		By similarity
	Disulfide bond	2064 ↔ 2076		By similarity
	Disulfide bond	2078 ↔ 2089		By similarity
	Disulfide bond	2095 ↔ 2108		By similarity
	Disulfide bond	2102 ↔ 2117		By similarity
	Disulfide bond	2119 ↔ 2130		By similarity
	Disulfide bond	2136 ↔ 2150		By similarity
	Disulfide bond	2144 ↔ 2160		By similarity
	Disulfide bond	2162 ↔ 2173		By similarity
	Disulfide bond	2230 ↔ 2299		By similarity
	Disulfide bond	2254 ↔ 2275		By similarity
Natural variations
	Alternative sequence	746 – 803	58	CSDGI…GVCQQ → VSPILSWGEVWGTQGLLHRL ASDWLCVWAKPATLALGFSY LCSGKLDQIISHILIKNN in isoform 2. Ref.2		VSP_050764
	Alternative sequence	804 – 2570	1767	Missing in isoform 2. Ref.2		VSP_050765
	Natural variant	672	1	L → M. Corresponds to variant rs12636502 [ dbSNP | Ensembl ].		VAR_060338
	Natural variant	912	1	M → V. Ref.1 Ref.2 Ref.3 Ref.6 Corresponds to variant rs9835659 [ dbSNP | Ensembl ].		VAR_060339
	Natural variant	1127	1	G → R. Corresponds to variant rs2286786 [ dbSNP | Ensembl ].		VAR_055774
	Natural variant	1833	1	A → P. Ref.1 Ref.3 Ref.6 Corresponds to variant rs7630214 [ dbSNP | Ensembl ].		VAR_060340
	Natural variant	2282	1	I → V. Ref.1 Corresponds to variant rs4434138 [ dbSNP | Ensembl ].		VAR_055775
	Natural variant	2506	1	M → T. Corresponds to variant rs13303 [ dbSNP | Ensembl ].		VAR_019078
Experimental info
	Sequence conflict	913	1	R → G in CAB61827. Ref.1
	Sequence conflict	2200	1	L → Q in CAB61827. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified May 18, 2010. Version 3. Checksum: FA55D191D9D30FAD	FASTA	2,570	275,482
	10 20 30 40 50 60 MAGPRGLLPL CLLAFCLAGF SFVRGQVLFK GCDVKTTFVT HVPCTSCAAI KKQTCPSGWL 70 80 90 100 110 120 RELPDQITQD CRYEVQLGGS MVSMSGCRRK CRKQVVQKAC CPGYWGSRCH ECPGGAETPC 130 140 150 160 170 180 NGHGTCLDGM DRNGTCVCQE NFRGSACQEC QDPNRFGPDC QSVCSCVHGV CNHGPRGDGS 190 200 210 220 230 240 CLCFAGYTGP HCDQELPVCQ ELRCPQNTQC SAEAPSCRCL PGYTQQGSEC RAPNPCWPSP 250 260 270 280 290 300 CSLLAQCSVS PKGQAQCHCP ENYHGDGMVC LPKDPCTDNL GGCPSNSTLC VYQKPGQAFC 310 320 330 340 350 360 TCRPGLVSIN SNASAGCFAF CSPFSCDRSA TCQVTADGKT SCVCRESEVG DGRACYGHLL 370 380 390 400 410 420 HEVQKATQTG RVFLQLRVAV AMMDQGCREI LTTAGPFTVL VPSVSSFSSR TMNASLAQQL 430 440 450 460 470 480 CRQHIIAGQH ILEDTRTQQT RRWWTLAGQE ITVTFNQFTK YSYKYKDQPQ QTFNIYKANN 490 500 510 520 530 540 IAANGVFHVV TGLRWQAPSG TPGDPKRTIG QILASTEAFS RFETILENCG LPSILDGPGP 550 560 570 580 590 600 FTVFAPSNEA VDSLRDGRLI YLFTAGLSKL QELVRYHIYN HGQLTVEKLI SKGRILTMAN 610 620 630 640 650 660 QVLAVNISEE GRILLGPEGV PLQRVDVMAA NGVIHMLDGI LLPPTILPIL PKHCSEEQHK 670 680 690 700 710 720 IVAGSCVDCQ ALNTSTCPPN SVKLDIFPKE CVYIHDPTGL NVLKKGCASY CNQTIMEQGC 730 740 750 760 770 780 CKGFFGPDCT QCPGGFSNPC YGKGNCSDGI QGNGACLCFP DYKGIACHIC SNPNKHGEQC 790 800 810 820 830 840 QEDCGCVHGL CDNRPGSGGV CQQGTCAPGF SGRFCNESMG DCGPTGLAQH CHLHARCVSQ 850 860 870 880 890 900 EGVARCRCLD GFEGDGFSCT PSNPCSHPDR GGCSENAECV PGSLGTHHCT CHKGWSGDGR 910 920 930 940 950 960 VCVAIDECEL DMRGGCHTDA LCSYVGPGQS RCTCKLGFAG DGYQCSPIDP CRAGNGGCHG 970 980 990 1000 1010 1020 LATCRAVGGG QRVCTCPPGF GGDGFSCYGD IFRELEANAH FSIFYQWLKS AGITLPADRR 1030 1040 1050 1060 1070 1080 VTALVPSEAA VRQLSPEDRA FWLQPRTLPN LVRAHFLQGA LFEEELARLG GQEVATLNPT 1090 1100 1110 1120 1130 1140 TRWEIRNISG RVWVQNASVD VADLLATNGV LHILSQVLLP PRGDVPGGQG LLQQLDLVPA 1150 1160 1170 1180 1190 1200 FSLFRELLQH HGLVPQIEAA TAYTIFVPTN RSLEAQGNSS HLDADTVRHH VVLGEALSME 1210 1220 1230 1240 1250 1260 TLRKGGHRNS LLGPAHWIVF YNHSGQPEVN HVPLEGPMLE APGRSLIGLS GVLTVGSSRC 1270 1280 1290 1300 1310 1320 LHSHAEALRE KCVNCTRRFR CTQGFQLQDT PRKSCVYRSG FSFSRGCSYT CAKKIQVPDC 1330 1340 1350 1360 1370 1380 CPGFFGTLCE PCPGGLGGVC SGHGQCQDRF LGSGECHCHE GFHGTACEVC ELGRYGPNCT 1390 1400 1410 1420 1430 1440 GVCDCAHGLC QEGLQGDGSC VCNVGWQGLR CDQKITSPQC PRKCDPNANC VQDSAGASTC 1450 1460 1470 1480 1490 1500 ACAAGYSGNG IFCSEVDPCA HGHGGCSPHA NCTKVAPGQR TCTCQDGYMG DGELCQEINS 1510 1520 1530 1540 1550 1560 CLIHHGGCHI HAECIPTGPQ QVSCSCREGY SGDGIRTCEL LDPCSKNNGG CSPYATCKST 1570 1580 1590 1600 1610 1620 GDGQRTCTCD TAHTVGDGLT CRARVGLELL RDKHASFFSL RLLEYKELKG DGPFTIFVPH 1630 1640 1650 1660 1670 1680 ADLMSNLSQD ELARIRAHRQ LVFRYHVVGC RRLRSEDLLE QGYATALSGH PLRFSEREGS 1690 1700 1710 1720 1730 1740 IYLNDFARVV SSDHEAVNGI LHFIDRVLLP PEALHWEPDD APIPRRNVTA AAQGFGYKIF 1750 1760 1770 1780 1790 1800 SGLLKVAGLL PLLREASHRP FTMLWPTDAA FRALPPDRQA WLYHEDHRDK LAAILRGHMI 1810 1820 1830 1840 1850 1860 RNVEALASDL PNLGPLRTMH GTPISFSCSR TRAGELMVGE DDARIVQRHL PFEGGLAYGI 1870 1880 1890 1900 1910 1920 DQLLEPPGLG ARCDHFETRP LRLNTCSICG LEPPCPEGSQ EQGSPEACWR FYPKFWTSPP 1930 1940 1950 1960 1970 1980 LHSLGLRSVW VHPSLWGRPQ GLGRGCHRNC VTTTWKPSCC PGHYGSECQA CPGGPSSPCS 1990 2000 2010 2020 2030 2040 DRGVCMDGMS GSGQCLCRSG FAGTACELCA PGAFGPHCQA CRCTVHGRCD EGLGGSGSCF 2050 2060 2070 2080 2090 2100 CDEGWTGPRC EVQLELQPVC TPPCAPEAVC RAGNSCECSL GYEGDGRVCT VADLCQDGHG 2110 2120 2130 2140 2150 2160 GCSEHANCSQ VGTMVTCTCL PDYEGDGWSC RARNPCTDGH RGGCSEHANC LSTGLNTRRC 2170 2180 2190 2200 2210 2220 ECHAGYVGDG LQCLEESEPP VDRCLGQPPP CHSDAMCTDL HFQEKRAGVF HLQATSGPYG 2230 2240 2250 2260 2270 2280 LNFSEAEAAC EAQGAVLASF PQLSAAQQLG FHLCLMGWLA NGSTAHPVVF PVADCGNGRV 2290 2300 2310 2320 2330 2340 GIVSLGARKN LSERWDAYCF RVQDVACRCR NGFVGDGIST CNGKLLDVLA ATANFSTFYG 2350 2360 2370 2380 2390 2400 MLLGYANATQ RGLDFLDFLD DELTYKTLFV PVNEGFVDNM TLSGPDLELH ASNATLLSAN 2410 2420 2430 2440 2450 2460 ASQGKLLPAH SGLSLIISDA GPDNSSWAPV APGTVVVSRI IVWDIMAFNG IIHALASPLL 2470 2480 2490 2500 2510 2520 APPQPQAVLA PEAPPVAAGV GAVLAAGALL GLVAGALYLR ARGKPMGFGF SAFQAEDDAD 2530 2540 2550 2560 2570 DDFSPWQEGT NPTLVSVPNP VFGSDTFCEP FDDSLLEEDF PDTQRILTVK
	Isoform 2 [UniParc]. Checksum: 1A833922D0F223FB	FASTA	803	87,026
	10 20 30 40 50 60 MAGPRGLLPL CLLAFCLAGF SFVRGQVLFK GCDVKTTFVT HVPCTSCAAI KKQTCPSGWL 70 80 90 100 110 120 RELPDQITQD CRYEVQLGGS MVSMSGCRRK CRKQVVQKAC CPGYWGSRCH ECPGGAETPC 130 140 150 160 170 180 NGHGTCLDGM DRNGTCVCQE NFRGSACQEC QDPNRFGPDC QSVCSCVHGV CNHGPRGDGS 190 200 210 220 230 240 CLCFAGYTGP HCDQELPVCQ ELRCPQNTQC SAEAPSCRCL PGYTQQGSEC RAPNPCWPSP 250 260 270 280 290 300 CSLLAQCSVS PKGQAQCHCP ENYHGDGMVC LPKDPCTDNL GGCPSNSTLC VYQKPGQAFC 310 320 330 340 350 360 TCRPGLVSIN SNASAGCFAF CSPFSCDRSA TCQVTADGKT SCVCRESEVG DGRACYGHLL 370 380 390 400 410 420 HEVQKATQTG RVFLQLRVAV AMMDQGCREI LTTAGPFTVL VPSVSSFSSR TMNASLAQQL 430 440 450 460 470 480 CRQHIIAGQH ILEDTRTQQT RRWWTLAGQE ITVTFNQFTK YSYKYKDQPQ QTFNIYKANN 490 500 510 520 530 540 IAANGVFHVV TGLRWQAPSG TPGDPKRTIG QILASTEAFS RFETILENCG LPSILDGPGP 550 560 570 580 590 600 FTVFAPSNEA VDSLRDGRLI YLFTAGLSKL QELVRYHIYN HGQLTVEKLI SKGRILTMAN 610 620 630 640 650 660 QVLAVNISEE GRILLGPEGV PLQRVDVMAA NGVIHMLDGI LLPPTILPIL PKHCSEEQHK 670 680 690 700 710 720 IVAGSCVDCQ ALNTSTCPPN SVKLDIFPKE CVYIHDPTGL NVLKKGCASY CNQTIMEQGC 730 740 750 760 770 780 CKGFFGPDCT QCPGGFSNPC YGKGNVSPIL SWGEVWGTQG LLHRLASDWL CVWAKPATLA 790 800 LGFSYLCSGK LDQIISHILI KNN

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Stabilin-1 and -2 constitute a novel family of fasciclin-like hyaluronan receptor homologues." Politz O., Gratchev A., McCourt P.A.G., Schledzewski K., Guillot P., Johansson S., Svineng G., Franke P., Kannicht C., Kzhyshkowska J., Longati P., Velten F.W., Johansson S., Goerdt S. Biochem. J. 362:155-164(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, VARIANTS VARIANTS VAL-912; PRO-1833 AND VAL-2282.
[2]	"FEEL-1, a novel scavenger receptor with in vitro bacteria-binding and angiogenesis-modulating activities." Adachi H., Tsujimoto M. J. Biol. Chem. 277:34264-34270(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), FUNCTION, TISSUE SPECIFICITY, VARIANT VAL-912.
[3]	"Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain." Nagase T., Seki N., Ishikawa K., Ohira M., Kawarabayasi Y., Ohara O., Tanaka A., Kotani H., Miyajima N., Nomura N. DNA Res. 3:321-329(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANTS VAL-912 AND PRO-1833. Tissue: Brain.
[4]	"Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones." Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T. DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract] Cited for: SEQUENCE REVISION.
[5]	"The DNA sequence, annotation and analysis of human chromosome 3." Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J. , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A. Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANTS VAL-912 AND PRO-1833.
[7]	"Novel stabilin-1 interacting chitinase-like protein (SI-CLP) is up-regulated in alternatively activated macrophages and secreted via lysosomal pathway." Kzhyshkowska J., Mamidi S., Gratchev A., Kremmer E., Schmuttermaier C., Krusell L., Haus G., Utikal J., Schledzewski K., Scholtze J., Goerdt S. Blood 107:3221-3228(2006) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, INTERACTION WITH CHID1.
[8]	"Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry." Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H. J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract] Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-1096; ASN-1626; ASN-1727; ASN-2347 AND ASN-2424, MASS SPECTROMETRY. Tissue: Liver.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ275213 mRNA. Translation: CAB61827.1. AB052956 mRNA. Translation: BAC15606.1. AB052957 mRNA. Translation: BAC15607.1. D87433 mRNA. Translation: BAA13377.2. Different initiation. AC006208 Genomic DNA. No translation available. AC112215 Genomic DNA. No translation available. BC150250 mRNA. Translation: AAI50251.1.
IPI	IPI00383337. IPI00419565.
RefSeq	NP_055951.2. NM_015136.2.
UniGene	Hs.301989.
3D structure databases
ProteinModelPortal	Q9NY15.
SMR	Q9NY15. Positions 77-304, 518-643, 738-768, 803-988, 1340-1570, 1939-2194, 2208-2300.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9NY15. 69 interactions.
MINT	MINT-4831401.
STRING	9606.ENSP00000312946.
PTM databases
PhosphoSite	Q9NY15.
Polymorphism databases
DMDM	296452949.
Proteomic databases
PaxDb	Q9NY15.
PRIDE	Q9NY15.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000321725; ENSP00000312946; ENSG00000010327.
GeneID	23166.
KEGG	hsa:23166.
UCSC	uc003dei.1. human. uc003dej.3. human.
Organism-specific databases
CTD	23166.
GeneCards	GC03P052529.
H-InvDB	HIX0003360.
HGNC	HGNC:18628. STAB1.
HPA	HPA005434.
MIM	608560. gene.
neXtProt	NX_Q9NY15.
PharmGKB	PA38610.
HUGE	Search...
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG2335.
HOGENOM	HOG000154436.
HOVERGEN	HBG079218.
InParanoid	Q9NY15.
OMA	AECIPTG.
OrthoDB	EOG4VQ9NC.
Gene expression databases
Bgee	Q9NY15.
CleanEx	HS_STAB1.
Genevestigator	Q9NY15.
GermOnline	ENSG00000010327. Homo sapiens.
Family and domain databases
Gene3D	2.30.180.10. 7 hits. 2.40.155.10. 3 hits. 3.10.100.10. 1 hit.
InterPro	IPR016186. C-type_lectin-like. IPR016187. C-type_lectin_fold. IPR000742. EG-like_dom. IPR013032. EGF-like_CS. IPR024731. EGF_dom_MSP1-like. IPR002049. EGF_laminin. IPR000782. FAS1_domain. IPR023413. GFP_like. IPR000538. Link. [Graphical view]
Pfam	PF12947. EGF_3. 5 hits. PF02469. Fasciclin. 6 hits. PF00193. Xlink. 1 hit. [Graphical view]
SMART	SM00181. EGF. 17 hits. SM00180. EGF_Lam. 1 hit. SM00554. FAS1. 7 hits. SM00445. LINK. 1 hit. [Graphical view]
SUPFAM	SSF82153. BIgH3_FAS1. 7 hits. SSF56436. C-type_lectin_fold. 1 hit.
PROSITE	PS00022. EGF_1. 7 hits. PS01186. EGF_2. 16 hits. PS50026. EGF_3. 20 hits. PS01248. EGF_LAM_1. 2 hits. PS50027. EGF_LAM_2. False negative. PS50213. FAS1. 7 hits. PS01241. LINK_1. 1 hit. PS50963. LINK_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	STAB1. human.
GenomeRNAi	23166.
NextBio	44560.
SOURCE	Search...

Entry information

Entry name

STAB1_HUMAN

Accession

Primary (citable) accession number: Q9NY15
Secondary accession number(s): A7E297 , Q8IUH0, Q8IUH1, Q93072

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 5, 2004
Last sequence update:	May 18, 2010
Last modified:	May 1, 2013
This is version 111 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.