SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q9NY15

- STAB1_HUMAN

UniProt

Q9NY15 - STAB1_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Stabilin-1
Gene
STAB1, FEEL1, KIAA0246
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Acts as a scavenger receptor for acetylated low density lipoprotein. Binds to both Gram-positive and Gram-negative bacteria and may play a role in defense against bacterial infection. When inhibited in endothelial tube formation assays, there is a marked decrease in cell-cell interactions, suggesting a role in angiogenesis. Involved in the delivery of newly synthesized CHID1/SI-CLP from the biosynthetic compartment to the endosomal/lysosomal system.2 Publications

GO - Molecular functioni

  1. hyaluronic acid binding Source: InterPro
  2. low-density lipoprotein particle binding Source: UniProtKB
  3. low-density lipoprotein receptor activity Source: UniProtKB
  4. protein binding Source: UniProt
  5. protein disulfide oxidoreductase activity Source: UniProtKB
  6. scavenger receptor activity Source: UniProtKB

GO - Biological processi

  1. cell adhesion Source: UniProtKB
  2. cell-cell signaling Source: UniProtKB
  3. defense response to bacterium Source: UniProtKB
  4. inflammatory response Source: UniProtKB-KW
  5. negative regulation of angiogenesis Source: UniProtKB
  6. oxidation-reduction process Source: GOC
  7. receptor-mediated endocytosis Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Inflammatory response

Enzyme and pathway databases

ReactomeiREACT_164002. Scavenging by Class H Receptors.

Names & Taxonomyi

Protein namesi
Recommended name:
Stabilin-1
Alternative name(s):
Fasciclin, EGF-like, laminin-type EGF-like and link domain-containing scavenger receptor 1
Short name:
FEEL-1
MS-1 antigen
Gene namesi
Name:STAB1
Synonyms:FEEL1, KIAA0246
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 3

Organism-specific databases

HGNCiHGNC:18628. STAB1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini26 – 24782453Extracellular Reviewed prediction
Add
BLAST
Transmembranei2479 – 249921Helical; Reviewed prediction
Add
BLAST
Topological domaini2500 – 257071Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. endocytic vesicle membrane Source: Reactome
  2. integral component of plasma membrane Source: UniProtKB
  3. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA38610.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2525 Reviewed prediction
Add
BLAST
Chaini26 – 25702545Stabilin-1
PRO_0000007710Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi112 ↔ 126 By similarity
Disulfide bondi120 ↔ 136 By similarity
Glycosylationi133 – 1331N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi138 ↔ 147 By similarity
Disulfide bondi160 ↔ 171 By similarity
Disulfide bondi164 ↔ 181 By similarity
Disulfide bondi183 ↔ 192 By similarity
Disulfide bondi199 ↔ 210 By similarity
Disulfide bondi204 ↔ 217 By similarity
Disulfide bondi236 ↔ 247 By similarity
Disulfide bondi241 ↔ 257 By similarity
Disulfide bondi259 ↔ 270 By similarity
Glycosylationi286 – 2861N-linked (GlcNAc...) Reviewed prediction
Glycosylationi312 – 3121N-linked (GlcNAc...) Reviewed prediction
Glycosylationi413 – 4131N-linked (GlcNAc...) Reviewed prediction
Glycosylationi606 – 6061N-linked (GlcNAc...) Reviewed prediction
Glycosylationi673 – 6731N-linked (GlcNAc...) Reviewed prediction
Glycosylationi712 – 7121N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi732 ↔ 746 By similarity
Disulfide bondi740 ↔ 756 By similarity
Glycosylationi745 – 7451N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi758 ↔ 767 By similarity
Glycosylationi816 – 8161N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi822 ↔ 837 By similarity
Disulfide bondi831 ↔ 846 By similarity
Disulfide bondi865 ↔ 879 By similarity
Disulfide bondi873 ↔ 889 By similarity
Disulfide bondi891 ↔ 902 By similarity
Disulfide bondi908 ↔ 922 By similarity
Disulfide bondi916 ↔ 932 By similarity
Disulfide bondi934 ↔ 945 By similarity
Disulfide bondi951 ↔ 964 By similarity
Disulfide bondi958 ↔ 974 By similarity
Glycosylationi1087 – 10871N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1096 – 10961N-linked (GlcNAc...)1 Publication
Glycosylationi1170 – 11701N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1178 – 11781N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1222 – 12221N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1274 – 12741N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi1332 ↔ 1346 By similarity
Disulfide bondi1340 ↔ 1356 By similarity
Disulfide bondi1358 ↔ 1367 By similarity
Glycosylationi1378 – 13781N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi1379 ↔ 1390 By similarity
Disulfide bondi1383 ↔ 1400 By similarity
Disulfide bondi1402 ↔ 1411 By similarity
Disulfide bondi1420 ↔ 1430 By similarity
Disulfide bondi1424 ↔ 1440 By similarity
Disulfide bondi1442 ↔ 1453 By similarity
Disulfide bondi1459 ↔ 1472 By similarity
Disulfide bondi1466 ↔ 1482 By similarity
Glycosylationi1471 – 14711N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi1484 ↔ 1495 By similarity
Disulfide bondi1501 ↔ 1514 By similarity
Disulfide bondi1508 ↔ 1524 By similarity
Disulfide bondi1526 ↔ 1538 By similarity
Disulfide bondi1544 ↔ 1557 By similarity
Disulfide bondi1551 ↔ 1567 By similarity
Disulfide bondi1569 ↔ 1581 By similarity
Glycosylationi1626 – 16261N-linked (GlcNAc...)1 Publication
Glycosylationi1727 – 17271N-linked (GlcNAc...)1 Publication
Disulfide bondi1971 ↔ 1985 By similarity
Disulfide bondi1979 ↔ 1995 By similarity
Disulfide bondi1997 ↔ 2006 By similarity
Disulfide bondi2018 ↔ 2029 By similarity
Disulfide bondi2023 ↔ 2039 By similarity
Disulfide bondi2041 ↔ 2050 By similarity
Disulfide bondi2060 ↔ 2070 By similarity
Disulfide bondi2064 ↔ 2076 By similarity
Disulfide bondi2078 ↔ 2089 By similarity
Disulfide bondi2095 ↔ 2108 By similarity
Disulfide bondi2102 ↔ 2117 By similarity
Glycosylationi2107 – 21071N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi2119 ↔ 2130 By similarity
Disulfide bondi2136 ↔ 2150 By similarity
Disulfide bondi2144 ↔ 2160 By similarity
Disulfide bondi2162 ↔ 2173 By similarity
Glycosylationi2222 – 22221N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi2230 ↔ 2299 By similarity
Disulfide bondi2254 ↔ 2275 By similarity
Glycosylationi2261 – 22611N-linked (GlcNAc...) Reviewed prediction
Glycosylationi2290 – 22901N-linked (GlcNAc...) Reviewed prediction
Glycosylationi2334 – 23341N-linked (GlcNAc...) Reviewed prediction
Glycosylationi2347 – 23471N-linked (GlcNAc...)1 Publication
Glycosylationi2379 – 23791N-linked (GlcNAc...) Reviewed prediction
Glycosylationi2393 – 23931N-linked (GlcNAc...) Reviewed prediction
Glycosylationi2400 – 24001N-linked (GlcNAc...) Reviewed prediction
Glycosylationi2424 – 24241N-linked (GlcNAc...)1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9NY15.
PRIDEiQ9NY15.

PTM databases

PhosphoSiteiQ9NY15.

Expressioni

Tissue specificityi

High levels found in spleen, lymph node, liver and placenta. Also expressed in endothelial cells.2 Publications

Gene expression databases

BgeeiQ9NY15.
CleanExiHS_STAB1.
GenevestigatoriQ9NY15.

Organism-specific databases

HPAiHPA005434.

Interactioni

Subunit structurei

Interacts with CHID1.1 Publication

Protein-protein interaction databases

BioGridi116778. 5 interactions.
IntActiQ9NY15. 71 interactions.
MINTiMINT-4831401.
STRINGi9606.ENSP00000312946.

Structurei

3D structure databases

ProteinModelPortaliQ9NY15.
SMRiQ9NY15. Positions 77-311, 325-350, 518-643, 803-984, 1320-1574, 1939-2300.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini110 – 14839EGF-like 1
Add
BLAST
Domaini156 – 19338EGF-like 2
Add
BLAST
Domaini195 – 22935EGF-like 3
Add
BLAST
Domaini232 – 27140EGF-like 4
Add
BLAST
Domaini356 – 494139FAS1 1
Add
BLAST
Domaini506 – 641136FAS1 2
Add
BLAST
Domaini728 – 76841EGF-like 5
Add
BLAST
Domaini818 – 85841EGF-like 6
Add
BLAST
Domaini861 – 90343EGF-like 7
Add
BLAST
Domaini904 – 94643EGF-like 8
Add
BLAST
Domaini947 – 98640EGF-like 9
Add
BLAST
Domaini988 – 1118131FAS1 3
Add
BLAST
Domaini1128 – 1253126FAS1 4
Add
BLAST
Domaini1327 – 139266Laminin EGF-like 1
Add
BLAST
Domaini1416 – 145439EGF-like 10
Add
BLAST
Domaini1455 – 149642EGF-like 11
Add
BLAST
Domaini1497 – 153943EGF-like 12
Add
BLAST
Domaini1540 – 158243EGF-like 13
Add
BLAST
Domaini1582 – 1708127FAS1 5
Add
BLAST
Domaini1724 – 1864141FAS1 6
Add
BLAST
Domaini1966 – 203166Laminin EGF-like 2
Add
BLAST
Domaini2056 – 209035EGF-like 14
Add
BLAST
Domaini2091 – 213141EGF-like 15
Add
BLAST
Domaini2132 – 217443EGF-like 16
Add
BLAST
Domaini2206 – 230196Link
Add
BLAST
Domaini2322 – 2459138FAS1 7
Add
BLAST

Sequence similaritiesi

Contains 16 EGF-like domains.
Contains 7 FAS1 domains.
Contains 1 Link domain.

Keywords - Domaini

EGF-like domain, Laminin EGF-like domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG2335.
HOGENOMiHOG000154436.
HOVERGENiHBG079218.
InParanoidiQ9NY15.
OMAiGNCSDGI.
OrthoDBiEOG7PS1DH.
PhylomeDBiQ9NY15.
TreeFamiTF331489.

Family and domain databases

Gene3Di2.30.180.10. 7 hits.
2.40.155.10. 3 hits.
3.10.100.10. 1 hit.
InterProiIPR016186. C-type_lectin-like.
IPR016187. C-type_lectin_fold.
IPR000742. EG-like_dom.
IPR013032. EGF-like_CS.
IPR024731. EGF_dom_MSP1-like.
IPR002049. EGF_laminin.
IPR000782. FAS1_domain.
IPR023413. GFP_like.
IPR000538. Link.
[Graphical view]
PfamiPF12947. EGF_3. 5 hits.
PF02469. Fasciclin. 6 hits.
PF00193. Xlink. 1 hit.
[Graphical view]
SMARTiSM00181. EGF. 17 hits.
SM00180. EGF_Lam. 1 hit.
SM00554. FAS1. 7 hits.
SM00445. LINK. 1 hit.
[Graphical view]
SUPFAMiSSF56436. SSF56436. 1 hit.
SSF82153. SSF82153. 8 hits.
PROSITEiPS00022. EGF_1. 7 hits.
PS01186. EGF_2. 16 hits.
PS50026. EGF_3. 20 hits.
PS01248. EGF_LAM_1. 2 hits.
PS50213. FAS1. 7 hits.
PS01241. LINK_1. 1 hit.
PS50963. LINK_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 11 Publication (identifier: Q9NY15-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MAGPRGLLPL CLLAFCLAGF SFVRGQVLFK GCDVKTTFVT HVPCTSCAAI     50
KKQTCPSGWL RELPDQITQD CRYEVQLGGS MVSMSGCRRK CRKQVVQKAC 100
CPGYWGSRCH ECPGGAETPC NGHGTCLDGM DRNGTCVCQE NFRGSACQEC 150
QDPNRFGPDC QSVCSCVHGV CNHGPRGDGS CLCFAGYTGP HCDQELPVCQ 200
ELRCPQNTQC SAEAPSCRCL PGYTQQGSEC RAPNPCWPSP CSLLAQCSVS 250
PKGQAQCHCP ENYHGDGMVC LPKDPCTDNL GGCPSNSTLC VYQKPGQAFC 300
TCRPGLVSIN SNASAGCFAF CSPFSCDRSA TCQVTADGKT SCVCRESEVG 350
DGRACYGHLL HEVQKATQTG RVFLQLRVAV AMMDQGCREI LTTAGPFTVL 400
VPSVSSFSSR TMNASLAQQL CRQHIIAGQH ILEDTRTQQT RRWWTLAGQE 450
ITVTFNQFTK YSYKYKDQPQ QTFNIYKANN IAANGVFHVV TGLRWQAPSG 500
TPGDPKRTIG QILASTEAFS RFETILENCG LPSILDGPGP FTVFAPSNEA 550
VDSLRDGRLI YLFTAGLSKL QELVRYHIYN HGQLTVEKLI SKGRILTMAN 600
QVLAVNISEE GRILLGPEGV PLQRVDVMAA NGVIHMLDGI LLPPTILPIL 650
PKHCSEEQHK IVAGSCVDCQ ALNTSTCPPN SVKLDIFPKE CVYIHDPTGL 700
NVLKKGCASY CNQTIMEQGC CKGFFGPDCT QCPGGFSNPC YGKGNCSDGI 750
QGNGACLCFP DYKGIACHIC SNPNKHGEQC QEDCGCVHGL CDNRPGSGGV 800
CQQGTCAPGF SGRFCNESMG DCGPTGLAQH CHLHARCVSQ EGVARCRCLD 850
GFEGDGFSCT PSNPCSHPDR GGCSENAECV PGSLGTHHCT CHKGWSGDGR 900
VCVAIDECEL DMRGGCHTDA LCSYVGPGQS RCTCKLGFAG DGYQCSPIDP 950
CRAGNGGCHG LATCRAVGGG QRVCTCPPGF GGDGFSCYGD IFRELEANAH 1000
FSIFYQWLKS AGITLPADRR VTALVPSEAA VRQLSPEDRA FWLQPRTLPN 1050
LVRAHFLQGA LFEEELARLG GQEVATLNPT TRWEIRNISG RVWVQNASVD 1100
VADLLATNGV LHILSQVLLP PRGDVPGGQG LLQQLDLVPA FSLFRELLQH 1150
HGLVPQIEAA TAYTIFVPTN RSLEAQGNSS HLDADTVRHH VVLGEALSME 1200
TLRKGGHRNS LLGPAHWIVF YNHSGQPEVN HVPLEGPMLE APGRSLIGLS 1250
GVLTVGSSRC LHSHAEALRE KCVNCTRRFR CTQGFQLQDT PRKSCVYRSG 1300
FSFSRGCSYT CAKKIQVPDC CPGFFGTLCE PCPGGLGGVC SGHGQCQDRF 1350
LGSGECHCHE GFHGTACEVC ELGRYGPNCT GVCDCAHGLC QEGLQGDGSC 1400
VCNVGWQGLR CDQKITSPQC PRKCDPNANC VQDSAGASTC ACAAGYSGNG 1450
IFCSEVDPCA HGHGGCSPHA NCTKVAPGQR TCTCQDGYMG DGELCQEINS 1500
CLIHHGGCHI HAECIPTGPQ QVSCSCREGY SGDGIRTCEL LDPCSKNNGG 1550
CSPYATCKST GDGQRTCTCD TAHTVGDGLT CRARVGLELL RDKHASFFSL 1600
RLLEYKELKG DGPFTIFVPH ADLMSNLSQD ELARIRAHRQ LVFRYHVVGC 1650
RRLRSEDLLE QGYATALSGH PLRFSEREGS IYLNDFARVV SSDHEAVNGI 1700
LHFIDRVLLP PEALHWEPDD APIPRRNVTA AAQGFGYKIF SGLLKVAGLL 1750
PLLREASHRP FTMLWPTDAA FRALPPDRQA WLYHEDHRDK LAAILRGHMI 1800
RNVEALASDL PNLGPLRTMH GTPISFSCSR TRAGELMVGE DDARIVQRHL 1850
PFEGGLAYGI DQLLEPPGLG ARCDHFETRP LRLNTCSICG LEPPCPEGSQ 1900
EQGSPEACWR FYPKFWTSPP LHSLGLRSVW VHPSLWGRPQ GLGRGCHRNC 1950
VTTTWKPSCC PGHYGSECQA CPGGPSSPCS DRGVCMDGMS GSGQCLCRSG 2000
FAGTACELCA PGAFGPHCQA CRCTVHGRCD EGLGGSGSCF CDEGWTGPRC 2050
EVQLELQPVC TPPCAPEAVC RAGNSCECSL GYEGDGRVCT VADLCQDGHG 2100
GCSEHANCSQ VGTMVTCTCL PDYEGDGWSC RARNPCTDGH RGGCSEHANC 2150
LSTGLNTRRC ECHAGYVGDG LQCLEESEPP VDRCLGQPPP CHSDAMCTDL 2200
HFQEKRAGVF HLQATSGPYG LNFSEAEAAC EAQGAVLASF PQLSAAQQLG 2250
FHLCLMGWLA NGSTAHPVVF PVADCGNGRV GIVSLGARKN LSERWDAYCF 2300
RVQDVACRCR NGFVGDGIST CNGKLLDVLA ATANFSTFYG MLLGYANATQ 2350
RGLDFLDFLD DELTYKTLFV PVNEGFVDNM TLSGPDLELH ASNATLLSAN 2400
ASQGKLLPAH SGLSLIISDA GPDNSSWAPV APGTVVVSRI IVWDIMAFNG 2450
IIHALASPLL APPQPQAVLA PEAPPVAAGV GAVLAAGALL GLVAGALYLR 2500
ARGKPMGFGF SAFQAEDDAD DDFSPWQEGT NPTLVSVPNP VFGSDTFCEP 2550
FDDSLLEEDF PDTQRILTVK 2570
Length:2,570
Mass (Da):275,482
Last modified:May 18, 2010 - v3
Checksum:iFA55D191D9D30FAD
GO
Isoform 21 Publication (identifier: Q9NY15-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     746-803: CSDGIQGNGA...RPGSGGVCQQ → VSPILSWGEV...IISHILIKNN
     804-2570: Missing.

Show »
Length:803
Mass (Da):87,026
Checksum:i1A833922D0F223FB
GO

Sequence cautioni

The sequence BAA13377.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti672 – 6721L → M.
Corresponds to variant rs12636502 [ dbSNP | Ensembl ].
VAR_060338
Natural varianti912 – 9121M → V.4 Publications
Corresponds to variant rs9835659 [ dbSNP | Ensembl ].
VAR_060339
Natural varianti1127 – 11271G → R.
Corresponds to variant rs2286786 [ dbSNP | Ensembl ].
VAR_055774
Natural varianti1833 – 18331A → P.3 Publications
Corresponds to variant rs7630214 [ dbSNP | Ensembl ].
VAR_060340
Natural varianti2282 – 22821I → V.1 Publication
Corresponds to variant rs4434138 [ dbSNP | Ensembl ].
VAR_055775
Natural varianti2506 – 25061M → T.
Corresponds to variant rs13303 [ dbSNP | Ensembl ].
VAR_019078

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei746 – 80358CSDGI…GVCQQ → VSPILSWGEVWGTQGLLHRL ASDWLCVWAKPATLALGFSY LCSGKLDQIISHILIKNN in isoform 2. 1 Publication
VSP_050764Add
BLAST
Alternative sequencei804 – 25701767Missing in isoform 2. 1 Publication
VSP_050765Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti913 – 9131R → G in CAB61827. 1 Publication
Sequence conflicti2200 – 22001L → Q in CAB61827. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ275213 mRNA. Translation: CAB61827.1.
AB052956 mRNA. Translation: BAC15606.1.
AB052957 mRNA. Translation: BAC15607.1.
D87433 mRNA. Translation: BAA13377.2. Different initiation.
AC006208 Genomic DNA. No translation available.
AC112215 Genomic DNA. No translation available.
BC150250 mRNA. Translation: AAI50251.1.
CCDSiCCDS33768.1. [Q9NY15-1]
RefSeqiNP_055951.2. NM_015136.2. [Q9NY15-1]
UniGeneiHs.301989.

Genome annotation databases

EnsembliENST00000321725; ENSP00000312946; ENSG00000010327. [Q9NY15-1]
GeneIDi23166.
KEGGihsa:23166.
UCSCiuc003dei.1. human. [Q9NY15-2]
uc003dej.3. human. [Q9NY15-1]

Polymorphism databases

DMDMi296452949.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ275213 mRNA. Translation: CAB61827.1 .
AB052956 mRNA. Translation: BAC15606.1 .
AB052957 mRNA. Translation: BAC15607.1 .
D87433 mRNA. Translation: BAA13377.2 . Different initiation.
AC006208 Genomic DNA. No translation available.
AC112215 Genomic DNA. No translation available.
BC150250 mRNA. Translation: AAI50251.1 .
CCDSi CCDS33768.1. [Q9NY15-1 ]
RefSeqi NP_055951.2. NM_015136.2. [Q9NY15-1 ]
UniGenei Hs.301989.

3D structure databases

ProteinModelPortali Q9NY15.
SMRi Q9NY15. Positions 77-311, 325-350, 518-643, 803-984, 1320-1574, 1939-2300.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 116778. 5 interactions.
IntActi Q9NY15. 71 interactions.
MINTi MINT-4831401.
STRINGi 9606.ENSP00000312946.

PTM databases

PhosphoSitei Q9NY15.

Polymorphism databases

DMDMi 296452949.

Proteomic databases

PaxDbi Q9NY15.
PRIDEi Q9NY15.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000321725 ; ENSP00000312946 ; ENSG00000010327 . [Q9NY15-1 ]
GeneIDi 23166.
KEGGi hsa:23166.
UCSCi uc003dei.1. human. [Q9NY15-2 ]
uc003dej.3. human. [Q9NY15-1 ]

Organism-specific databases

CTDi 23166.
GeneCardsi GC03P052529.
H-InvDB HIX0003360.
HGNCi HGNC:18628. STAB1.
HPAi HPA005434.
MIMi 608560. gene.
neXtProti NX_Q9NY15.
PharmGKBi PA38610.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG2335.
HOGENOMi HOG000154436.
HOVERGENi HBG079218.
InParanoidi Q9NY15.
OMAi GNCSDGI.
OrthoDBi EOG7PS1DH.
PhylomeDBi Q9NY15.
TreeFami TF331489.

Enzyme and pathway databases

Reactomei REACT_164002. Scavenging by Class H Receptors.

Miscellaneous databases

ChiTaRSi STAB1. human.
GeneWikii STAB1.
GenomeRNAii 23166.
NextBioi 44560.
PROi Q9NY15.
SOURCEi Search...

Gene expression databases

Bgeei Q9NY15.
CleanExi HS_STAB1.
Genevestigatori Q9NY15.

Family and domain databases

Gene3Di 2.30.180.10. 7 hits.
2.40.155.10. 3 hits.
3.10.100.10. 1 hit.
InterProi IPR016186. C-type_lectin-like.
IPR016187. C-type_lectin_fold.
IPR000742. EG-like_dom.
IPR013032. EGF-like_CS.
IPR024731. EGF_dom_MSP1-like.
IPR002049. EGF_laminin.
IPR000782. FAS1_domain.
IPR023413. GFP_like.
IPR000538. Link.
[Graphical view ]
Pfami PF12947. EGF_3. 5 hits.
PF02469. Fasciclin. 6 hits.
PF00193. Xlink. 1 hit.
[Graphical view ]
SMARTi SM00181. EGF. 17 hits.
SM00180. EGF_Lam. 1 hit.
SM00554. FAS1. 7 hits.
SM00445. LINK. 1 hit.
[Graphical view ]
SUPFAMi SSF56436. SSF56436. 1 hit.
SSF82153. SSF82153. 8 hits.
PROSITEi PS00022. EGF_1. 7 hits.
PS01186. EGF_2. 16 hits.
PS50026. EGF_3. 20 hits.
PS01248. EGF_LAM_1. 2 hits.
PS50213. FAS1. 7 hits.
PS01241. LINK_1. 1 hit.
PS50963. LINK_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, VARIANTS VARIANTS VAL-912; PRO-1833 AND VAL-2282.
  2. "FEEL-1, a novel scavenger receptor with in vitro bacteria-binding and angiogenesis-modulating activities."
    Adachi H., Tsujimoto M.
    J. Biol. Chem. 277:34264-34270(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), FUNCTION, TISSUE SPECIFICITY, VARIANT VAL-912.
  3. "Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain."
    Nagase T., Seki N., Ishikawa K., Ohira M., Kawarabayasi Y., Ohara O., Tanaka A., Kotani H., Miyajima N., Nomura N.
    DNA Res. 3:321-329(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANTS VAL-912 AND PRO-1833.
    Tissue: Brain.
  4. "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."
    Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T.
    DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: SEQUENCE REVISION.
  5. "The DNA sequence, annotation and analysis of human chromosome 3."
    Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
    , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
    Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANTS VAL-912 AND PRO-1833.
  7. "Novel stabilin-1 interacting chitinase-like protein (SI-CLP) is up-regulated in alternatively activated macrophages and secreted via lysosomal pathway."
    Kzhyshkowska J., Mamidi S., Gratchev A., Kremmer E., Schmuttermaier C., Krusell L., Haus G., Utikal J., Schledzewski K., Scholtze J., Goerdt S.
    Blood 107:3221-3228(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH CHID1.
  8. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
    Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
    J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-1096; ASN-1626; ASN-1727; ASN-2347 AND ASN-2424.
    Tissue: Liver.

Entry informationi

Entry nameiSTAB1_HUMAN
AccessioniPrimary (citable) accession number: Q9NY15
Secondary accession number(s): A7E297
, Q8IUH0, Q8IUH1, Q93072
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 5, 2004
Last sequence update: May 18, 2010
Last modified: September 3, 2014
This is version 123 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi