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Q9NY15

- STAB1_HUMAN

UniProt

Q9NY15 - STAB1_HUMAN

Protein

Stabilin-1

Gene

STAB1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 124 (01 Oct 2014)
      Sequence version 3 (18 May 2010)
      Previous versions | rss
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    Functioni

    Acts as a scavenger receptor for acetylated low density lipoprotein. Binds to both Gram-positive and Gram-negative bacteria and may play a role in defense against bacterial infection. When inhibited in endothelial tube formation assays, there is a marked decrease in cell-cell interactions, suggesting a role in angiogenesis. Involved in the delivery of newly synthesized CHID1/SI-CLP from the biosynthetic compartment to the endosomal/lysosomal system.2 Publications

    GO - Molecular functioni

    1. hyaluronic acid binding Source: InterPro
    2. low-density lipoprotein particle binding Source: UniProtKB
    3. low-density lipoprotein receptor activity Source: UniProtKB
    4. protein binding Source: UniProt
    5. protein disulfide oxidoreductase activity Source: UniProtKB
    6. scavenger receptor activity Source: UniProtKB

    GO - Biological processi

    1. cell adhesion Source: UniProtKB
    2. cell-cell signaling Source: UniProtKB
    3. defense response to bacterium Source: UniProtKB
    4. inflammatory response Source: UniProtKB-KW
    5. negative regulation of angiogenesis Source: UniProtKB
    6. oxidation-reduction process Source: GOC
    7. receptor-mediated endocytosis Source: UniProtKB

    Keywords - Molecular functioni

    Receptor

    Keywords - Biological processi

    Inflammatory response

    Enzyme and pathway databases

    ReactomeiREACT_164002. Scavenging by Class H Receptors.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Stabilin-1
    Alternative name(s):
    Fasciclin, EGF-like, laminin-type EGF-like and link domain-containing scavenger receptor 1
    Short name:
    FEEL-1
    MS-1 antigen
    Gene namesi
    Name:STAB1
    Synonyms:FEEL1, KIAA0246
    OrganismiHomo sapiens (Human)Imported
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 3

    Organism-specific databases

    HGNCiHGNC:18628. STAB1.

    Subcellular locationi

    GO - Cellular componenti

    1. endocytic vesicle membrane Source: Reactome
    2. integral component of plasma membrane Source: UniProtKB
    3. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA38610.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2525Sequence AnalysisAdd
    BLAST
    Chaini26 – 25702545Stabilin-1PRO_0000007710Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi112 ↔ 126By similarity
    Disulfide bondi120 ↔ 136By similarity
    Glycosylationi133 – 1331N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi138 ↔ 147By similarity
    Disulfide bondi160 ↔ 171By similarity
    Disulfide bondi164 ↔ 181By similarity
    Disulfide bondi183 ↔ 192By similarity
    Disulfide bondi199 ↔ 210By similarity
    Disulfide bondi204 ↔ 217By similarity
    Disulfide bondi236 ↔ 247By similarity
    Disulfide bondi241 ↔ 257By similarity
    Disulfide bondi259 ↔ 270By similarity
    Glycosylationi286 – 2861N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi312 – 3121N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi413 – 4131N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi606 – 6061N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi673 – 6731N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi712 – 7121N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi732 ↔ 746By similarity
    Disulfide bondi740 ↔ 756By similarity
    Glycosylationi745 – 7451N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi758 ↔ 767By similarity
    Glycosylationi816 – 8161N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi822 ↔ 837By similarity
    Disulfide bondi831 ↔ 846By similarity
    Disulfide bondi865 ↔ 879By similarity
    Disulfide bondi873 ↔ 889By similarity
    Disulfide bondi891 ↔ 902By similarity
    Disulfide bondi908 ↔ 922By similarity
    Disulfide bondi916 ↔ 932By similarity
    Disulfide bondi934 ↔ 945By similarity
    Disulfide bondi951 ↔ 964By similarity
    Disulfide bondi958 ↔ 974By similarity
    Glycosylationi1087 – 10871N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi1096 – 10961N-linked (GlcNAc...)1 Publication
    Glycosylationi1170 – 11701N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi1178 – 11781N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi1222 – 12221N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi1274 – 12741N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi1332 ↔ 1346By similarity
    Disulfide bondi1340 ↔ 1356By similarity
    Disulfide bondi1358 ↔ 1367By similarity
    Glycosylationi1378 – 13781N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi1379 ↔ 1390By similarity
    Disulfide bondi1383 ↔ 1400By similarity
    Disulfide bondi1402 ↔ 1411By similarity
    Disulfide bondi1420 ↔ 1430By similarity
    Disulfide bondi1424 ↔ 1440By similarity
    Disulfide bondi1442 ↔ 1453By similarity
    Disulfide bondi1459 ↔ 1472By similarity
    Disulfide bondi1466 ↔ 1482By similarity
    Glycosylationi1471 – 14711N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi1484 ↔ 1495By similarity
    Disulfide bondi1501 ↔ 1514By similarity
    Disulfide bondi1508 ↔ 1524By similarity
    Disulfide bondi1526 ↔ 1538By similarity
    Disulfide bondi1544 ↔ 1557By similarity
    Disulfide bondi1551 ↔ 1567By similarity
    Disulfide bondi1569 ↔ 1581By similarity
    Glycosylationi1626 – 16261N-linked (GlcNAc...)1 Publication
    Glycosylationi1727 – 17271N-linked (GlcNAc...)1 Publication
    Disulfide bondi1971 ↔ 1985By similarity
    Disulfide bondi1979 ↔ 1995By similarity
    Disulfide bondi1997 ↔ 2006By similarity
    Disulfide bondi2018 ↔ 2029By similarity
    Disulfide bondi2023 ↔ 2039By similarity
    Disulfide bondi2041 ↔ 2050By similarity
    Disulfide bondi2060 ↔ 2070By similarity
    Disulfide bondi2064 ↔ 2076By similarity
    Disulfide bondi2078 ↔ 2089By similarity
    Disulfide bondi2095 ↔ 2108By similarity
    Disulfide bondi2102 ↔ 2117By similarity
    Glycosylationi2107 – 21071N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi2119 ↔ 2130By similarity
    Disulfide bondi2136 ↔ 2150By similarity
    Disulfide bondi2144 ↔ 2160By similarity
    Disulfide bondi2162 ↔ 2173By similarity
    Glycosylationi2222 – 22221N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi2230 ↔ 2299By similarity
    Disulfide bondi2254 ↔ 2275By similarity
    Glycosylationi2261 – 22611N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi2290 – 22901N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi2334 – 23341N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi2347 – 23471N-linked (GlcNAc...)1 Publication
    Glycosylationi2379 – 23791N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi2393 – 23931N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi2400 – 24001N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi2424 – 24241N-linked (GlcNAc...)1 Publication

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ9NY15.
    PRIDEiQ9NY15.

    PTM databases

    PhosphoSiteiQ9NY15.

    Expressioni

    Tissue specificityi

    High levels found in spleen, lymph node, liver and placenta. Also expressed in endothelial cells.2 Publications

    Gene expression databases

    BgeeiQ9NY15.
    CleanExiHS_STAB1.
    GenevestigatoriQ9NY15.

    Organism-specific databases

    HPAiHPA005434.

    Interactioni

    Subunit structurei

    Interacts with CHID1.1 Publication

    Protein-protein interaction databases

    BioGridi116778. 5 interactions.
    IntActiQ9NY15. 71 interactions.
    MINTiMINT-4831401.
    STRINGi9606.ENSP00000312946.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9NY15.
    SMRiQ9NY15. Positions 77-311, 325-350, 518-643, 803-984, 1320-1574, 1939-2300.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini26 – 24782453ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini2500 – 257071CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei2479 – 249921HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini110 – 14839EGF-like 1CuratedPROSITE-ProRule annotationAdd
    BLAST
    Domaini156 – 19338EGF-like 2CuratedPROSITE-ProRule annotationAdd
    BLAST
    Domaini195 – 22935EGF-like 3CuratedPROSITE-ProRule annotationAdd
    BLAST
    Domaini232 – 27140EGF-like 4CuratedPROSITE-ProRule annotationAdd
    BLAST
    Domaini356 – 494139FAS1 1CuratedPROSITE-ProRule annotationAdd
    BLAST
    Domaini506 – 641136FAS1 2CuratedPROSITE-ProRule annotationAdd
    BLAST
    Domaini728 – 76841EGF-like 5CuratedPROSITE-ProRule annotationAdd
    BLAST
    Domaini818 – 85841EGF-like 6CuratedPROSITE-ProRule annotationAdd
    BLAST
    Domaini861 – 90343EGF-like 7CuratedPROSITE-ProRule annotationAdd
    BLAST
    Domaini904 – 94643EGF-like 8CuratedPROSITE-ProRule annotationAdd
    BLAST
    Domaini947 – 98640EGF-like 9CuratedPROSITE-ProRule annotationAdd
    BLAST
    Domaini988 – 1118131FAS1 3CuratedPROSITE-ProRule annotationAdd
    BLAST
    Domaini1128 – 1253126FAS1 4CuratedPROSITE-ProRule annotationAdd
    BLAST
    Domaini1327 – 139266Laminin EGF-like 1CuratedAdd
    BLAST
    Domaini1416 – 145439EGF-like 10CuratedPROSITE-ProRule annotationAdd
    BLAST
    Domaini1455 – 149642EGF-like 11CuratedPROSITE-ProRule annotationAdd
    BLAST
    Domaini1497 – 153943EGF-like 12CuratedPROSITE-ProRule annotationAdd
    BLAST
    Domaini1540 – 158243EGF-like 13CuratedPROSITE-ProRule annotationAdd
    BLAST
    Domaini1582 – 1708127FAS1 5CuratedPROSITE-ProRule annotationAdd
    BLAST
    Domaini1724 – 1864141FAS1 6CuratedPROSITE-ProRule annotationAdd
    BLAST
    Domaini1966 – 203166Laminin EGF-like 2CuratedAdd
    BLAST
    Domaini2056 – 209035EGF-like 14CuratedPROSITE-ProRule annotationAdd
    BLAST
    Domaini2091 – 213141EGF-like 15CuratedPROSITE-ProRule annotationAdd
    BLAST
    Domaini2132 – 217443EGF-like 16CuratedPROSITE-ProRule annotationAdd
    BLAST
    Domaini2206 – 230196LinkCuratedPROSITE-ProRule annotationAdd
    BLAST
    Domaini2322 – 2459138FAS1 7CuratedPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 16 EGF-like domains.CuratedPROSITE-ProRule annotation
    Contains 7 FAS1 domains.CuratedPROSITE-ProRule annotation
    Contains 2 laminin EGF-like domains.Curated
    Contains 1 Link domain.CuratedPROSITE-ProRule annotation

    Keywords - Domaini

    EGF-like domain, Laminin EGF-like domain, Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG2335.
    HOGENOMiHOG000154436.
    HOVERGENiHBG079218.
    InParanoidiQ9NY15.
    OMAiGNCSDGI.
    OrthoDBiEOG7PS1DH.
    PhylomeDBiQ9NY15.
    TreeFamiTF331489.

    Family and domain databases

    Gene3Di2.30.180.10. 7 hits.
    2.40.155.10. 3 hits.
    3.10.100.10. 1 hit.
    InterProiIPR016186. C-type_lectin-like.
    IPR016187. C-type_lectin_fold.
    IPR000742. EG-like_dom.
    IPR013032. EGF-like_CS.
    IPR024731. EGF_dom_MSP1-like.
    IPR002049. EGF_laminin.
    IPR000782. FAS1_domain.
    IPR023413. GFP_like.
    IPR000538. Link.
    [Graphical view]
    PfamiPF12947. EGF_3. 5 hits.
    PF02469. Fasciclin. 6 hits.
    PF00193. Xlink. 1 hit.
    [Graphical view]
    SMARTiSM00181. EGF. 17 hits.
    SM00180. EGF_Lam. 1 hit.
    SM00554. FAS1. 7 hits.
    SM00445. LINK. 1 hit.
    [Graphical view]
    SUPFAMiSSF56436. SSF56436. 1 hit.
    SSF82153. SSF82153. 8 hits.
    PROSITEiPS00022. EGF_1. 7 hits.
    PS01186. EGF_2. 16 hits.
    PS50026. EGF_3. 20 hits.
    PS01248. EGF_LAM_1. 2 hits.
    PS50213. FAS1. 7 hits.
    PS01241. LINK_1. 1 hit.
    PS50963. LINK_2. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 11 Publication (identifier: Q9NY15-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAGPRGLLPL CLLAFCLAGF SFVRGQVLFK GCDVKTTFVT HVPCTSCAAI     50
    KKQTCPSGWL RELPDQITQD CRYEVQLGGS MVSMSGCRRK CRKQVVQKAC 100
    CPGYWGSRCH ECPGGAETPC NGHGTCLDGM DRNGTCVCQE NFRGSACQEC 150
    QDPNRFGPDC QSVCSCVHGV CNHGPRGDGS CLCFAGYTGP HCDQELPVCQ 200
    ELRCPQNTQC SAEAPSCRCL PGYTQQGSEC RAPNPCWPSP CSLLAQCSVS 250
    PKGQAQCHCP ENYHGDGMVC LPKDPCTDNL GGCPSNSTLC VYQKPGQAFC 300
    TCRPGLVSIN SNASAGCFAF CSPFSCDRSA TCQVTADGKT SCVCRESEVG 350
    DGRACYGHLL HEVQKATQTG RVFLQLRVAV AMMDQGCREI LTTAGPFTVL 400
    VPSVSSFSSR TMNASLAQQL CRQHIIAGQH ILEDTRTQQT RRWWTLAGQE 450
    ITVTFNQFTK YSYKYKDQPQ QTFNIYKANN IAANGVFHVV TGLRWQAPSG 500
    TPGDPKRTIG QILASTEAFS RFETILENCG LPSILDGPGP FTVFAPSNEA 550
    VDSLRDGRLI YLFTAGLSKL QELVRYHIYN HGQLTVEKLI SKGRILTMAN 600
    QVLAVNISEE GRILLGPEGV PLQRVDVMAA NGVIHMLDGI LLPPTILPIL 650
    PKHCSEEQHK IVAGSCVDCQ ALNTSTCPPN SVKLDIFPKE CVYIHDPTGL 700
    NVLKKGCASY CNQTIMEQGC CKGFFGPDCT QCPGGFSNPC YGKGNCSDGI 750
    QGNGACLCFP DYKGIACHIC SNPNKHGEQC QEDCGCVHGL CDNRPGSGGV 800
    CQQGTCAPGF SGRFCNESMG DCGPTGLAQH CHLHARCVSQ EGVARCRCLD 850
    GFEGDGFSCT PSNPCSHPDR GGCSENAECV PGSLGTHHCT CHKGWSGDGR 900
    VCVAIDECEL DMRGGCHTDA LCSYVGPGQS RCTCKLGFAG DGYQCSPIDP 950
    CRAGNGGCHG LATCRAVGGG QRVCTCPPGF GGDGFSCYGD IFRELEANAH 1000
    FSIFYQWLKS AGITLPADRR VTALVPSEAA VRQLSPEDRA FWLQPRTLPN 1050
    LVRAHFLQGA LFEEELARLG GQEVATLNPT TRWEIRNISG RVWVQNASVD 1100
    VADLLATNGV LHILSQVLLP PRGDVPGGQG LLQQLDLVPA FSLFRELLQH 1150
    HGLVPQIEAA TAYTIFVPTN RSLEAQGNSS HLDADTVRHH VVLGEALSME 1200
    TLRKGGHRNS LLGPAHWIVF YNHSGQPEVN HVPLEGPMLE APGRSLIGLS 1250
    GVLTVGSSRC LHSHAEALRE KCVNCTRRFR CTQGFQLQDT PRKSCVYRSG 1300
    FSFSRGCSYT CAKKIQVPDC CPGFFGTLCE PCPGGLGGVC SGHGQCQDRF 1350
    LGSGECHCHE GFHGTACEVC ELGRYGPNCT GVCDCAHGLC QEGLQGDGSC 1400
    VCNVGWQGLR CDQKITSPQC PRKCDPNANC VQDSAGASTC ACAAGYSGNG 1450
    IFCSEVDPCA HGHGGCSPHA NCTKVAPGQR TCTCQDGYMG DGELCQEINS 1500
    CLIHHGGCHI HAECIPTGPQ QVSCSCREGY SGDGIRTCEL LDPCSKNNGG 1550
    CSPYATCKST GDGQRTCTCD TAHTVGDGLT CRARVGLELL RDKHASFFSL 1600
    RLLEYKELKG DGPFTIFVPH ADLMSNLSQD ELARIRAHRQ LVFRYHVVGC 1650
    RRLRSEDLLE QGYATALSGH PLRFSEREGS IYLNDFARVV SSDHEAVNGI 1700
    LHFIDRVLLP PEALHWEPDD APIPRRNVTA AAQGFGYKIF SGLLKVAGLL 1750
    PLLREASHRP FTMLWPTDAA FRALPPDRQA WLYHEDHRDK LAAILRGHMI 1800
    RNVEALASDL PNLGPLRTMH GTPISFSCSR TRAGELMVGE DDARIVQRHL 1850
    PFEGGLAYGI DQLLEPPGLG ARCDHFETRP LRLNTCSICG LEPPCPEGSQ 1900
    EQGSPEACWR FYPKFWTSPP LHSLGLRSVW VHPSLWGRPQ GLGRGCHRNC 1950
    VTTTWKPSCC PGHYGSECQA CPGGPSSPCS DRGVCMDGMS GSGQCLCRSG 2000
    FAGTACELCA PGAFGPHCQA CRCTVHGRCD EGLGGSGSCF CDEGWTGPRC 2050
    EVQLELQPVC TPPCAPEAVC RAGNSCECSL GYEGDGRVCT VADLCQDGHG 2100
    GCSEHANCSQ VGTMVTCTCL PDYEGDGWSC RARNPCTDGH RGGCSEHANC 2150
    LSTGLNTRRC ECHAGYVGDG LQCLEESEPP VDRCLGQPPP CHSDAMCTDL 2200
    HFQEKRAGVF HLQATSGPYG LNFSEAEAAC EAQGAVLASF PQLSAAQQLG 2250
    FHLCLMGWLA NGSTAHPVVF PVADCGNGRV GIVSLGARKN LSERWDAYCF 2300
    RVQDVACRCR NGFVGDGIST CNGKLLDVLA ATANFSTFYG MLLGYANATQ 2350
    RGLDFLDFLD DELTYKTLFV PVNEGFVDNM TLSGPDLELH ASNATLLSAN 2400
    ASQGKLLPAH SGLSLIISDA GPDNSSWAPV APGTVVVSRI IVWDIMAFNG 2450
    IIHALASPLL APPQPQAVLA PEAPPVAAGV GAVLAAGALL GLVAGALYLR 2500
    ARGKPMGFGF SAFQAEDDAD DDFSPWQEGT NPTLVSVPNP VFGSDTFCEP 2550
    FDDSLLEEDF PDTQRILTVK 2570
    Length:2,570
    Mass (Da):275,482
    Last modified:May 18, 2010 - v3
    Checksum:iFA55D191D9D30FAD
    GO
    Isoform 21 Publication (identifier: Q9NY15-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         746-803: CSDGIQGNGA...RPGSGGVCQQ → VSPILSWGEV...IISHILIKNN
         804-2570: Missing.

    Show »
    Length:803
    Mass (Da):87,026
    Checksum:i1A833922D0F223FB
    GO

    Sequence cautioni

    The sequence BAA13377.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti913 – 9131R → G in CAB61827. (PubMed:11829752)Curated
    Sequence conflicti2200 – 22001L → Q in CAB61827. (PubMed:11829752)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti672 – 6721L → M.
    Corresponds to variant rs12636502 [ dbSNP | Ensembl ].
    VAR_060338
    Natural varianti912 – 9121M → V.4 Publications
    Corresponds to variant rs9835659 [ dbSNP | Ensembl ].
    VAR_060339
    Natural varianti1127 – 11271G → R.
    Corresponds to variant rs2286786 [ dbSNP | Ensembl ].
    VAR_055774
    Natural varianti1833 – 18331A → P.3 Publications
    Corresponds to variant rs7630214 [ dbSNP | Ensembl ].
    VAR_060340
    Natural varianti2282 – 22821I → V.1 Publication
    Corresponds to variant rs4434138 [ dbSNP | Ensembl ].
    VAR_055775
    Natural varianti2506 – 25061M → T.
    Corresponds to variant rs13303 [ dbSNP | Ensembl ].
    VAR_019078

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei746 – 80358CSDGI…GVCQQ → VSPILSWGEVWGTQGLLHRL ASDWLCVWAKPATLALGFSY LCSGKLDQIISHILIKNN in isoform 2. 1 PublicationVSP_050764Add
    BLAST
    Alternative sequencei804 – 25701767Missing in isoform 2. 1 PublicationVSP_050765Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ275213 mRNA. Translation: CAB61827.1.
    AB052956 mRNA. Translation: BAC15606.1.
    AB052957 mRNA. Translation: BAC15607.1.
    D87433 mRNA. Translation: BAA13377.2. Different initiation.
    AC006208 Genomic DNA. No translation available.
    AC112215 Genomic DNA. No translation available.
    BC150250 mRNA. Translation: AAI50251.1.
    CCDSiCCDS33768.1. [Q9NY15-1]
    RefSeqiNP_055951.2. NM_015136.2. [Q9NY15-1]
    UniGeneiHs.301989.

    Genome annotation databases

    EnsembliENST00000321725; ENSP00000312946; ENSG00000010327. [Q9NY15-1]
    GeneIDi23166.
    KEGGihsa:23166.
    UCSCiuc003dei.1. human. [Q9NY15-2]
    uc003dej.3. human. [Q9NY15-1]

    Polymorphism databases

    DMDMi296452949.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ275213 mRNA. Translation: CAB61827.1 .
    AB052956 mRNA. Translation: BAC15606.1 .
    AB052957 mRNA. Translation: BAC15607.1 .
    D87433 mRNA. Translation: BAA13377.2 . Different initiation.
    AC006208 Genomic DNA. No translation available.
    AC112215 Genomic DNA. No translation available.
    BC150250 mRNA. Translation: AAI50251.1 .
    CCDSi CCDS33768.1. [Q9NY15-1 ]
    RefSeqi NP_055951.2. NM_015136.2. [Q9NY15-1 ]
    UniGenei Hs.301989.

    3D structure databases

    ProteinModelPortali Q9NY15.
    SMRi Q9NY15. Positions 77-311, 325-350, 518-643, 803-984, 1320-1574, 1939-2300.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 116778. 5 interactions.
    IntActi Q9NY15. 71 interactions.
    MINTi MINT-4831401.
    STRINGi 9606.ENSP00000312946.

    PTM databases

    PhosphoSitei Q9NY15.

    Polymorphism databases

    DMDMi 296452949.

    Proteomic databases

    PaxDbi Q9NY15.
    PRIDEi Q9NY15.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000321725 ; ENSP00000312946 ; ENSG00000010327 . [Q9NY15-1 ]
    GeneIDi 23166.
    KEGGi hsa:23166.
    UCSCi uc003dei.1. human. [Q9NY15-2 ]
    uc003dej.3. human. [Q9NY15-1 ]

    Organism-specific databases

    CTDi 23166.
    GeneCardsi GC03P052529.
    H-InvDB HIX0003360.
    HGNCi HGNC:18628. STAB1.
    HPAi HPA005434.
    MIMi 608560. gene.
    neXtProti NX_Q9NY15.
    PharmGKBi PA38610.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG2335.
    HOGENOMi HOG000154436.
    HOVERGENi HBG079218.
    InParanoidi Q9NY15.
    OMAi GNCSDGI.
    OrthoDBi EOG7PS1DH.
    PhylomeDBi Q9NY15.
    TreeFami TF331489.

    Enzyme and pathway databases

    Reactomei REACT_164002. Scavenging by Class H Receptors.

    Miscellaneous databases

    ChiTaRSi STAB1. human.
    GeneWikii STAB1.
    GenomeRNAii 23166.
    NextBioi 44560.
    PROi Q9NY15.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9NY15.
    CleanExi HS_STAB1.
    Genevestigatori Q9NY15.

    Family and domain databases

    Gene3Di 2.30.180.10. 7 hits.
    2.40.155.10. 3 hits.
    3.10.100.10. 1 hit.
    InterProi IPR016186. C-type_lectin-like.
    IPR016187. C-type_lectin_fold.
    IPR000742. EG-like_dom.
    IPR013032. EGF-like_CS.
    IPR024731. EGF_dom_MSP1-like.
    IPR002049. EGF_laminin.
    IPR000782. FAS1_domain.
    IPR023413. GFP_like.
    IPR000538. Link.
    [Graphical view ]
    Pfami PF12947. EGF_3. 5 hits.
    PF02469. Fasciclin. 6 hits.
    PF00193. Xlink. 1 hit.
    [Graphical view ]
    SMARTi SM00181. EGF. 17 hits.
    SM00180. EGF_Lam. 1 hit.
    SM00554. FAS1. 7 hits.
    SM00445. LINK. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56436. SSF56436. 1 hit.
    SSF82153. SSF82153. 8 hits.
    PROSITEi PS00022. EGF_1. 7 hits.
    PS01186. EGF_2. 16 hits.
    PS50026. EGF_3. 20 hits.
    PS01248. EGF_LAM_1. 2 hits.
    PS50213. FAS1. 7 hits.
    PS01241. LINK_1. 1 hit.
    PS50963. LINK_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, VARIANTS VARIANTS VAL-912; PRO-1833 AND VAL-2282.
    2. "FEEL-1, a novel scavenger receptor with in vitro bacteria-binding and angiogenesis-modulating activities."
      Adachi H., Tsujimoto M.
      J. Biol. Chem. 277:34264-34270(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), FUNCTION, TISSUE SPECIFICITY, VARIANT VAL-912.
    3. "Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain."
      Nagase T., Seki N., Ishikawa K., Ohira M., Kawarabayasi Y., Ohara O., Tanaka A., Kotani H., Miyajima N., Nomura N.
      DNA Res. 3:321-329(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANTS VAL-912 AND PRO-1833.
      Tissue: BrainImported.
    4. "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."
      Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T.
      DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: SEQUENCE REVISION.
    5. "The DNA sequence, annotation and analysis of human chromosome 3."
      Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
      , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
      Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANTS VAL-912 AND PRO-1833.
    7. "Novel stabilin-1 interacting chitinase-like protein (SI-CLP) is up-regulated in alternatively activated macrophages and secreted via lysosomal pathway."
      Kzhyshkowska J., Mamidi S., Gratchev A., Kremmer E., Schmuttermaier C., Krusell L., Haus G., Utikal J., Schledzewski K., Scholtze J., Goerdt S.
      Blood 107:3221-3228(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH CHID1.
    8. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
      Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
      J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-1096; ASN-1626; ASN-1727; ASN-2347 AND ASN-2424.
      Tissue: Liver.

    Entry informationi

    Entry nameiSTAB1_HUMAN
    AccessioniPrimary (citable) accession number: Q9NY15
    Secondary accession number(s): A7E297
    , Q8IUH0, Q8IUH1, Q93072
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 5, 2004
    Last sequence update: May 18, 2010
    Last modified: October 1, 2014
    This is version 124 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 3
      Human chromosome 3: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3