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Q9NY15 (STAB1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 119. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Stabilin-1
Alternative name(s):
Fasciclin, EGF-like, laminin-type EGF-like and link domain-containing scavenger receptor 1
Short name=FEEL-1
MS-1 antigen
Gene names
Name:STAB1
Synonyms:FEEL1, KIAA0246
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length2570 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Acts as a scavenger receptor for acetylated low density lipoprotein. Binds to both Gram-positive and Gram-negative bacteria and may play a role in defense against bacterial infection. When inhibited in endothelial tube formation assays, there is a marked decrease in cell-cell interactions, suggesting a role in angiogenesis. Involved in the delivery of newly synthesized CHID1/SI-CLP from the biosynthetic compartment to the endosomal/lysosomal system. Ref.2 Ref.7

Subunit structure

Interacts with CHID1. Ref.7

Subcellular location

Membrane; Single-pass type I membrane protein Potential.

Tissue specificity

High levels found in spleen, lymph node, liver and placenta. Also expressed in endothelial cells. Ref.1 Ref.2

Sequence similarities

Contains 16 EGF-like domains.

Contains 7 FAS1 domains.

Contains 2 laminin EGF-like domains.

Contains 1 Link domain.

Sequence caution

The sequence BAA13377.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Ontologies

Keywords
   Biological processInflammatory response
   Cellular componentMembrane
   Coding sequence diversityAlternative splicing
Polymorphism
   DomainEGF-like domain
Laminin EGF-like domain
Repeat
Signal
Transmembrane
Transmembrane helix
   Molecular functionReceptor
   PTMDisulfide bond
Glycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processcell adhesion

Non-traceable author statement Ref.2. Source: UniProtKB

cell-cell signaling

Inferred from direct assay Ref.2. Source: UniProtKB

defense response to bacterium

Inferred from direct assay Ref.2. Source: UniProtKB

inflammatory response

Inferred from electronic annotation. Source: UniProtKB-KW

negative regulation of angiogenesis

Inferred from mutant phenotype Ref.2. Source: UniProtKB

oxidation-reduction process

Non-traceable author statement Ref.2. Source: GOC

receptor-mediated endocytosis

Traceable author statement Ref.2. Source: UniProtKB

   Cellular_componentendocytic vesicle membrane

Traceable author statement. Source: Reactome

integral component of plasma membrane

Inferred from direct assay Ref.2. Source: UniProtKB

plasma membrane

Traceable author statement. Source: Reactome

   Molecular_functionhyaluronic acid binding

Inferred from electronic annotation. Source: InterPro

low-density lipoprotein particle binding

Inferred from direct assay Ref.2. Source: UniProtKB

low-density lipoprotein receptor activity

Inferred from direct assay Ref.2. Source: UniProtKB

protein disulfide oxidoreductase activity

Non-traceable author statement Ref.2. Source: UniProtKB

scavenger receptor activity

Inferred from direct assay Ref.2. Source: UniProtKB

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 Ref.2 (identifier: Q9NY15-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 Ref.2 (identifier: Q9NY15-2)

The sequence of this isoform differs from the canonical sequence as follows:
     746-803: CSDGIQGNGA...RPGSGGVCQQ → VSPILSWGEV...IISHILIKNN
     804-2570: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2525 Potential
Chain26 – 25702545Stabilin-1
PRO_0000007710

Regions

Topological domain26 – 24782453Extracellular Potential
Transmembrane2479 – 249921Helical; Potential
Topological domain2500 – 257071Cytoplasmic Potential
Domain110 – 14839EGF-like 1
Domain156 – 19338EGF-like 2
Domain195 – 22935EGF-like 3
Domain232 – 27140EGF-like 4
Domain356 – 494139FAS1 1
Domain506 – 641136FAS1 2
Domain728 – 76841EGF-like 5
Domain818 – 85841EGF-like 6
Domain861 – 90343EGF-like 7
Domain904 – 94643EGF-like 8
Domain947 – 98640EGF-like 9
Domain988 – 1118131FAS1 3
Domain1128 – 1253126FAS1 4
Domain1327 – 139266Laminin EGF-like 1
Domain1416 – 145439EGF-like 10
Domain1455 – 149642EGF-like 11
Domain1497 – 153943EGF-like 12
Domain1540 – 158243EGF-like 13
Domain1582 – 1708127FAS1 5
Domain1724 – 1864141FAS1 6
Domain1966 – 203166Laminin EGF-like 2
Domain2056 – 209035EGF-like 14
Domain2091 – 213141EGF-like 15
Domain2132 – 217443EGF-like 16
Domain2206 – 230196Link
Domain2322 – 2459138FAS1 7

Amino acid modifications

Glycosylation1331N-linked (GlcNAc...) Potential
Glycosylation2861N-linked (GlcNAc...) Potential
Glycosylation3121N-linked (GlcNAc...) Potential
Glycosylation4131N-linked (GlcNAc...) Potential
Glycosylation6061N-linked (GlcNAc...) Potential
Glycosylation6731N-linked (GlcNAc...) Potential
Glycosylation7121N-linked (GlcNAc...) Potential
Glycosylation7451N-linked (GlcNAc...) Potential
Glycosylation8161N-linked (GlcNAc...) Potential
Glycosylation10871N-linked (GlcNAc...) Potential
Glycosylation10961N-linked (GlcNAc...) Ref.8
Glycosylation11701N-linked (GlcNAc...) Potential
Glycosylation11781N-linked (GlcNAc...) Potential
Glycosylation12221N-linked (GlcNAc...) Potential
Glycosylation12741N-linked (GlcNAc...) Potential
Glycosylation13781N-linked (GlcNAc...) Potential
Glycosylation14711N-linked (GlcNAc...) Potential
Glycosylation16261N-linked (GlcNAc...) Ref.8
Glycosylation17271N-linked (GlcNAc...) Ref.8
Glycosylation21071N-linked (GlcNAc...) Potential
Glycosylation22221N-linked (GlcNAc...) Potential
Glycosylation22611N-linked (GlcNAc...) Potential
Glycosylation22901N-linked (GlcNAc...) Potential
Glycosylation23341N-linked (GlcNAc...) Potential
Glycosylation23471N-linked (GlcNAc...) Ref.8
Glycosylation23791N-linked (GlcNAc...) Potential
Glycosylation23931N-linked (GlcNAc...) Potential
Glycosylation24001N-linked (GlcNAc...) Potential
Glycosylation24241N-linked (GlcNAc...) Ref.8
Disulfide bond112 ↔ 126 By similarity
Disulfide bond120 ↔ 136 By similarity
Disulfide bond138 ↔ 147 By similarity
Disulfide bond160 ↔ 171 By similarity
Disulfide bond164 ↔ 181 By similarity
Disulfide bond183 ↔ 192 By similarity
Disulfide bond199 ↔ 210 By similarity
Disulfide bond204 ↔ 217 By similarity
Disulfide bond236 ↔ 247 By similarity
Disulfide bond241 ↔ 257 By similarity
Disulfide bond259 ↔ 270 By similarity
Disulfide bond732 ↔ 746 By similarity
Disulfide bond740 ↔ 756 By similarity
Disulfide bond758 ↔ 767 By similarity
Disulfide bond822 ↔ 837 By similarity
Disulfide bond831 ↔ 846 By similarity
Disulfide bond865 ↔ 879 By similarity
Disulfide bond873 ↔ 889 By similarity
Disulfide bond891 ↔ 902 By similarity
Disulfide bond908 ↔ 922 By similarity
Disulfide bond916 ↔ 932 By similarity
Disulfide bond934 ↔ 945 By similarity
Disulfide bond951 ↔ 964 By similarity
Disulfide bond958 ↔ 974 By similarity
Disulfide bond1332 ↔ 1346 By similarity
Disulfide bond1340 ↔ 1356 By similarity
Disulfide bond1358 ↔ 1367 By similarity
Disulfide bond1379 ↔ 1390 By similarity
Disulfide bond1383 ↔ 1400 By similarity
Disulfide bond1402 ↔ 1411 By similarity
Disulfide bond1420 ↔ 1430 By similarity
Disulfide bond1424 ↔ 1440 By similarity
Disulfide bond1442 ↔ 1453 By similarity
Disulfide bond1459 ↔ 1472 By similarity
Disulfide bond1466 ↔ 1482 By similarity
Disulfide bond1484 ↔ 1495 By similarity
Disulfide bond1501 ↔ 1514 By similarity
Disulfide bond1508 ↔ 1524 By similarity
Disulfide bond1526 ↔ 1538 By similarity
Disulfide bond1544 ↔ 1557 By similarity
Disulfide bond1551 ↔ 1567 By similarity
Disulfide bond1569 ↔ 1581 By similarity
Disulfide bond1971 ↔ 1985 By similarity
Disulfide bond1979 ↔ 1995 By similarity
Disulfide bond1997 ↔ 2006 By similarity
Disulfide bond2018 ↔ 2029 By similarity
Disulfide bond2023 ↔ 2039 By similarity
Disulfide bond2041 ↔ 2050 By similarity
Disulfide bond2060 ↔ 2070 By similarity
Disulfide bond2064 ↔ 2076 By similarity
Disulfide bond2078 ↔ 2089 By similarity
Disulfide bond2095 ↔ 2108 By similarity
Disulfide bond2102 ↔ 2117 By similarity
Disulfide bond2119 ↔ 2130 By similarity
Disulfide bond2136 ↔ 2150 By similarity
Disulfide bond2144 ↔ 2160 By similarity
Disulfide bond2162 ↔ 2173 By similarity
Disulfide bond2230 ↔ 2299 By similarity
Disulfide bond2254 ↔ 2275 By similarity

Natural variations

Alternative sequence746 – 80358CSDGI…GVCQQ → VSPILSWGEVWGTQGLLHRL ASDWLCVWAKPATLALGFSY LCSGKLDQIISHILIKNN in isoform 2. Ref.2
VSP_050764
Alternative sequence804 – 25701767Missing in isoform 2. Ref.2
VSP_050765
Natural variant6721L → M.
Corresponds to variant rs12636502 [ dbSNP | Ensembl ].
VAR_060338
Natural variant9121M → V. Ref.1 Ref.2 Ref.3 Ref.6
Corresponds to variant rs9835659 [ dbSNP | Ensembl ].
VAR_060339
Natural variant11271G → R.
Corresponds to variant rs2286786 [ dbSNP | Ensembl ].
VAR_055774
Natural variant18331A → P. Ref.1 Ref.3 Ref.6
Corresponds to variant rs7630214 [ dbSNP | Ensembl ].
VAR_060340
Natural variant22821I → V. Ref.1
Corresponds to variant rs4434138 [ dbSNP | Ensembl ].
VAR_055775
Natural variant25061M → T.
Corresponds to variant rs13303 [ dbSNP | Ensembl ].
VAR_019078

Experimental info

Sequence conflict9131R → G in CAB61827. Ref.1
Sequence conflict22001L → Q in CAB61827. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified May 18, 2010. Version 3.
Checksum: FA55D191D9D30FAD

FASTA2,570275,482
        10         20         30         40         50         60 
MAGPRGLLPL CLLAFCLAGF SFVRGQVLFK GCDVKTTFVT HVPCTSCAAI KKQTCPSGWL 

        70         80         90        100        110        120 
RELPDQITQD CRYEVQLGGS MVSMSGCRRK CRKQVVQKAC CPGYWGSRCH ECPGGAETPC 

       130        140        150        160        170        180 
NGHGTCLDGM DRNGTCVCQE NFRGSACQEC QDPNRFGPDC QSVCSCVHGV CNHGPRGDGS 

       190        200        210        220        230        240 
CLCFAGYTGP HCDQELPVCQ ELRCPQNTQC SAEAPSCRCL PGYTQQGSEC RAPNPCWPSP 

       250        260        270        280        290        300 
CSLLAQCSVS PKGQAQCHCP ENYHGDGMVC LPKDPCTDNL GGCPSNSTLC VYQKPGQAFC 

       310        320        330        340        350        360 
TCRPGLVSIN SNASAGCFAF CSPFSCDRSA TCQVTADGKT SCVCRESEVG DGRACYGHLL 

       370        380        390        400        410        420 
HEVQKATQTG RVFLQLRVAV AMMDQGCREI LTTAGPFTVL VPSVSSFSSR TMNASLAQQL 

       430        440        450        460        470        480 
CRQHIIAGQH ILEDTRTQQT RRWWTLAGQE ITVTFNQFTK YSYKYKDQPQ QTFNIYKANN 

       490        500        510        520        530        540 
IAANGVFHVV TGLRWQAPSG TPGDPKRTIG QILASTEAFS RFETILENCG LPSILDGPGP 

       550        560        570        580        590        600 
FTVFAPSNEA VDSLRDGRLI YLFTAGLSKL QELVRYHIYN HGQLTVEKLI SKGRILTMAN 

       610        620        630        640        650        660 
QVLAVNISEE GRILLGPEGV PLQRVDVMAA NGVIHMLDGI LLPPTILPIL PKHCSEEQHK 

       670        680        690        700        710        720 
IVAGSCVDCQ ALNTSTCPPN SVKLDIFPKE CVYIHDPTGL NVLKKGCASY CNQTIMEQGC 

       730        740        750        760        770        780 
CKGFFGPDCT QCPGGFSNPC YGKGNCSDGI QGNGACLCFP DYKGIACHIC SNPNKHGEQC 

       790        800        810        820        830        840 
QEDCGCVHGL CDNRPGSGGV CQQGTCAPGF SGRFCNESMG DCGPTGLAQH CHLHARCVSQ 

       850        860        870        880        890        900 
EGVARCRCLD GFEGDGFSCT PSNPCSHPDR GGCSENAECV PGSLGTHHCT CHKGWSGDGR 

       910        920        930        940        950        960 
VCVAIDECEL DMRGGCHTDA LCSYVGPGQS RCTCKLGFAG DGYQCSPIDP CRAGNGGCHG 

       970        980        990       1000       1010       1020 
LATCRAVGGG QRVCTCPPGF GGDGFSCYGD IFRELEANAH FSIFYQWLKS AGITLPADRR 

      1030       1040       1050       1060       1070       1080 
VTALVPSEAA VRQLSPEDRA FWLQPRTLPN LVRAHFLQGA LFEEELARLG GQEVATLNPT 

      1090       1100       1110       1120       1130       1140 
TRWEIRNISG RVWVQNASVD VADLLATNGV LHILSQVLLP PRGDVPGGQG LLQQLDLVPA 

      1150       1160       1170       1180       1190       1200 
FSLFRELLQH HGLVPQIEAA TAYTIFVPTN RSLEAQGNSS HLDADTVRHH VVLGEALSME 

      1210       1220       1230       1240       1250       1260 
TLRKGGHRNS LLGPAHWIVF YNHSGQPEVN HVPLEGPMLE APGRSLIGLS GVLTVGSSRC 

      1270       1280       1290       1300       1310       1320 
LHSHAEALRE KCVNCTRRFR CTQGFQLQDT PRKSCVYRSG FSFSRGCSYT CAKKIQVPDC 

      1330       1340       1350       1360       1370       1380 
CPGFFGTLCE PCPGGLGGVC SGHGQCQDRF LGSGECHCHE GFHGTACEVC ELGRYGPNCT 

      1390       1400       1410       1420       1430       1440 
GVCDCAHGLC QEGLQGDGSC VCNVGWQGLR CDQKITSPQC PRKCDPNANC VQDSAGASTC 

      1450       1460       1470       1480       1490       1500 
ACAAGYSGNG IFCSEVDPCA HGHGGCSPHA NCTKVAPGQR TCTCQDGYMG DGELCQEINS 

      1510       1520       1530       1540       1550       1560 
CLIHHGGCHI HAECIPTGPQ QVSCSCREGY SGDGIRTCEL LDPCSKNNGG CSPYATCKST 

      1570       1580       1590       1600       1610       1620 
GDGQRTCTCD TAHTVGDGLT CRARVGLELL RDKHASFFSL RLLEYKELKG DGPFTIFVPH 

      1630       1640       1650       1660       1670       1680 
ADLMSNLSQD ELARIRAHRQ LVFRYHVVGC RRLRSEDLLE QGYATALSGH PLRFSEREGS 

      1690       1700       1710       1720       1730       1740 
IYLNDFARVV SSDHEAVNGI LHFIDRVLLP PEALHWEPDD APIPRRNVTA AAQGFGYKIF 

      1750       1760       1770       1780       1790       1800 
SGLLKVAGLL PLLREASHRP FTMLWPTDAA FRALPPDRQA WLYHEDHRDK LAAILRGHMI 

      1810       1820       1830       1840       1850       1860 
RNVEALASDL PNLGPLRTMH GTPISFSCSR TRAGELMVGE DDARIVQRHL PFEGGLAYGI 

      1870       1880       1890       1900       1910       1920 
DQLLEPPGLG ARCDHFETRP LRLNTCSICG LEPPCPEGSQ EQGSPEACWR FYPKFWTSPP 

      1930       1940       1950       1960       1970       1980 
LHSLGLRSVW VHPSLWGRPQ GLGRGCHRNC VTTTWKPSCC PGHYGSECQA CPGGPSSPCS 

      1990       2000       2010       2020       2030       2040 
DRGVCMDGMS GSGQCLCRSG FAGTACELCA PGAFGPHCQA CRCTVHGRCD EGLGGSGSCF 

      2050       2060       2070       2080       2090       2100 
CDEGWTGPRC EVQLELQPVC TPPCAPEAVC RAGNSCECSL GYEGDGRVCT VADLCQDGHG 

      2110       2120       2130       2140       2150       2160 
GCSEHANCSQ VGTMVTCTCL PDYEGDGWSC RARNPCTDGH RGGCSEHANC LSTGLNTRRC 

      2170       2180       2190       2200       2210       2220 
ECHAGYVGDG LQCLEESEPP VDRCLGQPPP CHSDAMCTDL HFQEKRAGVF HLQATSGPYG 

      2230       2240       2250       2260       2270       2280 
LNFSEAEAAC EAQGAVLASF PQLSAAQQLG FHLCLMGWLA NGSTAHPVVF PVADCGNGRV 

      2290       2300       2310       2320       2330       2340 
GIVSLGARKN LSERWDAYCF RVQDVACRCR NGFVGDGIST CNGKLLDVLA ATANFSTFYG 

      2350       2360       2370       2380       2390       2400 
MLLGYANATQ RGLDFLDFLD DELTYKTLFV PVNEGFVDNM TLSGPDLELH ASNATLLSAN 

      2410       2420       2430       2440       2450       2460 
ASQGKLLPAH SGLSLIISDA GPDNSSWAPV APGTVVVSRI IVWDIMAFNG IIHALASPLL 

      2470       2480       2490       2500       2510       2520 
APPQPQAVLA PEAPPVAAGV GAVLAAGALL GLVAGALYLR ARGKPMGFGF SAFQAEDDAD 

      2530       2540       2550       2560       2570 
DDFSPWQEGT NPTLVSVPNP VFGSDTFCEP FDDSLLEEDF PDTQRILTVK 

« Hide

Isoform 2 [UniParc].

Checksum: 1A833922D0F223FB
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FASTA80387,026

References

« Hide 'large scale' references
[1]"Stabilin-1 and -2 constitute a novel family of fasciclin-like hyaluronan receptor homologues."
Politz O., Gratchev A., McCourt P.A.G., Schledzewski K., Guillot P., Johansson S., Svineng G., Franke P., Kannicht C., Kzhyshkowska J., Longati P., Velten F.W., Johansson S., Goerdt S.
Biochem. J. 362:155-164(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, VARIANTS VARIANTS VAL-912; PRO-1833 AND VAL-2282.
[2]"FEEL-1, a novel scavenger receptor with in vitro bacteria-binding and angiogenesis-modulating activities."
Adachi H., Tsujimoto M.
J. Biol. Chem. 277:34264-34270(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), FUNCTION, TISSUE SPECIFICITY, VARIANT VAL-912.
[3]"Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain."
Nagase T., Seki N., Ishikawa K., Ohira M., Kawarabayasi Y., Ohara O., Tanaka A., Kotani H., Miyajima N., Nomura N.
DNA Res. 3:321-329(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANTS VAL-912 AND PRO-1833.
Tissue: Brain.
[4]"Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."
Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T.
DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: SEQUENCE REVISION.
[5]"The DNA sequence, annotation and analysis of human chromosome 3."
Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J. expand/collapse author list , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANTS VAL-912 AND PRO-1833.
[7]"Novel stabilin-1 interacting chitinase-like protein (SI-CLP) is up-regulated in alternatively activated macrophages and secreted via lysosomal pathway."
Kzhyshkowska J., Mamidi S., Gratchev A., Kremmer E., Schmuttermaier C., Krusell L., Haus G., Utikal J., Schledzewski K., Scholtze J., Goerdt S.
Blood 107:3221-3228(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, INTERACTION WITH CHID1.
[8]"Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-1096; ASN-1626; ASN-1727; ASN-2347 AND ASN-2424.
Tissue: Liver.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ275213 mRNA. Translation: CAB61827.1.
AB052956 mRNA. Translation: BAC15606.1.
AB052957 mRNA. Translation: BAC15607.1.
D87433 mRNA. Translation: BAA13377.2. Different initiation.
AC006208 Genomic DNA. No translation available.
AC112215 Genomic DNA. No translation available.
BC150250 mRNA. Translation: AAI50251.1.
RefSeqNP_055951.2. NM_015136.2.
UniGeneHs.301989.

3D structure databases

ProteinModelPortalQ9NY15.
SMRQ9NY15. Positions 29-356, 518-643, 728-983, 1320-1578, 1939-2199, 2208-2300, 2315-2463.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid116778. 5 interactions.
IntActQ9NY15. 71 interactions.
MINTMINT-4831401.
STRING9606.ENSP00000312946.

PTM databases

PhosphoSiteQ9NY15.

Polymorphism databases

DMDM296452949.

Proteomic databases

PaxDbQ9NY15.
PRIDEQ9NY15.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000321725; ENSP00000312946; ENSG00000010327. [Q9NY15-1]
GeneID23166.
KEGGhsa:23166.
UCSCuc003dei.1. human. [Q9NY15-2]
uc003dej.3. human. [Q9NY15-1]

Organism-specific databases

CTD23166.
GeneCardsGC03P052529.
H-InvDBHIX0003360.
HGNCHGNC:18628. STAB1.
HPAHPA005434.
MIM608560. gene.
neXtProtNX_Q9NY15.
PharmGKBPA38610.
HUGESearch...
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG2335.
HOGENOMHOG000154436.
HOVERGENHBG079218.
InParanoidQ9NY15.
OMACIPTGPQ.
OrthoDBEOG7PS1DH.
PhylomeDBQ9NY15.
TreeFamTF331489.

Enzyme and pathway databases

ReactomeREACT_160300. Binding and Uptake of Ligands by Scavenger Receptors.

Gene expression databases

BgeeQ9NY15.
CleanExHS_STAB1.
GenevestigatorQ9NY15.

Family and domain databases

Gene3D2.30.180.10. 7 hits.
2.40.155.10. 3 hits.
3.10.100.10. 1 hit.
InterProIPR016186. C-type_lectin-like.
IPR016187. C-type_lectin_fold.
IPR000742. EG-like_dom.
IPR013032. EGF-like_CS.
IPR024731. EGF_dom_MSP1-like.
IPR002049. EGF_laminin.
IPR000782. FAS1_domain.
IPR023413. GFP_like.
IPR000538. Link.
[Graphical view]
PfamPF12947. EGF_3. 5 hits.
PF02469. Fasciclin. 6 hits.
PF00193. Xlink. 1 hit.
[Graphical view]
SMARTSM00181. EGF. 17 hits.
SM00180. EGF_Lam. 1 hit.
SM00554. FAS1. 7 hits.
SM00445. LINK. 1 hit.
[Graphical view]
SUPFAMSSF56436. SSF56436. 1 hit.
SSF82153. SSF82153. 8 hits.
PROSITEPS00022. EGF_1. 7 hits.
PS01186. EGF_2. 16 hits.
PS50026. EGF_3. 20 hits.
PS01248. EGF_LAM_1. 2 hits.
PS50213. FAS1. 7 hits.
PS01241. LINK_1. 1 hit.
PS50963. LINK_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSSTAB1. human.
GeneWikiSTAB1.
GenomeRNAi23166.
NextBio44560.
PROQ9NY15.
SOURCESearch...

Entry information

Entry nameSTAB1_HUMAN
AccessionPrimary (citable) accession number: Q9NY15
Secondary accession number(s): A7E297 expand/collapse secondary AC list , Q8IUH0, Q8IUH1, Q93072
Entry history
Integrated into UniProtKB/Swiss-Prot: July 5, 2004
Last sequence update: May 18, 2010
Last modified: April 16, 2014
This is version 119 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 3

Human chromosome 3: entries, gene names and cross-references to MIM