Q9NXZ1 (SAGE1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Sarcoma antigen 1

Alternative name(s):
Cancer/testis antigen 14
Short name=CT14

Gene names

Name:	SAGE1
Synonyms:	SAGE

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	904 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Tissue specificity

Expressed mainly in bladder, lung, head and neck carcinomas. Not expressed in normal tissues except for testis. Ref.1

Ontologies

Keywords
Coding sequence diversity	Polymorphism
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	nucleus Inferred from direct assay. Source: HPA
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 904	904	Sarcoma antigen 1		PRO_0000286971
Natural variations
	Natural variant	741	1	N → K. Corresponds to variant rs35470903 [ dbSNP | Ensembl ].		VAR_032243
	Natural variant	805	1	L → S. Ref.1 Corresponds to variant rs4829799 [ dbSNP | Ensembl ].		VAR_032244

Sequences

	Sequence		Length	Mass (Da)
	Q9NXZ1 [UniParc]. Last modified May 15, 2007. Version 2. Checksum: 0537E3F0E1858CE5	FASTA	904	99,225
	10 20 30 40 50 60 MQASPLQTSQ PTPPEELHAA AYVFTNDGQQ MRSDEVNLVA TGHQSKKKHS RKSKRHSSSK 70 80 90 100 110 120 RRKSMSSWLD KQEDAAVTHS ICEERINNGQ PVADNVLSTA PPWPDATIAH NIREERMENG 130 140 150 160 170 180 QSRTDKVLST APPQLVHMAA AGIPSMSTRD LHSTVTHNIR EERMENGQPQ PDNVLSTGPT 190 200 210 220 230 240 GLINMAATPI PAMSARDLYA TVTHNVCEQK MENVQPAPDN VLLTLRPRRI NMTDTGISPM 250 260 270 280 290 300 STRDPYATIT YNVPEEKMEK GQPQPDNILS TASTGLINVA GAGTPAISTN GLYSTVPHNV 310 320 330 340 350 360 CEEKMENDQP QPNNVLSTVQ PVIIYLTATG IPGMNTRDQY ATITHNVCEE RVVNNQPLPS 370 380 390 400 410 420 NALSTVLPGL AYLATADMPA MSTRDQHATI IHNLREEKKD NSQPTPDNVL SAVTPELINL 430 440 450 460 470 480 AGAGIPPMST RDQYATVNHH VHEARMENGQ RKQDNVLSNV LSGLINMAGA SIPAMSSRDL 490 500 510 520 530 540 YATITHSVRE EKMESGKPQT DKVISNDAPQ LGHMAAGGIP SMSTKDLYAT VTQNVHEERM 550 560 570 580 590 600 ENNQPQPSYD LSTVLPGLTY LTVAGIPAMS TRDQYATVTH NVHEEKIKNG QAASDNVFST 610 620 630 640 650 660 VPPAFINMAA TGVSSMSTRD QYAAVTHNIR EEKINNSQPA PGNILSTAPP WLRHMAAAGI 670 680 690 700 710 720 SSTITRDLYV TATHSVHEEK MTNGQQAPDN SLSTVPPGCI NLSGAGISCR STRDLYATVI 730 740 750 760 770 780 HDIQEEEMEN DQTPPDGFLS NSDSPELINM TGHCMPPNAL DSFSHDFTSL SKDELLYKPD 790 800 810 820 830 840 SNEFAVGTKN YSVSAGDPPV TVMSLVETVP NTPQISPAMA KKINDDIKYQ LMKEVRRFGQ 850 860 870 880 890 900 NYERIFILLE EVQGSMKVKR QFVEFTIKEA ARFKKVVLIQ QLEKALKEID SHCHLRKVKH MRKR

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Identification on a human sarcoma of two new genes with tumor-specific expression." Martelange V.M.F., De Smet C., De Plaen E., Lurquin C., Boon T. Cancer Res. 60:3848-3855(2000) [PubMed: 10919659] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, VARIANT SER-805.
[2]	"The DNA sequence of the human X chromosome." Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C. , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R. Nature 434:325-337(2005) [PubMed: 15772651] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ278111 mRNA. Translation: CAB92443.1. AL953870 Genomic DNA. Translation: CAI41374.1.
IPI	IPI00032901.
RefSeq	NP_061136.2. NM_018666.2.
UniGene	Hs.195292.
3D structure databases
ProteinModelPortal	Q9NXZ1.
ModBase	Search...
Protein-protein interaction databases
STRING	Q9NXZ1.
Polymorphism databases
DMDM	147732638.
Proteomic databases
PRIDE	Q9NXZ1.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000324447; ENSP00000323191; ENSG00000181433. ENST00000370709; ENSP00000359743; ENSG00000181433.
GeneID	55511.
KEGG	hsa:55511.
UCSC	uc004ezh.1. human.
Organism-specific databases
CTD	55511.
GeneCards	GC0XP134971.
H-InvDB	HIX0056182.
HGNC	HGNC:30369. SAGE1.
HPA	HPA003033. HPA003208.
MIM	300359. gene.
neXtProt	NX_Q9NXZ1.
PharmGKB	PA134909712.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG20231.
GeneTree	ENSGT00390000016655.
HOVERGEN	HBG108482.
InParanoid	Q9NXZ1.
OMA	THNIREE.
OrthoDB	EOG49KFPW.
PhylomeDB	Q9NXZ1.
Gene expression databases
ArrayExpress	Q9NXZ1.
Bgee	Q9NXZ1.
CleanEx	HS_SAGE1.
Genevestigator	Q9NXZ1.
Family and domain databases
ProtoNet	Search...
Other
NextBio	59922.
SOURCE	Search...

Entry information

Entry name

SAGE1_HUMAN

Accession

Primary (citable) accession number: Q9NXZ1
Secondary accession number(s): Q5JNW0

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 15, 2007
Last sequence update:	May 15, 2007
Last modified:	January 25, 2012
This is version 50 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.