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Protein

Sarcoma antigen 1

Gene

SAGE1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Sarcoma antigen 1
Alternative name(s):
Cancer/testis antigen 14
Short name:
CT14
Gene namesi
Name:SAGE1
Synonyms:SAGE
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

HGNCiHGNC:30369. SAGE1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134909712.

Polymorphism and mutation databases

BioMutaiSAGE1.
DMDMi147732638.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 904904Sarcoma antigen 1PRO_0000286971Add
BLAST

Proteomic databases

MaxQBiQ9NXZ1.
PaxDbiQ9NXZ1.
PRIDEiQ9NXZ1.

PTM databases

iPTMnetiQ9NXZ1.
PhosphoSiteiQ9NXZ1.

Expressioni

Tissue specificityi

Expressed mainly in bladder, lung, head and neck carcinomas. Not expressed in normal tissues except for testis.1 Publication

Gene expression databases

BgeeiQ9NXZ1.
CleanExiHS_SAGE1.
ExpressionAtlasiQ9NXZ1. baseline and differential.
GenevisibleiQ9NXZ1. HS.

Organism-specific databases

HPAiHPA003033.
HPA003208.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000323191.

Structurei

3D structure databases

ProteinModelPortaliQ9NXZ1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiENOG410J0UH. Eukaryota.
ENOG410Z00D. LUCA.
GeneTreeiENSGT00390000016655.
HOGENOMiHOG000154247.
HOVERGENiHBG108482.
InParanoidiQ9NXZ1.
OMAiTVTHNVC.
PhylomeDBiQ9NXZ1.
TreeFamiTF323386.

Family and domain databases

InterProiIPR029307. INT_SG_DDX_CT_C.
[Graphical view]
PfamiPF15300. INT_SG_DDX_CT_C. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9NXZ1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQASPLQTSQ PTPPEELHAA AYVFTNDGQQ MRSDEVNLVA TGHQSKKKHS
60 70 80 90 100
RKSKRHSSSK RRKSMSSWLD KQEDAAVTHS ICEERINNGQ PVADNVLSTA
110 120 130 140 150
PPWPDATIAH NIREERMENG QSRTDKVLST APPQLVHMAA AGIPSMSTRD
160 170 180 190 200
LHSTVTHNIR EERMENGQPQ PDNVLSTGPT GLINMAATPI PAMSARDLYA
210 220 230 240 250
TVTHNVCEQK MENVQPAPDN VLLTLRPRRI NMTDTGISPM STRDPYATIT
260 270 280 290 300
YNVPEEKMEK GQPQPDNILS TASTGLINVA GAGTPAISTN GLYSTVPHNV
310 320 330 340 350
CEEKMENDQP QPNNVLSTVQ PVIIYLTATG IPGMNTRDQY ATITHNVCEE
360 370 380 390 400
RVVNNQPLPS NALSTVLPGL AYLATADMPA MSTRDQHATI IHNLREEKKD
410 420 430 440 450
NSQPTPDNVL SAVTPELINL AGAGIPPMST RDQYATVNHH VHEARMENGQ
460 470 480 490 500
RKQDNVLSNV LSGLINMAGA SIPAMSSRDL YATITHSVRE EKMESGKPQT
510 520 530 540 550
DKVISNDAPQ LGHMAAGGIP SMSTKDLYAT VTQNVHEERM ENNQPQPSYD
560 570 580 590 600
LSTVLPGLTY LTVAGIPAMS TRDQYATVTH NVHEEKIKNG QAASDNVFST
610 620 630 640 650
VPPAFINMAA TGVSSMSTRD QYAAVTHNIR EEKINNSQPA PGNILSTAPP
660 670 680 690 700
WLRHMAAAGI SSTITRDLYV TATHSVHEEK MTNGQQAPDN SLSTVPPGCI
710 720 730 740 750
NLSGAGISCR STRDLYATVI HDIQEEEMEN DQTPPDGFLS NSDSPELINM
760 770 780 790 800
TGHCMPPNAL DSFSHDFTSL SKDELLYKPD SNEFAVGTKN YSVSAGDPPV
810 820 830 840 850
TVMSLVETVP NTPQISPAMA KKINDDIKYQ LMKEVRRFGQ NYERIFILLE
860 870 880 890 900
EVQGSMKVKR QFVEFTIKEA ARFKKVVLIQ QLEKALKEID SHCHLRKVKH

MRKR
Length:904
Mass (Da):99,225
Last modified:May 15, 2007 - v2
Checksum:i0537E3F0E1858CE5
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti741 – 7411N → K.
Corresponds to variant rs35470903 [ dbSNP | Ensembl ].
VAR_032243
Natural varianti805 – 8051L → S.1 Publication
Corresponds to variant rs4829799 [ dbSNP | Ensembl ].
VAR_032244

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ278111 mRNA. Translation: CAB92443.1.
AL953870 Genomic DNA. Translation: CAI41374.1.
CCDSiCCDS14652.1.
RefSeqiNP_061136.2. NM_018666.2.
UniGeneiHs.195292.

Genome annotation databases

EnsembliENST00000324447; ENSP00000323191; ENSG00000181433.
ENST00000370709; ENSP00000359743; ENSG00000181433.
GeneIDi55511.
KEGGihsa:55511.
UCSCiuc065bgk.1. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ278111 mRNA. Translation: CAB92443.1.
AL953870 Genomic DNA. Translation: CAI41374.1.
CCDSiCCDS14652.1.
RefSeqiNP_061136.2. NM_018666.2.
UniGeneiHs.195292.

3D structure databases

ProteinModelPortaliQ9NXZ1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000323191.

PTM databases

iPTMnetiQ9NXZ1.
PhosphoSiteiQ9NXZ1.

Polymorphism and mutation databases

BioMutaiSAGE1.
DMDMi147732638.

Proteomic databases

MaxQBiQ9NXZ1.
PaxDbiQ9NXZ1.
PRIDEiQ9NXZ1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000324447; ENSP00000323191; ENSG00000181433.
ENST00000370709; ENSP00000359743; ENSG00000181433.
GeneIDi55511.
KEGGihsa:55511.
UCSCiuc065bgk.1. human.

Organism-specific databases

CTDi55511.
GeneCardsiSAGE1.
H-InvDBHIX0056182.
HGNCiHGNC:30369. SAGE1.
HPAiHPA003033.
HPA003208.
MIMi300359. gene.
neXtProtiNX_Q9NXZ1.
PharmGKBiPA134909712.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J0UH. Eukaryota.
ENOG410Z00D. LUCA.
GeneTreeiENSGT00390000016655.
HOGENOMiHOG000154247.
HOVERGENiHBG108482.
InParanoidiQ9NXZ1.
OMAiTVTHNVC.
PhylomeDBiQ9NXZ1.
TreeFamiTF323386.

Miscellaneous databases

GenomeRNAii55511.
PROiQ9NXZ1.
SOURCEiSearch...

Gene expression databases

BgeeiQ9NXZ1.
CleanExiHS_SAGE1.
ExpressionAtlasiQ9NXZ1. baseline and differential.
GenevisibleiQ9NXZ1. HS.

Family and domain databases

InterProiIPR029307. INT_SG_DDX_CT_C.
[Graphical view]
PfamiPF15300. INT_SG_DDX_CT_C. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Identification on a human sarcoma of two new genes with tumor-specific expression."
    Martelange V.M.F., De Smet C., De Plaen E., Lurquin C., Boon T.
    Cancer Res. 60:3848-3855(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, VARIANT SER-805.
  2. "The DNA sequence of the human X chromosome."
    Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
    , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
    Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.

Entry informationi

Entry nameiSAGE1_HUMAN
AccessioniPrimary (citable) accession number: Q9NXZ1
Secondary accession number(s): Q5JNW0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: May 15, 2007
Last modified: June 8, 2016
This is version 81 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.