Reviewed,
UniProtKB/Swiss-Prot Q9NXW9 (ALKB4_HUMAN)
Last modified
November 24, 2009.
Version 51.
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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Alternative products · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents
Names and origin
| Protein names | Recommended name: Alkylated DNA repair protein alkB homolog 4 | ||
| Gene names |
| ||
| Organism | Homo sapiens (Human) [Complete proteome] | ||
| Taxonomic identifier | 9606 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 302 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Sequence similarities | Belongs to the alkB family. |
| Sequence caution | The sequence BAB15358.1 differs from that shown. Reason: Erroneous translation. Wrong choice of CDS. |
Ontologies
| Keywords | |
|---|---|
| Coding sequence diversity | Alternative splicing |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| None. [Check GOA] | |
Alternative products
| This entry describes 2 isoforms produced by alternative splicing. [Align] [Select] | ||||||
| Isoform 1 (identifier: Q9NXW9-1) This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. | ||||||
| Isoform 2 (identifier: Q9NXW9-2) The sequence of this isoform differs from the canonical sequence as follows: 42-42: K → E 43-302: Missing. | ||||||
| Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. No experimental confirmation available. |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 302 | 302 | Alkylated DNA repair protein alkB homolog 4 | PRO_0000239281 | |||||
Natural variations | |||||||||
| Alternative sequence | 42 | 1 | K → E in isoform 2. | VSP_019128 | |||||
| Alternative sequence | 43 – 302 | 260 | Missing in isoform 2. | VSP_036841 | |||||
Experimental info | |||||||||
| Sequence conflict | 210 | 1 | A → V in BAD96409. Ref.2 | ||||||
Sequences
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References
| [1] | "Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. Sugano S.Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2). Tissue: Adipose tissue and Epithelium. |
| [2] | Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S. Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Brain. |
| [3] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Lung and Placenta. |
| [4] | Colinge J., Superti-Furga G., Bennett K.L. Submitted (OCT-2008) to UniProtKB Cited for: IDENTIFICATION [LARGE SCALE ANALYSIS], MASS SPECTROMETRY. |
Cross-references
Sequence databases | |
|---|---|
| AK000020 mRNA. Translation: BAA90888.1. AK026097 mRNA. Translation: BAB15358.1. Sequence problems. AK222689 mRNA. Translation: BAD96409.1. BC002820 mRNA. Translation: AAH02820.1. BC017096 mRNA. Translation: AAH17096.1. | |
| IPI | IPI00033770. IPI00759604. |
| RefSeq | NP_060091.1. |
| UniGene | Hs.658598 |
3D structure databases | |
| ModBase | Search... |
Proteomic databases | |
| PRIDE | Q9NXW9. |
Genome annotation databases | |
| Ensembl | ENST00000292566; ENSP00000292566; ENSG00000160993; Homo sapiens. [Genome view] |
| GeneID | 54784. |
| KEGG | hsa:54784. |
| UCSC | uc003uzl.1. human. uc003uzm.1. human. |
Organism-specific databases | |
| CTD | 54784. |
| GeneCards | GC07M101883. |
| HGNC | HGNC:21900. ALKBH4. |
| GenAtlas | Search... |
Phylogenomic databases | |
| HOGENOM | Q9NXW9. |
| HOVERGEN | Q9NXW9. |
| OMA | DAWLWGE |
| OrthoDB | EOG9J13TC |
Gene expression databases | |
| ArrayExpress | Q9NXW9. |
| Bgee | Q9NXW9. |
| CleanEx | HS_ALKBH4. |
| Genevestigator | Q9NXW9. |
| GermOnline | ENSG00000160993. Homo sapiens. |
Family and domain databases | |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 57445. |
Entry information
| Entry name | ALKB4_HUMAN | ||||||||
| Accession | Primary (citable) accession number: Q9NXW9 Secondary accession number(s): Q53H92, Q9H6A4 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
| Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. | ||||||||
Relevant documents
| Human chromosome 7 Human chromosome 7: entries, gene names and cross-references to MIM |
| SIMILARITY comments Index of protein domains and families |

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