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Protein

CDKN2A-interacting protein

Gene

CDKN2AIP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Regulates DNA damage response in a dose-dependent manner through a number of signaling pathways involved in cell proliferation, apoptosis and senescence.2 Publications

GO - Molecular functioni

  • p53 binding Source: BHF-UCL
  • RNA binding Source: UniProtKB-KW

GO - Biological processi

  • cellular response to DNA damage stimulus Source: UniProtKB
  • negative regulation of cell growth Source: BHF-UCL
  • positive regulation of cell growth Source: UniProtKB
  • positive regulation of signal transduction Source: BHF-UCL
  • regulation of protein stability Source: BHF-UCL
  • regulation of transcription, DNA-templated Source: GO_Central
Complete GO annotation...

Keywords - Ligandi

RNA-binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000167207-MONOMER.
SIGNORiQ9NXV6.

Names & Taxonomyi

Protein namesi
Recommended name:
CDKN2A-interacting protein
Alternative name(s):
Collaborator of ARF
Gene namesi
Name:CDKN2AIP
Synonyms:CARF
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

HGNCiHGNC:24325. CDKN2AIP.

Subcellular locationi

GO - Cellular componenti

  • granular component Source: BHF-UCL
  • nucleolus Source: BHF-UCL
  • nucleoplasm Source: BHF-UCL
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000168564.
PharmGKBiPA162382149.

Polymorphism and mutation databases

BioMutaiCDKN2AIP.
DMDMi327478591.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources1 Publication
ChainiPRO_00003243392 – 580CDKN2A-interacting proteinAdd BLAST579

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1 Publication1
Modified residuei131PhosphoserineCombined sources1
Cross-linki184Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)Combined sources
Modified residuei241PhosphoserineBy similarity1
Modified residuei346PhosphothreonineCombined sources1
Modified residuei389PhosphoserineCombined sources1

Post-translational modificationi

May be ubiquitinated.

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ9NXV6.
MaxQBiQ9NXV6.
PaxDbiQ9NXV6.
PeptideAtlasiQ9NXV6.
PRIDEiQ9NXV6.

PTM databases

iPTMnetiQ9NXV6.
PhosphoSitePlusiQ9NXV6.

Expressioni

Tissue specificityi

Ubiquitously expressed.1 Publication

Inductioni

Up-regulated during replicative senescence, in response to DNA-damaging drugs, telomere unprotection and oncogenic Ras-induced stress. Induced by proteasomal inhibitor MG132. Up-regulated at G1 and G2 stages of cell cycle.1 Publication

Gene expression databases

BgeeiENSG00000168564.
CleanExiHS_CDKN2AIP.
ExpressionAtlasiQ9NXV6. baseline and differential.
GenevisibleiQ9NXV6. HS.

Organism-specific databases

HPAiHPA041397.
HPA062142.

Interactioni

Subunit structurei

Interacts with CDKN2A/p14ARF, p53/TP53 and MDM2. Interacts with CHEK2 and MAPK3. Interacts with XRN2 (PubMed:24462208).6 Publications

GO - Molecular functioni

  • p53 binding Source: BHF-UCL

Protein-protein interaction databases

BioGridi120743. 55 interactors.
DIPiDIP-24170N.
IntActiQ9NXV6. 28 interactors.
MINTiMINT-5010033.
STRINGi9606.ENSP00000427108.

Structurei

3D structure databases

ProteinModelPortaliQ9NXV6.
SMRiQ9NXV6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini19 – 124XTBDSequence analysisAdd BLAST106
Domaini462 – 537DRBMPROSITE-ProRule annotationAdd BLAST76

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi175 – 425Ser-richAdd BLAST251

Sequence similaritiesi

Belongs to the CARF family.Curated
Contains 1 DRBM (double-stranded RNA-binding) domain.PROSITE-ProRule annotation
Contains 1 XTBD domain.Curated

Phylogenomic databases

eggNOGiENOG410IE8W. Eukaryota.
ENOG4111PSZ. LUCA.
GeneTreeiENSGT00530000063234.
HOGENOMiHOG000049179.
HOVERGENiHBG101830.
InParanoidiQ9NXV6.
OMAiVSFSMAW.
OrthoDBiEOG091G0HNZ.
PhylomeDBiQ9NXV6.
TreeFamiTF333807.

Family and domain databases

Gene3Di3.30.160.20. 1 hit.
InterProiIPR014720. dsRBD_dom.
IPR021859. XTBD.
[Graphical view]
PfamiPF11952. XTBD. 1 hit.
[Graphical view]
PROSITEiPS50137. DS_RBD. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9NXV6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAQEVSEYLS QNPRVAAWVE ALRCDGETDK HWRHRRDFLL RNAGDLAPAG
60 70 80 90 100
GAASASTDEA ADAESGTRNR QLQQLISFSM AWANHVFLGC RYPQKVMDKI
110 120 130 140 150
LSMAEGIKVT DAPTYTTRDE LVAKVKKRGI SSSNEGVEEP SKKRVIEGKN
160 170 180 190 200
SSAVEQDHAK TSAKTERASA QQENSSTCIG SAIKSESGNS ARSSGISSQN
210 220 230 240 250
SSTSDGDRSV SSQSSSSVSS QVTTAGSGKA SEAEAPDKHG SASFVSLLKS
260 270 280 290 300
SVNSHMTQST DSRQQSGSPK KSALEGSSAS ASQSSSEIEV PLLGSSGSSE
310 320 330 340 350
VELPLLSSKP SSETASSGLT SKTSSEASVS SSVAKNSSSS GTSLLTPKSS
360 370 380 390 400
SSTNTSLLTS KSTSQVAASL LASKSSSQTS GSLVSKSTSL ASVSQLASKS
410 420 430 440 450
SSQTSTSQLP SKSTSQSSES SVKFSCKLTN EDVKQKQPFF NRLYKTVAWK
460 470 480 490 500
LVAVGGFSPN VNHGELLNAA IEALKATLDV FFVPLKELAD LPQNKSSQES
510 520 530 540 550
IVCELRCKSV YLGTGCGKSK ENAKAVASRE ALKLFLKKKV VVKICKRKYR
560 570 580
GSEIEDLVLL DEESRPVNLP PALKHPQELL
Length:580
Mass (Da):61,125
Last modified:April 5, 2011 - v3
Checksum:i5CFCB5DFEE50A475
GO

Sequence cautioni

The sequence AAF68967 differs from that shown. Reason: Frameshift at position 4.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti242Missing in EAX04691 (Ref. 3) Curated1
Sequence conflicti242Missing in AAH22270 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF246705 mRNA. Translation: AAF68967.1. Frameshift.
AK000043 mRNA. Translation: BAA90902.1.
CH471056 Genomic DNA. Translation: EAX04691.1.
BC022270 mRNA. Translation: AAH22270.1.
CCDSiCCDS34110.1.
RefSeqiNP_001304272.1. NM_001317343.1.
NP_060102.1. NM_017632.3.
UniGeneiHs.592508.
Hs.644077.

Genome annotation databases

EnsembliENST00000504169; ENSP00000427108; ENSG00000168564.
GeneIDi55602.
KEGGihsa:55602.
UCSCiuc003ivp.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF246705 mRNA. Translation: AAF68967.1. Frameshift.
AK000043 mRNA. Translation: BAA90902.1.
CH471056 Genomic DNA. Translation: EAX04691.1.
BC022270 mRNA. Translation: AAH22270.1.
CCDSiCCDS34110.1.
RefSeqiNP_001304272.1. NM_001317343.1.
NP_060102.1. NM_017632.3.
UniGeneiHs.592508.
Hs.644077.

3D structure databases

ProteinModelPortaliQ9NXV6.
SMRiQ9NXV6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120743. 55 interactors.
DIPiDIP-24170N.
IntActiQ9NXV6. 28 interactors.
MINTiMINT-5010033.
STRINGi9606.ENSP00000427108.

PTM databases

iPTMnetiQ9NXV6.
PhosphoSitePlusiQ9NXV6.

Polymorphism and mutation databases

BioMutaiCDKN2AIP.
DMDMi327478591.

Proteomic databases

EPDiQ9NXV6.
MaxQBiQ9NXV6.
PaxDbiQ9NXV6.
PeptideAtlasiQ9NXV6.
PRIDEiQ9NXV6.

Protocols and materials databases

DNASUi55602.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000504169; ENSP00000427108; ENSG00000168564.
GeneIDi55602.
KEGGihsa:55602.
UCSCiuc003ivp.2. human.

Organism-specific databases

CTDi55602.
GeneCardsiCDKN2AIP.
H-InvDBHIX0004662.
HGNCiHGNC:24325. CDKN2AIP.
HPAiHPA041397.
HPA062142.
MIMi615914. gene.
neXtProtiNX_Q9NXV6.
OpenTargetsiENSG00000168564.
PharmGKBiPA162382149.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IE8W. Eukaryota.
ENOG4111PSZ. LUCA.
GeneTreeiENSGT00530000063234.
HOGENOMiHOG000049179.
HOVERGENiHBG101830.
InParanoidiQ9NXV6.
OMAiVSFSMAW.
OrthoDBiEOG091G0HNZ.
PhylomeDBiQ9NXV6.
TreeFamiTF333807.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000167207-MONOMER.
SIGNORiQ9NXV6.

Miscellaneous databases

GenomeRNAii55602.
PROiQ9NXV6.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000168564.
CleanExiHS_CDKN2AIP.
ExpressionAtlasiQ9NXV6. baseline and differential.
GenevisibleiQ9NXV6. HS.

Family and domain databases

Gene3Di3.30.160.20. 1 hit.
InterProiIPR014720. dsRBD_dom.
IPR021859. XTBD.
[Graphical view]
PfamiPF11952. XTBD. 1 hit.
[Graphical view]
PROSITEiPS50137. DS_RBD. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCARF_HUMAN
AccessioniPrimary (citable) accession number: Q9NXV6
Secondary accession number(s): Q8TBM5, Q9NYH0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: April 5, 2011
Last modified: November 2, 2016
This is version 112 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.