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Protein

CDKN2A-interacting protein

Gene

CDKN2AIP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regulates DNA damage response in a dose-dependent manner through a number of signaling pathways involved in cell proliferation, apoptosis and senescence.2 Publications

GO - Molecular functioni

  • p53 binding Source: BHF-UCL
  • RNA binding Source: UniProtKB-KW

GO - Biological processi

  • cellular response to DNA damage stimulus Source: UniProtKB
  • negative regulation of cell growth Source: BHF-UCL
  • positive regulation of cell growth Source: UniProtKB
  • positive regulation of signal transduction Source: BHF-UCL
  • regulation of protein stability Source: BHF-UCL

Keywordsi

Molecular functionRNA-binding

Enzyme and pathway databases

SIGNORiQ9NXV6

Names & Taxonomyi

Protein namesi
Recommended name:
CDKN2A-interacting protein
Alternative name(s):
Collaborator of ARF
Gene namesi
Name:CDKN2AIP
Synonyms:CARF
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

EuPathDBiHostDB:ENSG00000168564.5
HGNCiHGNC:24325 CDKN2AIP
MIMi615914 gene
neXtProtiNX_Q9NXV6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000168564
PharmGKBiPA162382149

Polymorphism and mutation databases

BioMutaiCDKN2AIP
DMDMi327478591

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources1 Publication
ChainiPRO_00003243392 – 580CDKN2A-interacting proteinAdd BLAST579

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1 Publication1
Modified residuei131PhosphoserineCombined sources1
Cross-linki184Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)Combined sources
Modified residuei241PhosphoserineBy similarity1
Modified residuei346PhosphothreonineCombined sources1
Modified residuei389PhosphoserineCombined sources1

Post-translational modificationi

May be ubiquitinated.

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ9NXV6
MaxQBiQ9NXV6
PaxDbiQ9NXV6
PeptideAtlasiQ9NXV6
PRIDEiQ9NXV6
ProteomicsDBi83138

PTM databases

iPTMnetiQ9NXV6
PhosphoSitePlusiQ9NXV6

Expressioni

Tissue specificityi

Ubiquitously expressed.1 Publication

Inductioni

Up-regulated during replicative senescence, in response to DNA-damaging drugs, telomere unprotection and oncogenic Ras-induced stress. Induced by proteasomal inhibitor MG132. Up-regulated at G1 and G2 stages of cell cycle.1 Publication

Gene expression databases

BgeeiENSG00000168564
CleanExiHS_CDKN2AIP
ExpressionAtlasiQ9NXV6 baseline and differential
GenevisibleiQ9NXV6 HS

Organism-specific databases

HPAiHPA041397
HPA062142

Interactioni

Subunit structurei

Interacts with CDKN2A/p14ARF, p53/TP53 and MDM2. Interacts with CHEK2 and MAPK3. Interacts with XRN2 (PubMed:24462208).6 Publications

GO - Molecular functioni

  • p53 binding Source: BHF-UCL

Protein-protein interaction databases

BioGridi120743, 57 interactors
DIPiDIP-24170N
IntActiQ9NXV6, 28 interactors
MINTiQ9NXV6
STRINGi9606.ENSP00000427108

Structurei

3D structure databases

ProteinModelPortaliQ9NXV6
SMRiQ9NXV6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini19 – 133XRN2-binding (XTBD)PROSITE-ProRule annotationAdd BLAST115
Domaini462 – 537DRBMPROSITE-ProRule annotationAdd BLAST76

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi175 – 425Ser-richAdd BLAST251

Sequence similaritiesi

Belongs to the CARF family.Curated

Phylogenomic databases

eggNOGiENOG410IE8W Eukaryota
ENOG4111PSZ LUCA
GeneTreeiENSGT00530000063234
HOGENOMiHOG000049179
HOVERGENiHBG101830
InParanoidiQ9NXV6
OMAiRCEGETD
OrthoDBiEOG091G0HNZ
PhylomeDBiQ9NXV6
TreeFamiTF333807

Family and domain databases

InterProiView protein in InterPro
IPR014720 dsRBD_dom
IPR021859 XTBD
IPR037526 XTBD_dom_prot
PANTHERiPTHR16148 PTHR16148, 2 hits
PfamiView protein in Pfam
PF11952 XTBD, 1 hit
PROSITEiView protein in PROSITE
PS50137 DS_RBD, 1 hit
PS51827 XTBD, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9NXV6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAQEVSEYLS QNPRVAAWVE ALRCDGETDK HWRHRRDFLL RNAGDLAPAG
60 70 80 90 100
GAASASTDEA ADAESGTRNR QLQQLISFSM AWANHVFLGC RYPQKVMDKI
110 120 130 140 150
LSMAEGIKVT DAPTYTTRDE LVAKVKKRGI SSSNEGVEEP SKKRVIEGKN
160 170 180 190 200
SSAVEQDHAK TSAKTERASA QQENSSTCIG SAIKSESGNS ARSSGISSQN
210 220 230 240 250
SSTSDGDRSV SSQSSSSVSS QVTTAGSGKA SEAEAPDKHG SASFVSLLKS
260 270 280 290 300
SVNSHMTQST DSRQQSGSPK KSALEGSSAS ASQSSSEIEV PLLGSSGSSE
310 320 330 340 350
VELPLLSSKP SSETASSGLT SKTSSEASVS SSVAKNSSSS GTSLLTPKSS
360 370 380 390 400
SSTNTSLLTS KSTSQVAASL LASKSSSQTS GSLVSKSTSL ASVSQLASKS
410 420 430 440 450
SSQTSTSQLP SKSTSQSSES SVKFSCKLTN EDVKQKQPFF NRLYKTVAWK
460 470 480 490 500
LVAVGGFSPN VNHGELLNAA IEALKATLDV FFVPLKELAD LPQNKSSQES
510 520 530 540 550
IVCELRCKSV YLGTGCGKSK ENAKAVASRE ALKLFLKKKV VVKICKRKYR
560 570 580
GSEIEDLVLL DEESRPVNLP PALKHPQELL
Length:580
Mass (Da):61,125
Last modified:April 5, 2011 - v3
Checksum:i5CFCB5DFEE50A475
GO

Sequence cautioni

The sequence AAF68967 differs from that shown. Reason: Frameshift at position 4.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti242Missing in EAX04691 (Ref. 3) Curated1
Sequence conflicti242Missing in AAH22270 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF246705 mRNA Translation: AAF68967.1 Frameshift.
AK000043 mRNA Translation: BAA90902.1
CH471056 Genomic DNA Translation: EAX04691.1
BC022270 mRNA Translation: AAH22270.1
CCDSiCCDS34110.1
RefSeqiNP_001304272.1, NM_001317343.1
NP_060102.1, NM_017632.3
UniGeneiHs.592508
Hs.644077

Genome annotation databases

EnsembliENST00000504169; ENSP00000427108; ENSG00000168564
GeneIDi55602
KEGGihsa:55602
UCSCiuc003ivp.2 human

Similar proteinsi

Entry informationi

Entry nameiCARF_HUMAN
AccessioniPrimary (citable) accession number: Q9NXV6
Secondary accession number(s): Q8TBM5, Q9NYH0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: April 5, 2011
Last modified: June 20, 2018
This is version 121 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

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