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Q9NXV2

- KCTD5_HUMAN

UniProt

Q9NXV2 - KCTD5_HUMAN

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Protein

BTB/POZ domain-containing protein KCTD5

Gene

KCTD5

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Its interaction with CUL3 suggests that it may act as a substrate adapter in some E3 ligase complex. Does not affect the function of Kv channel Kv2.1/KCNB1, Kv1.2/KCNA2, Kv4.2/KCND2 and Kv3.4/KCNC4.

GO - Molecular functioni

  1. protein complex binding Source: MGI

GO - Biological processi

  1. protein homooligomerization Source: InterPro
  2. viral process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Host-virus interaction

Names & Taxonomyi

Protein namesi
Recommended name:
BTB/POZ domain-containing protein KCTD5
Gene namesi
Name:KCTD5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 16

Organism-specific databases

HGNCiHGNC:21423. KCTD5.

Subcellular locationi

Cytoplasmcytosol. Nucleus
Note: Predominantly cytoplasmic, translocated to the nucleus upon interaction with Rep proteins.

GO - Cellular componenti

  1. cytosol Source: UniProtKB
  2. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134923177.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed2 Publications
Chaini2 – 234233BTB/POZ domain-containing protein KCTD5PRO_0000191291Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanine2 Publications
Modified residuei10 – 101Phosphoserine1 Publication

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ9NXV2.
PaxDbiQ9NXV2.
PRIDEiQ9NXV2.

PTM databases

PhosphoSiteiQ9NXV2.

Expressioni

Inductioni

Up-regulated in peripheral blood lymphocytes stimulated through the T-cell receptor.1 Publication

Gene expression databases

BgeeiQ9NXV2.
ExpressionAtlasiQ9NXV2. baseline and differential.
GenevestigatoriQ9NXV2.

Interactioni

Subunit structurei

Homopentamer. Interacts (via C-terminus) with GRASP55/GORASP2. Interacts with CUL3 and with ubiquitinated proteins. Interacts with adeno-associated virus 2 (AAV-2) REP proteins.3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
Rep68P031323EBI-1056857,EBI-7387242From a different organism.

Protein-protein interaction databases

BioGridi119958. 21 interactions.
IntActiQ9NXV2. 9 interactions.
STRINGi9606.ENSP00000301738.

Structurei

Secondary structure

1
234
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi45 – 506
Beta strandi53 – 586
Helixi59 – 624
Helixi69 – 746
Helixi78 – 836
Beta strandi90 – 923
Helixi96 – 10813
Beta strandi115 – 1173
Helixi119 – 12911
Helixi132 – 14413
Turni146 – 1483
Beta strandi157 – 1637
Helixi167 – 1737
Beta strandi180 – 1867
Beta strandi201 – 2077

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3DRXX-ray3.11A/B/C/D/E34-234[»]
3DRYX-ray3.30A/B/C/D/E34-234[»]
3DRZX-ray1.90A/B/C/D/E40-145[»]
ProteinModelPortaliQ9NXV2.
SMRiQ9NXV2. Positions 35-211.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9NXV2.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini44 – 146103BTBAdd
BLAST

Domaini

The BTB (POZ) domain is atypical and mediates the formation of a homopentamer instead of a homotetramer. Homopentamerization is due to the presence of 4 residues in the BTB (POZ) domain: Leu-56, Gly-100, Val-112 and Ala-118.1 Publication

Sequence similaritiesi

Contains 1 BTB (POZ) domain.Curated

Phylogenomic databases

eggNOGiNOG267996.
GeneTreeiENSGT00530000062980.
HOGENOMiHOG000231167.
HOVERGENiHBG053302.
InParanoidiQ9NXV2.
OMAiFINSRKS.
OrthoDBiEOG7JDQZF.
PhylomeDBiQ9NXV2.
TreeFamiTF313754.

Family and domain databases

Gene3Di3.30.710.10. 1 hit.
InterProiIPR000210. BTB/POZ-like.
IPR011333. BTB/POZ_fold.
IPR003131. T1-type_BTB.
[Graphical view]
PfamiPF02214. BTB_2. 1 hit.
[Graphical view]
SMARTiSM00225. BTB. 1 hit.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9NXV2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAENHCELLS PARGGIGAGL GGGLCRRCSA GLGALAQRPG SVSKWVRLNV
60 70 80 90 100
GGTYFLTTRQ TLCRDPKSFL YRLCQADPDL DSDKDETGAY LIDRDPTYFG
110 120 130 140 150
PVLNYLRHGK LVINKDLAEE GVLEEAEFYN ITSLIKLVKD KIRERDSKTS
160 170 180 190 200
QVPVKHVYRV LQCQEEELTQ MVSTMSDGWK FEQLVSIGSS YNYGNEDQAE
210 220 230
FLCVVSKELH NTPYGTASEP SEKAKILQER GSRM
Length:234
Mass (Da):26,093
Last modified:October 1, 2000 - v1
Checksum:i22097CF5F41CD43D
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti178 – 1781G → R(PubMed:17239418)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK000047 mRNA. Translation: BAA90906.1.
CH471112 Genomic DNA. Translation: EAW85489.1.
CH471112 Genomic DNA. Translation: EAW85491.1.
BC007314 mRNA. Translation: AAH07314.1.
CCDSiCCDS10475.1.
RefSeqiNP_061865.1. NM_018992.3.
UniGeneiHs.61960.

Genome annotation databases

EnsembliENST00000301738; ENSP00000301738; ENSG00000167977.
GeneIDi54442.
KEGGihsa:54442.
UCSCiuc002crd.3. human.

Polymorphism databases

DMDMi50401182.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK000047 mRNA. Translation: BAA90906.1 .
CH471112 Genomic DNA. Translation: EAW85489.1 .
CH471112 Genomic DNA. Translation: EAW85491.1 .
BC007314 mRNA. Translation: AAH07314.1 .
CCDSi CCDS10475.1.
RefSeqi NP_061865.1. NM_018992.3.
UniGenei Hs.61960.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3DRX X-ray 3.11 A/B/C/D/E 34-234 [» ]
3DRY X-ray 3.30 A/B/C/D/E 34-234 [» ]
3DRZ X-ray 1.90 A/B/C/D/E 40-145 [» ]
ProteinModelPortali Q9NXV2.
SMRi Q9NXV2. Positions 35-211.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 119958. 21 interactions.
IntActi Q9NXV2. 9 interactions.
STRINGi 9606.ENSP00000301738.

PTM databases

PhosphoSitei Q9NXV2.

Polymorphism databases

DMDMi 50401182.

Proteomic databases

MaxQBi Q9NXV2.
PaxDbi Q9NXV2.
PRIDEi Q9NXV2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000301738 ; ENSP00000301738 ; ENSG00000167977 .
GeneIDi 54442.
KEGGi hsa:54442.
UCSCi uc002crd.3. human.

Organism-specific databases

CTDi 54442.
GeneCardsi GC16P002732.
HGNCi HGNC:21423. KCTD5.
MIMi 611285. gene.
neXtProti NX_Q9NXV2.
PharmGKBi PA134923177.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG267996.
GeneTreei ENSGT00530000062980.
HOGENOMi HOG000231167.
HOVERGENi HBG053302.
InParanoidi Q9NXV2.
OMAi FINSRKS.
OrthoDBi EOG7JDQZF.
PhylomeDBi Q9NXV2.
TreeFami TF313754.

Miscellaneous databases

ChiTaRSi KCTD5. human.
EvolutionaryTracei Q9NXV2.
GenomeRNAii 54442.
NextBioi 56673.
PROi Q9NXV2.
SOURCEi Search...

Gene expression databases

Bgeei Q9NXV2.
ExpressionAtlasi Q9NXV2. baseline and differential.
Genevestigatori Q9NXV2.

Family and domain databases

Gene3Di 3.30.710.10. 1 hit.
InterProi IPR000210. BTB/POZ-like.
IPR011333. BTB/POZ_fold.
IPR003131. T1-type_BTB.
[Graphical view ]
Pfami PF02214. BTB_2. 1 hit.
[Graphical view ]
SMARTi SM00225. BTB. 1 hit.
[Graphical view ]
SUPFAMi SSF54695. SSF54695. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of a cytoplasmic interaction partner of the large regulatory proteins Rep78/Rep68 of adeno-associated virus type 2 (AAV-2)."
    Weger S., Hammer E., Goetz A., Heilbronn R.
    Virology 362:192-206(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, INTERACTION WITH AAV-S REP.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Colon.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lymph.
  5. Bienvenut W.V., Heiserich L., Gottlieb E.
    Submitted (OCT-2008) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 2-13 AND 48-59, CLEAVAGE OF INITIATOR METHIONINE, ACETYLATION AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY.
    Tissue: Colon carcinoma.
  6. Cited for: POSSIBLE FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH CUL3, INDUCTION.
  7. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-10, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  9. "Pentameric assembly of potassium channel tetramerization domain-containing protein 5."
    Dementieva I.S., Tereshko V., McCrossan Z.A., Solomaha E., Araki D., Xu C., Grigorieff N., Goldstein S.A.
    J. Mol. Biol. 387:175-191(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.90 ANGSTROMS) OF 34-234, SUBUNIT, DOMAIN BTB, INTERACTION WITH GORASP2.

Entry informationi

Entry nameiKCTD5_HUMAN
AccessioniPrimary (citable) accession number: Q9NXV2
Secondary accession number(s): D3DU96
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: October 1, 2000
Last modified: October 29, 2014
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3