Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q9NXV2

- KCTD5_HUMAN

UniProt

Q9NXV2 - KCTD5_HUMAN

Protein

BTB/POZ domain-containing protein KCTD5

Gene

KCTD5

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 101 (01 Oct 2014)
      Sequence version 1 (01 Oct 2000)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Its interaction with CUL3 suggests that it may act as a substrate adapter in some E3 ligase complex. Does not affect the function of Kv channel Kv2.1/KCNB1, Kv1.2/KCNA2, Kv4.2/KCND2 and Kv3.4/KCNC4.

    GO - Molecular functioni

    1. protein binding Source: UniProtKB
    2. protein complex binding Source: MGI

    GO - Biological processi

    1. protein homooligomerization Source: InterPro
    2. viral process Source: UniProtKB-KW

    Keywords - Biological processi

    Host-virus interaction

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    BTB/POZ domain-containing protein KCTD5
    Gene namesi
    Name:KCTD5
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 16

    Organism-specific databases

    HGNCiHGNC:21423. KCTD5.

    Subcellular locationi

    Cytoplasmcytosol. Nucleus
    Note: Predominantly cytoplasmic, translocated to the nucleus upon interaction with Rep proteins.

    GO - Cellular componenti

    1. cytosol Source: UniProtKB
    2. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134923177.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed2 Publications
    Chaini2 – 234233BTB/POZ domain-containing protein KCTD5PRO_0000191291Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylalanine2 Publications
    Modified residuei10 – 101Phosphoserine1 Publication

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    MaxQBiQ9NXV2.
    PaxDbiQ9NXV2.
    PRIDEiQ9NXV2.

    PTM databases

    PhosphoSiteiQ9NXV2.

    Expressioni

    Inductioni

    Up-regulated in peripheral blood lymphocytes stimulated through the T-cell receptor.1 Publication

    Gene expression databases

    ArrayExpressiQ9NXV2.
    BgeeiQ9NXV2.
    GenevestigatoriQ9NXV2.

    Interactioni

    Subunit structurei

    Homopentamer. Interacts (via C-terminus) with GRASP55/GORASP2. Interacts with CUL3 and with ubiquitinated proteins. Interacts with adeno-associated virus 2 (AAV-2) REP proteins.3 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    Rep68P031323EBI-1056857,EBI-7387242From a different organism.

    Protein-protein interaction databases

    BioGridi119958. 18 interactions.
    IntActiQ9NXV2. 9 interactions.
    STRINGi9606.ENSP00000301738.

    Structurei

    Secondary structure

    1
    234
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi45 – 506
    Beta strandi53 – 586
    Helixi59 – 624
    Helixi69 – 746
    Helixi78 – 836
    Beta strandi90 – 923
    Helixi96 – 10813
    Beta strandi115 – 1173
    Helixi119 – 12911
    Helixi132 – 14413
    Turni146 – 1483
    Beta strandi157 – 1637
    Helixi167 – 1737
    Beta strandi180 – 1867
    Beta strandi201 – 2077

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3DRXX-ray3.11A/B/C/D/E34-234[»]
    3DRYX-ray3.30A/B/C/D/E34-234[»]
    3DRZX-ray1.90A/B/C/D/E40-145[»]
    ProteinModelPortaliQ9NXV2.
    SMRiQ9NXV2. Positions 35-211.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ9NXV2.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini44 – 146103BTBAdd
    BLAST

    Domaini

    The BTB (POZ) domain is atypical and mediates the formation of a homopentamer instead of a homotetramer. Homopentamerization is due to the presence of 4 residues in the BTB (POZ) domain: Leu-56, Gly-100, Val-112 and Ala-118.1 Publication

    Sequence similaritiesi

    Contains 1 BTB (POZ) domain.Curated

    Phylogenomic databases

    eggNOGiNOG267996.
    HOGENOMiHOG000231167.
    HOVERGENiHBG053302.
    InParanoidiQ9NXV2.
    OMAiFINSRKS.
    OrthoDBiEOG7JDQZF.
    PhylomeDBiQ9NXV2.
    TreeFamiTF313754.

    Family and domain databases

    Gene3Di3.30.710.10. 1 hit.
    InterProiIPR000210. BTB/POZ-like.
    IPR011333. BTB/POZ_fold.
    IPR003131. T1-type_BTB.
    [Graphical view]
    PfamiPF02214. BTB_2. 1 hit.
    [Graphical view]
    SMARTiSM00225. BTB. 1 hit.
    [Graphical view]
    SUPFAMiSSF54695. SSF54695. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9NXV2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAENHCELLS PARGGIGAGL GGGLCRRCSA GLGALAQRPG SVSKWVRLNV    50
    GGTYFLTTRQ TLCRDPKSFL YRLCQADPDL DSDKDETGAY LIDRDPTYFG 100
    PVLNYLRHGK LVINKDLAEE GVLEEAEFYN ITSLIKLVKD KIRERDSKTS 150
    QVPVKHVYRV LQCQEEELTQ MVSTMSDGWK FEQLVSIGSS YNYGNEDQAE 200
    FLCVVSKELH NTPYGTASEP SEKAKILQER GSRM 234
    Length:234
    Mass (Da):26,093
    Last modified:October 1, 2000 - v1
    Checksum:i22097CF5F41CD43D
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti178 – 1781G → R(PubMed:17239418)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK000047 mRNA. Translation: BAA90906.1.
    CH471112 Genomic DNA. Translation: EAW85489.1.
    CH471112 Genomic DNA. Translation: EAW85491.1.
    BC007314 mRNA. Translation: AAH07314.1.
    CCDSiCCDS10475.1.
    RefSeqiNP_061865.1. NM_018992.3.
    UniGeneiHs.61960.

    Genome annotation databases

    EnsembliENST00000301738; ENSP00000301738; ENSG00000167977.
    GeneIDi54442.
    KEGGihsa:54442.
    UCSCiuc002crd.3. human.

    Polymorphism databases

    DMDMi50401182.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK000047 mRNA. Translation: BAA90906.1 .
    CH471112 Genomic DNA. Translation: EAW85489.1 .
    CH471112 Genomic DNA. Translation: EAW85491.1 .
    BC007314 mRNA. Translation: AAH07314.1 .
    CCDSi CCDS10475.1.
    RefSeqi NP_061865.1. NM_018992.3.
    UniGenei Hs.61960.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3DRX X-ray 3.11 A/B/C/D/E 34-234 [» ]
    3DRY X-ray 3.30 A/B/C/D/E 34-234 [» ]
    3DRZ X-ray 1.90 A/B/C/D/E 40-145 [» ]
    ProteinModelPortali Q9NXV2.
    SMRi Q9NXV2. Positions 35-211.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 119958. 18 interactions.
    IntActi Q9NXV2. 9 interactions.
    STRINGi 9606.ENSP00000301738.

    PTM databases

    PhosphoSitei Q9NXV2.

    Polymorphism databases

    DMDMi 50401182.

    Proteomic databases

    MaxQBi Q9NXV2.
    PaxDbi Q9NXV2.
    PRIDEi Q9NXV2.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000301738 ; ENSP00000301738 ; ENSG00000167977 .
    GeneIDi 54442.
    KEGGi hsa:54442.
    UCSCi uc002crd.3. human.

    Organism-specific databases

    CTDi 54442.
    GeneCardsi GC16P002732.
    HGNCi HGNC:21423. KCTD5.
    MIMi 611285. gene.
    neXtProti NX_Q9NXV2.
    PharmGKBi PA134923177.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG267996.
    HOGENOMi HOG000231167.
    HOVERGENi HBG053302.
    InParanoidi Q9NXV2.
    OMAi FINSRKS.
    OrthoDBi EOG7JDQZF.
    PhylomeDBi Q9NXV2.
    TreeFami TF313754.

    Miscellaneous databases

    ChiTaRSi KCTD5. human.
    EvolutionaryTracei Q9NXV2.
    GenomeRNAii 54442.
    NextBioi 56673.
    PROi Q9NXV2.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9NXV2.
    Bgeei Q9NXV2.
    Genevestigatori Q9NXV2.

    Family and domain databases

    Gene3Di 3.30.710.10. 1 hit.
    InterProi IPR000210. BTB/POZ-like.
    IPR011333. BTB/POZ_fold.
    IPR003131. T1-type_BTB.
    [Graphical view ]
    Pfami PF02214. BTB_2. 1 hit.
    [Graphical view ]
    SMARTi SM00225. BTB. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54695. SSF54695. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Identification of a cytoplasmic interaction partner of the large regulatory proteins Rep78/Rep68 of adeno-associated virus type 2 (AAV-2)."
      Weger S., Hammer E., Goetz A., Heilbronn R.
      Virology 362:192-206(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, INTERACTION WITH AAV-S REP.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Colon.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Lymph.
    5. Bienvenut W.V., Heiserich L., Gottlieb E.
      Submitted (OCT-2008) to UniProtKB
      Cited for: PROTEIN SEQUENCE OF 2-13 AND 48-59, CLEAVAGE OF INITIATOR METHIONINE, ACETYLATION AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY.
      Tissue: Colon carcinoma.
    6. Cited for: POSSIBLE FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH CUL3, INDUCTION.
    7. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-10, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    9. "Pentameric assembly of potassium channel tetramerization domain-containing protein 5."
      Dementieva I.S., Tereshko V., McCrossan Z.A., Solomaha E., Araki D., Xu C., Grigorieff N., Goldstein S.A.
      J. Mol. Biol. 387:175-191(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.90 ANGSTROMS) OF 34-234, SUBUNIT, DOMAIN BTB, INTERACTION WITH GORASP2.

    Entry informationi

    Entry nameiKCTD5_HUMAN
    AccessioniPrimary (citable) accession number: Q9NXV2
    Secondary accession number(s): D3DU96
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 19, 2004
    Last sequence update: October 1, 2000
    Last modified: October 1, 2014
    This is version 101 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 16
      Human chromosome 16: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3