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Protein

BTB/POZ domain-containing protein KCTD5

Gene

KCTD5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Its interaction with CUL3 suggests that it may act as a substrate adapter in some E3 ligase complex. Does not affect the function of Kv channel Kv2.1/KCNB1, Kv1.2/KCNA2, Kv4.2/KCND2 and Kv3.4/KCNC4.

GO - Molecular functioni

  • cullin family protein binding Source: GO_Central
  • protein complex binding Source: MGI

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Host-virus interaction

Enzyme and pathway databases

BioCyciZFISH:ENSG00000167977-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
BTB/POZ domain-containing protein KCTD5
Gene namesi
Name:KCTD5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

HGNCiHGNC:21423. KCTD5.

Subcellular locationi

  • Cytoplasmcytosol
  • Nucleus

  • Note: Predominantly cytoplasmic, translocated to the nucleus upon interaction with Rep proteins.

GO - Cellular componenti

  • Cul3-RING ubiquitin ligase complex Source: GO_Central
  • cytosol Source: UniProtKB
  • nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000167977.
PharmGKBiPA134923177.

Polymorphism and mutation databases

BioMutaiKCTD5.
DMDMi50401182.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources1 Publication
ChainiPRO_00001912912 – 234BTB/POZ domain-containing protein KCTD5Add BLAST233

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1 Publication1
Modified residuei10PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9NXV2.
MaxQBiQ9NXV2.
PaxDbiQ9NXV2.
PeptideAtlasiQ9NXV2.
PRIDEiQ9NXV2.

PTM databases

iPTMnetiQ9NXV2.
PhosphoSitePlusiQ9NXV2.

Expressioni

Inductioni

Up-regulated in peripheral blood lymphocytes stimulated through the T-cell receptor.1 Publication

Gene expression databases

BgeeiENSG00000167977.
ExpressionAtlasiQ9NXV2. baseline and differential.
GenevisibleiQ9NXV2. HS.

Interactioni

Subunit structurei

Homopentamer. Interacts (via C-terminus) with GRASP55/GORASP2. Interacts with CUL3 and with ubiquitinated proteins. Interacts with adeno-associated virus 2 (AAV-2) REP proteins.3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
Rep68P031323EBI-1056857,EBI-7387242From a different organism.

GO - Molecular functioni

  • cullin family protein binding Source: GO_Central
  • protein complex binding Source: MGI

Protein-protein interaction databases

BioGridi119958. 29 interactors.
IntActiQ9NXV2. 14 interactors.
STRINGi9606.ENSP00000301738.

Structurei

Secondary structure

1234
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi45 – 50Combined sources6
Beta strandi53 – 58Combined sources6
Helixi59 – 62Combined sources4
Helixi69 – 74Combined sources6
Helixi78 – 83Combined sources6
Beta strandi90 – 92Combined sources3
Helixi96 – 108Combined sources13
Beta strandi115 – 117Combined sources3
Helixi119 – 129Combined sources11
Helixi132 – 144Combined sources13
Turni146 – 148Combined sources3
Beta strandi157 – 163Combined sources7
Helixi167 – 173Combined sources7
Beta strandi180 – 186Combined sources7
Turni190 – 194Combined sources5
Beta strandi201 – 207Combined sources7

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3DRXX-ray3.11A/B/C/D/E34-234[»]
3DRYX-ray3.30A/B/C/D/E34-234[»]
3DRZX-ray1.90A/B/C/D/E40-145[»]
ProteinModelPortaliQ9NXV2.
SMRiQ9NXV2.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9NXV2.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini44 – 146BTBAdd BLAST103

Domaini

The BTB (POZ) domain is atypical and mediates the formation of a homopentamer instead of a homotetramer. Homopentamerization is due to the presence of 4 residues in the BTB (POZ) domain: Leu-56, Gly-100, Val-112 and Ala-118.1 Publication

Sequence similaritiesi

Contains 1 BTB (POZ) domain.Curated

Phylogenomic databases

eggNOGiKOG2715. Eukaryota.
ENOG410XT4J. LUCA.
GeneTreeiENSGT00530000062980.
HOGENOMiHOG000231167.
HOVERGENiHBG053302.
InParanoidiQ9NXV2.
OMAiYGTNSEP.
PhylomeDBiQ9NXV2.
TreeFamiTF313754.

Family and domain databases

InterProiIPR000210. BTB/POZ_dom.
IPR011333. SKP1/BTB/POZ.
IPR003131. T1-type_BTB.
[Graphical view]
PfamiPF02214. BTB_2. 1 hit.
[Graphical view]
SMARTiSM00225. BTB. 1 hit.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9NXV2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAENHCELLS PARGGIGAGL GGGLCRRCSA GLGALAQRPG SVSKWVRLNV
60 70 80 90 100
GGTYFLTTRQ TLCRDPKSFL YRLCQADPDL DSDKDETGAY LIDRDPTYFG
110 120 130 140 150
PVLNYLRHGK LVINKDLAEE GVLEEAEFYN ITSLIKLVKD KIRERDSKTS
160 170 180 190 200
QVPVKHVYRV LQCQEEELTQ MVSTMSDGWK FEQLVSIGSS YNYGNEDQAE
210 220 230
FLCVVSKELH NTPYGTASEP SEKAKILQER GSRM
Length:234
Mass (Da):26,093
Last modified:October 1, 2000 - v1
Checksum:i22097CF5F41CD43D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti178G → R (PubMed:17239418).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK000047 mRNA. Translation: BAA90906.1.
CH471112 Genomic DNA. Translation: EAW85489.1.
CH471112 Genomic DNA. Translation: EAW85491.1.
BC007314 mRNA. Translation: AAH07314.1.
CCDSiCCDS10475.1.
RefSeqiNP_061865.1. NM_018992.3.
UniGeneiHs.61960.

Genome annotation databases

EnsembliENST00000301738; ENSP00000301738; ENSG00000167977.
GeneIDi54442.
KEGGihsa:54442.
UCSCiuc002crd.5. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK000047 mRNA. Translation: BAA90906.1.
CH471112 Genomic DNA. Translation: EAW85489.1.
CH471112 Genomic DNA. Translation: EAW85491.1.
BC007314 mRNA. Translation: AAH07314.1.
CCDSiCCDS10475.1.
RefSeqiNP_061865.1. NM_018992.3.
UniGeneiHs.61960.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3DRXX-ray3.11A/B/C/D/E34-234[»]
3DRYX-ray3.30A/B/C/D/E34-234[»]
3DRZX-ray1.90A/B/C/D/E40-145[»]
ProteinModelPortaliQ9NXV2.
SMRiQ9NXV2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119958. 29 interactors.
IntActiQ9NXV2. 14 interactors.
STRINGi9606.ENSP00000301738.

PTM databases

iPTMnetiQ9NXV2.
PhosphoSitePlusiQ9NXV2.

Polymorphism and mutation databases

BioMutaiKCTD5.
DMDMi50401182.

Proteomic databases

EPDiQ9NXV2.
MaxQBiQ9NXV2.
PaxDbiQ9NXV2.
PeptideAtlasiQ9NXV2.
PRIDEiQ9NXV2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000301738; ENSP00000301738; ENSG00000167977.
GeneIDi54442.
KEGGihsa:54442.
UCSCiuc002crd.5. human.

Organism-specific databases

CTDi54442.
GeneCardsiKCTD5.
HGNCiHGNC:21423. KCTD5.
MIMi611285. gene.
neXtProtiNX_Q9NXV2.
OpenTargetsiENSG00000167977.
PharmGKBiPA134923177.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2715. Eukaryota.
ENOG410XT4J. LUCA.
GeneTreeiENSGT00530000062980.
HOGENOMiHOG000231167.
HOVERGENiHBG053302.
InParanoidiQ9NXV2.
OMAiYGTNSEP.
PhylomeDBiQ9NXV2.
TreeFamiTF313754.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000167977-MONOMER.

Miscellaneous databases

ChiTaRSiKCTD5. human.
EvolutionaryTraceiQ9NXV2.
GenomeRNAii54442.
PROiQ9NXV2.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000167977.
ExpressionAtlasiQ9NXV2. baseline and differential.
GenevisibleiQ9NXV2. HS.

Family and domain databases

InterProiIPR000210. BTB/POZ_dom.
IPR011333. SKP1/BTB/POZ.
IPR003131. T1-type_BTB.
[Graphical view]
PfamiPF02214. BTB_2. 1 hit.
[Graphical view]
SMARTiSM00225. BTB. 1 hit.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiKCTD5_HUMAN
AccessioniPrimary (citable) accession number: Q9NXV2
Secondary accession number(s): D3DU96
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: October 1, 2000
Last modified: November 30, 2016
This is version 123 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.