ID   ARL15_HUMAN             Reviewed;         204 AA.
AC   Q9NXU5; Q6IAD0;
DT   03-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   27-MAR-2024, entry version 155.
DE   RecName: Full=ADP-ribosylation factor-like protein 15;
DE   AltName: Full=ADP-ribosylation factor-related protein 2;
DE            Short=ARF-related protein 2;
GN   Name=ARL15; Synonyms=ARFRP2;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Colon;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA   Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA   Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA   Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA   Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA   Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA   Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA   Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA   Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA   Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA   Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA   Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA   Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.;
RT   "Cloning of human full open reading frames in Gateway(TM) system entry
RT   vector (pDONR201).";
RL   Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [4]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA   Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T.,
RA   Bennett K.L., Superti-Furga G., Colinge J.;
RT   "Initial characterization of the human central proteome.";
RL   BMC Syst. Biol. 5:17-17(2011).
CC   -!- INTERACTION:
CC       Q9NXU5; Q6FHY5: MEOX2; NbExp=3; IntAct=EBI-711759, EBI-16439278;
CC       Q9NXU5; O43924: PDE6D; NbExp=4; IntAct=EBI-711759, EBI-712685;
CC       Q9NXU5; Q13432: UNC119; NbExp=4; IntAct=EBI-711759, EBI-711260;
CC   -!- SIMILARITY: Belongs to the small GTPase superfamily. Arf family.
CC       {ECO:0000305}.
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DR   EMBL; AK000058; BAA90915.1; -; mRNA.
DR   EMBL; CR457225; CAG33506.1; -; mRNA.
DR   EMBL; BC026093; AAH26093.1; -; mRNA.
DR   CCDS; CCDS54850.1; -.
DR   RefSeq; NP_061960.1; NM_019087.2.
DR   PDB; 8F6D; X-ray; 3.20 A; B/D/F/H=32-197.
DR   PDBsum; 8F6D; -.
DR   AlphaFoldDB; Q9NXU5; -.
DR   SASBDB; Q9NXU5; -.
DR   SMR; Q9NXU5; -.
DR   BioGRID; 120080; 112.
DR   IntAct; Q9NXU5; 30.
DR   MINT; Q9NXU5; -.
DR   STRING; 9606.ENSP00000433427; -.
DR   iPTMnet; Q9NXU5; -.
DR   PhosphoSitePlus; Q9NXU5; -.
DR   SwissPalm; Q9NXU5; -.
DR   BioMuta; ARL15; -.
DR   DMDM; 74734700; -.
DR   EPD; Q9NXU5; -.
DR   jPOST; Q9NXU5; -.
DR   MassIVE; Q9NXU5; -.
DR   MaxQB; Q9NXU5; -.
DR   PaxDb; 9606-ENSP00000433427; -.
DR   PeptideAtlas; Q9NXU5; -.
DR   ProteomicsDB; 83136; -.
DR   Pumba; Q9NXU5; -.
DR   Antibodypedia; 51587; 138 antibodies from 30 providers.
DR   DNASU; 54622; -.
DR   Ensembl; ENST00000504924.6; ENSP00000433427.1; ENSG00000185305.12.
DR   GeneID; 54622; -.
DR   KEGG; hsa:54622; -.
DR   MANE-Select; ENST00000504924.6; ENSP00000433427.1; NM_019087.3; NP_061960.1.
DR   UCSC; uc003jpg.1; human.
DR   AGR; HGNC:25945; -.
DR   CTD; 54622; -.
DR   DisGeNET; 54622; -.
DR   GeneCards; ARL15; -.
DR   HGNC; HGNC:25945; ARL15.
DR   HPA; ENSG00000185305; Low tissue specificity.
DR   neXtProt; NX_Q9NXU5; -.
DR   OpenTargets; ENSG00000185305; -.
DR   PharmGKB; PA134960964; -.
DR   VEuPathDB; HostDB:ENSG00000185305; -.
DR   eggNOG; KOG0071; Eukaryota.
DR   GeneTree; ENSGT00940000156244; -.
DR   InParanoid; Q9NXU5; -.
DR   OrthoDB; 3106766at2759; -.
DR   PhylomeDB; Q9NXU5; -.
DR   TreeFam; TF329693; -.
DR   PathwayCommons; Q9NXU5; -.
DR   SignaLink; Q9NXU5; -.
DR   BioGRID-ORCS; 54622; 22 hits in 1164 CRISPR screens.
DR   ChiTaRS; ARL15; human.
DR   GenomeRNAi; 54622; -.
DR   Pharos; Q9NXU5; Tbio.
DR   PRO; PR:Q9NXU5; -.
DR   Proteomes; UP000005640; Chromosome 5.
DR   RNAct; Q9NXU5; Protein.
DR   Bgee; ENSG00000185305; Expressed in endothelial cell and 180 other cell types or tissues.
DR   ExpressionAtlas; Q9NXU5; baseline and differential.
DR   GO; GO:0070062; C:extracellular exosome; HDA:UniProtKB.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR006689; Small_GTPase_ARF/SAR.
DR   PANTHER; PTHR46693; ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 15; 1.
DR   PANTHER; PTHR46693:SF1; ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 15; 1.
DR   Pfam; PF00025; Arf; 1.
DR   PRINTS; PR00328; SAR1GTPBP.
DR   SMART; SM00177; ARF; 1.
DR   SMART; SM00178; SAR; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   PROSITE; PS51417; ARF; 1.
DR   Genevisible; Q9NXU5; HS.
PE   1: Evidence at protein level;
KW   3D-structure; GTP-binding; Nucleotide-binding; Reference proteome.
FT   CHAIN           1..204
FT                   /note="ADP-ribosylation factor-like protein 15"
FT                   /id="PRO_0000282387"
FT   BINDING         39..46
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250"
FT   BINDING         82..86
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250"
FT   BINDING         142..145
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250"
FT   CONFLICT        204
FT                   /note="M -> I (in Ref. 2; CAG33506)"
FT                   /evidence="ECO:0000305"
FT   STRAND          34..41
FT                   /evidence="ECO:0007829|PDB:8F6D"
FT   HELIX           42..52
FT                   /evidence="ECO:0007829|PDB:8F6D"
FT   STRAND          79..82
FT                   /evidence="ECO:0007829|PDB:8F6D"
FT   HELIX           87..92
FT                   /evidence="ECO:0007829|PDB:8F6D"
FT   HELIX           93..95
FT                   /evidence="ECO:0007829|PDB:8F6D"
FT   STRAND          101..106
FT                   /evidence="ECO:0007829|PDB:8F6D"
FT   HELIX           113..127
FT                   /evidence="ECO:0007829|PDB:8F6D"
FT   HELIX           130..133
FT                   /evidence="ECO:0007829|PDB:8F6D"
FT   STRAND          137..141
FT                   /evidence="ECO:0007829|PDB:8F6D"
FT   HELIX           152..158
FT                   /evidence="ECO:0007829|PDB:8F6D"
FT   TURN            159..163
FT                   /evidence="ECO:0007829|PDB:8F6D"
FT   STRAND          167..172
FT                   /evidence="ECO:0007829|PDB:8F6D"
FT   HELIX           180..194
FT                   /evidence="ECO:0007829|PDB:8F6D"
SQ   SEQUENCE   204 AA;  22876 MW;  22CE5654057B734C CRC64;
     MSDLRITEAF LYMDYLCFRA LCCKGPPPAR PEYDLVCIGL TGSGKTSLLS KLCSESPDNV
     VSTTGFSIKA VPFQNAILNV KELGGADNIR KYWSRYYQGS QGVIFVLDSA SSEDDLEAAR
     NELHSALQHP QLCTLPFLIL ANHQDKPAAR SVQEIKKYFE LEPLARGKRW ILQPCSLDDM
     DALKDSFSQL INLLEEKDHE AVRM
//