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Protein

ADP-ribosylation factor-like protein 15

Gene

ARL15

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi39 – 468GTPBy similarity
Nucleotide bindingi82 – 865GTPBy similarity
Nucleotide bindingi142 – 1454GTPBy similarity

GO - Molecular functioni

  1. GTP binding Source: UniProtKB-KW

GO - Biological processi

  1. small GTPase mediated signal transduction Source: InterPro
Complete GO annotation...

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
ADP-ribosylation factor-like protein 15
Alternative name(s):
ADP-ribosylation factor-related protein 2
Short name:
ARF-related protein 2
Gene namesi
Name:ARL15
Synonyms:ARFRP2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 5

Organism-specific databases

HGNCiHGNC:25945. ARL15.

Subcellular locationi

GO - Cellular componenti

  1. extracellular vesicular exosome Source: UniProtKB
  2. intracellular Source: InterPro
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134960964.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 204204ADP-ribosylation factor-like protein 15PRO_0000282387Add
BLAST

Proteomic databases

MaxQBiQ9NXU5.
PaxDbiQ9NXU5.
PRIDEiQ9NXU5.

PTM databases

PhosphoSiteiQ9NXU5.

Expressioni

Gene expression databases

BgeeiQ9NXU5.
CleanExiHS_ARL15.
ExpressionAtlasiQ9NXU5. baseline and differential.
GenevestigatoriQ9NXU5.

Organism-specific databases

HPAiHPA044604.

Interactioni

Protein-protein interaction databases

BioGridi120080. 14 interactions.
IntActiQ9NXU5. 14 interactions.
MINTiMINT-1368894.

Structurei

3D structure databases

ProteinModelPortaliQ9NXU5.
SMRiQ9NXU5. Positions 32-190.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the small GTPase superfamily. Arf family.Curated

Phylogenomic databases

eggNOGiCOG1100.
GeneTreeiENSGT00780000121865.
HOVERGENiHBG106645.
InParanoidiQ9NXU5.
KOiK17201.
OMAiFLYMDYL.
PhylomeDBiQ9NXU5.
TreeFamiTF329693.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR024156. Small_GTPase_ARF.
IPR006689. Small_GTPase_ARF/SAR.
[Graphical view]
PfamiPF00025. Arf. 1 hit.
[Graphical view]
PRINTSiPR00328. SAR1GTPBP.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS51417. ARF. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9NXU5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSDLRITEAF LYMDYLCFRA LCCKGPPPAR PEYDLVCIGL TGSGKTSLLS
60 70 80 90 100
KLCSESPDNV VSTTGFSIKA VPFQNAILNV KELGGADNIR KYWSRYYQGS
110 120 130 140 150
QGVIFVLDSA SSEDDLEAAR NELHSALQHP QLCTLPFLIL ANHQDKPAAR
160 170 180 190 200
SVQEIKKYFE LEPLARGKRW ILQPCSLDDM DALKDSFSQL INLLEEKDHE

AVRM
Length:204
Mass (Da):22,876
Last modified:October 1, 2000 - v1
Checksum:i22CE5654057B734C
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti204 – 2041M → I in CAG33506. 1 PublicationCurated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK000058 mRNA. Translation: BAA90915.1.
CR457225 mRNA. Translation: CAG33506.1.
BC026093 mRNA. Translation: AAH26093.1.
CCDSiCCDS54850.1.
RefSeqiNP_061960.1. NM_019087.2.
UniGeneiHs.659125.

Genome annotation databases

EnsembliENST00000504924; ENSP00000433427; ENSG00000185305.
GeneIDi54622.
KEGGihsa:54622.
UCSCiuc003jpg.1. human.

Polymorphism databases

DMDMi74734700.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK000058 mRNA. Translation: BAA90915.1.
CR457225 mRNA. Translation: CAG33506.1.
BC026093 mRNA. Translation: AAH26093.1.
CCDSiCCDS54850.1.
RefSeqiNP_061960.1. NM_019087.2.
UniGeneiHs.659125.

3D structure databases

ProteinModelPortaliQ9NXU5.
SMRiQ9NXU5. Positions 32-190.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120080. 14 interactions.
IntActiQ9NXU5. 14 interactions.
MINTiMINT-1368894.

PTM databases

PhosphoSiteiQ9NXU5.

Polymorphism databases

DMDMi74734700.

Proteomic databases

MaxQBiQ9NXU5.
PaxDbiQ9NXU5.
PRIDEiQ9NXU5.

Protocols and materials databases

DNASUi54622.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000504924; ENSP00000433427; ENSG00000185305.
GeneIDi54622.
KEGGihsa:54622.
UCSCiuc003jpg.1. human.

Organism-specific databases

CTDi54622.
GeneCardsiGC05M053180.
HGNCiHGNC:25945. ARL15.
HPAiHPA044604.
neXtProtiNX_Q9NXU5.
PharmGKBiPA134960964.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG1100.
GeneTreeiENSGT00780000121865.
HOVERGENiHBG106645.
InParanoidiQ9NXU5.
KOiK17201.
OMAiFLYMDYL.
PhylomeDBiQ9NXU5.
TreeFamiTF329693.

Miscellaneous databases

ChiTaRSiARL15. human.
GenomeRNAii54622.
NextBioi57154.
PROiQ9NXU5.

Gene expression databases

BgeeiQ9NXU5.
CleanExiHS_ARL15.
ExpressionAtlasiQ9NXU5. baseline and differential.
GenevestigatoriQ9NXU5.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR024156. Small_GTPase_ARF.
IPR006689. Small_GTPase_ARF/SAR.
[Graphical view]
PfamiPF00025. Arf. 1 hit.
[Graphical view]
PRINTSiPR00328. SAR1GTPBP.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS51417. ARF. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Colon.
  2. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiARL15_HUMAN
AccessioniPrimary (citable) accession number: Q9NXU5
Secondary accession number(s): Q6IAD0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: October 1, 2000
Last modified: February 4, 2015
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.