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Q9NXU5

- ARL15_HUMAN

UniProt

Q9NXU5 - ARL15_HUMAN

Protein

ADP-ribosylation factor-like protein 15

Gene

ARL15

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 94 (01 Oct 2014)
      Sequence version 1 (01 Oct 2000)
      Previous versions | rss
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    Functioni

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi39 – 468GTPBy similarity
    Nucleotide bindingi82 – 865GTPBy similarity
    Nucleotide bindingi142 – 1454GTPBy similarity

    GO - Molecular functioni

    1. GTP binding Source: UniProtKB-KW

    GO - Biological processi

    1. small GTPase mediated signal transduction Source: InterPro

    Keywords - Ligandi

    GTP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    ADP-ribosylation factor-like protein 15
    Alternative name(s):
    ADP-ribosylation factor-related protein 2
    Short name:
    ARF-related protein 2
    Gene namesi
    Name:ARL15
    Synonyms:ARFRP2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 5

    Organism-specific databases

    HGNCiHGNC:25945. ARL15.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular vesicular exosome Source: UniProt
    2. intracellular Source: InterPro

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134960964.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 204204ADP-ribosylation factor-like protein 15PRO_0000282387Add
    BLAST

    Proteomic databases

    MaxQBiQ9NXU5.
    PaxDbiQ9NXU5.
    PRIDEiQ9NXU5.

    PTM databases

    PhosphoSiteiQ9NXU5.

    Expressioni

    Gene expression databases

    BgeeiQ9NXU5.
    CleanExiHS_ARL15.
    GenevestigatoriQ9NXU5.

    Organism-specific databases

    HPAiHPA044604.

    Interactioni

    Protein-protein interaction databases

    BioGridi120080. 14 interactions.
    IntActiQ9NXU5. 14 interactions.
    MINTiMINT-1368894.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9NXU5.
    SMRiQ9NXU5. Positions 32-190.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the small GTPase superfamily. Arf family.Curated

    Phylogenomic databases

    eggNOGiCOG1100.
    HOVERGENiHBG106645.
    KOiK17201.
    OMAiLYMDYLC.
    PhylomeDBiQ9NXU5.
    TreeFamiTF329693.

    Family and domain databases

    Gene3Di3.40.50.300. 1 hit.
    InterProiIPR027417. P-loop_NTPase.
    IPR024156. Small_GTPase_ARF.
    IPR006689. Small_GTPase_ARF/SAR.
    [Graphical view]
    PfamiPF00025. Arf. 1 hit.
    [Graphical view]
    PRINTSiPR00328. SAR1GTPBP.
    SUPFAMiSSF52540. SSF52540. 1 hit.
    PROSITEiPS51417. ARF. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9NXU5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSDLRITEAF LYMDYLCFRA LCCKGPPPAR PEYDLVCIGL TGSGKTSLLS    50
    KLCSESPDNV VSTTGFSIKA VPFQNAILNV KELGGADNIR KYWSRYYQGS 100
    QGVIFVLDSA SSEDDLEAAR NELHSALQHP QLCTLPFLIL ANHQDKPAAR 150
    SVQEIKKYFE LEPLARGKRW ILQPCSLDDM DALKDSFSQL INLLEEKDHE 200
    AVRM 204
    Length:204
    Mass (Da):22,876
    Last modified:October 1, 2000 - v1
    Checksum:i22CE5654057B734C
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti204 – 2041M → I in CAG33506. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK000058 mRNA. Translation: BAA90915.1.
    CR457225 mRNA. Translation: CAG33506.1.
    BC026093 mRNA. Translation: AAH26093.1.
    CCDSiCCDS54850.1.
    RefSeqiNP_061960.1. NM_019087.2.
    UniGeneiHs.659125.

    Genome annotation databases

    EnsembliENST00000504924; ENSP00000433427; ENSG00000185305.
    GeneIDi54622.
    KEGGihsa:54622.
    UCSCiuc003jpg.1. human.

    Polymorphism databases

    DMDMi74734700.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK000058 mRNA. Translation: BAA90915.1 .
    CR457225 mRNA. Translation: CAG33506.1 .
    BC026093 mRNA. Translation: AAH26093.1 .
    CCDSi CCDS54850.1.
    RefSeqi NP_061960.1. NM_019087.2.
    UniGenei Hs.659125.

    3D structure databases

    ProteinModelPortali Q9NXU5.
    SMRi Q9NXU5. Positions 32-190.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 120080. 14 interactions.
    IntActi Q9NXU5. 14 interactions.
    MINTi MINT-1368894.

    PTM databases

    PhosphoSitei Q9NXU5.

    Polymorphism databases

    DMDMi 74734700.

    Proteomic databases

    MaxQBi Q9NXU5.
    PaxDbi Q9NXU5.
    PRIDEi Q9NXU5.

    Protocols and materials databases

    DNASUi 54622.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000504924 ; ENSP00000433427 ; ENSG00000185305 .
    GeneIDi 54622.
    KEGGi hsa:54622.
    UCSCi uc003jpg.1. human.

    Organism-specific databases

    CTDi 54622.
    GeneCardsi GC05M053180.
    HGNCi HGNC:25945. ARL15.
    HPAi HPA044604.
    neXtProti NX_Q9NXU5.
    PharmGKBi PA134960964.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG1100.
    HOVERGENi HBG106645.
    KOi K17201.
    OMAi LYMDYLC.
    PhylomeDBi Q9NXU5.
    TreeFami TF329693.

    Miscellaneous databases

    ChiTaRSi ARL15. human.
    GenomeRNAii 54622.
    NextBioi 57154.
    PROi Q9NXU5.

    Gene expression databases

    Bgeei Q9NXU5.
    CleanExi HS_ARL15.
    Genevestigatori Q9NXU5.

    Family and domain databases

    Gene3Di 3.40.50.300. 1 hit.
    InterProi IPR027417. P-loop_NTPase.
    IPR024156. Small_GTPase_ARF.
    IPR006689. Small_GTPase_ARF/SAR.
    [Graphical view ]
    Pfami PF00025. Arf. 1 hit.
    [Graphical view ]
    PRINTSi PR00328. SAR1GTPBP.
    SUPFAMi SSF52540. SSF52540. 1 hit.
    PROSITEi PS51417. ARF. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Colon.
    2. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
      Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Testis.
    4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiARL15_HUMAN
    AccessioniPrimary (citable) accession number: Q9NXU5
    Secondary accession number(s): Q6IAD0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 3, 2007
    Last sequence update: October 1, 2000
    Last modified: October 1, 2014
    This is version 94 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 5
      Human chromosome 5: entries, gene names and cross-references to MIM
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3