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Protein

Zinc finger protein 586

Gene

ZNF586

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri88 – 11629C2H2-type 1; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri122 – 14423C2H2-type 2; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri150 – 17223C2H2-type 3; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri178 – 20023C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri206 – 22823C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri234 – 25623C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri262 – 28423C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri290 – 31223C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri317 – 33923C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri345 – 36723C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri373 – 39523C2H2-type 11PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 586
Gene namesi
Name:ZNF586
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:25949. ZNF586.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134946358.

Polymorphism and mutation databases

BioMutaiZNF586.
DMDMi215273915.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 402402Zinc finger protein 586PRO_0000241449Add
BLAST

Proteomic databases

MaxQBiQ9NXT0.
PaxDbiQ9NXT0.
PeptideAtlasiQ9NXT0.
PRIDEiQ9NXT0.

PTM databases

iPTMnetiQ9NXT0.
PhosphoSiteiQ9NXT0.

Expressioni

Gene expression databases

BgeeiQ9NXT0.
CleanExiHS_ZNF586.
ExpressionAtlasiQ9NXT0. baseline and differential.
GenevisibleiQ9NXT0. HS.

Organism-specific databases

HPAiHPA060782.

Interactioni

Protein-protein interaction databases

BioGridi120164. 3 interactions.
IntActiQ9NXT0. 2 interactions.
STRINGi9606.ENSP00000379458.

Structurei

3D structure databases

ProteinModelPortaliQ9NXT0.
SMRiQ9NXT0. Positions 9-67, 77-402.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini15 – 8773KRABPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 11 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri88 – 11629C2H2-type 1; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri122 – 14423C2H2-type 2; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri150 – 17223C2H2-type 3; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri178 – 20023C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri206 – 22823C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri234 – 25623C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri262 – 28423C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri290 – 31223C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri317 – 33923C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri345 – 36723C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri373 – 39523C2H2-type 11PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00760000119107.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ9NXT0.
OMAiGERHECG.
OrthoDBiEOG7KSX7Q.
PhylomeDBiQ9NXT0.
TreeFamiTF339848.

Family and domain databases

Gene3Di3.30.160.60. 11 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 6 hits.
PF13912. zf-C2H2_6. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 10 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 8 hits.
PS50157. ZINC_FINGER_C2H2_2. 10 hits.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9NXT0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAAAALRAP AQSSVTFEDV AVNFSLEEWS LLNEAQRCLY RDVMLETLTL
60 70 80 90 100
ISSLGCWHGG EDEAAPSKQS TCIHIYKDQG GHSGERPYEC GEYRKLFKNK
110 120 130 140 150
SCLTEPRRDH KHRNVRTGER PYECSKYGKL FHQKPTLHIH ERFHTGQKTY
160 170 180 190 200
ECSECGKSFH QSSSLLQRQT LHTRERPYEC IECGKAFAEK SSLINHRKVH
210 220 230 240 250
SGAKRYECNE CGKSFAYTSS LIKHRRIHTG ERPYECSECG RSFAENSSLI
260 270 280 290 300
KHLRVHTGER PYECVECGKS FRRSSSLLQH QRVHTRERPY ECSECGKSFS
310 320 330 340 350
LRSNLIHHQR VHTGERHECG QCGKSFSRKS SLIIHLRVHT GERPYECSDC
360 370 380 390 400
GKSFAENSSL IKHLRVHTGE RPYECIDCGK SFRHSSSFRR HQRVHTGMRP

YK
Length:402
Mass (Da):46,413
Last modified:November 25, 2008 - v2
Checksum:iFC2A189A0A0E696E
GO
Isoform 2 (identifier: Q9NXT0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     13-210: SSVTFEDVAV...SGAKRYECNE → VVGMEGKMRQ...LLKTPVLLNT
     211-402: Missing.

Note: No experimental confirmation available.
Show »
Length:210
Mass (Da):22,779
Checksum:iE8140FCD813EE424
GO
Isoform 3 (identifier: Q9NXT0-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-43: Missing.

Note: No experimental confirmation available.
Show »
Length:359
Mass (Da):41,687
Checksum:i6E79F94314EDB574
GO

Sequence cautioni

The sequence BAA90930.1 differs from that shown. Reason: Frameshift at position 145. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti306 – 3061I → T in BAG63522 (PubMed:14702039).Curated
Sequence conflicti370 – 3701E → G in BAA90930 (PubMed:14702039).Curated
Sequence conflicti393 – 3931R → G in BAA90930 (PubMed:14702039).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 4343Missing in isoform 3. 1 PublicationVSP_044808Add
BLAST
Alternative sequencei13 – 210198SSVTF…YECNE → VVGMEGKMRQHLLSRARVYI YTKTREVIVEKGLMSVGNIG NYLRTSPASLNPEEITNTGM FALEKGLMSAANMGNYFTKS LHSIFMRDFILGKRPMSAVS VENHFTKALHSCSVRHFTLE KGLMSVLNVGKPLLKSPVSL TTGKFTLEQSVMNAMNVGSP LLIHLVSLNTGGFTLERGLM SAVNVGDPLLKTPVLLNT in isoform 2. 1 PublicationVSP_043420Add
BLAST
Alternative sequencei211 – 402192Missing in isoform 2. 1 PublicationVSP_043421Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK000077 mRNA. Translation: BAA90930.1. Frameshift.
AK095993 mRNA. Translation: BAG53191.1.
AK302151 mRNA. Translation: BAG63522.1.
AC003006 Genomic DNA. No translation available.
AC010645 Genomic DNA. No translation available.
AC093037 Genomic DNA. No translation available.
CH471135 Genomic DNA. Translation: EAW72533.1.
CH471135 Genomic DNA. Translation: EAW72534.1.
BC124558 mRNA. Translation: AAI24559.2.
CCDSiCCDS42640.1. [Q9NXT0-1]
CCDS56107.1. [Q9NXT0-2]
CCDS56108.1. [Q9NXT0-3]
RefSeqiNP_001070894.1. NM_001077426.2. [Q9NXT0-2]
NP_001191743.1. NM_001204814.1. [Q9NXT0-3]
NP_060122.2. NM_017652.3. [Q9NXT0-1]
UniGeneiHs.625133.

Genome annotation databases

EnsembliENST00000391702; ENSP00000375583; ENSG00000083828. [Q9NXT0-3]
ENST00000396150; ENSP00000379454; ENSG00000083828. [Q9NXT0-2]
ENST00000396154; ENSP00000379458; ENSG00000083828. [Q9NXT0-1]
GeneIDi54807.
KEGGihsa:54807.
UCSCiuc002qqd.4. human. [Q9NXT0-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK000077 mRNA. Translation: BAA90930.1. Frameshift.
AK095993 mRNA. Translation: BAG53191.1.
AK302151 mRNA. Translation: BAG63522.1.
AC003006 Genomic DNA. No translation available.
AC010645 Genomic DNA. No translation available.
AC093037 Genomic DNA. No translation available.
CH471135 Genomic DNA. Translation: EAW72533.1.
CH471135 Genomic DNA. Translation: EAW72534.1.
BC124558 mRNA. Translation: AAI24559.2.
CCDSiCCDS42640.1. [Q9NXT0-1]
CCDS56107.1. [Q9NXT0-2]
CCDS56108.1. [Q9NXT0-3]
RefSeqiNP_001070894.1. NM_001077426.2. [Q9NXT0-2]
NP_001191743.1. NM_001204814.1. [Q9NXT0-3]
NP_060122.2. NM_017652.3. [Q9NXT0-1]
UniGeneiHs.625133.

3D structure databases

ProteinModelPortaliQ9NXT0.
SMRiQ9NXT0. Positions 9-67, 77-402.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120164. 3 interactions.
IntActiQ9NXT0. 2 interactions.
STRINGi9606.ENSP00000379458.

PTM databases

iPTMnetiQ9NXT0.
PhosphoSiteiQ9NXT0.

Polymorphism and mutation databases

BioMutaiZNF586.
DMDMi215273915.

Proteomic databases

MaxQBiQ9NXT0.
PaxDbiQ9NXT0.
PeptideAtlasiQ9NXT0.
PRIDEiQ9NXT0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000391702; ENSP00000375583; ENSG00000083828. [Q9NXT0-3]
ENST00000396150; ENSP00000379454; ENSG00000083828. [Q9NXT0-2]
ENST00000396154; ENSP00000379458; ENSG00000083828. [Q9NXT0-1]
GeneIDi54807.
KEGGihsa:54807.
UCSCiuc002qqd.4. human. [Q9NXT0-1]

Organism-specific databases

CTDi54807.
GeneCardsiZNF586.
HGNCiHGNC:25949. ZNF586.
HPAiHPA060782.
neXtProtiNX_Q9NXT0.
PharmGKBiPA134946358.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00760000119107.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ9NXT0.
OMAiGERHECG.
OrthoDBiEOG7KSX7Q.
PhylomeDBiQ9NXT0.
TreeFamiTF339848.

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Miscellaneous databases

GenomeRNAii54807.
PROiQ9NXT0.

Gene expression databases

BgeeiQ9NXT0.
CleanExiHS_ZNF586.
ExpressionAtlasiQ9NXT0. baseline and differential.
GenevisibleiQ9NXT0. HS.

Family and domain databases

Gene3Di3.30.160.60. 11 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 6 hits.
PF13912. zf-C2H2_6. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 10 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 8 hits.
PS50157. ZINC_FINGER_C2H2_2. 10 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
    Tissue: Colon and Testis.
  2. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).

Entry informationi

Entry nameiZN586_HUMAN
AccessioniPrimary (citable) accession number: Q9NXT0
Secondary accession number(s): A0JLV8
, A8MY63, B3KTS9, E7ERT1, G3XAH3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: November 25, 2008
Last modified: July 6, 2016
This is version 114 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.