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Protein

Kelch-like protein 28

Gene

KLHL28

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:ENSG00000179454-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Kelch-like protein 28
Alternative name(s):
BTB/POZ domain-containing protein 5
Gene namesi
Name:KLHL28
Synonyms:BTBD5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

HGNCiHGNC:19741. KLHL28.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000179454.
PharmGKBiPA162393472.

Polymorphism and mutation databases

BioMutaiKLHL28.
DMDMi48474985.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001190641 – 571Kelch-like protein 28Add BLAST571

Proteomic databases

PaxDbiQ9NXS3.
PRIDEiQ9NXS3.

PTM databases

iPTMnetiQ9NXS3.
PhosphoSitePlusiQ9NXS3.

Expressioni

Gene expression databases

BgeeiENSG00000179454.
CleanExiHS_KLHL28.
ExpressionAtlasiQ9NXS3. baseline and differential.
GenevisibleiQ9NXS3. HS.

Organism-specific databases

HPAiHPA000988.

Interactioni

Protein-protein interaction databases

BioGridi120170. 12 interactors.
STRINGi9606.ENSP00000379434.

Structurei

3D structure databases

ProteinModelPortaliQ9NXS3.
SMRiQ9NXS3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini35 – 102BTBPROSITE-ProRule annotationAdd BLAST68
Repeati284 – 331Kelch 1Add BLAST48
Repeati332 – 386Kelch 2Add BLAST55
Repeati387 – 433Kelch 3Add BLAST47
Repeati435 – 479Kelch 4Add BLAST45
Repeati480 – 526Kelch 5Add BLAST47
Repeati528 – 570Kelch 6Add BLAST43

Sequence similaritiesi

Contains 1 BTB (POZ) domain.PROSITE-ProRule annotation
Contains 6 Kelch repeats.Curated

Keywords - Domaini

Kelch repeat, Repeat

Phylogenomic databases

eggNOGiKOG4441. Eukaryota.
ENOG410XNX8. LUCA.
GeneTreeiENSGT00760000118931.
HOGENOMiHOG000230814.
HOVERGENiHBG014286.
InParanoidiQ9NXS3.
KOiK10464.
PhylomeDBiQ9NXS3.
TreeFamiTF329218.

Family and domain databases

Gene3Di2.130.10.80. 1 hit.
InterProiIPR011705. BACK.
IPR017096. BTB-kelch_protein.
IPR000210. BTB/POZ_dom.
IPR011043. Gal_Oxase/kelch_b-propeller.
IPR015916. Gal_Oxidase_b-propeller.
IPR006652. Kelch_1.
IPR030569. KLHL28.
IPR011333. SKP1/BTB/POZ.
[Graphical view]
PANTHERiPTHR24412:SF30. PTHR24412:SF30. 1 hit.
PfamiPF07707. BACK. 1 hit.
PF00651. BTB. 1 hit.
PF01344. Kelch_1. 5 hits.
[Graphical view]
PIRSFiPIRSF037037. Kelch-like_protein_gigaxonin. 1 hit.
SMARTiSM00875. BACK. 1 hit.
SM00225. BTB. 1 hit.
SM00612. Kelch. 6 hits.
[Graphical view]
SUPFAMiSSF50965. SSF50965. 2 hits.
SSF54695. SSF54695. 1 hit.
PROSITEiPS50097. BTB. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9NXS3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDHTSPTYML ANLTHLHSEQ LLQGLNLLRQ HHELCDIILR VGDVKIHAHK
60 70 80 90 100
VVLASVSPYF KAMFTGNLSE KENSEVEFQC IDETALQAIV EYAYTGTVFI
110 120 130 140 150
SQDTVESLLP AANLLQIKLV LKECCAFLES QLDPGNCIGI SRFAETYGCR
160 170 180 190 200
DLYLAATKYI CQNFEAVCQT EEFFELTHAD LDEIVSNDCL NVATEETVFY
210 220 230 240 250
ALESWIKYDV QERQKYLAQL LNSVRLPLLS VKFLTRLYEA NHLIRDDRTC
260 270 280 290 300
KHLLNEALKY HFMPEHRLSH QTVLMTRPRC APKVLCAVGG KSGLFACLDS
310 320 330 340 350
VEMYFPQNDS WIGLAPLNIP RYEFGICVLD QKVYVIGGIA TNVRPGVTIR
360 370 380 390 400
KHENSVECWN PDTNTWTSLE RMNESRSTLG VVVLAGELYA LGGYDGQSYL
410 420 430 440 450
QSVEKYIPKI RKWQPVAPMT TTRSCFAAAV LDGMIYAIGG YGPAHMNSVE
460 470 480 490 500
RYDPSKDSWE MVASMADKRI HFGVGVMLGF IFVVGGHNGV SHLSSIERYD
510 520 530 540 550
PHQNQWTVCR PMKEPRTGVG AAVIDNYLYV VGGHSGSSYL NTVQKYDPIS
560 570
DTWLDSAGMI YCRCNFGLTA L
Length:571
Mass (Da):64,192
Last modified:March 29, 2004 - v2
Checksum:i0E26AEABCAD51220
GO
Isoform 2 (identifier: Q9NXS3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     301-571: Missing.

Note: No experimental confirmation available.
Show »
Length:300
Mass (Da):34,112
Checksum:i7E366AED404FBB18
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti10L → P in BAA90937 (PubMed:14702039).Curated1
Sequence conflicti89I → F in BAA90937 (PubMed:14702039).Curated1
Sequence conflicti300S → R in BAA90937 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_061339349I → V.Corresponds to variant rs35728857dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_009800301 – 571Missing in isoform 2. 1 PublicationAdd BLAST271

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK000088 mRNA. Translation: BAA90937.1.
BC121009 mRNA. Translation: AAI21010.1.
BC121010 mRNA. Translation: AAI21011.1.
CCDSiCCDS9680.1. [Q9NXS3-1]
RefSeqiNP_060128.2. NM_017658.4. [Q9NXS3-1]
XP_005267827.1. XM_005267770.3. [Q9NXS3-1]
XP_011535149.1. XM_011536847.2. [Q9NXS3-1]
UniGeneiHs.550906.

Genome annotation databases

EnsembliENST00000396128; ENSP00000379434; ENSG00000179454. [Q9NXS3-1]
GeneIDi54813.
KEGGihsa:54813.
UCSCiuc001wvr.4. human. [Q9NXS3-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK000088 mRNA. Translation: BAA90937.1.
BC121009 mRNA. Translation: AAI21010.1.
BC121010 mRNA. Translation: AAI21011.1.
CCDSiCCDS9680.1. [Q9NXS3-1]
RefSeqiNP_060128.2. NM_017658.4. [Q9NXS3-1]
XP_005267827.1. XM_005267770.3. [Q9NXS3-1]
XP_011535149.1. XM_011536847.2. [Q9NXS3-1]
UniGeneiHs.550906.

3D structure databases

ProteinModelPortaliQ9NXS3.
SMRiQ9NXS3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120170. 12 interactors.
STRINGi9606.ENSP00000379434.

PTM databases

iPTMnetiQ9NXS3.
PhosphoSitePlusiQ9NXS3.

Polymorphism and mutation databases

BioMutaiKLHL28.
DMDMi48474985.

Proteomic databases

PaxDbiQ9NXS3.
PRIDEiQ9NXS3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000396128; ENSP00000379434; ENSG00000179454. [Q9NXS3-1]
GeneIDi54813.
KEGGihsa:54813.
UCSCiuc001wvr.4. human. [Q9NXS3-1]

Organism-specific databases

CTDi54813.
GeneCardsiKLHL28.
HGNCiHGNC:19741. KLHL28.
HPAiHPA000988.
neXtProtiNX_Q9NXS3.
OpenTargetsiENSG00000179454.
PharmGKBiPA162393472.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4441. Eukaryota.
ENOG410XNX8. LUCA.
GeneTreeiENSGT00760000118931.
HOGENOMiHOG000230814.
HOVERGENiHBG014286.
InParanoidiQ9NXS3.
KOiK10464.
PhylomeDBiQ9NXS3.
TreeFamiTF329218.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000179454-MONOMER.

Miscellaneous databases

ChiTaRSiKLHL28. human.
GenomeRNAii54813.
PROiQ9NXS3.

Gene expression databases

BgeeiENSG00000179454.
CleanExiHS_KLHL28.
ExpressionAtlasiQ9NXS3. baseline and differential.
GenevisibleiQ9NXS3. HS.

Family and domain databases

Gene3Di2.130.10.80. 1 hit.
InterProiIPR011705. BACK.
IPR017096. BTB-kelch_protein.
IPR000210. BTB/POZ_dom.
IPR011043. Gal_Oxase/kelch_b-propeller.
IPR015916. Gal_Oxidase_b-propeller.
IPR006652. Kelch_1.
IPR030569. KLHL28.
IPR011333. SKP1/BTB/POZ.
[Graphical view]
PANTHERiPTHR24412:SF30. PTHR24412:SF30. 1 hit.
PfamiPF07707. BACK. 1 hit.
PF00651. BTB. 1 hit.
PF01344. Kelch_1. 5 hits.
[Graphical view]
PIRSFiPIRSF037037. Kelch-like_protein_gigaxonin. 1 hit.
SMARTiSM00875. BACK. 1 hit.
SM00225. BTB. 1 hit.
SM00612. Kelch. 6 hits.
[Graphical view]
SUPFAMiSSF50965. SSF50965. 2 hits.
SSF54695. SSF54695. 1 hit.
PROSITEiPS50097. BTB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiKLH28_HUMAN
AccessioniPrimary (citable) accession number: Q9NXS3
Secondary accession number(s): Q0VAL5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 29, 2004
Last sequence update: March 29, 2004
Last modified: November 2, 2016
This is version 117 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.