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Q9NXS2

- QPCTL_HUMAN

UniProt

Q9NXS2 - QPCTL_HUMAN

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Protein

Glutaminyl-peptide cyclotransferase-like protein

Gene

QPCTL

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Responsible for the biosynthesis of pyroglutamyl peptides.2 Publications

Catalytic activityi

L-glutaminyl-peptide = 5-oxoprolyl-peptide + NH3.2 Publications

Cofactori

Zn2+1 PublicationNote: Binds 1 zinc ion per subunit.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi186 – 1861Zinc; catalytic
Active sitei225 – 2251Proton acceptor
Metal bindingi226 – 2261Zinc; catalytic
Active sitei269 – 2691Proton acceptor
Metal bindingi351 – 3511Zinc; catalytic

GO - Molecular functioni

  1. glutaminyl-peptide cyclotransferase activity Source: UniProtKB
  2. zinc ion binding Source: UniProtKB

GO - Biological processi

  1. peptidyl-pyroglutamic acid biosynthetic process, using glutaminyl-peptide cyclotransferase Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Keywords - Ligandi

Metal-binding, Zinc

Protein family/group databases

MEROPSiM28.016.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutaminyl-peptide cyclotransferase-like protein (EC:2.3.2.5)
Alternative name(s):
Golgi-resident glutaminyl-peptide cyclotransferase
isoQC
Short name:
gQC
Gene namesi
Name:QPCTL
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 19

Organism-specific databases

HGNCiHGNC:25952. QPCTL.

Subcellular locationi

Golgi apparatus membrane 1 Publication; Single-pass type I membrane protein 1 Publication

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei35 – 5521HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. Golgi apparatus Source: MGI
  2. integral component of membrane Source: UniProtKB-KW
  3. membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134922163.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 382382Glutaminyl-peptide cyclotransferase-like proteinPRO_0000302002Add
BLAST

Proteomic databases

MaxQBiQ9NXS2.
PaxDbiQ9NXS2.
PRIDEiQ9NXS2.

Expressioni

Gene expression databases

BgeeiQ9NXS2.
CleanExiHS_QPCTL.
ExpressionAtlasiQ9NXS2. baseline and differential.
GenevestigatoriQ9NXS2.

Organism-specific databases

HPAiHPA040797.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
POLR1EQ9GZS11EBI-1052839,EBI-359458

Protein-protein interaction databases

BioGridi120171. 16 interactions.
IntActiQ9NXS2. 5 interactions.
STRINGi9606.ENSP00000012049.

Structurei

Secondary structure

1
382
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi78 – 869Combined sources
Helixi90 – 967Combined sources
Helixi99 – 1013Combined sources
Helixi110 – 12516Combined sources
Beta strandi131 – 14111Combined sources
Beta strandi144 – 15512Combined sources
Beta strandi159 – 16810Combined sources
Beta strandi176 – 1794Combined sources
Turni184 – 1874Combined sources
Helixi188 – 20013Combined sources
Helixi202 – 2109Combined sources
Beta strandi214 – 22310Combined sources
Beta strandi228 – 2303Combined sources
Helixi238 – 24912Combined sources
Beta strandi253 – 2575Combined sources
Turni258 – 2614Combined sources
Beta strandi262 – 2709Combined sources
Beta strandi272 – 2754Combined sources
Helixi283 – 2853Combined sources
Helixi286 – 30116Combined sources
Beta strandi313 – 3153Combined sources
Helixi329 – 3324Combined sources
Turni333 – 3353Combined sources
Beta strandi338 – 3425Combined sources
Turni348 – 3514Combined sources
Helixi357 – 3593Combined sources
Helixi362 – 38019Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3PB4X-ray1.13X53-382[»]
3PB6X-ray1.05X53-382[»]
3PB7X-ray1.40X53-382[»]
3PB8X-ray1.13X53-382[»]
3PB9X-ray1.12X53-382[»]
ProteinModelPortaliQ9NXS2.
SMRiQ9NXS2. Positions 70-382.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9NXS2.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG298226.
GeneTreeiENSGT00390000003107.
HOGENOMiHOG000189291.
HOVERGENiHBG009812.
InParanoidiQ9NXS2.
OMAiQTYFRKD.
OrthoDBiEOG76472W.
PhylomeDBiQ9NXS2.
TreeFamiTF315071.

Family and domain databases

InterProiIPR007484. Peptidase_M28.
[Graphical view]
PfamiPF04389. Peptidase_M28. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9NXS2-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRSGGRGRPR LRLGERGLME PLLPPKRRLL PRVRLLPLLL ALAVGSAFYT
60 70 80 90 100
IWSGWHRRTE ELPLGRELRV PLIGSLPEAR LRRVVGQLDP QRLWSTYLRP
110 120 130 140 150
LLVVRTPGSP GNLQVRKFLE ATLRSLTAGW HVELDPFTAS TPLGPVDFGN
160 170 180 190 200
VVATLDPRAA RHLTLACHYD SKLFPPGSTP FVGATDSAVP CALLLELAQA
210 220 230 240 250
LDLELSRAKK QAAPVTLQLL FLDGEEALKE WGPKDSLYGS RHLAQLMESI
260 270 280 290 300
PHSPGPTRIQ AIELFMLLDL LGAPNPTFYS HFPRTVRWFH RLRSIEKRLH
310 320 330 340 350
RLNLLQSHPQ EVMYFQPGEP FGSVEDDHIP FLRRGVPVLH LISTPFPAVW
360 370 380
HTPADTEVNL HPPTVHNLCR ILAVFLAEYL GL
Length:382
Mass (Da):42,924
Last modified:May 18, 2010 - v2
Checksum:i2DCA79BED029DD4B
GO
Isoform 2 (identifier: Q9NXS2-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     118-211: Missing.

Show »
Length:288
Mass (Da):32,912
Checksum:i9F23194B62336AD3
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti295 – 2951I → T in BAD96356. 1 PublicationCurated
Sequence conflicti321 – 3211F → S in BAA90938. (PubMed:14702039)Curated
Sequence conflicti321 – 3211F → S in BAD18747. (PubMed:14702039)Curated
Sequence conflicti334 – 3341R → G in BAD96356. 1 PublicationCurated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti214 – 2141P → L.
Corresponds to variant rs28708996 [ dbSNP | Ensembl ].
VAR_034937

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei118 – 21194Missing in isoform 2. 1 PublicationVSP_054066Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK000091 mRNA. Translation: BAA90938.1.
AK172764 mRNA. Translation: BAD18747.1.
AK222636 mRNA. Translation: BAD96356.1.
AC007191 Genomic DNA. No translation available.
BC011553 mRNA. Translation: AAH11553.1.
CCDSiCCDS12672.1. [Q9NXS2-1]
CCDS54282.1. [Q9NXS2-3]
RefSeqiNP_001156849.1. NM_001163377.1. [Q9NXS2-3]
NP_060129.2. NM_017659.3. [Q9NXS2-1]
UniGeneiHs.631556.

Genome annotation databases

EnsembliENST00000012049; ENSP00000012049; ENSG00000011478. [Q9NXS2-1]
ENST00000366382; ENSP00000387944; ENSG00000011478. [Q9NXS2-3]
GeneIDi54814.
KEGGihsa:54814.
UCSCiuc010ekn.3. human. [Q9NXS2-1]

Polymorphism databases

DMDMi296452875.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK000091 mRNA. Translation: BAA90938.1 .
AK172764 mRNA. Translation: BAD18747.1 .
AK222636 mRNA. Translation: BAD96356.1 .
AC007191 Genomic DNA. No translation available.
BC011553 mRNA. Translation: AAH11553.1 .
CCDSi CCDS12672.1. [Q9NXS2-1 ]
CCDS54282.1. [Q9NXS2-3 ]
RefSeqi NP_001156849.1. NM_001163377.1. [Q9NXS2-3 ]
NP_060129.2. NM_017659.3. [Q9NXS2-1 ]
UniGenei Hs.631556.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3PB4 X-ray 1.13 X 53-382 [» ]
3PB6 X-ray 1.05 X 53-382 [» ]
3PB7 X-ray 1.40 X 53-382 [» ]
3PB8 X-ray 1.13 X 53-382 [» ]
3PB9 X-ray 1.12 X 53-382 [» ]
ProteinModelPortali Q9NXS2.
SMRi Q9NXS2. Positions 70-382.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 120171. 16 interactions.
IntActi Q9NXS2. 5 interactions.
STRINGi 9606.ENSP00000012049.

Protein family/group databases

MEROPSi M28.016.

Polymorphism databases

DMDMi 296452875.

Proteomic databases

MaxQBi Q9NXS2.
PaxDbi Q9NXS2.
PRIDEi Q9NXS2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000012049 ; ENSP00000012049 ; ENSG00000011478 . [Q9NXS2-1 ]
ENST00000366382 ; ENSP00000387944 ; ENSG00000011478 . [Q9NXS2-3 ]
GeneIDi 54814.
KEGGi hsa:54814.
UCSCi uc010ekn.3. human. [Q9NXS2-1 ]

Organism-specific databases

CTDi 54814.
GeneCardsi GC19P046195.
H-InvDB HIX0015239.
HGNCi HGNC:25952. QPCTL.
HPAi HPA040797.
neXtProti NX_Q9NXS2.
PharmGKBi PA134922163.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG298226.
GeneTreei ENSGT00390000003107.
HOGENOMi HOG000189291.
HOVERGENi HBG009812.
InParanoidi Q9NXS2.
OMAi QTYFRKD.
OrthoDBi EOG76472W.
PhylomeDBi Q9NXS2.
TreeFami TF315071.

Miscellaneous databases

EvolutionaryTracei Q9NXS2.
GenomeRNAii 54814.
NextBioi 57549.
PROi Q9NXS2.

Gene expression databases

Bgeei Q9NXS2.
CleanExi HS_QPCTL.
ExpressionAtlasi Q9NXS2. baseline and differential.
Genevestigatori Q9NXS2.

Family and domain databases

InterProi IPR007484. Peptidase_M28.
[Graphical view ]
Pfami PF04389. Peptidase_M28. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Colon.
  2. Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.
    Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Cerebellum.
  3. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Kidney.
  5. "Isolation of an isoenzyme of human glutaminyl cyclase: retention in the Golgi complex suggests involvement in the protein maturation machinery."
    Cynis H., Rahfeld J.U., Stephan A., Kehlen A., Koch B., Wermann M., Demuth H.U., Schilling S.
    J. Mol. Biol. 379:966-980(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, CATALYTIC ACTIVITY, SUBCELLULAR LOCATION.
  6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  7. "Structures of human Golgi-resident glutaminyl cyclase and its complexes with inhibitors reveal a large loop movement upon inhibitor binding."
    Huang K.F., Liaw S.S., Huang W.L., Chia C.Y., Lo Y.C., Chen Y.L., Wang A.H.
    J. Biol. Chem. 286:12439-12449(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.05 ANGSTROMS) OF 53-382 IN COMPLEXES WITH SYNTHETIC INHIBITORS PBD150 AND ZINC IONS, FUNCTION, CATALYTIC ACTIVITY, COFACTOR.

Entry informationi

Entry nameiQPCTL_HUMAN
AccessioniPrimary (citable) accession number: Q9NXS2
Secondary accession number(s): Q53HE4, Q96F74
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: May 18, 2010
Last modified: November 26, 2014
This is version 98 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3