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Q9NXR7

- BRE_HUMAN

UniProt

Q9NXR7 - BRE_HUMAN

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Protein
BRCA1-A complex subunit BRE
Gene
BRE, BRCC45
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it acts as an adapter that bridges the interaction between BABAM1/NBA1 and the rest of the complex, thereby being required for the complex integrity and modulating the E3 ubiquitin ligase activity of the BRCA1-BARD1 heterodimer. Probably also plays a role as a component of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin. May play a role in homeostasis or cellular differentiation in cells of neural, epithelial and germline origins. May also act as a death receptor-associated anti-apoptotic protein, which inhibits the mitochondrial apoptotic pathway. May regulate TNF-alpha signaling through its interactions with TNFRSF1A; however these effects may be indirect.4 Publications

GO - Molecular functioni

  1. peroxisome targeting sequence binding Source: UniProtKB
  2. polyubiquitin binding Source: UniProtKB
  3. protein binding Source: UniProtKB
  4. tumor necrosis factor receptor binding Source: UniProtKB

GO - Biological processi

  1. G2 DNA damage checkpoint Source: UniProtKB
  2. apoptotic process Source: UniProtKB-KW
  3. cellular response to DNA damage stimulus Source: UniProtKB
  4. chromatin modification Source: UniProtKB-KW
  5. double-strand break repair Source: UniProtKB
  6. positive regulation of DNA repair Source: UniProtKB
  7. response to ionizing radiation Source: UniProtKB
  8. signal transduction Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulator

Keywords - Biological processi

Apoptosis, DNA damage, DNA repair

Names & Taxonomyi

Protein namesi
Recommended name:
BRCA1-A complex subunit BRE
Alternative name(s):
BRCA1/BRCA2-containing complex subunit 45
Brain and reproductive organ-expressed protein
Gene namesi
Name:BRE
Synonyms:BRCC45
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 2

Organism-specific databases

HGNCiHGNC:1106. BRE.

Subcellular locationi

Cytoplasm. Nucleus
Note: Localizes at sites of DNA damage at double-strand breaks (DSBs).2 Publications

GO - Cellular componenti

  1. BRCA1-A complex Source: UniProtKB
  2. BRISC complex Source: UniProtKB
  3. cytoplasm Source: UniProtKB
  4. nuclear ubiquitin ligase complex Source: UniProtKB
  5. nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA25419.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 383383BRCA1-A complex subunit BRE
PRO_0000224189Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionine3 Publications
Modified residuei2 – 21Phosphoserine1 Publication

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ9NXR7.
PaxDbiQ9NXR7.
PRIDEiQ9NXR7.

PTM databases

PhosphoSiteiQ9NXR7.

Expressioni

Tissue specificityi

Expressed in all cell lines examined. Highly expressed in placenta.1 Publication

Inductioni

Down-regulated by DNA-damaging agents in fibroblasts, by retinoic acid in brain glioma U-251MG and promyelocytic HL-60 cell lines, and by bacterial lipopolysaccharides (LPS) in peripheral blood mononuclear cells (PBMC).2 Publications

Gene expression databases

ArrayExpressiQ9NXR7.
BgeeiQ9NXR7.
CleanExiHS_BRE.
GenevestigatoriQ9NXR7.

Organism-specific databases

HPAiHPA017926.

Interactioni

Subunit structurei

Component of the BRCA1-A complex, at least composed of the BRCA1, BARD1, UIMC1/RAP80, FAM175A/Abraxas, BRCC3/BRCC36, BRE/BRCC45 and BABAM1/NBA1. In the BRCA1-A complex, interacts directly with FAM175A/Abraxas, BRCC3/BRCC36 and BABAM1/NBA1. Binds polyubiquitin. Component of the BRISC complex, at least composed of the FAM175B/ABRO1, BRCC3/BRCC36, BRE/BRCC45 and BABAM1/NBA1. Component of the BRCA1/BRCA2 containing complex (BRCC), which also contains BRCA1, BRCA2, BARD1, BRCC3/BRCC36 and RAD51. BRCC is a ubiquitin E3 ligase complex that enhances cellular survival following DNA damage. May interact with FAS and TNFRSF1A.7 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
BABAM1Q9NWV83EBI-949389,EBI-745725

Protein-protein interaction databases

BioGridi114946. 41 interactions.
IntActiQ9NXR7. 22 interactions.
MINTiMINT-2867020.
STRINGi9606.ENSP00000343412.

Structurei

3D structure databases

ProteinModelPortaliQ9NXR7.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni30 – 147118UEV-like 1
Add
BLAST
Regioni275 – 36490UEV-like 2
Add
BLAST

Domaini

Contains 2 ubiquitin-conjugating enzyme family-like (UEV-like) regions. These regions lack the critical Cys residues required for ubiquitination but retain the ability to bind ubiquitin.1 Publication

Sequence similaritiesi

Belongs to the BRE family.

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiNOG71563.
HOVERGENiHBG071492.
InParanoidiQ9NXR7.
KOiK12173.
OMAiHIPAFPS.
PhylomeDBiQ9NXR7.
TreeFamiTF328507.

Family and domain databases

InterProiIPR010358. Brain/reproduct-express_prot.
[Graphical view]
PfamiPF06113. BRE. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. Align

Note: Additional isoforms may exist.

Isoform 22 Publications (identifier: Q9NXR7-2) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MSPEVALNRI SPMLSPFISS VVRNGKVGLD ATNCLRITDL KSGCTSLTPG    50
PNCDRFKLHI PYAGETLKWD IIFNAQYPEL PPDFIFGEDA EFLPDPSALQ 100
NLASWNPSNP ECLLLVVKEL VQQYHQFQCS RLRESSRLMF EYQTLLEEPQ 150
YGENMEIYAG KKNNWTGEFS ARFLLKLPVD FSNIPTYLLK DVNEDPGEDV 200
ALLSVSFEDT EATQVYPKLY LSPRIEHALG GSSALHIPAF PGGGCLIDYV 250
PQVCHLLTNK VQYVIQGYHK RREYIAAFLS HFGTGVVEYD AEGFTKLTLL 300
LMWKDFCFLV HIDLPLFFPR DQPTLTFQSV YHFTNSGQLY SQAQKNYPYS 350
PRWDGNEMAK RAKAYFKTFV PQFQEAAFAN GKL 383
Length:383
Mass (Da):43,552
Last modified:May 5, 2009 - v2
Checksum:iD830226E2B8F2C4B
GO
Isoform 11 Publication (identifier: Q9NXR7-1) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     364-383: AYFKTFVPQFQEAAFANGKL → GCQGSRDACSPWEQVLAFAVAKTGCKLLQPQRNWPSSRGPPWRASEGERTAQ

Show »
Length:415
Mass (Da):46,974
Checksum:i0501C5447AAFB3BA
GO
Isoform 31 Publication (identifier: Q9NXR7-3) [UniParc]FASTAAdd to Basket

Also known as: Alpha a'

The sequence of this isoform differs from the canonical sequence as follows:
     363-383: KAYFKTFVPQFQEAAFANGKL → NSRRQHLPMESSRKHQS

Show »
Length:379
Mass (Da):43,224
Checksum:i2A8816CC439FDFB5
GO
Isoform 4 (identifier: Q9NXR7-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     364-383: AYFKTFVPQFQEAAFANGKL → RESNRDGEESSSA

Show »
Length:376
Mass (Da):42,697
Checksum:i56488D883F2A27AE
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei363 – 38321KAYFK…ANGKL → NSRRQHLPMESSRKHQS in isoform 3.
VSP_051957Add
BLAST
Alternative sequencei364 – 38320AYFKT…ANGKL → GCQGSRDACSPWEQVLAFAV AKTGCKLLQPQRNWPSSRGP PWRASEGERTAQ in isoform 1.
VSP_051956Add
BLAST
Alternative sequencei364 – 38320AYFKT…ANGKL → RESNRDGEESSSA in isoform 4.
VSP_037261Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti192 – 1921V → L in BAF83775. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L38616 mRNA. Translation: AAA64231.1.
AF420605 mRNA. Translation: AAL17818.1.
AY438031 mRNA. Translation: AAR30499.1.
AF015767 mRNA. Translation: AAB69387.1.
AF420602 mRNA. Translation: AAL17814.1.
AF420603 mRNA. Translation: AAL17816.1.
AK000097 mRNA. Translation: BAA90943.1.
AK291086 mRNA. Translation: BAF83775.1.
AC021171 Genomic DNA. Translation: AAY24156.1.
AC093690 Genomic DNA. No translation available.
AC096552 Genomic DNA. Translation: AAX88935.1.
CH471053 Genomic DNA. Translation: EAX00545.1.
CH471053 Genomic DNA. Translation: EAX00546.1.
CH471053 Genomic DNA. Translation: EAX00547.1.
CH471053 Genomic DNA. Translation: EAX00548.1.
BC001251 mRNA. Translation: AAH01251.1.
CCDSiCCDS1763.1. [Q9NXR7-2]
CCDS1764.1. [Q9NXR7-1]
CCDS1765.1. [Q9NXR7-4]
PIRiJC2472.
RefSeqiNP_001248769.1. NM_001261840.1. [Q9NXR7-3]
NP_004890.2. NM_004899.4. [Q9NXR7-1]
NP_954661.1. NM_199191.2. [Q9NXR7-2]
NP_954662.1. NM_199192.2. [Q9NXR7-4]
NP_954663.1. NM_199193.2. [Q9NXR7-4]
NP_954664.1. NM_199194.2. [Q9NXR7-2]
UniGeneiHs.258314.

Genome annotation databases

EnsembliENST00000342045; ENSP00000339371; ENSG00000158019. [Q9NXR7-2]
ENST00000344773; ENSP00000343412; ENSG00000158019. [Q9NXR7-1]
ENST00000361704; ENSP00000354699; ENSG00000158019. [Q9NXR7-4]
ENST00000379624; ENSP00000368945; ENSG00000158019. [Q9NXR7-2]
ENST00000379632; ENSP00000368953; ENSG00000158019. [Q9NXR7-4]
GeneIDi9577.
KEGGihsa:9577.
UCSCiuc002rlp.2. human. [Q9NXR7-3]
uc002rlq.3. human. [Q9NXR7-4]
uc002rlr.3. human. [Q9NXR7-2]
uc002rls.3. human. [Q9NXR7-1]

Polymorphism databases

DMDMi229462810.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L38616 mRNA. Translation: AAA64231.1 .
AF420605 mRNA. Translation: AAL17818.1 .
AY438031 mRNA. Translation: AAR30499.1 .
AF015767 mRNA. Translation: AAB69387.1 .
AF420602 mRNA. Translation: AAL17814.1 .
AF420603 mRNA. Translation: AAL17816.1 .
AK000097 mRNA. Translation: BAA90943.1 .
AK291086 mRNA. Translation: BAF83775.1 .
AC021171 Genomic DNA. Translation: AAY24156.1 .
AC093690 Genomic DNA. No translation available.
AC096552 Genomic DNA. Translation: AAX88935.1 .
CH471053 Genomic DNA. Translation: EAX00545.1 .
CH471053 Genomic DNA. Translation: EAX00546.1 .
CH471053 Genomic DNA. Translation: EAX00547.1 .
CH471053 Genomic DNA. Translation: EAX00548.1 .
BC001251 mRNA. Translation: AAH01251.1 .
CCDSi CCDS1763.1. [Q9NXR7-2 ]
CCDS1764.1. [Q9NXR7-1 ]
CCDS1765.1. [Q9NXR7-4 ]
PIRi JC2472.
RefSeqi NP_001248769.1. NM_001261840.1. [Q9NXR7-3 ]
NP_004890.2. NM_004899.4. [Q9NXR7-1 ]
NP_954661.1. NM_199191.2. [Q9NXR7-2 ]
NP_954662.1. NM_199192.2. [Q9NXR7-4 ]
NP_954663.1. NM_199193.2. [Q9NXR7-4 ]
NP_954664.1. NM_199194.2. [Q9NXR7-2 ]
UniGenei Hs.258314.

3D structure databases

ProteinModelPortali Q9NXR7.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 114946. 41 interactions.
IntActi Q9NXR7. 22 interactions.
MINTi MINT-2867020.
STRINGi 9606.ENSP00000343412.

PTM databases

PhosphoSitei Q9NXR7.

Polymorphism databases

DMDMi 229462810.

Proteomic databases

MaxQBi Q9NXR7.
PaxDbi Q9NXR7.
PRIDEi Q9NXR7.

Protocols and materials databases

DNASUi 9577.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000342045 ; ENSP00000339371 ; ENSG00000158019 . [Q9NXR7-2 ]
ENST00000344773 ; ENSP00000343412 ; ENSG00000158019 . [Q9NXR7-1 ]
ENST00000361704 ; ENSP00000354699 ; ENSG00000158019 . [Q9NXR7-4 ]
ENST00000379624 ; ENSP00000368945 ; ENSG00000158019 . [Q9NXR7-2 ]
ENST00000379632 ; ENSP00000368953 ; ENSG00000158019 . [Q9NXR7-4 ]
GeneIDi 9577.
KEGGi hsa:9577.
UCSCi uc002rlp.2. human. [Q9NXR7-3 ]
uc002rlq.3. human. [Q9NXR7-4 ]
uc002rlr.3. human. [Q9NXR7-2 ]
uc002rls.3. human. [Q9NXR7-1 ]

Organism-specific databases

CTDi 9577.
GeneCardsi GC02P028025.
HGNCi HGNC:1106. BRE.
HPAi HPA017926.
MIMi 610497. gene.
neXtProti NX_Q9NXR7.
PharmGKBi PA25419.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG71563.
HOVERGENi HBG071492.
InParanoidi Q9NXR7.
KOi K12173.
OMAi HIPAFPS.
PhylomeDBi Q9NXR7.
TreeFami TF328507.

Miscellaneous databases

ChiTaRSi BRE. human.
GeneWikii BRE_(gene).
GenomeRNAii 9577.
NextBioi 35917.
PROi Q9NXR7.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q9NXR7.
Bgeei Q9NXR7.
CleanExi HS_BRE.
Genevestigatori Q9NXR7.

Family and domain databases

InterProi IPR010358. Brain/reproduct-express_prot.
[Graphical view ]
Pfami PF06113. BRE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of a brain- and reproductive-organs-specific gene responsive to DNA damage and retinoic acid."
    Li L., Yoo H., Becker F.F., Ali-Osman F., Chan J.Y.-H.
    Biochem. Biophys. Res. Commun. 206:764-774(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), INDUCTION.
  2. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 3 AND 4), TISSUE SPECIFICITY, INDUCTION.
    Tissue: Monocyte.
  3. "Regulation of BRCC, a holoenzyme complex containing BRCA1 and BRCA2, by a signalosome-like subunit and its role in DNA repair."
    Dong Y., Hakimi M.-A., Chen X., Kumaraswamy E., Cooch N.S., Godwin A.K., Shiekhattar R.
    Mol. Cell 12:1087-1099(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), FUNCTION, IDENTIFICATION IN BRCC COMPLEX.
  4. Keeton K.R., Miles W.M.
    Submitted (JUL-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Colon and Teratocarcinoma.
  6. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Cervix.
  9. "A death receptor-associated anti-apoptotic protein, BRE, inhibits mitochondrial apoptotic pathway."
    Li Q., Ching A.K.-K., Chan B.C.-L., Chow S.K.-Y., Lim P.-L., Ho T.C.-Y., Ip W.-K., Wong C.-K., Lam C.W.-K., Lee K.K.-H., Chan J.Y.-H., Chui Y.-L.
    J. Biol. Chem. 279:52106-52116(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH FAS AND TNFRSF1A, SUBCELLULAR LOCATION.
  10. "RAP80 targets BRCA1 to specific ubiquitin structures at DNA damage sites."
    Sobhian B., Shao G., Lilli D.R., Culhane A.C., Moreau L.A., Xia B., Livingston D.M., Greenberg R.A.
    Science 316:1198-1202(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION IN THE BRCA1-A COMPLEX.
  11. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  12. "K63-specific deubiquitination by two JAMM/MPN+ complexes: BRISC-associated Brcc36 and proteasomal Poh1."
    Cooper E.M., Cutcliffe C., Kristiansen T.Z., Pandey A., Pickart C.M., Cohen R.E.
    EMBO J. 28:621-631(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION IN THE BRISC COMPLEX.
  13. "MERIT40 controls BRCA1-Rap80 complex integrity and recruitment to DNA double-strand breaks."
    Shao G., Patterson-Fortin J., Messick T.E., Feng D., Shanbhag N., Wang Y., Greenberg R.A.
    Genes Dev. 23:740-754(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION IN THE BRCA1-A COMPLEX.
  14. "NBA1, a new player in the Brca1 A complex, is required for DNA damage resistance and checkpoint control."
    Wang B., Hurov K., Hofmann K., Elledge S.J.
    Genes Dev. 23:729-739(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, IDENTIFICATION IN THE BRCA1-A COMPLEX, DOMAIN UEV-LIKE, UBIQUITIN-BINDING, INTERACTION WITH FAM175A.
  15. "MERIT40 facilitates BRCA1 localization and DNA damage repair."
    Feng L., Huang J., Chen J.
    Genes Dev. 23:719-728(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, IDENTIFICATION BY MASS SPECTROMETRY, IDENTIFICATION IN THE BRCA1-A COMPLEX, SUBCELLULAR LOCATION, INTERACTION WITH FAM175A; BABAM1 AND BRCC3.
  16. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  17. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  18. "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."
    Bienvenut W.V., Sumpton D., Martinez A., Lilla S., Espagne C., Meinnel T., Giglione C.
    Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  19. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiBRE_HUMAN
AccessioniPrimary (citable) accession number: Q9NXR7
Secondary accession number(s): A8K4X1
, D6W562, D6W563, Q13880, Q4ZFX8, Q53SD0, Q969X9, Q96P06
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 21, 2006
Last sequence update: May 5, 2009
Last modified: July 9, 2014
This is version 102 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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