Reviewed, UniProtKB/Swiss-Prot Q9NXR5 (ANR10_HUMAN)

Names and origin

Protein names

Recommended name:
    Ankyrin repeat domain-containing protein 10

Gene names

Name:

ANKRD10

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	420 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Sequence similarities

Contains 4 ANK repeats.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing Polymorphism
Domain	ANK repeat Repeat
Technical term	Complete proteome
Gene Ontology (GO)
None. [Check GOA]

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q9NXR5-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9NXR5-2)

The sequence of this isoform differs from the canonical sequence as follows:
     152-220: DLRNASGLTA...NRKRCLEDSE → EFISQSSVHS...PPELSSEPFL
     221-420: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 420	420	Ankyrin repeat domain-containing protein 10		PRO_0000066905
Regions
	Repeat	21 – 50	30	ANK 1
	Repeat	57 – 86	30	ANK 2
	Repeat	91 – 120	30	ANK 3
	Repeat	124 – 153	30	ANK 4
Natural variations
	Alternative sequence	152 – 220	69	DLRNA…LEDSE → EFISQSSVHSCLPGELQHGV TFDPSVLIQCLKPEKCQWPD SSRHCTNPGFPRVCPVSLEP PELSSEPFL in isoform 2.		VSP_034637
	Alternative sequence	221 – 420	200	Missing in isoform 2.		VSP_034638
	Natural variant	320	1	P → L: dbSNP rs3742185.		VAR_020095
Experimental info
	Sequence conflict	176	1	F → S in BAA90945. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified July 22, 2008. Version 2. Checksum: 3656BE31D8B9CB23	FASTA	420	44,768
	10 20 30 40 50 60 MSAAGAGAGV EAGFSSEELL SLRFPLHRAC RDGDLATLCS LLQQTPHAHL ASEDSFYGWT 70 80 90 100 110 120 PVHWAAHFGK LECLVQLVRA GATLNVSTTR YAQTPAHIAA FGGHPQCLVW LIQAGANINK 130 140 150 160 170 180 PDCEGETPIH KAARSGSLEC ISALVANGAH VDLRNASGLT AADIAQTQGF QECAQFLLNL 190 200 210 220 230 240 QNCHLNHFYN NGILNGGHQN VFPNHISVGT NRKRCLEDSE DFGVKKARTE AQSLDSAVPL 250 260 270 280 290 300 TNGDTEDDAD KMHVDREFAV VTDMKNSSSV SNTLTNGCVI NGHLDFPSTT PLSGMESRNG 310 320 330 340 350 360 QCLTGTNGIS SGLAPGQPFP SSQGSLCISG TEEPEKTLRA NPELCGSLHL NGSPSSCIAS 370 380 390 400 410 420 RPSWVEDIGD NLYYGHYHGF GDTAESIPEL NSVVEHSKSV KVQERYDSAV LGTMHLHHGS
	Isoform 2. Checksum: C800FCAA3B6F64BE	FASTA	220	23,529
	10 20 30 40 50 60 MSAAGAGAGV EAGFSSEELL SLRFPLHRAC RDGDLATLCS LLQQTPHAHL ASEDSFYGWT 70 80 90 100 110 120 PVHWAAHFGK LECLVQLVRA GATLNVSTTR YAQTPAHIAA FGGHPQCLVW LIQAGANINK 130 140 150 160 170 180 PDCEGETPIH KAARSGSLEC ISALVANGAH VEFISQSSVH SCLPGELQHG VTFDPSVLIQ 190 200 210 220 CLKPEKCQWP DSSRHCTNPG FPRVCPVSLE PPELSSEPFL

References

[1]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Colon.
[2]	"The DNA sequence and analysis of human chromosome 13." Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T. , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P., Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L., Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S., Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T. Nature 428:522-528(2004) [PubMed: 15057823] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Eye.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AK000100 mRNA. Translation: BAA90945.1. AL157875, AL442128 Genomic DNA. Translation: CAH70238.1. AL442128, AL157875 Genomic DNA. Translation: CAH73039.1. AL442128 Genomic DNA. Translation: CAH73037.1. CH471085 Genomic DNA. Translation: EAX09134.1. CH471085 Genomic DNA. Translation: EAX09135.1. BC001727 mRNA. Translation: AAH01727.1.
IPI	IPI00004437. IPI00014890.
RefSeq	NP_060134.2.
UniGene	Hs.525163
3D structure databases
ModBase	Search...
Genome annotation databases
Ensembl	ENST00000267339; ENSP00000267339; ENSG00000088448; Homo sapiens. [Genome view]
GeneID	55608.
KEGG	hsa:55608.
Organism-specific databases
CTD	55608.
GeneCards	GC13M110328.
H-InvDB	HIX0011459.
HGNC	HGNC:20265. ANKRD10.
PharmGKB	PA134911073.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	HBG402876.
HOVERGEN	Q9NXR5.
InParanoid	Q9NXR5.
OMA	EMCGSLH.
OrthoDB	EOG93XXP5.
Gene expression databases
ArrayExpress	Q9NXR5.
Bgee	Q9NXR5.
CleanEx	HS_ANKRD10.
Genevestigator	Q9NXR5.
GermOnline	ENSG00000088448. Homo sapiens.
Family and domain databases
InterPro	IPR002110. Ankyrin_rpt. IPR020683. Ankyrin_rpt-contain_dom. [Graphical view]
Gene3D	G3DSA:1.25.40.20. ANK. 1 hit.
Pfam	PF00023. Ank. 5 hits. [Graphical view]
SMART	SM00248. ANK. 4 hits. [Graphical view]
PROSITE	PS50297. ANK_REP_REGION. 1 hit. PS50088. ANK_REPEAT. 3 hits. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	60165.

Entry information

Entry name

ANR10_HUMAN

Accession

Primary (citable) accession number: Q9NXR5
Secondary accession number(s): Q5VW12, Q9BV12

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 22, 2003
Last sequence update:	July 22, 2008
Last modified:	December 15, 2009
This is version 64 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.