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Protein

Ankyrin repeat domain-containing protein 10

Gene

ANKRD10

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Ankyrin repeat domain-containing protein 10
Gene namesi
Name:ANKRD10
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 13

Organism-specific databases

HGNCiHGNC:20265. ANKRD10.

Pathology & Biotechi

Organism-specific databases

DisGeNETi55608.
OpenTargetsiENSG00000088448.
PharmGKBiPA134911073.

Polymorphism and mutation databases

BioMutaiANKRD10.
DMDMi212287924.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000669051 – 420Ankyrin repeat domain-containing protein 10Add BLAST420

Proteomic databases

EPDiQ9NXR5.
MaxQBiQ9NXR5.
PaxDbiQ9NXR5.
PeptideAtlasiQ9NXR5.
PRIDEiQ9NXR5.

PTM databases

iPTMnetiQ9NXR5.
PhosphoSitePlusiQ9NXR5.

Expressioni

Gene expression databases

BgeeiENSG00000088448.
CleanExiHS_ANKRD10.
ExpressionAtlasiQ9NXR5. baseline and differential.
GenevisibleiQ9NXR5. HS.

Organism-specific databases

HPAiCAB034211.
HPA038878.
HPA038879.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
APPBP2Q926243EBI-10316475,EBI-743771

Protein-protein interaction databases

BioGridi120748. 5 interactors.
IntActiQ9NXR5. 3 interactors.
STRINGi9606.ENSP00000267339.

Structurei

3D structure databases

ProteinModelPortaliQ9NXR5.
SMRiQ9NXR5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati21 – 50ANK 1Add BLAST30
Repeati57 – 86ANK 2Add BLAST30
Repeati91 – 120ANK 3Add BLAST30
Repeati124 – 153ANK 4Add BLAST30

Sequence similaritiesi

Contains 4 ANK repeats.PROSITE-ProRule annotation

Keywords - Domaini

ANK repeat, Repeat

Phylogenomic databases

eggNOGiKOG0504. Eukaryota.
COG0666. LUCA.
GeneTreeiENSGT00530000063667.
HOGENOMiHOG000294117.
HOVERGENiHBG050508.
InParanoidiQ9NXR5.
OMAiFQECAQF.
OrthoDBiEOG091G0DE3.
PhylomeDBiQ9NXR5.
TreeFamiTF330752.

Family and domain databases

Gene3Di1.25.40.20. 2 hits.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
[Graphical view]
PfamiPF12796. Ank_2. 2 hits.
[Graphical view]
SMARTiSM00248. ANK. 4 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 3 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9NXR5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSAAGAGAGV EAGFSSEELL SLRFPLHRAC RDGDLATLCS LLQQTPHAHL
60 70 80 90 100
ASEDSFYGWT PVHWAAHFGK LECLVQLVRA GATLNVSTTR YAQTPAHIAA
110 120 130 140 150
FGGHPQCLVW LIQAGANINK PDCEGETPIH KAARSGSLEC ISALVANGAH
160 170 180 190 200
VDLRNASGLT AADIAQTQGF QECAQFLLNL QNCHLNHFYN NGILNGGHQN
210 220 230 240 250
VFPNHISVGT NRKRCLEDSE DFGVKKARTE AQSLDSAVPL TNGDTEDDAD
260 270 280 290 300
KMHVDREFAV VTDMKNSSSV SNTLTNGCVI NGHLDFPSTT PLSGMESRNG
310 320 330 340 350
QCLTGTNGIS SGLAPGQPFP SSQGSLCISG TEEPEKTLRA NPELCGSLHL
360 370 380 390 400
NGSPSSCIAS RPSWVEDIGD NLYYGHYHGF GDTAESIPEL NSVVEHSKSV
410 420
KVQERYDSAV LGTMHLHHGS
Length:420
Mass (Da):44,768
Last modified:July 22, 2008 - v2
Checksum:i3656BE31D8B9CB23
GO
Isoform 2 (identifier: Q9NXR5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     152-220: DLRNASGLTA...NRKRCLEDSE → EFISQSSVHS...PPELSSEPFL
     221-420: Missing.

Show »
Length:220
Mass (Da):23,529
Checksum:iC800FCAA3B6F64BE
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti176F → S in BAA90945 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_020095320P → L.Corresponds to variant rs3742185dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_034637152 – 220DLRNA…LEDSE → EFISQSSVHSCLPGELQHGV TFDPSVLIQCLKPEKCQWPD SSRHCTNPGFPRVCPVSLEP PELSSEPFL in isoform 2. 1 PublicationAdd BLAST69
Alternative sequenceiVSP_034638221 – 420Missing in isoform 2. 1 PublicationAdd BLAST200

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK000100 mRNA. Translation: BAA90945.1.
AL157875, AL442128 Genomic DNA. Translation: CAH70238.1.
AL442128, AL157875 Genomic DNA. Translation: CAH73039.1.
AL442128 Genomic DNA. Translation: CAH73037.1.
CH471085 Genomic DNA. Translation: EAX09134.1.
CH471085 Genomic DNA. Translation: EAX09135.1.
BC001727 mRNA. Translation: AAH01727.1.
CCDSiCCDS66580.1. [Q9NXR5-2]
CCDS9520.1. [Q9NXR5-1]
RefSeqiNP_001273650.1. NM_001286721.1. [Q9NXR5-2]
NP_060134.2. NM_017664.3. [Q9NXR5-1]
UniGeneiHs.525163.

Genome annotation databases

EnsembliENST00000267339; ENSP00000267339; ENSG00000088448. [Q9NXR5-1]
ENST00000310847; ENSP00000312534; ENSG00000088448. [Q9NXR5-2]
GeneIDi55608.
KEGGihsa:55608.
UCSCiuc001vrn.5. human. [Q9NXR5-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK000100 mRNA. Translation: BAA90945.1.
AL157875, AL442128 Genomic DNA. Translation: CAH70238.1.
AL442128, AL157875 Genomic DNA. Translation: CAH73039.1.
AL442128 Genomic DNA. Translation: CAH73037.1.
CH471085 Genomic DNA. Translation: EAX09134.1.
CH471085 Genomic DNA. Translation: EAX09135.1.
BC001727 mRNA. Translation: AAH01727.1.
CCDSiCCDS66580.1. [Q9NXR5-2]
CCDS9520.1. [Q9NXR5-1]
RefSeqiNP_001273650.1. NM_001286721.1. [Q9NXR5-2]
NP_060134.2. NM_017664.3. [Q9NXR5-1]
UniGeneiHs.525163.

3D structure databases

ProteinModelPortaliQ9NXR5.
SMRiQ9NXR5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120748. 5 interactors.
IntActiQ9NXR5. 3 interactors.
STRINGi9606.ENSP00000267339.

PTM databases

iPTMnetiQ9NXR5.
PhosphoSitePlusiQ9NXR5.

Polymorphism and mutation databases

BioMutaiANKRD10.
DMDMi212287924.

Proteomic databases

EPDiQ9NXR5.
MaxQBiQ9NXR5.
PaxDbiQ9NXR5.
PeptideAtlasiQ9NXR5.
PRIDEiQ9NXR5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000267339; ENSP00000267339; ENSG00000088448. [Q9NXR5-1]
ENST00000310847; ENSP00000312534; ENSG00000088448. [Q9NXR5-2]
GeneIDi55608.
KEGGihsa:55608.
UCSCiuc001vrn.5. human. [Q9NXR5-1]

Organism-specific databases

CTDi55608.
DisGeNETi55608.
GeneCardsiANKRD10.
HGNCiHGNC:20265. ANKRD10.
HPAiCAB034211.
HPA038878.
HPA038879.
neXtProtiNX_Q9NXR5.
OpenTargetsiENSG00000088448.
PharmGKBiPA134911073.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0504. Eukaryota.
COG0666. LUCA.
GeneTreeiENSGT00530000063667.
HOGENOMiHOG000294117.
HOVERGENiHBG050508.
InParanoidiQ9NXR5.
OMAiFQECAQF.
OrthoDBiEOG091G0DE3.
PhylomeDBiQ9NXR5.
TreeFamiTF330752.

Miscellaneous databases

ChiTaRSiANKRD10. human.
GenomeRNAii55608.
PROiQ9NXR5.

Gene expression databases

BgeeiENSG00000088448.
CleanExiHS_ANKRD10.
ExpressionAtlasiQ9NXR5. baseline and differential.
GenevisibleiQ9NXR5. HS.

Family and domain databases

Gene3Di1.25.40.20. 2 hits.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
[Graphical view]
PfamiPF12796. Ank_2. 2 hits.
[Graphical view]
SMARTiSM00248. ANK. 4 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiANR10_HUMAN
AccessioniPrimary (citable) accession number: Q9NXR5
Secondary accession number(s): Q5VW12, Q9BV12
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 22, 2003
Last sequence update: July 22, 2008
Last modified: November 30, 2016
This is version 121 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.