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Q9NXR1

- NDE1_HUMAN

UniProt

Q9NXR1 - NDE1_HUMAN

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Protein

Nuclear distribution protein nudE homolog 1

Gene

NDE1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Required for centrosome duplication and formation and function of the mitotic spindle. Essential for the development of the cerebral cortex. May regulate the production of neurons by controlling the orientation of the mitotic spindle during division of cortical neuronal progenitors of the proliferative ventricular zone of the brain. Orientation of the division plane perpendicular to the layers of the cortex gives rise to two proliferative neuronal progenitors whereas parallel orientation of the division plane yields one proliferative neuronal progenitor and a post-mitotic neuron. A premature shift towards a neuronal fate within the progenitor population may result in an overall reduction in the final number of neurons and an increase in the number of neurons in the deeper layers of the cortex.2 Publications

GO - Molecular functioni

  1. microtubule binding Source: UniProtKB

GO - Biological processi

  1. centrosome duplication Source: UniProtKB
  2. cerebral cortex development Source: UniProtKB
  3. establishment of chromosome localization Source: UniProtKB
  4. establishment of mitotic spindle orientation Source: UniProtKB
  5. G2/M transition of mitotic cell cycle Source: Reactome
  6. microtubule nucleation Source: Ensembl
  7. mitotic cell cycle Source: Reactome
  8. mitotic nuclear division Source: UniProtKB-KW
  9. neuroblast proliferation Source: Ensembl
  10. neuron migration Source: Ensembl
  11. vesicle transport along microtubule Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Cell cycle, Cell division, Differentiation, Mitosis, Neurogenesis

Enzyme and pathway databases

ReactomeiREACT_150425. Resolution of Sister Chromatid Cohesion.
REACT_150471. Separation of Sister Chromatids.
REACT_15296. Recruitment of mitotic centrosome proteins and complexes.
REACT_15364. Loss of Nlp from mitotic centrosomes.
REACT_15451. Loss of proteins required for interphase microtubule organization from the centrosome.
REACT_160315. Regulation of PLK1 Activity at G2/M Transition.
REACT_682. Mitotic Prometaphase.

Names & Taxonomyi

Protein namesi
Recommended name:
Nuclear distribution protein nudE homolog 1
Short name:
NudE
Gene namesi
Name:NDE1
Synonyms:NUDE
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 16

Organism-specific databases

HGNCiHGNC:17619. NDE1.

Subcellular locationi

Cytoplasmcytoskeleton. Cytoplasmcytoskeletonmicrotubule organizing centercentrosome. Chromosomecentromerekinetochore. Cytoplasmcytoskeletonspindle. Cleavage furrow
Note: Localizes to the interphase and S phase centrosome. During mitosis, partially associated with the mitotic spindle. Concentrates at the plus ends of microtubules coincident with kinetochores in metaphase and anaphase in a CENPF-dependent manner. Also localizes to the cleavage furrow during cytokinesis. manner. Also localizes to the cleavage furrow during cytokinesis.

GO - Cellular componenti

  1. centrosome Source: UniProtKB
  2. cytosol Source: Reactome
  3. kinetochore Source: UniProtKB
  4. membrane Source: UniProtKB
  5. microtubule Source: UniProtKB-KW
  6. spindle pole centrosome Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Centromere, Chromosome, Cytoplasm, Cytoskeleton, Kinetochore, Microtubule

Pathology & Biotechi

Involvement in diseasei

Lissencephaly 4 (LIS4) [MIM:614019]: A neurodevelopmental disorder characterized by lissencephaly, severe brain atrophy, extreme microcephaly, and profound mental retardation.2 Publications
Note: The disease is caused by mutations affecting the gene represented in this entry.
Microhydranencephaly (MHAC) [MIM:605013]: A severe neurodevelopmental disorder characterized by microcephaly, severe motor and mental retardation, spasticity, and brain malformations that include gross dilation of the ventricles with complete absence of the cerebral hemispheres or severe delay in their development.1 Publication
Note: The disease is caused by mutations affecting the gene represented in this entry.

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi191 – 1911T → E: Loss of centrosomal localization and reduced ZNF365-binding; when associated with E-215; E-228; E-243; E-246 and E-282. 1 Publication
Mutagenesisi191 – 1911T → V: Retained on spindle poles during mitosis, no loss of phosphorylation in vivo and increased ZNF365-binding; when associated with V-215; V-228; V-243; V-246 and A-282. 1 Publication
Mutagenesisi215 – 2151T → E: Loss of centrosomal localization and reduced ZNF365-binding; when associated with E-191; E-228; E-243; E-246 and E-282. 1 Publication
Mutagenesisi215 – 2151T → V: Retained on spindle poles during mitosis, no loss of phosphorylation in vivo and increased ZNF365-binding; when associated with V-191; V-228; V-243; V-246 and A-282. 1 Publication
Mutagenesisi228 – 2281T → E: Loss of centrosomal localization and reduced ZNF365-binding; when associated with E-191; E-215; E-243; E-246 and E-282. 1 Publication
Mutagenesisi228 – 2281T → V: Retained on spindle poles during mitosis, no loss of phosphorylation in vivo and increased ZNF365-binding; when associated with V-191; V-215; V-243; V-246 and A-282. 1 Publication
Mutagenesisi243 – 2431T → E: Loss of centrosomal localization and reduced ZNF365-binding; when associated with E-191; E-215; E-228; E-246 and E-282. 1 Publication
Mutagenesisi243 – 2431T → V: Retained on spindle poles during mitosis, no loss of phosphorylation in vivo and increased ZNF365-binding; when associated with V-191; V-215; V-228; V-246 and A-282. 1 Publication
Mutagenesisi246 – 2461T → E: Loss of centrosomal localization and reduced ZNF365-binding; when associated with E-191; E-215; E-228; E-243 and E-282. 1 Publication
Mutagenesisi246 – 2461T → V: Retained on spindle poles during mitosis, no loss of phosphorylation in vivo and increased ZNF365-binding; when associated with V-191; V-215; V-228; V-243 and A-282. 1 Publication
Mutagenesisi282 – 2821S → A: Retained on spindle poles during mitosis, no loss of phosphorylation in vivo and increased ZNF365-binding; when associated with V-191; V-215; V-228; V-243 and V-246. 1 Publication
Mutagenesisi282 – 2821S → E: Loss of centrosomal localization and reduced ZNF365-binding; when associated with E-191; E-215; E-228; E-243 and E-246. 1 Publication

Keywords - Diseasei

Lissencephaly

Organism-specific databases

MIMi605013. phenotype.
614019. phenotype.
Orphaneti1665. Fetal brain disruption sequence.
2177. Hydranencephaly.
1083. Microlissencephaly.
PharmGKBiPA128394673.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 346346Nuclear distribution protein nudE homolog 1PRO_0000240202Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei211 – 2111Phosphoserine1 Publication
Modified residuei215 – 2151Phosphothreonine1 Publication
Modified residuei228 – 2281Phosphothreonine1 Publication
Modified residuei231 – 2311Phosphoserine1 Publication
Modified residuei239 – 2391Phosphoserine1 Publication
Modified residuei243 – 2431Phosphothreonine2 Publications
Modified residuei246 – 2461Phosphothreonine2 Publications
Lipidationi274 – 2741S-palmitoyl cysteine; by ZDHHC2, ZDHHC3 and ZDHHC71 Publication
Modified residuei282 – 2821Phosphoserine2 Publications

Post-translational modificationi

Phosphorylated in mitosis. Phosphorylated in vitro by CDC2. Phosphorylation at Thr-246 is essential for the G2/M transition (By similarity).By similarity

Keywords - PTMi

Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

MaxQBiQ9NXR1.
PaxDbiQ9NXR1.
PRIDEiQ9NXR1.

PTM databases

PhosphoSiteiQ9NXR1.

Expressioni

Tissue specificityi

Expressed in the neuroepithelium throughout the developing brain, including the cerebral cortex and cerebellum.1 Publication

Gene expression databases

BgeeiQ9NXR1.
CleanExiHS_NDE1.
ExpressionAtlasiQ9NXR1. baseline and differential.
GenevestigatoriQ9NXR1.

Organism-specific databases

HPAiHPA018536.
HPA024075.

Interactioni

Subunit structurei

Self-associates. Interacts with CNTRL, LIS1, dynein, SLMAP and TCP1 (By similarity). Interacts with CENPF, dynactin, tubulin gamma, PAFAH1B1, PCM1 and PCNT. Interacts with ZNF365.By similarity3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
ZNF365Q70YC54EBI-941227,EBI-941182

Protein-protein interaction databases

BioGridi120175. 35 interactions.
IntActiQ9NXR1. 7 interactions.
STRINGi9606.ENSP00000345892.

Structurei

3D structure databases

ProteinModelPortaliQ9NXR1.
SMRiQ9NXR1. Positions 8-167.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 9393Self-associationBy similarityAdd
BLAST
Regioni88 – 15669Interaction with PAFAH1B1By similarityAdd
BLAST
Regioni167 – 290124Interaction with CENPFBy similarityAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili18 – 188171Sequence AnalysisAdd
BLAST

Sequence similaritiesi

Belongs to the nudE family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG240815.
HOGENOMiHOG000280681.
HOVERGENiHBG082010.
InParanoidiQ9NXR1.
KOiK16738.
OMAiEVQHSEG.
OrthoDBiEOG74R1R5.
PhylomeDBiQ9NXR1.
TreeFamiTF325693.

Family and domain databases

InterProiIPR006964. NUDE_C.
[Graphical view]
PfamiPF04880. NUDE_C. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9NXR1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEDSGKTFSS EEEEANYWKD LAMTYKQRAE NTQEELREFQ EGSREYEAEL
60 70 80 90 100
ETQLQQIETR NRDLLSENNR LRMELETIKE KFEVQHSEGY RQISALEDDL
110 120 130 140 150
AQTKAIKDQL QKYIRELEQA NDDLERAKRA TIMSLEDFEQ RLNQAIERNA
160 170 180 190 200
FLESELDEKE NLLESVQRLK DEARDLRQEL AVQQKQEKPR TPMPSSVEAE
210 220 230 240 250
RTDTAVQATG SVPSTPIAHR GPSSSLNTPG SFRRGLDDST GGTPLTPAAR
260 270 280 290 300
ISALNIVGDL LRKVGALESK LASCRNLVYD QSPNRTGGPA SGRSSKNRDG
310 320 330 340
GERRPSSTSV PLGDKGLGKR LEFGKPPSHM SSSPLPSAQG VVKMLL
Length:346
Mass (Da):38,808
Last modified:June 13, 2006 - v2
Checksum:iA681DEF652B5ACE5
GO
Isoform 2 (identifier: Q9NXR1-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     318-346: GKRLEFGKPPSHMSSSPLPSAQGVVKMLL → DTSCRWLSKSTTRSSSSC

Show »
Length:335
Mass (Da):37,721
Checksum:iFC0BDD8BB90324B8
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti191 – 1911T → I in AAH33900. (PubMed:15489334)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei318 – 34629GKRLE…VKMLL → DTSCRWLSKSTTRSSSSC in isoform 2. 2 PublicationsVSP_019305Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK000108 mRNA. Translation: BAA90949.1.
AC026401 Genomic DNA. No translation available.
AF001548 Genomic DNA. No translation available.
BC001421 mRNA. Translation: AAH01421.1.
BC033900 mRNA. Translation: AAH33900.1.
CCDSiCCDS10564.1. [Q9NXR1-2]
RefSeqiNP_001137451.1. NM_001143979.1. [Q9NXR1-2]
NP_060138.1. NM_017668.2. [Q9NXR1-2]
UniGeneiHs.655378.

Genome annotation databases

EnsembliENST00000342673; ENSP00000345892; ENSG00000072864. [Q9NXR1-2]
ENST00000396354; ENSP00000379642; ENSG00000072864. [Q9NXR1-2]
ENST00000396355; ENSP00000379643; ENSG00000072864. [Q9NXR1-2]
GeneIDi54820.
KEGGihsa:54820.
UCSCiuc002dds.3. human. [Q9NXR1-2]
uc002ddt.1. human. [Q9NXR1-1]

Polymorphism databases

DMDMi108860813.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK000108 mRNA. Translation: BAA90949.1 .
AC026401 Genomic DNA. No translation available.
AF001548 Genomic DNA. No translation available.
BC001421 mRNA. Translation: AAH01421.1 .
BC033900 mRNA. Translation: AAH33900.1 .
CCDSi CCDS10564.1. [Q9NXR1-2 ]
RefSeqi NP_001137451.1. NM_001143979.1. [Q9NXR1-2 ]
NP_060138.1. NM_017668.2. [Q9NXR1-2 ]
UniGenei Hs.655378.

3D structure databases

ProteinModelPortali Q9NXR1.
SMRi Q9NXR1. Positions 8-167.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 120175. 35 interactions.
IntActi Q9NXR1. 7 interactions.
STRINGi 9606.ENSP00000345892.

PTM databases

PhosphoSitei Q9NXR1.

Polymorphism databases

DMDMi 108860813.

Proteomic databases

MaxQBi Q9NXR1.
PaxDbi Q9NXR1.
PRIDEi Q9NXR1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000342673 ; ENSP00000345892 ; ENSG00000072864 . [Q9NXR1-2 ]
ENST00000396354 ; ENSP00000379642 ; ENSG00000072864 . [Q9NXR1-2 ]
ENST00000396355 ; ENSP00000379643 ; ENSG00000072864 . [Q9NXR1-2 ]
GeneIDi 54820.
KEGGi hsa:54820.
UCSCi uc002dds.3. human. [Q9NXR1-2 ]
uc002ddt.1. human. [Q9NXR1-1 ]

Organism-specific databases

CTDi 54820.
GeneCardsi GC16P015745.
HGNCi HGNC:17619. NDE1.
HPAi HPA018536.
HPA024075.
MIMi 605013. phenotype.
609449. gene.
614019. phenotype.
neXtProti NX_Q9NXR1.
Orphaneti 1665. Fetal brain disruption sequence.
2177. Hydranencephaly.
1083. Microlissencephaly.
PharmGKBi PA128394673.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG240815.
HOGENOMi HOG000280681.
HOVERGENi HBG082010.
InParanoidi Q9NXR1.
KOi K16738.
OMAi EVQHSEG.
OrthoDBi EOG74R1R5.
PhylomeDBi Q9NXR1.
TreeFami TF325693.

Enzyme and pathway databases

Reactomei REACT_150425. Resolution of Sister Chromatid Cohesion.
REACT_150471. Separation of Sister Chromatids.
REACT_15296. Recruitment of mitotic centrosome proteins and complexes.
REACT_15364. Loss of Nlp from mitotic centrosomes.
REACT_15451. Loss of proteins required for interphase microtubule organization from the centrosome.
REACT_160315. Regulation of PLK1 Activity at G2/M Transition.
REACT_682. Mitotic Prometaphase.

Miscellaneous databases

ChiTaRSi NDE1. human.
GeneWikii NDE1.
GenomeRNAii 54820.
NextBioi 57569.
PROi Q9NXR1.
SOURCEi Search...

Gene expression databases

Bgeei Q9NXR1.
CleanExi HS_NDE1.
ExpressionAtlasi Q9NXR1. baseline and differential.
Genevestigatori Q9NXR1.

Family and domain databases

InterProi IPR006964. NUDE_C.
[Graphical view ]
Pfami PF04880. NUDE_C. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Colon.
  2. "The sequence and analysis of duplication-rich human chromosome 16."
    Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J.
    , Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J., Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D., Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M., Rubin E.M., Pennacchio L.A.
    Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Placenta and Testis.
  4. "Human Nudel and NudE as regulators of cytoplasmic dynein in poleward protein transport along the mitotic spindle."
    Yan X., Li F., Liang Y., Shen Y., Zhao X., Huang Q., Zhu X.
    Mol. Cell. Biol. 23:1239-1250(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, PHOSPHORYLATION.
  5. "Nudel contributes to microtubule anchoring at the mother centriole and is involved in both dynein-dependent and -independent centrosomal protein assembly."
    Guo J., Yang Z., Song W., Chen Q., Wang F., Zhang Q., Zhu X.
    Mol. Biol. Cell 17:680-689(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH DYNACTIN; TUBULIN GAMMA; PAFAH1B1; PCM1 AND PCNT.
  6. "Centrosomal proteins Nde1 and Su48 form a complex regulated by phosphorylation."
    Hirohashi Y., Wang Q., Liu Q., Li B., Du X., Zhang H., Furuuchi K., Masuda K., Sato N., Greene M.I.
    Oncogene 25:6048-6055(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH ZNF365, SUBCELLULAR LOCATION, PHOSPHORYLATION, MUTAGENESIS OF THR-191; THR-215; THR-228; THR-243; THR-246 AND SER-282.
  7. "Cenp-F links kinetochores to Ndel1/Nde1/Lis1/dynein microtubule motor complexes."
    Vergnolle M.A.S., Taylor S.S.
    Curr. Biol. 17:1173-1179(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH CENPF, SUBCELLULAR LOCATION.
  8. "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."
    Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III
    J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  9. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-211; THR-215; THR-228; SER-231; SER-239; THR-243; THR-246 AND SER-282, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  10. "Ndel1 palmitoylation: a new mean to regulate cytoplasmic dynein activity."
    Shmueli A., Segal M., Sapir T., Tsutsumi R., Noritake J., Bar A., Sapoznik S., Fukata Y., Orr I., Fukata M., Reiner O.
    EMBO J. 29:107-119(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PALMITOYLATION AT CYS-274 BY ZDHHC2; ZDHHC3 AND ZDHHC7.
  11. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-243; THR-246 AND SER-282, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  12. Cited for: FUNCTION, TISSUE SPECIFICITY, SUBCELLULAR LOCATION, INVOLVEMENT IN LIS4.
  13. Cited for: INVOLVEMENT IN LIS4.
  14. "Novel NDE1 homozygous mutation resulting in microhydranencephaly and not microlyssencephaly."
    Guven A., Gunduz A., Bozoglu T.M., Yalcinkaya C., Tolun A.
    Neurogenetics 13:189-194(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: INVOLVEMENT IN MHAC.

Entry informationi

Entry nameiNDE1_HUMAN
AccessioniPrimary (citable) accession number: Q9NXR1
Secondary accession number(s): Q49AQ2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 13, 2006
Last sequence update: June 13, 2006
Last modified: October 29, 2014
This is version 110 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3