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Protein

Gypsy retrotransposon integrase-like protein 1

Gene

GIN1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Gypsy retrotransposon integrase-like protein 1
Short name:
GIN-1
Alternative name(s):
Ty3/Gypsy integrase 1
Zinc finger H2C2 domain-containing protein
Gene namesi
Name:GIN1
Synonyms:TGIN1, ZH2C2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000145723.16
HGNCiHGNC:25959 GIN1
neXtProtiNX_Q9NXP7

Pathology & Biotechi

Organism-specific databases

DisGeNETi54826
OpenTargetsiENSG00000145723
PharmGKBiPA162389674

Polymorphism and mutation databases

BioMutaiGIN1
DMDMi296439336

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003330161 – 522Gypsy retrotransposon integrase-like protein 1Add BLAST522

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei502PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9NXP7
PaxDbiQ9NXP7
PeptideAtlasiQ9NXP7
PRIDEiQ9NXP7

PTM databases

iPTMnetiQ9NXP7
PhosphoSitePlusiQ9NXP7

Expressioni

Tissue specificityi

Widely expressed. Also found in tumors originating from parathyroid gland, colon, stomach, bladder, uterus and prostate.1 Publication

Gene expression databases

BgeeiENSG00000145723
CleanExiHS_GIN1
GenevisibleiQ9NXP7 HS

Organism-specific databases

HPAiHPA037402
HPA061362

Interactioni

Protein-protein interaction databases

BioGridi120180, 3 interactors
IntActiQ9NXP7, 2 interactors
STRINGi9606.ENSP00000381970

Structurei

3D structure databases

ProteinModelPortaliQ9NXP7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini135 – 292Integrase catalyticPROSITE-ProRule annotationAdd BLAST158

Phylogenomic databases

eggNOGiKOG0017 Eukaryota
COG2801 LUCA
GeneTreeiENSGT00910000144222
HOGENOMiHOG000074147
HOVERGENiHBG107947
InParanoidiQ9NXP7
OMAiYGPPQKI
OrthoDBiEOG091G00AJ
PhylomeDBiQ9NXP7
TreeFamiTF352301

Family and domain databases

Gene3Di3.30.420.10, 1 hit
InterProiView protein in InterPro
IPR001584 Integrase_cat-core
IPR012337 RNaseH-like_sf
IPR036397 RNaseH_sf
SUPFAMiSSF53098 SSF53098, 1 hit
PROSITEiView protein in PROSITE
PS50994 INTEGRASE, 1 hit

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9NXP7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVRSGKNGDL HLKQIAYYKR TGEYHSTTLP SERSGIRRAA KKFVFKEKKL
60 70 80 90 100
FYVGKDRKQN RLVIVSEEEK KKVLRECHEN DSGAHHGISR TLTLVESNYY
110 120 130 140 150
WTSVTNDVKQ WVYACQHCQV AKNTVIVAPK QHLLKVENPW SLVTVDLMGP
160 170 180 190 200
FHTSNRSHVY AIIMTDLFTK WIVILPLCDV SASEVSKAII NIFFLYGPPQ
210 220 230 240 250
KIIMDQRDEF IQQINIELYR LFGIKQIVIS HTSGTVNPTE STPNTIKAFL
260 270 280 290 300
SKHCADHPNN WDDHLSAVSF AFNVTHLEPT KNTPYFQMFS RNPYMPETSD
310 320 330 340 350
SLHEVDGDNT SMFAKILDAI KEADKIMENK TTSLGQMENN NLDELNKSKI
360 370 380 390 400
IVKKKPKQLN PFHLKVGHEV LRQRKNWWKD GRFQSEWVGP CVIDYITESG
410 420 430 440 450
CAVLRDNTGV RLKRPIKMSH LKPYIRESSE QESLYLLQGS VVADHDYIGL
460 470 480 490 500
PEIPIGAYQA NILVEDATIG IVDNELLTSS KDRELLEYRN TKISPLIDDH
510 520
SSLEKQTFSL LDSSNQVLEY LS
Length:522
Mass (Da):59,842
Last modified:May 18, 2010 - v3
Checksum:i5375EC9B009D8B9F
GO
Isoform 2 (identifier: Q9NXP7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     47-80: EKKLFYVGKDRKQNRLVIVSEEEKKKVLRECHEN → GICLSALPSGKKYSYCSTETAPSQGGKSMEFSYC
     81-522: Missing.

Note: No experimental confirmation available. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Show »
Length:80
Mass (Da):8,891
Checksum:i12EF0D2C163C56EF
GO
Isoform 3 (identifier: Q9NXP7-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     214-222: INIELYRLF → KVFISCKVQ
     223-522: Missing.

Show »
Length:222
Mass (Da):25,703
Checksum:i9241917EAEB27B52
GO

Sequence cautioni

The sequence BAA90963 differs from that shown. Reason: Frameshift at position 375.Curated
The sequence CAH10511 differs from that shown. Wrong choice of CDS.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti108V → A in BAA90963 (PubMed:14702039).Curated1
Sequence conflicti313F → L in CAH10511 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04304122G → C1 PublicationCorresponds to variant dbSNP:rs17851289Ensembl.1
Natural variantiVAR_043042239T → M2 PublicationsCorresponds to variant dbSNP:rs34813Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_03851847 – 80EKKLF…ECHEN → GICLSALPSGKKYSYCSTET APSQGGKSMEFSYC in isoform 2. 1 PublicationAdd BLAST34
Alternative sequenceiVSP_03851981 – 522Missing in isoform 2. 1 PublicationAdd BLAST442
Alternative sequenceiVSP_033438214 – 222INIELYRLF → KVFISCKVQ in isoform 3. 1 Publication9
Alternative sequenceiVSP_033439223 – 522Missing in isoform 3. 1 PublicationAdd BLAST300

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK000132 mRNA Translation: BAA90963.1 Frameshift.
AK295796 mRNA Translation: BAG58616.1
CR627424 mRNA Translation: CAH10511.1 Sequence problems.
AC008447 Genomic DNA No translation available.
CH471086 Genomic DNA Translation: EAW49080.1
BC015325 mRNA Translation: AAH15325.1
BC151135 mRNA Translation: AAI51136.1
BC157835 mRNA Translation: AAI57836.1
CCDSiCCDS43349.1 [Q9NXP7-1]
RefSeqiNP_001304883.1, NM_001317954.1
NP_060146.2, NM_017676.2 [Q9NXP7-1]
XP_016865088.1, XM_017009599.1 [Q9NXP7-1]
UniGeneiHs.24088

Genome annotation databases

EnsembliENST00000399004; ENSP00000381970; ENSG00000145723 [Q9NXP7-1]
ENST00000508629; ENSP00000427162; ENSG00000145723 [Q9NXP7-3]
ENST00000512248; ENSP00000422960; ENSG00000145723 [Q9NXP7-2]
ENST00000513747; ENSP00000423031; ENSG00000145723 [Q9NXP7-2]
GeneIDi54826
KEGGihsa:54826
UCSCiuc003koa.2 human [Q9NXP7-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiGIN1_HUMAN
AccessioniPrimary (citable) accession number: Q9NXP7
Secondary accession number(s): B2RXF7
, B4DIV4, Q6AI03, Q96BR2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: May 18, 2010
Last modified: April 25, 2018
This is version 115 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health