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Q9NXL9

- MCM9_HUMAN

UniProt

Q9NXL9 - MCM9_HUMAN

Protein

DNA helicase MCM9

Gene

MCM9

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 95 (01 Oct 2014)
      Sequence version 4 (16 May 2012)
      Previous versions | rss
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    Functioni

    Component of the MCM8-MCM9 complex, a complex involved in homologous recombination repair following DNA interstrand cross-links and plays a key role during gametogenesis. The MCM8-MCM9 complex probably acts as a hexameric helicase downstream of the Fanconi anemia proteins BRCA2 and RAD51 and is required to process aberrant forks into homologous recombination substrates and to orchestrate homologous recombination with resection, fork stabilization and fork restart.1 Publication

    Catalytic activityi

    ATP + H2O = ADP + phosphate.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi352 – 3598ATPSequence Analysis

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. DNA binding Source: UniProtKB-KW
    3. helicase activity Source: UniProtKB-KW

    GO - Biological processi

    1. cellular response to DNA damage stimulus Source: UniProtKB
    2. DNA replication Source: InterPro
    3. double-strand break repair via homologous recombination Source: UniProtKB
    4. female gamete generation Source: UniProtKB

    Keywords - Molecular functioni

    Helicase, Hydrolase

    Keywords - Biological processi

    DNA damage, DNA repair

    Keywords - Ligandi

    ATP-binding, DNA-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    DNA helicase MCM9 (EC:3.6.4.12)
    Short name:
    hMCM9
    Alternative name(s):
    Mini-chromosome maintenance deficient domain-containing protein 1
    Minichromosome maintenance 9
    Gene namesi
    Name:MCM9
    Synonyms:C6orf61, MCMDC1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 6

    Organism-specific databases

    HGNCiHGNC:21484. MCM9.

    Subcellular locationi

    Nucleus By similarity
    Note: Localizes to nuclear foci and colocalizes with RAD51.By similarity

    GO - Cellular componenti

    1. MCM8-MCM9 complex Source: UniProtKB
    2. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA162395071.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 11431143DNA helicase MCM9PRO_0000089513Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei762 – 7621Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ9NXL9.
    PaxDbiQ9NXL9.
    PRIDEiQ9NXL9.

    PTM databases

    PhosphoSiteiQ9NXL9.

    Expressioni

    Developmental stagei

    The expression of isoform L and isoform M is cell cycle regulated: induced in S-phase, decreases through G2/M, and becomes constant through G1.1 Publication

    Gene expression databases

    ArrayExpressiQ9NXL9.
    BgeeiQ9NXL9.
    CleanExiHS_MCM9.
    GenevestigatoriQ9NXL9.

    Organism-specific databases

    HPAiHPA031137.

    Interactioni

    Subunit structurei

    Component of the MCM8-MCM9 complex, which forms a hexamer composed of MCM8 and MCM9.1 Publication

    Protein-protein interaction databases

    BioGridi129033. 2 interactions.
    IntActiQ9NXL9. 2 interactions.
    STRINGi9606.ENSP00000312870.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9NXL9.
    SMRiQ9NXL9. Positions 82-271, 347-605.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini300 – 505206MCMAdd
    BLAST

    Sequence similaritiesi

    Belongs to the MCM family.Curated
    Contains 1 MCM domain.Curated

    Phylogenomic databases

    eggNOGiCOG1241.
    HOGENOMiHOG000169812.
    HOVERGENiHBG108122.
    InParanoidiQ9NXL9.
    KOiK10738.
    OMAiEDFWEHY.
    OrthoDBiEOG7TQV0G.
    PhylomeDBiQ9NXL9.
    TreeFamiTF329421.

    Family and domain databases

    Gene3Di2.40.50.140. 2 hits.
    3.40.50.300. 1 hit.
    InterProiIPR003593. AAA+_ATPase.
    IPR001208. MCM_DNA-dep_ATPase.
    IPR012340. NA-bd_OB-fold.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PfamiPF00493. MCM. 1 hit.
    [Graphical view]
    PRINTSiPR01657. MCMFAMILY.
    SMARTiSM00382. AAA. 1 hit.
    SM00350. MCM. 1 hit.
    [Graphical view]
    SUPFAMiSSF50249. SSF50249. 1 hit.
    SSF52540. SSF52540. 1 hit.
    PROSITEiPS50051. MCM_2. 1 hit.
    [Graphical view]

    Sequences (4)i

    Sequence statusi: Complete.

    This entry describes 4 isoformsi produced by alternative splicing. Align

    Isoform L (identifier: Q9NXL9-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MNSDQVTLVG QVFESYVSEY HKNDILLILK ERDEDAHYPV VVNAMTLFET     50
    NMEIGEYFNM FPSEVLTIFD SALRRSALTI LQSLSQPEAV SMKQNLHARI 100
    SGLPVCPELV REHIPKTKDV GHFLSVTGTV IRTSLVKVLE FERDYMCNKC 150
    KHVFVIKADF EQYYTFCRPS SCPSLESCDS SKFTCLSGLS SSPTRCRDYQ 200
    EIKIQEQVQR LSVGSIPRSM KVILEDDLVD SCKSGDDLTI YGIVMQRWKP 250
    FQQDVRCEVE IVLKANYIQV NNEQSSGIIM DEEVQKEFED FWEYYKSDPF 300
    AGRNVILASL CPQVFGMYLV KLAVAMVLAG GIQRTDATGT RVRGESHLLL 350
    VGDPGTGKSQ FLKYAAKITP RSVLTTGIGS TSAGLTVTAV KDSGEWNLEA 400
    GALVLADAGL CCIDEFNSLK EHDRTSIHEA MEQQTISVAK AGLVCKLNTR 450
    TTILAATNPK GQYDPQESVS VNIALGSPLL SRFDLILVLL DTKNEDWDRI 500
    ISSFILENKG YPSKSEKLWS MEKMKTYFCL IRNLQPTLSD VGNQVLLRYY 550
    QMQRQSDCRN AARTTIRLLE SLIRLAEAHA RLMFRDTVTL EDAITVVSVM 600
    ESSMQGGALL GGVNALHTSF PENPGEQYQR QCELILEKLE LQSLLSEELR 650
    RLERLQNQSV HQSQPRVLEV ETTPGSLRNG PGEESNFRTS SQQEINYSTH 700
    IFSPGGSPEG SPVLDPPPHL EPNRSTSRKH SAQHKNNRDD SLDWFDFMAT 750
    HQSEPKNTVV VSPHPKTSGE NMASKISNST SQGKEKSEPG QRSKVDIGLL 800
    PSPGETGVPW RADNVESNKK KRLALDSEAA VSADKPDSVL THHVPRNLQK 850
    LCKERAQKLC RNSTRVPAQC TVPSHPQSTP VHSPDRMLDS PKRKRPKSLA 900
    QVEEPAIENV KPPGSPVAKL AKFTFKQKSK LIHSFEDHSH VSPGATKIAV 950
    HSPKISQRRT RRDAALPVKR PGKLTSTPGN QISSQPQGET KEVSQQPPEK 1000
    HGPREKVMCA PEKRIIQPEL ELGNETGCAH LTCEGDKKEE VSGSNKSGKV 1050
    HACTLARLAN FCFTPPSESK SKSPPPERKN RGERGPSSPP TTTAPMRVSK 1100
    RKSFQLRGST EKLIVSKESL FTLPELGDEA FDCDWDEEMR KKS 1143

    Note: Most abundant isoform.

    Length:1,143
    Mass (Da):127,313
    Last modified:May 16, 2012 - v4
    Checksum:i3C35C8B3476A470F
    GO
    Isoform M (identifier: Q9NXL9-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         606-648: GGALLGGVNA...LELQSLLSEE → VTESECAPIP...QNFITAGNQL
         649-1143: Missing.

    Show »
    Length:648
    Mass (Da):72,737
    Checksum:i344DC7E1E4BB7C40
    GO
    Isoform S (identifier: Q9NXL9-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         383-391: AGLTVTAVK → AGIVCDNFK
         392-1143: Missing.

    Show »
    Length:391
    Mass (Da):43,983
    Checksum:i1AB5A6CFBCF4E40C
    GO
    Isoform 4 (identifier: Q9NXL9-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-381: Missing.
         382-383: SA → MS

    Note: No experimental confirmation available.

    Show »
    Length:762
    Mass (Da):84,442
    Checksum:i2C3190DA9ACCA977
    GO

    Sequence cautioni

    The sequence BAA90991.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
    The sequence BAG61142.1 differs from that shown. Reason: Erroneous termination at position 1070. Translated as Lys.
    The sequence CAX30832.1 differs from that shown. Reason: Erroneous gene model prediction.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti433 – 4331Q → R in BAG61142. (PubMed:14702039)Curated
    Sequence conflicti558 – 5581C → S in BAG61142. (PubMed:14702039)Curated
    Sequence conflicti1063 – 10631F → V in BAA90991. (PubMed:14702039)Curated
    Sequence conflicti1136 – 11361D → G in BAA90991. (PubMed:14702039)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 381381Missing in isoform 4. 1 PublicationVSP_044180Add
    BLAST
    Alternative sequencei382 – 3832SA → MS in isoform 4. 1 PublicationVSP_044181
    Alternative sequencei383 – 3919AGLTVTAVK → AGIVCDNFK in isoform S. 1 PublicationVSP_028013
    Alternative sequencei392 – 1143752Missing in isoform S. 1 PublicationVSP_028014Add
    BLAST
    Alternative sequencei606 – 64843GGALL…LLSEE → VTESECAPIPTTGIGGRDYS RILEKWSRGRIKLQNFITAG NQL in isoform M. CuratedVSP_047462Add
    BLAST
    Alternative sequencei649 – 1143495Missing in isoform M. CuratedVSP_047463Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK299076 mRNA. Translation: BAG61142.1. Sequence problems.
    AK000177 mRNA. Translation: BAA90991.1. Different initiation.
    AL132874, AL359634 Genomic DNA. Translation: CAX30832.1. Sequence problems.
    BC031658 mRNA. Translation: AAH31658.1.
    BN000882 mRNA. Translation: CAJ70648.1.
    CCDSiCCDS5121.1. [Q9NXL9-3]
    CCDS56447.1. [Q9NXL9-1]
    RefSeqiNP_060166.2. NM_017696.2. [Q9NXL9-1]
    NP_694987.1. NM_153255.4. [Q9NXL9-3]
    UniGeneiHs.279008.
    Hs.733116.
    Hs.736853.

    Genome annotation databases

    EnsembliENST00000316068; ENSP00000312870; ENSG00000111877. [Q9NXL9-3]
    ENST00000316316; ENSP00000314505; ENSG00000111877. [Q9NXL9-1]
    GeneIDi254394.
    KEGGihsa:254394.
    UCSCiuc003pyh.3. human. [Q9NXL9-2]
    uc021zeh.1. human. [Q9NXL9-1]

    Polymorphism databases

    DMDMi387912921.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK299076 mRNA. Translation: BAG61142.1 . Sequence problems.
    AK000177 mRNA. Translation: BAA90991.1 . Different initiation.
    AL132874 , AL359634 Genomic DNA. Translation: CAX30832.1 . Sequence problems.
    BC031658 mRNA. Translation: AAH31658.1 .
    BN000882 mRNA. Translation: CAJ70648.1 .
    CCDSi CCDS5121.1. [Q9NXL9-3 ]
    CCDS56447.1. [Q9NXL9-1 ]
    RefSeqi NP_060166.2. NM_017696.2. [Q9NXL9-1 ]
    NP_694987.1. NM_153255.4. [Q9NXL9-3 ]
    UniGenei Hs.279008.
    Hs.733116.
    Hs.736853.

    3D structure databases

    ProteinModelPortali Q9NXL9.
    SMRi Q9NXL9. Positions 82-271, 347-605.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 129033. 2 interactions.
    IntActi Q9NXL9. 2 interactions.
    STRINGi 9606.ENSP00000312870.

    PTM databases

    PhosphoSitei Q9NXL9.

    Polymorphism databases

    DMDMi 387912921.

    Proteomic databases

    MaxQBi Q9NXL9.
    PaxDbi Q9NXL9.
    PRIDEi Q9NXL9.

    Protocols and materials databases

    DNASUi 254394.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000316068 ; ENSP00000312870 ; ENSG00000111877 . [Q9NXL9-3 ]
    ENST00000316316 ; ENSP00000314505 ; ENSG00000111877 . [Q9NXL9-1 ]
    GeneIDi 254394.
    KEGGi hsa:254394.
    UCSCi uc003pyh.3. human. [Q9NXL9-2 ]
    uc021zeh.1. human. [Q9NXL9-1 ]

    Organism-specific databases

    CTDi 254394.
    GeneCardsi GC06M119136.
    HGNCi HGNC:21484. MCM9.
    HPAi HPA031137.
    MIMi 610098. gene.
    neXtProti NX_Q9NXL9.
    PharmGKBi PA162395071.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG1241.
    HOGENOMi HOG000169812.
    HOVERGENi HBG108122.
    InParanoidi Q9NXL9.
    KOi K10738.
    OMAi EDFWEHY.
    OrthoDBi EOG7TQV0G.
    PhylomeDBi Q9NXL9.
    TreeFami TF329421.

    Miscellaneous databases

    GenomeRNAii 254394.
    NextBioi 92339.
    PROi Q9NXL9.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9NXL9.
    Bgeei Q9NXL9.
    CleanExi HS_MCM9.
    Genevestigatori Q9NXL9.

    Family and domain databases

    Gene3Di 2.40.50.140. 2 hits.
    3.40.50.300. 1 hit.
    InterProi IPR003593. AAA+_ATPase.
    IPR001208. MCM_DNA-dep_ATPase.
    IPR012340. NA-bd_OB-fold.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    Pfami PF00493. MCM. 1 hit.
    [Graphical view ]
    PRINTSi PR01657. MCMFAMILY.
    SMARTi SM00382. AAA. 1 hit.
    SM00350. MCM. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50249. SSF50249. 1 hit.
    SSF52540. SSF52540. 1 hit.
    PROSITEi PS50051. MCM_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 865-1143 (ISOFORM L).
      Tissue: Teratocarcinoma.
    2. "The DNA sequence and analysis of human chromosome 6."
      Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
      , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
      Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM S).
      Tissue: Brain.
    4. "Identification of full genes and proteins of MCM9, a novel, vertebrate-specific member of the MCM2-8 protein family."
      Lutzmann M., Maiorano D., Mechali M.
      Gene 362:51-56(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION.
    5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    6. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-762, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    7. "Mcm8 and Mcm9 form a complex that functions in homologous recombination repair induced by DNA interstrand crosslinks."
      Nishimura K., Ishiai M., Horikawa K., Fukagawa T., Takata M., Takisawa H., Kanemaki M.T.
      Mol. Cell 47:511-522(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, IDENTIFICATION IN THE MCM8-MCM9 COMPLEX.
    8. "Identification, quantification, and evolutionary analysis of a novel isoform of MCM9."
      Jeffries E.P., Denq W.I., Bartko J.C., Trakselis M.A.
      Gene 519:41-49(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: ALTERNATIVE SPLICING (ISOFORM M), DEVELOPMENTAL STAGE.

    Entry informationi

    Entry nameiMCM9_HUMAN
    AccessioniPrimary (citable) accession number: Q9NXL9
    Secondary accession number(s): B4DR30
    , B9DI77, Q2KHJ0, Q8N5S5, Q9HCV5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 5, 2005
    Last sequence update: May 16, 2012
    Last modified: October 1, 2014
    This is version 95 of the entry and version 4 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 6
      Human chromosome 6: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3