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Q9NXL9

- MCM9_HUMAN

UniProt

Q9NXL9 - MCM9_HUMAN

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Protein

DNA helicase MCM9

Gene

MCM9

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Component of the MCM8-MCM9 complex, a complex involved in homologous recombination repair following DNA interstrand cross-links and plays a key role during gametogenesis. The MCM8-MCM9 complex probably acts as a hexameric helicase downstream of the Fanconi anemia proteins BRCA2 and RAD51 and is required to process aberrant forks into homologous recombination substrates and to orchestrate homologous recombination with resection, fork stabilization and fork restart.1 Publication

Catalytic activityi

ATP + H2O = ADP + phosphate.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi352 – 3598ATPSequence Analysis

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. DNA binding Source: UniProtKB-KW
  3. helicase activity Source: UniProtKB-KW

GO - Biological processi

  1. cellular response to DNA damage stimulus Source: UniProtKB
  2. DNA replication Source: InterPro
  3. double-strand break repair via homologous recombination Source: UniProtKB
  4. female gamete generation Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Helicase, Hydrolase

Keywords - Biological processi

DNA damage, DNA repair

Keywords - Ligandi

ATP-binding, DNA-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
DNA helicase MCM9 (EC:3.6.4.12)
Short name:
hMCM9
Alternative name(s):
Mini-chromosome maintenance deficient domain-containing protein 1
Minichromosome maintenance 9
Gene namesi
Name:MCM9
Synonyms:C6orf61, MCMDC1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 6

Organism-specific databases

HGNCiHGNC:21484. MCM9.

Subcellular locationi

Nucleus By similarity
Note: Localizes to nuclear foci and colocalizes with RAD51.By similarity

GO - Cellular componenti

  1. MCM8-MCM9 complex Source: UniProtKB
  2. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162395071.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 11431143DNA helicase MCM9PRO_0000089513Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei762 – 7621Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9NXL9.
PaxDbiQ9NXL9.
PRIDEiQ9NXL9.

PTM databases

PhosphoSiteiQ9NXL9.

Expressioni

Developmental stagei

The expression of isoform L and isoform M is cell cycle regulated: induced in S-phase, decreases through G2/M, and becomes constant through G1.1 Publication

Gene expression databases

BgeeiQ9NXL9.
CleanExiHS_MCM9.
ExpressionAtlasiQ9NXL9. baseline and differential.
GenevestigatoriQ9NXL9.

Organism-specific databases

HPAiHPA031137.

Interactioni

Subunit structurei

Component of the MCM8-MCM9 complex, which forms a hexamer composed of MCM8 and MCM9.1 Publication

Protein-protein interaction databases

BioGridi129033. 7 interactions.
IntActiQ9NXL9. 2 interactions.
STRINGi9606.ENSP00000312870.

Structurei

3D structure databases

ProteinModelPortaliQ9NXL9.
SMRiQ9NXL9. Positions 24-271, 347-605.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini300 – 505206MCMAdd
BLAST

Sequence similaritiesi

Belongs to the MCM family.Curated
Contains 1 MCM domain.Curated

Phylogenomic databases

eggNOGiCOG1241.
GeneTreeiENSGT00740000115337.
HOGENOMiHOG000169812.
HOVERGENiHBG108122.
InParanoidiQ9NXL9.
KOiK10738.
OMAiEDFWEHY.
OrthoDBiEOG7TQV0G.
PhylomeDBiQ9NXL9.
TreeFamiTF329421.

Family and domain databases

Gene3Di2.40.50.140. 2 hits.
3.40.50.300. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR001208. MCM_DNA-dep_ATPase.
IPR012340. NA-bd_OB-fold.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00493. MCM. 1 hit.
[Graphical view]
PRINTSiPR01657. MCMFAMILY.
SMARTiSM00382. AAA. 1 hit.
SM00350. MCM. 1 hit.
[Graphical view]
SUPFAMiSSF50249. SSF50249. 1 hit.
SSF52540. SSF52540. 1 hit.
PROSITEiPS50051. MCM_2. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. Align

Isoform L (identifier: Q9NXL9-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MNSDQVTLVG QVFESYVSEY HKNDILLILK ERDEDAHYPV VVNAMTLFET
60 70 80 90 100
NMEIGEYFNM FPSEVLTIFD SALRRSALTI LQSLSQPEAV SMKQNLHARI
110 120 130 140 150
SGLPVCPELV REHIPKTKDV GHFLSVTGTV IRTSLVKVLE FERDYMCNKC
160 170 180 190 200
KHVFVIKADF EQYYTFCRPS SCPSLESCDS SKFTCLSGLS SSPTRCRDYQ
210 220 230 240 250
EIKIQEQVQR LSVGSIPRSM KVILEDDLVD SCKSGDDLTI YGIVMQRWKP
260 270 280 290 300
FQQDVRCEVE IVLKANYIQV NNEQSSGIIM DEEVQKEFED FWEYYKSDPF
310 320 330 340 350
AGRNVILASL CPQVFGMYLV KLAVAMVLAG GIQRTDATGT RVRGESHLLL
360 370 380 390 400
VGDPGTGKSQ FLKYAAKITP RSVLTTGIGS TSAGLTVTAV KDSGEWNLEA
410 420 430 440 450
GALVLADAGL CCIDEFNSLK EHDRTSIHEA MEQQTISVAK AGLVCKLNTR
460 470 480 490 500
TTILAATNPK GQYDPQESVS VNIALGSPLL SRFDLILVLL DTKNEDWDRI
510 520 530 540 550
ISSFILENKG YPSKSEKLWS MEKMKTYFCL IRNLQPTLSD VGNQVLLRYY
560 570 580 590 600
QMQRQSDCRN AARTTIRLLE SLIRLAEAHA RLMFRDTVTL EDAITVVSVM
610 620 630 640 650
ESSMQGGALL GGVNALHTSF PENPGEQYQR QCELILEKLE LQSLLSEELR
660 670 680 690 700
RLERLQNQSV HQSQPRVLEV ETTPGSLRNG PGEESNFRTS SQQEINYSTH
710 720 730 740 750
IFSPGGSPEG SPVLDPPPHL EPNRSTSRKH SAQHKNNRDD SLDWFDFMAT
760 770 780 790 800
HQSEPKNTVV VSPHPKTSGE NMASKISNST SQGKEKSEPG QRSKVDIGLL
810 820 830 840 850
PSPGETGVPW RADNVESNKK KRLALDSEAA VSADKPDSVL THHVPRNLQK
860 870 880 890 900
LCKERAQKLC RNSTRVPAQC TVPSHPQSTP VHSPDRMLDS PKRKRPKSLA
910 920 930 940 950
QVEEPAIENV KPPGSPVAKL AKFTFKQKSK LIHSFEDHSH VSPGATKIAV
960 970 980 990 1000
HSPKISQRRT RRDAALPVKR PGKLTSTPGN QISSQPQGET KEVSQQPPEK
1010 1020 1030 1040 1050
HGPREKVMCA PEKRIIQPEL ELGNETGCAH LTCEGDKKEE VSGSNKSGKV
1060 1070 1080 1090 1100
HACTLARLAN FCFTPPSESK SKSPPPERKN RGERGPSSPP TTTAPMRVSK
1110 1120 1130 1140
RKSFQLRGST EKLIVSKESL FTLPELGDEA FDCDWDEEMR KKS

Note: Most abundant isoform.

Length:1,143
Mass (Da):127,313
Last modified:May 16, 2012 - v4
Checksum:i3C35C8B3476A470F
GO
Isoform M (identifier: Q9NXL9-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     606-648: GGALLGGVNA...LELQSLLSEE → VTESECAPIP...QNFITAGNQL
     649-1143: Missing.

Show »
Length:648
Mass (Da):72,737
Checksum:i344DC7E1E4BB7C40
GO
Isoform S (identifier: Q9NXL9-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     383-391: AGLTVTAVK → AGIVCDNFK
     392-1143: Missing.

Show »
Length:391
Mass (Da):43,983
Checksum:i1AB5A6CFBCF4E40C
GO
Isoform 4 (identifier: Q9NXL9-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-381: Missing.
     382-383: SA → MS

Note: No experimental confirmation available.

Show »
Length:762
Mass (Da):84,442
Checksum:i2C3190DA9ACCA977
GO

Sequence cautioni

The sequence BAA90991.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAG61142.1 differs from that shown. Reason: Erroneous termination at position 1070. Translated as Lys.Curated
The sequence CAX30832.1 differs from that shown. Reason: Erroneous gene model prediction. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti433 – 4331Q → R in BAG61142. (PubMed:14702039)Curated
Sequence conflicti558 – 5581C → S in BAG61142. (PubMed:14702039)Curated
Sequence conflicti1063 – 10631F → V in BAA90991. (PubMed:14702039)Curated
Sequence conflicti1136 – 11361D → G in BAA90991. (PubMed:14702039)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 381381Missing in isoform 4. 1 PublicationVSP_044180Add
BLAST
Alternative sequencei382 – 3832SA → MS in isoform 4. 1 PublicationVSP_044181
Alternative sequencei383 – 3919AGLTVTAVK → AGIVCDNFK in isoform S. 1 PublicationVSP_028013
Alternative sequencei392 – 1143752Missing in isoform S. 1 PublicationVSP_028014Add
BLAST
Alternative sequencei606 – 64843GGALL…LLSEE → VTESECAPIPTTGIGGRDYS RILEKWSRGRIKLQNFITAG NQL in isoform M. CuratedVSP_047462Add
BLAST
Alternative sequencei649 – 1143495Missing in isoform M. CuratedVSP_047463Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK299076 mRNA. Translation: BAG61142.1. Sequence problems.
AK000177 mRNA. Translation: BAA90991.1. Different initiation.
AL132874, AL359634 Genomic DNA. Translation: CAX30832.1. Sequence problems.
BC031658 mRNA. Translation: AAH31658.1.
BN000882 mRNA. Translation: CAJ70648.1.
CCDSiCCDS5121.1. [Q9NXL9-3]
CCDS56447.1. [Q9NXL9-1]
RefSeqiNP_060166.2. NM_017696.2. [Q9NXL9-1]
NP_694987.1. NM_153255.4. [Q9NXL9-3]
UniGeneiHs.279008.
Hs.733116.
Hs.736853.

Genome annotation databases

EnsembliENST00000316068; ENSP00000312870; ENSG00000111877. [Q9NXL9-3]
ENST00000316316; ENSP00000314505; ENSG00000111877. [Q9NXL9-1]
ENST00000619706; ENSP00000480469; ENSG00000111877. [Q9NXL9-1]
GeneIDi254394.
KEGGihsa:254394.
UCSCiuc003pyh.3. human. [Q9NXL9-2]
uc021zeh.1. human. [Q9NXL9-1]

Polymorphism databases

DMDMi387912921.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK299076 mRNA. Translation: BAG61142.1 . Sequence problems.
AK000177 mRNA. Translation: BAA90991.1 . Different initiation.
AL132874 , AL359634 Genomic DNA. Translation: CAX30832.1 . Sequence problems.
BC031658 mRNA. Translation: AAH31658.1 .
BN000882 mRNA. Translation: CAJ70648.1 .
CCDSi CCDS5121.1. [Q9NXL9-3 ]
CCDS56447.1. [Q9NXL9-1 ]
RefSeqi NP_060166.2. NM_017696.2. [Q9NXL9-1 ]
NP_694987.1. NM_153255.4. [Q9NXL9-3 ]
UniGenei Hs.279008.
Hs.733116.
Hs.736853.

3D structure databases

ProteinModelPortali Q9NXL9.
SMRi Q9NXL9. Positions 24-271, 347-605.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 129033. 7 interactions.
IntActi Q9NXL9. 2 interactions.
STRINGi 9606.ENSP00000312870.

PTM databases

PhosphoSitei Q9NXL9.

Polymorphism databases

DMDMi 387912921.

Proteomic databases

MaxQBi Q9NXL9.
PaxDbi Q9NXL9.
PRIDEi Q9NXL9.

Protocols and materials databases

DNASUi 254394.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000316068 ; ENSP00000312870 ; ENSG00000111877 . [Q9NXL9-3 ]
ENST00000316316 ; ENSP00000314505 ; ENSG00000111877 . [Q9NXL9-1 ]
ENST00000619706 ; ENSP00000480469 ; ENSG00000111877 . [Q9NXL9-1 ]
GeneIDi 254394.
KEGGi hsa:254394.
UCSCi uc003pyh.3. human. [Q9NXL9-2 ]
uc021zeh.1. human. [Q9NXL9-1 ]

Organism-specific databases

CTDi 254394.
GeneCardsi GC06M119136.
HGNCi HGNC:21484. MCM9.
HPAi HPA031137.
MIMi 610098. gene.
neXtProti NX_Q9NXL9.
PharmGKBi PA162395071.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG1241.
GeneTreei ENSGT00740000115337.
HOGENOMi HOG000169812.
HOVERGENi HBG108122.
InParanoidi Q9NXL9.
KOi K10738.
OMAi EDFWEHY.
OrthoDBi EOG7TQV0G.
PhylomeDBi Q9NXL9.
TreeFami TF329421.

Miscellaneous databases

ChiTaRSi MCM9. human.
GenomeRNAii 254394.
NextBioi 92339.
PROi Q9NXL9.
SOURCEi Search...

Gene expression databases

Bgeei Q9NXL9.
CleanExi HS_MCM9.
ExpressionAtlasi Q9NXL9. baseline and differential.
Genevestigatori Q9NXL9.

Family and domain databases

Gene3Di 2.40.50.140. 2 hits.
3.40.50.300. 1 hit.
InterProi IPR003593. AAA+_ATPase.
IPR001208. MCM_DNA-dep_ATPase.
IPR012340. NA-bd_OB-fold.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF00493. MCM. 1 hit.
[Graphical view ]
PRINTSi PR01657. MCMFAMILY.
SMARTi SM00382. AAA. 1 hit.
SM00350. MCM. 1 hit.
[Graphical view ]
SUPFAMi SSF50249. SSF50249. 1 hit.
SSF52540. SSF52540. 1 hit.
PROSITEi PS50051. MCM_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 865-1143 (ISOFORM L).
    Tissue: Teratocarcinoma.
  2. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM S).
    Tissue: Brain.
  4. "Identification of full genes and proteins of MCM9, a novel, vertebrate-specific member of the MCM2-8 protein family."
    Lutzmann M., Maiorano D., Mechali M.
    Gene 362:51-56(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION.
  5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  6. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-762, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  7. "Mcm8 and Mcm9 form a complex that functions in homologous recombination repair induced by DNA interstrand crosslinks."
    Nishimura K., Ishiai M., Horikawa K., Fukagawa T., Takata M., Takisawa H., Kanemaki M.T.
    Mol. Cell 47:511-522(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, IDENTIFICATION IN THE MCM8-MCM9 COMPLEX.
  8. "Identification, quantification, and evolutionary analysis of a novel isoform of MCM9."
    Jeffries E.P., Denq W.I., Bartko J.C., Trakselis M.A.
    Gene 519:41-49(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: ALTERNATIVE SPLICING (ISOFORM M), DEVELOPMENTAL STAGE.

Entry informationi

Entry nameiMCM9_HUMAN
AccessioniPrimary (citable) accession number: Q9NXL9
Secondary accession number(s): B4DR30
, B9DI77, Q2KHJ0, Q8N5S5, Q9HCV5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: May 16, 2012
Last modified: November 26, 2014
This is version 97 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3