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Protein

SID1 transmembrane family member 1

Gene

SIDT1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:ENSG00000072858-MONOMER.

Protein family/group databases

TCDBi1.A.79.1.2. the cholesterol uptake protein (chup) or double stranded rna uptake family.

Names & Taxonomyi

Protein namesi
Recommended name:
SID1 transmembrane family member 1
Gene namesi
Name:SIDT1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:25967. SIDT1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini20 – 309ExtracellularSequence analysisAdd BLAST290
Transmembranei310 – 330HelicalSequence analysisAdd BLAST21
Topological domaini331 – 442CytoplasmicSequence analysisAdd BLAST112
Transmembranei443 – 463HelicalSequence analysisAdd BLAST21
Topological domaini464 – 494ExtracellularSequence analysisAdd BLAST31
Transmembranei495 – 515HelicalSequence analysisAdd BLAST21
Topological domaini516 – 541CytoplasmicSequence analysisAdd BLAST26
Transmembranei542 – 562HelicalSequence analysisAdd BLAST21
Topological domaini563 – 572ExtracellularSequence analysis10
Transmembranei573 – 590HelicalSequence analysisAdd BLAST18
Topological domaini591 – 600CytoplasmicSequence analysis10
Transmembranei601 – 621HelicalSequence analysisAdd BLAST21
Topological domaini622 – 626ExtracellularSequence analysis5
Transmembranei627 – 647HelicalSequence analysisAdd BLAST21
Topological domaini648 – 683CytoplasmicSequence analysisAdd BLAST36
Transmembranei684 – 704HelicalSequence analysisAdd BLAST21
Topological domaini705 – 710ExtracellularSequence analysis6
Transmembranei711 – 731HelicalSequence analysisAdd BLAST21
Topological domaini732 – 741CytoplasmicSequence analysis10
Transmembranei742 – 762HelicalSequence analysisAdd BLAST21
Topological domaini763 – 791ExtracellularSequence analysisAdd BLAST29
Transmembranei792 – 812HelicalSequence analysisAdd BLAST21
Topological domaini813 – 827CytoplasmicSequence analysisAdd BLAST15

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi54847.
OpenTargetsiENSG00000072858.
PharmGKBiPA134923837.

Polymorphism and mutation databases

BioMutaiSIDT1.
DMDMi296452905.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_000003257520 – 827SID1 transmembrane family member 1Add BLAST808

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi57N-linked (GlcNAc...)Sequence analysis1
Glycosylationi67N-linked (GlcNAc...)Sequence analysis1
Glycosylationi83N-linked (GlcNAc...)Sequence analysis1
Glycosylationi136N-linked (GlcNAc...)Sequence analysis1
Glycosylationi282N-linked (GlcNAc...)Sequence analysis1
Glycosylationi471N-linked (GlcNAc...)Sequence analysis1
Glycosylationi567N-linked (GlcNAc...)Sequence analysis1
Glycosylationi764N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9NXL6.
PeptideAtlasiQ9NXL6.
PRIDEiQ9NXL6.

PTM databases

iPTMnetiQ9NXL6.
PhosphoSitePlusiQ9NXL6.
SwissPalmiQ9NXL6.

Expressioni

Gene expression databases

BgeeiENSG00000072858.
CleanExiHS_SIDT1.
GenevisibleiQ9NXL6. HS.

Organism-specific databases

HPAiHPA035862.

Interactioni

Protein-protein interaction databases

IntActiQ9NXL6. 1 interactor.
STRINGi9606.ENSP00000264852.

Structurei

3D structure databases

ProteinModelPortaliQ9NXL6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SID1 family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IF6Z. Eukaryota.
ENOG410XPBN. LUCA.
GeneTreeiENSGT00390000010091.
HOGENOMiHOG000020635.
HOVERGENiHBG079188.
InParanoidiQ9NXL6.
OMAiFFIQEKE.
OrthoDBiEOG091G01Q2.
PhylomeDBiQ9NXL6.
TreeFamiTF313076.

Family and domain databases

InterProiIPR025958. SID1_TM_fam.
[Graphical view]
PfamiPF13965. SID-1_RNA_chan. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9NXL6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRGCLRLALL CALPWLLLAA SPGHPAKSPR QPPAPRRDPF DAARGADFDH
60 70 80 90 100
VYSGVVNLST ENIYSFNYTS QPDQVTAVRV YVNSSSENLN YPVLVVVRQQ
110 120 130 140 150
KEVLSWQVPL LFQGLYQRSY NYQEVSRTLC PSEATNETGP LQQLIFVDVA
160 170 180 190 200
SMAPLGAQYK LLVTKLKHFQ LRTNVAFHFT ASPSQPQYFL YKFPKDVDSV
210 220 230 240 250
IIKVVSEMAY PCSVVSVQNI MCPVYDLDHN VEFNGVYQSM TKKAAITLQK
260 270 280 290 300
KDFPGEQFFV VFVIKPEDYA CGGSFFIQEK ENQTWNLQRK KNLEVTIVPS
310 320 330 340 350
IKESVYVKSS LFSVFIFLSF YLGCLLVGFV HYLRFQRKSI DGSFGSNDGS
360 370 380 390 400
GNMVASHPIA ASTPEGSNYG TIDESSSSPG RQMSSSDGGP PGQSDTDSSV
410 420 430 440 450
EESDFDTMPD IESDKNIIRT KMFLYLSDLS RKDRRIVSKK YKIYFWNIIT
460 470 480 490 500
IAVFYALPVI QLVITYQTVV NVTGNQDICY YNFLCAHPLG VLSAFNNILS
510 520 530 540 550
NLGHVLLGFL FLLIVLRRDI LHRRALEAKD IFAVEYGIPK HFGLFYAMGI
560 570 580 590 600
ALMMEGVLSA CYHVCPNYSN FQFDTSFMYM IAGLCMLKLY QTRHPDINAS
610 620 630 640 650
AYSAYASFAV VIMVTVLGVV FGKNDVWFWV IFSAIHVLAS LALSTQIYYM
660 670 680 690 700
GRFKIDLGIF RRAAMVFYTD CIQQCSRPLY MDRMVLLVVG NLVNWSFALF
710 720 730 740 750
GLIYRPRDFA SYMLGIFICN LLLYLAFYII MKLRSSEKVL PVPLFCIVAT
760 770 780 790 800
AVMWAAALYF FFQNLSSWEG TPAESREKNR ECILLDFFDD HDIWHFLSAT
810 820
ALFFSFLVLL TLDDDLDVVR RDQIPVF
Length:827
Mass (Da):93,839
Last modified:May 18, 2010 - v2
Checksum:iE7C383DF74378B8C
GO
Isoform 2 (identifier: Q9NXL6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     655-655: I → IDVSDT

Note: No experimental confirmation available.
Show »
Length:832
Mass (Da):94,356
Checksum:iB0709610421A9D01
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti572Q → R in BAA90994 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0617933G → S.Corresponds to variant rs9879313dbSNPEnsembl.1
Natural variantiVAR_05718478V → M.Corresponds to variant rs2271496dbSNPEnsembl.1
Natural variantiVAR_057185363T → I.Corresponds to variant rs33990195dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_039174655I → IDVSDT in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK000181 mRNA. Translation: BAA90994.1.
AC055740 Genomic DNA. No translation available.
AC112128 Genomic DNA. No translation available.
BC117222 mRNA. Translation: AAI17223.1.
CCDSiCCDS2974.1. [Q9NXL6-1]
CCDS77790.1. [Q9NXL6-2]
RefSeqiNP_001295279.1. NM_001308350.1. [Q9NXL6-2]
NP_060169.2. NM_017699.2. [Q9NXL6-1]
UniGeneiHs.591291.

Genome annotation databases

EnsembliENST00000264852; ENSP00000264852; ENSG00000072858. [Q9NXL6-1]
ENST00000393830; ENSP00000377416; ENSG00000072858. [Q9NXL6-2]
GeneIDi54847.
KEGGihsa:54847.
UCSCiuc003eak.4. human. [Q9NXL6-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK000181 mRNA. Translation: BAA90994.1.
AC055740 Genomic DNA. No translation available.
AC112128 Genomic DNA. No translation available.
BC117222 mRNA. Translation: AAI17223.1.
CCDSiCCDS2974.1. [Q9NXL6-1]
CCDS77790.1. [Q9NXL6-2]
RefSeqiNP_001295279.1. NM_001308350.1. [Q9NXL6-2]
NP_060169.2. NM_017699.2. [Q9NXL6-1]
UniGeneiHs.591291.

3D structure databases

ProteinModelPortaliQ9NXL6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9NXL6. 1 interactor.
STRINGi9606.ENSP00000264852.

Protein family/group databases

TCDBi1.A.79.1.2. the cholesterol uptake protein (chup) or double stranded rna uptake family.

PTM databases

iPTMnetiQ9NXL6.
PhosphoSitePlusiQ9NXL6.
SwissPalmiQ9NXL6.

Polymorphism and mutation databases

BioMutaiSIDT1.
DMDMi296452905.

Proteomic databases

PaxDbiQ9NXL6.
PeptideAtlasiQ9NXL6.
PRIDEiQ9NXL6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000264852; ENSP00000264852; ENSG00000072858. [Q9NXL6-1]
ENST00000393830; ENSP00000377416; ENSG00000072858. [Q9NXL6-2]
GeneIDi54847.
KEGGihsa:54847.
UCSCiuc003eak.4. human. [Q9NXL6-1]

Organism-specific databases

CTDi54847.
DisGeNETi54847.
GeneCardsiSIDT1.
HGNCiHGNC:25967. SIDT1.
HPAiHPA035862.
MIMi606816. gene.
neXtProtiNX_Q9NXL6.
OpenTargetsiENSG00000072858.
PharmGKBiPA134923837.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IF6Z. Eukaryota.
ENOG410XPBN. LUCA.
GeneTreeiENSGT00390000010091.
HOGENOMiHOG000020635.
HOVERGENiHBG079188.
InParanoidiQ9NXL6.
OMAiFFIQEKE.
OrthoDBiEOG091G01Q2.
PhylomeDBiQ9NXL6.
TreeFamiTF313076.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000072858-MONOMER.

Miscellaneous databases

ChiTaRSiSIDT1. human.
GenomeRNAii54847.
PROiQ9NXL6.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000072858.
CleanExiHS_SIDT1.
GenevisibleiQ9NXL6. HS.

Family and domain databases

InterProiIPR025958. SID1_TM_fam.
[Graphical view]
PfamiPF13965. SID-1_RNA_chan. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSIDT1_HUMAN
AccessioniPrimary (citable) accession number: Q9NXL6
Secondary accession number(s): Q17RR4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: May 18, 2010
Last modified: November 2, 2016
This is version 99 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.