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Protein

SID1 transmembrane family member 1

Gene

SIDT1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

In vitro binds long double-stranded RNA (dsRNA) (500 and 700 base pairs), but not dsRNA shorter than 300 bp. Not involved in RNA autophagy, a process in which RNA is directly imported into lysosomes in an ATP-dependent manner, and degraded.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionRNA-binding

Protein family/group databases

TCDBi1.A.79.1.2 the cholesterol uptake protein (chup) or double stranded rna uptake family

Names & Taxonomyi

Protein namesi
Recommended name:
SID1 transmembrane family member 1
Gene namesi
Name:SIDT1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000072858.10
HGNCiHGNC:25967 SIDT1
MIMi606816 gene
neXtProtiNX_Q9NXL6

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini20 – 309ExtracellularSequence analysisAdd BLAST290
Transmembranei310 – 330HelicalSequence analysisAdd BLAST21
Topological domaini331 – 442CytoplasmicSequence analysisAdd BLAST112
Transmembranei443 – 463HelicalSequence analysisAdd BLAST21
Topological domaini464 – 494ExtracellularSequence analysisAdd BLAST31
Transmembranei495 – 515HelicalSequence analysisAdd BLAST21
Topological domaini516 – 541CytoplasmicSequence analysisAdd BLAST26
Transmembranei542 – 562HelicalSequence analysisAdd BLAST21
Topological domaini563 – 572ExtracellularSequence analysis10
Transmembranei573 – 590HelicalSequence analysisAdd BLAST18
Topological domaini591 – 600CytoplasmicSequence analysis10
Transmembranei601 – 621HelicalSequence analysisAdd BLAST21
Topological domaini622 – 626ExtracellularSequence analysis5
Transmembranei627 – 647HelicalSequence analysisAdd BLAST21
Topological domaini648 – 683CytoplasmicSequence analysisAdd BLAST36
Transmembranei684 – 704HelicalSequence analysisAdd BLAST21
Topological domaini705 – 710ExtracellularSequence analysis6
Transmembranei711 – 731HelicalSequence analysisAdd BLAST21
Topological domaini732 – 741CytoplasmicSequence analysis10
Transmembranei742 – 762HelicalSequence analysisAdd BLAST21
Topological domaini763 – 791ExtracellularSequence analysisAdd BLAST29
Transmembranei792 – 812HelicalSequence analysisAdd BLAST21
Topological domaini813 – 827CytoplasmicSequence analysisAdd BLAST15

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi54847
OpenTargetsiENSG00000072858
PharmGKBiPA134923837

Polymorphism and mutation databases

BioMutaiSIDT1
DMDMi296452905

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_000003257520 – 827SID1 transmembrane family member 1Add BLAST808

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi57N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi67N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi83N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi136N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi282N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi471N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi567N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi764N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9NXL6
PeptideAtlasiQ9NXL6
PRIDEiQ9NXL6
ProteomicsDBi83110
83111 [Q9NXL6-2]

PTM databases

iPTMnetiQ9NXL6
PhosphoSitePlusiQ9NXL6
SwissPalmiQ9NXL6

Expressioni

Gene expression databases

BgeeiENSG00000072858
CleanExiHS_SIDT1
GenevisibleiQ9NXL6 HS

Organism-specific databases

HPAiHPA035862

Interactioni

Protein-protein interaction databases

IntActiQ9NXL6, 1 interactor

Structurei

3D structure databases

ProteinModelPortaliQ9NXL6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SID1 family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IF6Z Eukaryota
ENOG410XPBN LUCA
GeneTreeiENSGT00390000010091
HOGENOMiHOG000020635
HOVERGENiHBG079188
InParanoidiQ9NXL6
OMAiFFIQEKE
OrthoDBiEOG091G01Q2
PhylomeDBiQ9NXL6
TreeFamiTF313076

Family and domain databases

InterProiView protein in InterPro
IPR025958 SID1_TM_fam
PANTHERiPTHR12185 PTHR12185, 1 hit
PfamiView protein in Pfam
PF13965 SID-1_RNA_chan, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9NXL6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRGCLRLALL CALPWLLLAA SPGHPAKSPR QPPAPRRDPF DAARGADFDH
60 70 80 90 100
VYSGVVNLST ENIYSFNYTS QPDQVTAVRV YVNSSSENLN YPVLVVVRQQ
110 120 130 140 150
KEVLSWQVPL LFQGLYQRSY NYQEVSRTLC PSEATNETGP LQQLIFVDVA
160 170 180 190 200
SMAPLGAQYK LLVTKLKHFQ LRTNVAFHFT ASPSQPQYFL YKFPKDVDSV
210 220 230 240 250
IIKVVSEMAY PCSVVSVQNI MCPVYDLDHN VEFNGVYQSM TKKAAITLQK
260 270 280 290 300
KDFPGEQFFV VFVIKPEDYA CGGSFFIQEK ENQTWNLQRK KNLEVTIVPS
310 320 330 340 350
IKESVYVKSS LFSVFIFLSF YLGCLLVGFV HYLRFQRKSI DGSFGSNDGS
360 370 380 390 400
GNMVASHPIA ASTPEGSNYG TIDESSSSPG RQMSSSDGGP PGQSDTDSSV
410 420 430 440 450
EESDFDTMPD IESDKNIIRT KMFLYLSDLS RKDRRIVSKK YKIYFWNIIT
460 470 480 490 500
IAVFYALPVI QLVITYQTVV NVTGNQDICY YNFLCAHPLG VLSAFNNILS
510 520 530 540 550
NLGHVLLGFL FLLIVLRRDI LHRRALEAKD IFAVEYGIPK HFGLFYAMGI
560 570 580 590 600
ALMMEGVLSA CYHVCPNYSN FQFDTSFMYM IAGLCMLKLY QTRHPDINAS
610 620 630 640 650
AYSAYASFAV VIMVTVLGVV FGKNDVWFWV IFSAIHVLAS LALSTQIYYM
660 670 680 690 700
GRFKIDLGIF RRAAMVFYTD CIQQCSRPLY MDRMVLLVVG NLVNWSFALF
710 720 730 740 750
GLIYRPRDFA SYMLGIFICN LLLYLAFYII MKLRSSEKVL PVPLFCIVAT
760 770 780 790 800
AVMWAAALYF FFQNLSSWEG TPAESREKNR ECILLDFFDD HDIWHFLSAT
810 820
ALFFSFLVLL TLDDDLDVVR RDQIPVF
Length:827
Mass (Da):93,839
Last modified:May 18, 2010 - v2
Checksum:iE7C383DF74378B8C
GO
Isoform 2 (identifier: Q9NXL6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     655-655: I → IDVSDT

Note: No experimental confirmation available.
Show »
Length:832
Mass (Da):94,356
Checksum:iB0709610421A9D01
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti572Q → R in BAA90994 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0617933G → S. Corresponds to variant dbSNP:rs9879313Ensembl.1
Natural variantiVAR_05718478V → M. Corresponds to variant dbSNP:rs2271496Ensembl.1
Natural variantiVAR_057185363T → I. Corresponds to variant dbSNP:rs33990195Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_039174655I → IDVSDT in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK000181 mRNA Translation: BAA90994.1
AC055740 Genomic DNA No translation available.
AC112128 Genomic DNA No translation available.
BC117222 mRNA Translation: AAI17223.1
CCDSiCCDS2974.1 [Q9NXL6-1]
CCDS77790.1 [Q9NXL6-2]
RefSeqiNP_001295279.1, NM_001308350.1 [Q9NXL6-2]
NP_060169.2, NM_017699.2 [Q9NXL6-1]
UniGeneiHs.591291

Genome annotation databases

EnsembliENST00000264852; ENSP00000264852; ENSG00000072858 [Q9NXL6-1]
ENST00000393830; ENSP00000377416; ENSG00000072858 [Q9NXL6-2]
GeneIDi54847
KEGGihsa:54847
UCSCiuc003eak.4 human [Q9NXL6-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiSIDT1_HUMAN
AccessioniPrimary (citable) accession number: Q9NXL6
Secondary accession number(s): Q17RR4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: May 18, 2010
Last modified: June 20, 2018
This is version 109 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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