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Protein

SID1 transmembrane family member 1

Gene

SIDT1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Protein family/group databases

TCDBi1.A.79.1.2. the cholesterol uptake protein (chup) or double stranded rna uptake family.

Names & Taxonomyi

Protein namesi
Recommended name:
SID1 transmembrane family member 1
Gene namesi
Name:SIDT1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:25967. SIDT1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini20 – 309290ExtracellularSequence analysisAdd
BLAST
Transmembranei310 – 33021HelicalSequence analysisAdd
BLAST
Topological domaini331 – 442112CytoplasmicSequence analysisAdd
BLAST
Transmembranei443 – 46321HelicalSequence analysisAdd
BLAST
Topological domaini464 – 49431ExtracellularSequence analysisAdd
BLAST
Transmembranei495 – 51521HelicalSequence analysisAdd
BLAST
Topological domaini516 – 54126CytoplasmicSequence analysisAdd
BLAST
Transmembranei542 – 56221HelicalSequence analysisAdd
BLAST
Topological domaini563 – 57210ExtracellularSequence analysis
Transmembranei573 – 59018HelicalSequence analysisAdd
BLAST
Topological domaini591 – 60010CytoplasmicSequence analysis
Transmembranei601 – 62121HelicalSequence analysisAdd
BLAST
Topological domaini622 – 6265ExtracellularSequence analysis
Transmembranei627 – 64721HelicalSequence analysisAdd
BLAST
Topological domaini648 – 68336CytoplasmicSequence analysisAdd
BLAST
Transmembranei684 – 70421HelicalSequence analysisAdd
BLAST
Topological domaini705 – 7106ExtracellularSequence analysis
Transmembranei711 – 73121HelicalSequence analysisAdd
BLAST
Topological domaini732 – 74110CytoplasmicSequence analysis
Transmembranei742 – 76221HelicalSequence analysisAdd
BLAST
Topological domaini763 – 79129ExtracellularSequence analysisAdd
BLAST
Transmembranei792 – 81221HelicalSequence analysisAdd
BLAST
Topological domaini813 – 82715CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134923837.

Polymorphism and mutation databases

BioMutaiSIDT1.
DMDMi296452905.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919Sequence analysisAdd
BLAST
Chaini20 – 827808SID1 transmembrane family member 1PRO_0000032575Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi57 – 571N-linked (GlcNAc...)Sequence analysis
Glycosylationi67 – 671N-linked (GlcNAc...)Sequence analysis
Glycosylationi83 – 831N-linked (GlcNAc...)Sequence analysis
Glycosylationi136 – 1361N-linked (GlcNAc...)Sequence analysis
Glycosylationi282 – 2821N-linked (GlcNAc...)Sequence analysis
Modified residuei398 – 3981PhosphoserineBy similarity
Modified residuei399 – 3991PhosphoserineBy similarity
Glycosylationi471 – 4711N-linked (GlcNAc...)Sequence analysis
Glycosylationi567 – 5671N-linked (GlcNAc...)Sequence analysis
Glycosylationi764 – 7641N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ9NXL6.
PRIDEiQ9NXL6.

PTM databases

iPTMnetiQ9NXL6.
PhosphoSiteiQ9NXL6.
SwissPalmiQ9NXL6.

Expressioni

Gene expression databases

BgeeiQ9NXL6.
CleanExiHS_SIDT1.
GenevisibleiQ9NXL6. HS.

Organism-specific databases

HPAiHPA035862.

Interactioni

Protein-protein interaction databases

IntActiQ9NXL6. 1 interaction.
STRINGi9606.ENSP00000264852.

Structurei

3D structure databases

ProteinModelPortaliQ9NXL6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SID1 family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IF6Z. Eukaryota.
ENOG410XPBN. LUCA.
GeneTreeiENSGT00390000010091.
HOGENOMiHOG000020635.
HOVERGENiHBG079188.
InParanoidiQ9NXL6.
OMAiFFIQEKE.
OrthoDBiEOG7K3TKF.
PhylomeDBiQ9NXL6.
TreeFamiTF313076.

Family and domain databases

InterProiIPR025958. SID1_TM_fam.
[Graphical view]
PfamiPF13965. SID-1_RNA_chan. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9NXL6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRGCLRLALL CALPWLLLAA SPGHPAKSPR QPPAPRRDPF DAARGADFDH
60 70 80 90 100
VYSGVVNLST ENIYSFNYTS QPDQVTAVRV YVNSSSENLN YPVLVVVRQQ
110 120 130 140 150
KEVLSWQVPL LFQGLYQRSY NYQEVSRTLC PSEATNETGP LQQLIFVDVA
160 170 180 190 200
SMAPLGAQYK LLVTKLKHFQ LRTNVAFHFT ASPSQPQYFL YKFPKDVDSV
210 220 230 240 250
IIKVVSEMAY PCSVVSVQNI MCPVYDLDHN VEFNGVYQSM TKKAAITLQK
260 270 280 290 300
KDFPGEQFFV VFVIKPEDYA CGGSFFIQEK ENQTWNLQRK KNLEVTIVPS
310 320 330 340 350
IKESVYVKSS LFSVFIFLSF YLGCLLVGFV HYLRFQRKSI DGSFGSNDGS
360 370 380 390 400
GNMVASHPIA ASTPEGSNYG TIDESSSSPG RQMSSSDGGP PGQSDTDSSV
410 420 430 440 450
EESDFDTMPD IESDKNIIRT KMFLYLSDLS RKDRRIVSKK YKIYFWNIIT
460 470 480 490 500
IAVFYALPVI QLVITYQTVV NVTGNQDICY YNFLCAHPLG VLSAFNNILS
510 520 530 540 550
NLGHVLLGFL FLLIVLRRDI LHRRALEAKD IFAVEYGIPK HFGLFYAMGI
560 570 580 590 600
ALMMEGVLSA CYHVCPNYSN FQFDTSFMYM IAGLCMLKLY QTRHPDINAS
610 620 630 640 650
AYSAYASFAV VIMVTVLGVV FGKNDVWFWV IFSAIHVLAS LALSTQIYYM
660 670 680 690 700
GRFKIDLGIF RRAAMVFYTD CIQQCSRPLY MDRMVLLVVG NLVNWSFALF
710 720 730 740 750
GLIYRPRDFA SYMLGIFICN LLLYLAFYII MKLRSSEKVL PVPLFCIVAT
760 770 780 790 800
AVMWAAALYF FFQNLSSWEG TPAESREKNR ECILLDFFDD HDIWHFLSAT
810 820
ALFFSFLVLL TLDDDLDVVR RDQIPVF
Length:827
Mass (Da):93,839
Last modified:May 18, 2010 - v2
Checksum:iE7C383DF74378B8C
GO
Isoform 2 (identifier: Q9NXL6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     655-655: I → IDVSDT

Note: No experimental confirmation available.
Show »
Length:832
Mass (Da):94,356
Checksum:iB0709610421A9D01
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti572 – 5721Q → R in BAA90994 (PubMed:14702039).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti3 – 31G → S.
Corresponds to variant rs9879313 [ dbSNP | Ensembl ].
VAR_061793
Natural varianti78 – 781V → M.
Corresponds to variant rs2271496 [ dbSNP | Ensembl ].
VAR_057184
Natural varianti363 – 3631T → I.
Corresponds to variant rs33990195 [ dbSNP | Ensembl ].
VAR_057185

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei655 – 6551I → IDVSDT in isoform 2. 1 PublicationVSP_039174

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK000181 mRNA. Translation: BAA90994.1.
AC055740 Genomic DNA. No translation available.
AC112128 Genomic DNA. No translation available.
BC117222 mRNA. Translation: AAI17223.1.
CCDSiCCDS2974.1. [Q9NXL6-1]
CCDS77790.1. [Q9NXL6-2]
RefSeqiNP_001295279.1. NM_001308350.1. [Q9NXL6-2]
NP_060169.2. NM_017699.2. [Q9NXL6-1]
UniGeneiHs.591291.

Genome annotation databases

EnsembliENST00000264852; ENSP00000264852; ENSG00000072858. [Q9NXL6-1]
ENST00000393830; ENSP00000377416; ENSG00000072858. [Q9NXL6-2]
GeneIDi54847.
KEGGihsa:54847.
UCSCiuc003eak.4. human. [Q9NXL6-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK000181 mRNA. Translation: BAA90994.1.
AC055740 Genomic DNA. No translation available.
AC112128 Genomic DNA. No translation available.
BC117222 mRNA. Translation: AAI17223.1.
CCDSiCCDS2974.1. [Q9NXL6-1]
CCDS77790.1. [Q9NXL6-2]
RefSeqiNP_001295279.1. NM_001308350.1. [Q9NXL6-2]
NP_060169.2. NM_017699.2. [Q9NXL6-1]
UniGeneiHs.591291.

3D structure databases

ProteinModelPortaliQ9NXL6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9NXL6. 1 interaction.
STRINGi9606.ENSP00000264852.

Protein family/group databases

TCDBi1.A.79.1.2. the cholesterol uptake protein (chup) or double stranded rna uptake family.

PTM databases

iPTMnetiQ9NXL6.
PhosphoSiteiQ9NXL6.
SwissPalmiQ9NXL6.

Polymorphism and mutation databases

BioMutaiSIDT1.
DMDMi296452905.

Proteomic databases

PaxDbiQ9NXL6.
PRIDEiQ9NXL6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000264852; ENSP00000264852; ENSG00000072858. [Q9NXL6-1]
ENST00000393830; ENSP00000377416; ENSG00000072858. [Q9NXL6-2]
GeneIDi54847.
KEGGihsa:54847.
UCSCiuc003eak.4. human. [Q9NXL6-1]

Organism-specific databases

CTDi54847.
GeneCardsiSIDT1.
HGNCiHGNC:25967. SIDT1.
HPAiHPA035862.
MIMi606816. gene.
neXtProtiNX_Q9NXL6.
PharmGKBiPA134923837.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IF6Z. Eukaryota.
ENOG410XPBN. LUCA.
GeneTreeiENSGT00390000010091.
HOGENOMiHOG000020635.
HOVERGENiHBG079188.
InParanoidiQ9NXL6.
OMAiFFIQEKE.
OrthoDBiEOG7K3TKF.
PhylomeDBiQ9NXL6.
TreeFamiTF313076.

Miscellaneous databases

ChiTaRSiSIDT1. human.
GenomeRNAii54847.
PROiQ9NXL6.
SOURCEiSearch...

Gene expression databases

BgeeiQ9NXL6.
CleanExiHS_SIDT1.
GenevisibleiQ9NXL6. HS.

Family and domain databases

InterProiIPR025958. SID1_TM_fam.
[Graphical view]
PfamiPF13965. SID-1_RNA_chan. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Colon.
  2. "The DNA sequence, annotation and analysis of human chromosome 3."
    Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
    , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
    Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).

Entry informationi

Entry nameiSIDT1_HUMAN
AccessioniPrimary (citable) accession number: Q9NXL6
Secondary accession number(s): Q17RR4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: May 18, 2010
Last modified: June 8, 2016
This is version 95 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.