Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Rho guanine nucleotide exchange factor 38

Gene

ARHGEF38

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May act as a guanine-nucleotide releasing factor.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGuanine-nucleotide releasing factor

Enzyme and pathway databases

ReactomeiR-HSA-193648. NRAGE signals death through JNK.
R-HSA-194840. Rho GTPase cycle.
R-HSA-416482. G alpha (12/13) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Rho guanine nucleotide exchange factor 38
Gene namesi
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

EuPathDBiHostDB:ENSG00000236699.8.
HGNCiHGNC:25968. ARHGEF38.

Subcellular locationi

Pathology & Biotechi

Organism-specific databases

DisGeNETi54848.
OpenTargetsiENSG00000236699.
PharmGKBiPA165663186.

Polymorphism and mutation databases

BioMutaiARHGEF38.
DMDMi74725339.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003189871 – 777Rho guanine nucleotide exchange factor 38Add BLAST777

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei34PhosphothreonineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9NXL2.
PaxDbiQ9NXL2.
PeptideAtlasiQ9NXL2.
PRIDEiQ9NXL2.

PTM databases

iPTMnetiQ9NXL2.
PhosphoSitePlusiQ9NXL2.

Expressioni

Gene expression databases

BgeeiENSG00000236699.
GenevisibleiQ9NXL2. HS.

Organism-specific databases

HPAiHPA036510.
HPA045484.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi120198. 3 interactors.

Structurei

3D structure databases

ProteinModelPortaliQ9NXL2.
SMRiQ9NXL2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini94 – 285DHPROSITE-ProRule annotationAdd BLAST192
Domaini327 – 536BARPROSITE-ProRule annotationAdd BLAST210
Domaini582 – 645SH3 1PROSITE-ProRule annotationAdd BLAST64
Domaini713 – 776SH3 2PROSITE-ProRule annotationAdd BLAST64

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi689 – 694Poly-Ser6

Keywords - Domaini

Repeat, SH3 domain

Phylogenomic databases

eggNOGiKOG3519. Eukaryota.
ENOG410XWZ2. LUCA.
GeneTreeiENSGT00530000063159.
HOGENOMiHOG000015278.
HOVERGENiHBG094907.
InParanoidiQ9NXL2.
KOiK20711.
OMAiCGKFETN.
OrthoDBiEOG091G01C4.
PhylomeDBiQ9NXL2.
TreeFamiTF317245.

Family and domain databases

CDDicd00160. RhoGEF. 1 hit.
Gene3Di1.20.1270.60. 1 hit.
1.20.900.10. 1 hit.
InterProiView protein in InterPro
IPR027267. AH/BAR_dom_sf.
IPR004148. BAR_dom.
IPR035899. DBL_dom_sf.
IPR000219. DH-domain.
IPR036028. SH3-like_dom_sf.
IPR001452. SH3_domain.
PfamiView protein in Pfam
PF00621. RhoGEF. 1 hit.
PF07653. SH3_2. 1 hit.
PF14604. SH3_9. 1 hit.
SMARTiView protein in SMART
SM00721. BAR. 1 hit.
SM00325. RhoGEF. 1 hit.
SM00326. SH3. 2 hits.
SUPFAMiSSF103657. SSF103657. 1 hit.
SSF48065. SSF48065. 1 hit.
SSF50044. SSF50044. 2 hits.
PROSITEiView protein in PROSITE
PS51021. BAR. 1 hit.
PS50010. DH_2. 1 hit.
PS50002. SH3. 2 hits.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 2 (identifier: Q9NXL2-2) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEPKEATGKE NMVTKKKNLA FLRSRLYMLE RRKTDTVVES SVSGDHSGTL
60 70 80 90 100
RRSQSDRTEY NQKLQEKMTP QGECSVAETL TPEEEHHMKR MMAKREKIIK
110 120 130 140 150
ELIQTEKDYL NDLELCVREV VQPLRNKKTD RLDVDSLFSN IESVHQISAK
160 170 180 190 200
LLSLLEEATT DVEPAMQVIG EVFLQIKGPL EDIYKIYCYH HDEAHSILES
210 220 230 240 250
YEKEEELKEH LSHCIQSLKK IYMQEGKPNL LDMGSLMIKP IQRVMKYPLL
260 270 280 290 300
LCELRNSTPP SHPDYRALDD AFAAVKDINV NINELKRRKD LVLKYKKNDE
310 320 330 340 350
DESLKDKLSK LNIHSISKKS KRVTNHLKIL TRGESQVKDN TFNREEKLFR
360 370 380 390 400
ALEKTVRLCV KNISLCLQHI QDAMPLALQS VMDLQEISYN KDDEMDYSET
410 420 430 440 450
LSNALNSCHD FASHLQRLIL TPLSALLSLF PGPHKLIQKR YDKLLDCNSY
460 470 480 490 500
LQRSTGEESD LAKKEYEALN AQLVEELQAF NQAARKILLN CLCSFITLLR
510 520 530 540 550
DLMLVAQQAY STLVPMPLLV SSISEIQNQV LEEIQNLNCV KENSATFIER
560 570 580 590 600
KLSFEKKKPV QILPEMPHQT DIHRSKLLST YSAEELYQAK RKCNATQEYD
610 620 630 640 650
INLLEGDLVA VIEQKDPLGS TSRWLVDTGN VKGYVYSSFL KPYNPAKMQK
660 670 680 690 700
VDAENRFCDD DFENISLFVS SRPASDSVTG TSESSIGDSS SSLSGTCGKF
710 720 730 740 750
ETNGTDVDSF QEVDEQIFYA VHAFQARSDH ELSLQEYQRV HILRFCDLSG
760 770
NKEWWLAEAQ GQKGYVPANY LGKMTYA
Note: Gene prediction based on EST data.
Length:777
Mass (Da):89,078
Last modified:March 19, 2014 - v2
Checksum:i35F411FFD7704DFF
GO
Isoform 1 (identifier: Q9NXL2-1) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     220-777: Missing.

Show »
Length:219
Mass (Da):25,507
Checksum:iE997676477D9322D
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03892867K → N in a breast cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_03892988M → V. Corresponds to variant dbSNP:rs2276970Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_053830220 – 777Missing in isoform 1. 1 PublicationAdd BLAST558

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK000191 mRNA. Translation: BAA90998.1.
AC004066 Genomic DNA. No translation available.
AC105391 Genomic DNA. No translation available.
CH471057 Genomic DNA. Translation: EAX06187.1.
BC105695 mRNA. Translation: AAI05696.1.
CCDSiCCDS3670.1. [Q9NXL2-1]
CCDS56338.1. [Q9NXL2-2]
RefSeqiNP_001229658.1. NM_001242729.1. [Q9NXL2-2]
NP_060170.1. NM_017700.1. [Q9NXL2-1]
UniGeneiHs.585224.
Hs.652842.
Hs.744739.

Genome annotation databases

EnsembliENST00000265154; ENSP00000265154; ENSG00000236699. [Q9NXL2-1]
ENST00000420470; ENSP00000416125; ENSG00000236699. [Q9NXL2-2]
GeneIDi54848.
KEGGihsa:54848.
UCSCiuc003hxu.3. human. [Q9NXL2-2]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiARH38_HUMAN
AccessioniPrimary (citable) accession number: Q9NXL2
Secondary accession number(s): C9JIB4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: March 19, 2014
Last modified: November 22, 2017
This is version 118 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations