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Protein

Rho guanine nucleotide exchange factor 38

Gene

ARHGEF38

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May act as a guanine-nucleotide releasing factor.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGuanine-nucleotide releasing factor

Enzyme and pathway databases

ReactomeiR-HSA-193648 NRAGE signals death through JNK
R-HSA-194840 Rho GTPase cycle
R-HSA-416482 G alpha (12/13) signalling events

Names & Taxonomyi

Protein namesi
Recommended name:
Rho guanine nucleotide exchange factor 38
Gene namesi
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

EuPathDBiHostDB:ENSG00000236699.8
HGNCiHGNC:25968 ARHGEF38
neXtProtiNX_Q9NXL2

Subcellular locationi

Pathology & Biotechi

Organism-specific databases

DisGeNETi54848
OpenTargetsiENSG00000236699
PharmGKBiPA165663186

Polymorphism and mutation databases

BioMutaiARHGEF38
DMDMi74725339

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003189871 – 777Rho guanine nucleotide exchange factor 38Add BLAST777

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei34PhosphothreonineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ9NXL2
PeptideAtlasiQ9NXL2
PRIDEiQ9NXL2
ProteomicsDBi83109

PTM databases

iPTMnetiQ9NXL2
PhosphoSitePlusiQ9NXL2

Expressioni

Gene expression databases

BgeeiENSG00000236699
GenevisibleiQ9NXL2 HS

Organism-specific databases

HPAiHPA036510
HPA045484

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi120198, 3 interactors

Structurei

3D structure databases

ProteinModelPortaliQ9NXL2
SMRiQ9NXL2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini94 – 285DHPROSITE-ProRule annotationAdd BLAST192
Domaini327 – 536BARPROSITE-ProRule annotationAdd BLAST210
Domaini582 – 645SH3 1PROSITE-ProRule annotationAdd BLAST64
Domaini713 – 776SH3 2PROSITE-ProRule annotationAdd BLAST64

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi689 – 694Poly-Ser6

Keywords - Domaini

Repeat, SH3 domain

Phylogenomic databases

eggNOGiKOG3519 Eukaryota
ENOG410XWZ2 LUCA
GeneTreeiENSGT00530000063159
HOGENOMiHOG000015278
HOVERGENiHBG094907
InParanoidiQ9NXL2
KOiK20711
OMAiCGKFETN
OrthoDBiEOG091G01C4
PhylomeDBiQ9NXL2
TreeFamiTF317245

Family and domain databases

CDDicd00160 RhoGEF, 1 hit
Gene3Di1.20.1270.60, 1 hit
1.20.900.10, 1 hit
InterProiView protein in InterPro
IPR027267 AH/BAR_dom_sf
IPR004148 BAR_dom
IPR035899 DBL_dom_sf
IPR000219 DH-domain
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
PfamiView protein in Pfam
PF00621 RhoGEF, 1 hit
PF07653 SH3_2, 1 hit
PF14604 SH3_9, 1 hit
SMARTiView protein in SMART
SM00721 BAR, 1 hit
SM00325 RhoGEF, 1 hit
SM00326 SH3, 2 hits
SUPFAMiSSF103657 SSF103657, 1 hit
SSF48065 SSF48065, 1 hit
SSF50044 SSF50044, 2 hits
PROSITEiView protein in PROSITE
PS51021 BAR, 1 hit
PS50010 DH_2, 1 hit
PS50002 SH3, 2 hits

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 2 (identifier: Q9NXL2-2) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEPKEATGKE NMVTKKKNLA FLRSRLYMLE RRKTDTVVES SVSGDHSGTL
60 70 80 90 100
RRSQSDRTEY NQKLQEKMTP QGECSVAETL TPEEEHHMKR MMAKREKIIK
110 120 130 140 150
ELIQTEKDYL NDLELCVREV VQPLRNKKTD RLDVDSLFSN IESVHQISAK
160 170 180 190 200
LLSLLEEATT DVEPAMQVIG EVFLQIKGPL EDIYKIYCYH HDEAHSILES
210 220 230 240 250
YEKEEELKEH LSHCIQSLKK IYMQEGKPNL LDMGSLMIKP IQRVMKYPLL
260 270 280 290 300
LCELRNSTPP SHPDYRALDD AFAAVKDINV NINELKRRKD LVLKYKKNDE
310 320 330 340 350
DESLKDKLSK LNIHSISKKS KRVTNHLKIL TRGESQVKDN TFNREEKLFR
360 370 380 390 400
ALEKTVRLCV KNISLCLQHI QDAMPLALQS VMDLQEISYN KDDEMDYSET
410 420 430 440 450
LSNALNSCHD FASHLQRLIL TPLSALLSLF PGPHKLIQKR YDKLLDCNSY
460 470 480 490 500
LQRSTGEESD LAKKEYEALN AQLVEELQAF NQAARKILLN CLCSFITLLR
510 520 530 540 550
DLMLVAQQAY STLVPMPLLV SSISEIQNQV LEEIQNLNCV KENSATFIER
560 570 580 590 600
KLSFEKKKPV QILPEMPHQT DIHRSKLLST YSAEELYQAK RKCNATQEYD
610 620 630 640 650
INLLEGDLVA VIEQKDPLGS TSRWLVDTGN VKGYVYSSFL KPYNPAKMQK
660 670 680 690 700
VDAENRFCDD DFENISLFVS SRPASDSVTG TSESSIGDSS SSLSGTCGKF
710 720 730 740 750
ETNGTDVDSF QEVDEQIFYA VHAFQARSDH ELSLQEYQRV HILRFCDLSG
760 770
NKEWWLAEAQ GQKGYVPANY LGKMTYA
Note: Gene prediction based on EST data.
Length:777
Mass (Da):89,078
Last modified:March 19, 2014 - v2
Checksum:i35F411FFD7704DFF
GO
Isoform 1 (identifier: Q9NXL2-1) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     220-777: Missing.

Show »
Length:219
Mass (Da):25,507
Checksum:iE997676477D9322D
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03892867K → N in a breast cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_03892988M → V. Corresponds to variant dbSNP:rs2276970Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_053830220 – 777Missing in isoform 1. 1 PublicationAdd BLAST558

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK000191 mRNA Translation: BAA90998.1
AC004066 Genomic DNA No translation available.
AC105391 Genomic DNA No translation available.
CH471057 Genomic DNA Translation: EAX06187.1
BC105695 mRNA Translation: AAI05696.1
CCDSiCCDS3670.1 [Q9NXL2-1]
CCDS56338.1 [Q9NXL2-2]
RefSeqiNP_001229658.1, NM_001242729.1 [Q9NXL2-2]
NP_060170.1, NM_017700.1 [Q9NXL2-1]
UniGeneiHs.585224
Hs.652842
Hs.744739

Genome annotation databases

EnsembliENST00000265154; ENSP00000265154; ENSG00000236699 [Q9NXL2-1]
ENST00000420470; ENSP00000416125; ENSG00000236699 [Q9NXL2-2]
GeneIDi54848
KEGGihsa:54848
UCSCiuc003hxu.3 human [Q9NXL2-2]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiARH38_HUMAN
AccessioniPrimary (citable) accession number: Q9NXL2
Secondary accession number(s): C9JIB4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: March 19, 2014
Last modified: June 20, 2018
This is version 121 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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