ID   PAQR5_HUMAN             Reviewed;         330 AA.
AC   Q9NXK6; Q8IXU2;
DT   16-AUG-2004, integrated into UniProtKB/Swiss-Prot.
DT   03-APR-2007, sequence version 2.
DT   24-JAN-2024, entry version 153.
DE   RecName: Full=Membrane progestin receptor gamma {ECO:0000303|PubMed:23763432};
DE            Short=mPR gamma {ECO:0000303|PubMed:23763432};
DE   AltName: Full=Membrane progesterone P4 receptor gamma {ECO:0000303|PubMed:23763432};
DE   AltName: Full=Membrane progesterone receptor gamma {ECO:0000303|PubMed:23763432};
DE   AltName: Full=Progesterone and adipoQ receptor family member 5;
DE   AltName: Full=Progestin and adipoQ receptor family member 5 {ECO:0000303|PubMed:16044242};
DE   AltName: Full=Progestin and adipoQ receptor family member V;
GN   Name=PAQR5 {ECO:0000312|HGNC:HGNC:29645}; Synonyms=MPRG;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RX   PubMed=16044242; DOI=10.1007/s00239-004-0375-2;
RA   Tang Y.T., Hu T., Arterburn M., Boyle B., Bright J.M., Emtage P.C.,
RA   Funk W.D.;
RT   "PAQR proteins: a novel membrane receptor family defined by an ancient 7-
RT   transmembrane pass motif.";
RL   J. Mol. Evol. 61:372-380(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Colon mucosa;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA   Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA   Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA   Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA   Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA   Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA   Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA   Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA   Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA   Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA   Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA   Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT THR-24.
RC   TISSUE=Kidney;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [4]
RP   FUNCTION, AND TISSUE SPECIFICITY.
RX   PubMed=12601167; DOI=10.1073/pnas.0436133100;
RA   Zhu Y., Bond J., Thomas P.;
RT   "Identification, classification, and partial characterization of genes in
RT   humans and other vertebrates homologous to a fish membrane progestin
RT   receptor.";
RL   Proc. Natl. Acad. Sci. U.S.A. 100:2237-2242(2003).
RN   [5]
RP   REVIEW.
RX   PubMed=12606724; DOI=10.1073/pnas.0530224100;
RA   Hammes S.R.;
RT   "The further redefining of steroid-mediated signaling.";
RL   Proc. Natl. Acad. Sci. U.S.A. 100:2168-2170(2003).
RN   [6]
RP   FUNCTION, REVIEW, AND SUBCELLULAR LOCATION.
RX   PubMed=23763432; DOI=10.1111/jne.12060;
RA   Petersen S.L., Intlekofer K.A., Moura-Conlon P.J., Brewer D.N.,
RA   Del Pino Sans J., Lopez J.A.;
RT   "Nonclassical progesterone signalling molecules in the nervous system.";
RL   J. Neuroendocrinol. 25:991-1001(2013).
CC   -!- FUNCTION: Plasma membrane progesterone (P4) receptor coupled to G
CC       proteins (PubMed:23763432). Seems to act through a G(i) mediated
CC       pathway (PubMed:23763432). May be involved in oocyte maturation
CC       (PubMed:12601167). {ECO:0000269|PubMed:12601167,
CC       ECO:0000303|PubMed:23763432}.
CC   -!- INTERACTION:
CC       Q9NXK6; Q9Y282: ERGIC3; NbExp=3; IntAct=EBI-10316423, EBI-781551;
CC       Q9NXK6; Q8TED1: GPX8; NbExp=3; IntAct=EBI-10316423, EBI-11721746;
CC       Q9NXK6; Q9P2J2-2: IGSF9; NbExp=3; IntAct=EBI-10316423, EBI-17451184;
CC       Q9NXK6; P26951: IL3RA; NbExp=3; IntAct=EBI-10316423, EBI-1757512;
CC       Q9NXK6; O95470: SGPL1; NbExp=3; IntAct=EBI-10316423, EBI-1046170;
CC       Q9NXK6; Q8N205: SYNE4; NbExp=3; IntAct=EBI-10316423, EBI-7131783;
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000303|PubMed:23763432};
CC       Multi-pass membrane protein {ECO:0000255}.
CC   -!- TISSUE SPECIFICITY: Expressed in the brain, lung, kidney, colon,
CC       adrenal and lung. {ECO:0000269|PubMed:12601167,
CC       ECO:0000269|PubMed:16044242}.
CC   -!- MISCELLANEOUS: Non-classical progesterone receptors involved in
CC       extranuclear signaling are classified in 2 groups: the class II
CC       progestin and adipoQ receptor (PAQR) family (also called mPRs) (PAQR5,
CC       PAQR6, PAQR7, PAQR8 and PAQR9) and the b5-like heme/steroid-binding
CC       protein family (also called MAPRs) (PGRMC1, PGRMC2, NENF and CYB5D2).
CC       {ECO:0000303|PubMed:23763432}.
CC   -!- SIMILARITY: Belongs to the ADIPOR family. {ECO:0000305}.
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DR   EMBL; AY424283; AAR08371.1; -; mRNA.
DR   EMBL; AK000197; BAA91004.1; -; mRNA.
DR   EMBL; BC039234; AAH39234.1; -; mRNA.
DR   CCDS; CCDS10232.1; -.
DR   RefSeq; NP_001098024.1; NM_001104554.1.
DR   RefSeq; NP_060175.3; NM_017705.3.
DR   RefSeq; XP_011520022.1; XM_011521720.2.
DR   RefSeq; XP_011520024.1; XM_011521722.2.
DR   RefSeq; XP_016877849.1; XM_017022360.1.
DR   RefSeq; XP_016877850.1; XM_017022361.1.
DR   RefSeq; XP_016877851.1; XM_017022362.1.
DR   RefSeq; XP_016877852.1; XM_017022363.1.
DR   RefSeq; XP_016877853.1; XM_017022364.1.
DR   AlphaFoldDB; Q9NXK6; -.
DR   SMR; Q9NXK6; -.
DR   BioGRID; 120202; 13.
DR   IntAct; Q9NXK6; 9.
DR   STRING; 9606.ENSP00000378803; -.
DR   iPTMnet; Q9NXK6; -.
DR   PhosphoSitePlus; Q9NXK6; -.
DR   BioMuta; PAQR5; -.
DR   DMDM; 143811422; -.
DR   MassIVE; Q9NXK6; -.
DR   MaxQB; Q9NXK6; -.
DR   PaxDb; 9606-ENSP00000378803; -.
DR   PeptideAtlas; Q9NXK6; -.
DR   ProteomicsDB; 83106; -.
DR   Antibodypedia; 13981; 127 antibodies from 22 providers.
DR   DNASU; 54852; -.
DR   Ensembl; ENST00000340965.4; ENSP00000343877.3; ENSG00000137819.14.
DR   Ensembl; ENST00000395407.7; ENSP00000378803.2; ENSG00000137819.14.
DR   Ensembl; ENST00000561153.5; ENSP00000453526.1; ENSG00000137819.14.
DR   GeneID; 54852; -.
DR   KEGG; hsa:54852; -.
DR   MANE-Select; ENST00000395407.7; ENSP00000378803.2; NM_017705.4; NP_060175.3.
DR   UCSC; uc002arz.3; human.
DR   AGR; HGNC:29645; -.
DR   CTD; 54852; -.
DR   DisGeNET; 54852; -.
DR   GeneCards; PAQR5; -.
DR   HGNC; HGNC:29645; PAQR5.
DR   HPA; ENSG00000137819; Tissue enhanced (kidney).
DR   MIM; 607781; gene.
DR   neXtProt; NX_Q9NXK6; -.
DR   OpenTargets; ENSG00000137819; -.
DR   PharmGKB; PA142671199; -.
DR   VEuPathDB; HostDB:ENSG00000137819; -.
DR   eggNOG; KOG0748; Eukaryota.
DR   GeneTree; ENSGT00940000158844; -.
DR   HOGENOM; CLU_052356_1_0_1; -.
DR   InParanoid; Q9NXK6; -.
DR   OMA; KPGLCKM; -.
DR   OrthoDB; 2940815at2759; -.
DR   PhylomeDB; Q9NXK6; -.
DR   TreeFam; TF319738; -.
DR   PathwayCommons; Q9NXK6; -.
DR   SignaLink; Q9NXK6; -.
DR   BioGRID-ORCS; 54852; 15 hits in 1146 CRISPR screens.
DR   ChiTaRS; PAQR5; human.
DR   GenomeRNAi; 54852; -.
DR   Pharos; Q9NXK6; Tbio.
DR   PRO; PR:Q9NXK6; -.
DR   Proteomes; UP000005640; Chromosome 15.
DR   RNAct; Q9NXK6; Protein.
DR   Bgee; ENSG00000137819; Expressed in metanephros cortex and 96 other cell types or tissues.
DR   ExpressionAtlas; Q9NXK6; baseline and differential.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0038023; F:signaling receptor activity; IBA:GO_Central.
DR   GO; GO:0005496; F:steroid binding; IEA:UniProtKB-KW.
DR   GO; GO:0048477; P:oogenesis; IEA:UniProtKB-KW.
DR   InterPro; IPR004254; AdipoR/HlyIII-related.
DR   PANTHER; PTHR20855; ADIPOR/PROGESTIN RECEPTOR-RELATED; 1.
DR   PANTHER; PTHR20855:SF38; MEMBRANE PROGESTIN RECEPTOR GAMMA; 1.
DR   Pfam; PF03006; HlyIII; 1.
DR   Genevisible; Q9NXK6; HS.
PE   1: Evidence at protein level;
KW   Cell membrane; Developmental protein; Differentiation; Lipid-binding;
KW   Membrane; Oogenesis; Receptor; Reference proteome; Steroid-binding;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..330
FT                   /note="Membrane progestin receptor gamma"
FT                   /id="PRO_0000218843"
FT   TOPO_DOM        1..51
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        52..72
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        73..80
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        81..101
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        102..113
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        114..134
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        135..141
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        142..162
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        163..186
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        187..207
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        208..253
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        254..274
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        275..294
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        295..315
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        316..330
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   VARIANT         24
FT                   /note="I -> T (in dbSNP:rs17853893)"
FT                   /evidence="ECO:0000269|PubMed:15489334"
FT                   /id="VAR_031436"
FT   CONFLICT        175
FT                   /note="I -> V (in Ref. 1; AAR08371 and 2; BAA91004)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   330 AA;  38014 MW;  FA0AF2785EAAFFE8 CRC64;
     MLSLKLPRLF SIDQIPQVFH EQGILFGYRH PQSSATACIL SLFQMTNETL NIWTHLLPFW
     FFAWRFVTAL YMTDIKNDSY SWPMLVYMCT SCVYPLVSSC AHTFSSMSKN ARHICYFLDY
     GAVNLFSLGS AIAYSAYTFP DALMCTTFHD YYVALAVLNT ILSTGLSCYS RFLEIQKPRL
     CKVIRVLAFA YPYTWDSLPI FYRLFLFPGE SAQNEATSYH QKHMIMTLLA SFLYSAHLPE
     RLAPGRFDYI GHSHQLFHVC VILATHMQME AILLDKTLRK EWLLATSKPF SFSQIAGAIL
     LCIIFSLSNI IYFSAALYRI PKPELHKKET
//