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Q9NXK6 (MPRG_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 93. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Membrane progestin receptor gamma

Short name=mPR gamma
Alternative name(s):
Progestin and adipoQ receptor family member 5
Progestin and adipoQ receptor family member V
Gene names
Name:PAQR5
Synonyms:MPRG
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length330 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Steroid membrane receptor. Binds progesterone. May be involved in oocyte maturation. Ref.4

Subcellular location

Membrane; Multi-pass membrane protein By similarity.

Tissue specificity

Expressed in the brain, lung, kidney, colon, adrenal and lung. Ref.1 Ref.4

Sequence similarities

Belongs to the ADIPOR family.

Ontologies

Keywords
   Biological processDifferentiation
Oogenesis
   Cellular componentMembrane
   Coding sequence diversityPolymorphism
   DomainTransmembrane
Transmembrane helix
   LigandLipid-binding
Steroid-binding
   Molecular functionDevelopmental protein
Receptor
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processcell differentiation

Inferred from electronic annotation. Source: UniProtKB-KW

multicellular organismal development

Inferred from electronic annotation. Source: UniProtKB-KW

oogenesis

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionreceptor activity

Inferred from Biological aspect of Ancestor. Source: RefGenome

steroid binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 330330Membrane progestin receptor gamma
PRO_0000218843

Regions

Topological domain1 – 5151Cytoplasmic Potential
Transmembrane52 – 7221Helical; Name=1; Potential
Topological domain73 – 808Extracellular Potential
Transmembrane81 – 10121Helical; Name=2; Potential
Topological domain102 – 11312Cytoplasmic Potential
Transmembrane114 – 13421Helical; Name=3; Potential
Topological domain135 – 1417Extracellular Potential
Transmembrane142 – 16221Helical; Name=4; Potential
Topological domain163 – 18624Cytoplasmic Potential
Transmembrane187 – 20721Helical; Name=5; Potential
Topological domain208 – 25346Extracellular Potential
Transmembrane254 – 27421Helical; Name=6; Potential
Topological domain275 – 29420Cytoplasmic Potential
Transmembrane295 – 31521Helical; Name=7; Potential
Topological domain316 – 33015Extracellular Potential

Natural variations

Natural variant241I → T. Ref.3
Corresponds to variant rs17853893 [ dbSNP | Ensembl ].
VAR_031436

Experimental info

Sequence conflict1751I → V in AAR08371. Ref.1
Sequence conflict1751I → V in BAA91004. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Q9NXK6 [UniParc].

Last modified April 3, 2007. Version 2.
Checksum: FA0AF2785EAAFFE8

FASTA33038,014
        10         20         30         40         50         60 
MLSLKLPRLF SIDQIPQVFH EQGILFGYRH PQSSATACIL SLFQMTNETL NIWTHLLPFW 

        70         80         90        100        110        120 
FFAWRFVTAL YMTDIKNDSY SWPMLVYMCT SCVYPLVSSC AHTFSSMSKN ARHICYFLDY 

       130        140        150        160        170        180 
GAVNLFSLGS AIAYSAYTFP DALMCTTFHD YYVALAVLNT ILSTGLSCYS RFLEIQKPRL 

       190        200        210        220        230        240 
CKVIRVLAFA YPYTWDSLPI FYRLFLFPGE SAQNEATSYH QKHMIMTLLA SFLYSAHLPE 

       250        260        270        280        290        300 
RLAPGRFDYI GHSHQLFHVC VILATHMQME AILLDKTLRK EWLLATSKPF SFSQIAGAIL 

       310        320        330 
LCIIFSLSNI IYFSAALYRI PKPELHKKET 

« Hide

References

« Hide 'large scale' references
[1]"PAQR proteins: a novel membrane receptor family defined by an ancient 7-transmembrane pass motif."
Tang Y.T., Hu T., Arterburn M., Boyle B., Bright J.M., Emtage P.C., Funk W.D.
J. Mol. Evol. 61:372-380(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
[2]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Colon mucosa.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT THR-24.
Tissue: Kidney.
[4]"Identification, classification, and partial characterization of genes in humans and other vertebrates homologous to a fish membrane progestin receptor."
Zhu Y., Bond J., Thomas P.
Proc. Natl. Acad. Sci. U.S.A. 100:2237-2242(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, TISSUE SPECIFICITY.
[5]"The further redefining of steroid-mediated signaling."
Hammes S.R.
Proc. Natl. Acad. Sci. U.S.A. 100:2168-2170(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: REVIEW.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY424283 mRNA. Translation: AAR08371.1.
AK000197 mRNA. Translation: BAA91004.1.
BC039234 mRNA. Translation: AAH39234.1.
RefSeqNP_001098024.1. NM_001104554.1.
NP_060175.3. NM_017705.3.
XP_005254551.1. XM_005254494.2.
UniGeneHs.591096.

3D structure databases

ProteinModelPortalQ9NXK6.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteQ9NXK6.

Polymorphism databases

DMDM143811422.

Proteomic databases

PRIDEQ9NXK6.

Protocols and materials databases

DNASU54852.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000340965; ENSP00000343877; ENSG00000137819.
ENST00000395407; ENSP00000378803; ENSG00000137819.
ENST00000561153; ENSP00000453526; ENSG00000137819.
GeneID54852.
KEGGhsa:54852.
UCSCuc002arz.2. human.

Organism-specific databases

CTD54852.
GeneCardsGC15P069591.
H-InvDBHIX0012388.
HGNCHGNC:29645. PAQR5.
HPAHPA016507.
MIM607781. gene.
neXtProtNX_Q9NXK6.
PharmGKBPA142671199.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG1272.
HOGENOMHOG000067790.
HOVERGENHBG052505.
InParanoidQ9NXK6.
OMAPYTWDSL.
OrthoDBEOG7D59NW.
PhylomeDBQ9NXK6.
TreeFamTF319738.

Gene expression databases

ArrayExpressQ9NXK6.
BgeeQ9NXK6.
CleanExHS_PAQR5.
GenevestigatorQ9NXK6.

Family and domain databases

InterProIPR004254. HlyIII-related.
[Graphical view]
PANTHERPTHR20855. PTHR20855. 1 hit.
PfamPF03006. HlyIII. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi54852.
NextBio57704.
PROQ9NXK6.
SOURCESearch...

Entry information

Entry nameMPRG_HUMAN
AccessionPrimary (citable) accession number: Q9NXK6
Secondary accession number(s): Q8IXU2
Entry history
Integrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: April 3, 2007
Last modified: April 16, 2014
This is version 93 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 15

Human chromosome 15: entries, gene names and cross-references to MIM