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Q9NXK6

- MPRG_HUMAN

UniProt

Q9NXK6 - MPRG_HUMAN

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Protein

Membrane progestin receptor gamma

Gene

PAQR5

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Steroid membrane receptor. Binds progesterone. May be involved in oocyte maturation.1 Publication

GO - Molecular functioni

  1. receptor activity Source: RefGenome
  2. steroid binding Source: UniProtKB-KW

GO - Biological processi

  1. multicellular organismal development Source: UniProtKB-KW
  2. oogenesis Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Receptor

Keywords - Biological processi

Differentiation, Oogenesis

Keywords - Ligandi

Lipid-binding, Steroid-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Membrane progestin receptor gamma
Short name:
mPR gamma
Alternative name(s):
Progestin and adipoQ receptor family member 5
Progestin and adipoQ receptor family member V
Gene namesi
Name:PAQR5
Synonyms:MPRG
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 15

Organism-specific databases

HGNCiHGNC:29645. PAQR5.

Subcellular locationi

Membrane By similarity; Multi-pass membrane protein By similarity

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 5151CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei52 – 7221Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini73 – 808ExtracellularSequence Analysis
Transmembranei81 – 10121Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini102 – 11312CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei114 – 13421Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini135 – 1417ExtracellularSequence Analysis
Transmembranei142 – 16221Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini163 – 18624CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei187 – 20721Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini208 – 25346ExtracellularSequence AnalysisAdd
BLAST
Transmembranei254 – 27421Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini275 – 29420CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei295 – 31521Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini316 – 33015ExtracellularSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142671199.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 330330Membrane progestin receptor gammaPRO_0000218843Add
BLAST

Proteomic databases

MaxQBiQ9NXK6.
PRIDEiQ9NXK6.

PTM databases

PhosphoSiteiQ9NXK6.

Expressioni

Tissue specificityi

Expressed in the brain, lung, kidney, colon, adrenal and lung.2 Publications

Gene expression databases

BgeeiQ9NXK6.
CleanExiHS_PAQR5.
ExpressionAtlasiQ9NXK6. baseline and differential.
GenevestigatoriQ9NXK6.

Organism-specific databases

HPAiHPA016507.

Interactioni

Protein-protein interaction databases

BioGridi120202. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ9NXK6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ADIPOR family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1272.
GeneTreeiENSGT00530000062965.
HOGENOMiHOG000067790.
HOVERGENiHBG052505.
InParanoidiQ9NXK6.
OMAiPYTWDSL.
OrthoDBiEOG7D59NW.
PhylomeDBiQ9NXK6.
TreeFamiTF319738.

Family and domain databases

InterProiIPR004254. HlyIII-related.
[Graphical view]
PANTHERiPTHR20855. PTHR20855. 1 hit.
PfamiPF03006. HlyIII. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9NXK6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLSLKLPRLF SIDQIPQVFH EQGILFGYRH PQSSATACIL SLFQMTNETL
60 70 80 90 100
NIWTHLLPFW FFAWRFVTAL YMTDIKNDSY SWPMLVYMCT SCVYPLVSSC
110 120 130 140 150
AHTFSSMSKN ARHICYFLDY GAVNLFSLGS AIAYSAYTFP DALMCTTFHD
160 170 180 190 200
YYVALAVLNT ILSTGLSCYS RFLEIQKPRL CKVIRVLAFA YPYTWDSLPI
210 220 230 240 250
FYRLFLFPGE SAQNEATSYH QKHMIMTLLA SFLYSAHLPE RLAPGRFDYI
260 270 280 290 300
GHSHQLFHVC VILATHMQME AILLDKTLRK EWLLATSKPF SFSQIAGAIL
310 320 330
LCIIFSLSNI IYFSAALYRI PKPELHKKET
Length:330
Mass (Da):38,014
Last modified:April 3, 2007 - v2
Checksum:iFA0AF2785EAAFFE8
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti175 – 1751I → V in AAR08371. (PubMed:16044242)Curated
Sequence conflicti175 – 1751I → V in BAA91004. (PubMed:14702039)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti24 – 241I → T.1 Publication
Corresponds to variant rs17853893 [ dbSNP | Ensembl ].
VAR_031436

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY424283 mRNA. Translation: AAR08371.1.
AK000197 mRNA. Translation: BAA91004.1.
BC039234 mRNA. Translation: AAH39234.1.
CCDSiCCDS10232.1.
RefSeqiNP_001098024.1. NM_001104554.1.
NP_060175.3. NM_017705.3.
XP_005254551.1. XM_005254494.2.
XP_006720646.1. XM_006720583.1.
UniGeneiHs.591096.

Genome annotation databases

EnsembliENST00000340965; ENSP00000343877; ENSG00000137819.
ENST00000395407; ENSP00000378803; ENSG00000137819.
ENST00000561153; ENSP00000453526; ENSG00000137819.
GeneIDi54852.
KEGGihsa:54852.
UCSCiuc002arz.2. human.

Polymorphism databases

DMDMi143811422.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY424283 mRNA. Translation: AAR08371.1 .
AK000197 mRNA. Translation: BAA91004.1 .
BC039234 mRNA. Translation: AAH39234.1 .
CCDSi CCDS10232.1.
RefSeqi NP_001098024.1. NM_001104554.1.
NP_060175.3. NM_017705.3.
XP_005254551.1. XM_005254494.2.
XP_006720646.1. XM_006720583.1.
UniGenei Hs.591096.

3D structure databases

ProteinModelPortali Q9NXK6.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 120202. 1 interaction.

PTM databases

PhosphoSitei Q9NXK6.

Polymorphism databases

DMDMi 143811422.

Proteomic databases

MaxQBi Q9NXK6.
PRIDEi Q9NXK6.

Protocols and materials databases

DNASUi 54852.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000340965 ; ENSP00000343877 ; ENSG00000137819 .
ENST00000395407 ; ENSP00000378803 ; ENSG00000137819 .
ENST00000561153 ; ENSP00000453526 ; ENSG00000137819 .
GeneIDi 54852.
KEGGi hsa:54852.
UCSCi uc002arz.2. human.

Organism-specific databases

CTDi 54852.
GeneCardsi GC15P069591.
H-InvDB HIX0012388.
HGNCi HGNC:29645. PAQR5.
HPAi HPA016507.
MIMi 607781. gene.
neXtProti NX_Q9NXK6.
PharmGKBi PA142671199.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG1272.
GeneTreei ENSGT00530000062965.
HOGENOMi HOG000067790.
HOVERGENi HBG052505.
InParanoidi Q9NXK6.
OMAi PYTWDSL.
OrthoDBi EOG7D59NW.
PhylomeDBi Q9NXK6.
TreeFami TF319738.

Miscellaneous databases

GenomeRNAii 54852.
NextBioi 57704.
PROi Q9NXK6.
SOURCEi Search...

Gene expression databases

Bgeei Q9NXK6.
CleanExi HS_PAQR5.
ExpressionAtlasi Q9NXK6. baseline and differential.
Genevestigatori Q9NXK6.

Family and domain databases

InterProi IPR004254. HlyIII-related.
[Graphical view ]
PANTHERi PTHR20855. PTHR20855. 1 hit.
Pfami PF03006. HlyIII. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "PAQR proteins: a novel membrane receptor family defined by an ancient 7-transmembrane pass motif."
    Tang Y.T., Hu T., Arterburn M., Boyle B., Bright J.M., Emtage P.C., Funk W.D.
    J. Mol. Evol. 61:372-380(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Colon mucosa.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT THR-24.
    Tissue: Kidney.
  4. "Identification, classification, and partial characterization of genes in humans and other vertebrates homologous to a fish membrane progestin receptor."
    Zhu Y., Bond J., Thomas P.
    Proc. Natl. Acad. Sci. U.S.A. 100:2237-2242(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, TISSUE SPECIFICITY.
  5. "The further redefining of steroid-mediated signaling."
    Hammes S.R.
    Proc. Natl. Acad. Sci. U.S.A. 100:2168-2170(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW.

Entry informationi

Entry nameiMPRG_HUMAN
AccessioniPrimary (citable) accession number: Q9NXK6
Secondary accession number(s): Q8IXU2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: April 3, 2007
Last modified: October 29, 2014
This is version 97 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3