Q9NXK6 (MPRG_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Membrane progestin receptor gamma
Short name=mPR gamma

Alternative name(s):
Progestin and adipoQ receptor family member 5
Progestin and adipoQ receptor family member V

Gene names

Name:	PAQR5
Synonyms:	MPRG

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	330 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Steroid membrane receptor. Binds progesterone. May be involved in oocyte maturation. Ref.4
Subcellular location	Membrane; Multi-pass membrane protein By similarity.
Tissue specificity	Expressed in the brain, lung, kidney, colon, adrenal and lung. Ref.1 Ref.4
Sequence similarities	Belongs to the ADIPOR family.

Ontologies

Keywords
Biological process	Differentiation Oogenesis
Cellular component	Membrane
Coding sequence diversity	Polymorphism
Domain	Transmembrane Transmembrane helix
Ligand	Lipid-binding Steroid-binding
Molecular function	Developmental protein Receptor
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cell differentiation Inferred from electronic annotation. Source: UniProtKB-KW multicellular organismal development Inferred from electronic annotation. Source: UniProtKB-KW oogenesis Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	steroid binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 330	330	Membrane progestin receptor gamma		PRO_0000218843
Regions
	Topological domain	1 – 51	51	Cytoplasmic Potential
	Transmembrane	52 – 72	21	Helical; Name=1; Potential
	Topological domain	73 – 80	8	Extracellular Potential
	Transmembrane	81 – 101	21	Helical; Name=2; Potential
	Topological domain	102 – 113	12	Cytoplasmic Potential
	Transmembrane	114 – 134	21	Helical; Name=3; Potential
	Topological domain	135 – 141	7	Extracellular Potential
	Transmembrane	142 – 162	21	Helical; Name=4; Potential
	Topological domain	163 – 186	24	Cytoplasmic Potential
	Transmembrane	187 – 207	21	Helical; Name=5; Potential
	Topological domain	208 – 253	46	Extracellular Potential
	Transmembrane	254 – 274	21	Helical; Name=6; Potential
	Topological domain	275 – 294	20	Cytoplasmic Potential
	Transmembrane	295 – 315	21	Helical; Name=7; Potential
	Topological domain	316 – 330	15	Extracellular Potential
Natural variations
	Natural variant	24	1	I → T. Ref.3 Corresponds to variant rs17853893 [ dbSNP | Ensembl ].		VAR_031436
Experimental info
	Sequence conflict	175	1	I → V in AAR08371. Ref.1
	Sequence conflict	175	1	I → V in BAA91004. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Q9NXK6 [UniParc]. Last modified April 3, 2007. Version 2. Checksum: FA0AF2785EAAFFE8	FASTA	330	38,014
	10 20 30 40 50 60 MLSLKLPRLF SIDQIPQVFH EQGILFGYRH PQSSATACIL SLFQMTNETL NIWTHLLPFW 70 80 90 100 110 120 FFAWRFVTAL YMTDIKNDSY SWPMLVYMCT SCVYPLVSSC AHTFSSMSKN ARHICYFLDY 130 140 150 160 170 180 GAVNLFSLGS AIAYSAYTFP DALMCTTFHD YYVALAVLNT ILSTGLSCYS RFLEIQKPRL 190 200 210 220 230 240 CKVIRVLAFA YPYTWDSLPI FYRLFLFPGE SAQNEATSYH QKHMIMTLLA SFLYSAHLPE 250 260 270 280 290 300 RLAPGRFDYI GHSHQLFHVC VILATHMQME AILLDKTLRK EWLLATSKPF SFSQIAGAIL 310 320 330 LCIIFSLSNI IYFSAALYRI PKPELHKKET

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"PAQR proteins: a novel membrane receptor family defined by an ancient 7-transmembrane pass motif." Tang Y.T., Hu T., Arterburn M., Boyle B., Bright J.M., Emtage P.C., Funk W.D. J. Mol. Evol. 61:372-380(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Colon mucosa.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT THR-24. Tissue: Kidney.
[4]	"Identification, classification, and partial characterization of genes in humans and other vertebrates homologous to a fish membrane progestin receptor." Zhu Y., Bond J., Thomas P. Proc. Natl. Acad. Sci. U.S.A. 100:2237-2242(2003) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, TISSUE SPECIFICITY.
[5]	"The further redefining of steroid-mediated signaling." Hammes S.R. Proc. Natl. Acad. Sci. U.S.A. 100:2168-2170(2003) [PubMed] [Europe PMC] [Abstract] Cited for: REVIEW.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY424283 mRNA. Translation: AAR08371.1. AK000197 mRNA. Translation: BAA91004.1. BC039234 mRNA. Translation: AAH39234.1.
IPI	IPI00293360.
RefSeq	NP_001098024.1. NM_001104554.1. NP_060175.3. NM_017705.3.
UniGene	Hs.591096.
3D structure databases
ProteinModelPortal	Q9NXK6.
ModBase	Search...
PTM databases
PhosphoSite	Q9NXK6.
Polymorphism databases
DMDM	143811422.
Proteomic databases
PRIDE	Q9NXK6.
Protocols and materials databases
DNASU	54852.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000340965; ENSP00000343877; ENSG00000137819. ENST00000395407; ENSP00000378803; ENSG00000137819. ENST00000561153; ENSP00000453526; ENSG00000137819.
GeneID	54852.
KEGG	hsa:54852.
UCSC	uc002arz.2. human.
Organism-specific databases
CTD	54852.
GeneCards	GC15P069591.
H-InvDB	HIX0012388.
HGNC	HGNC:29645. PAQR5.
HPA	HPA016507.
MIM	607781. gene.
neXtProt	NX_Q9NXK6.
PharmGKB	PA142671199.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG1272.
HOGENOM	HOG000067790.
HOVERGEN	HBG052505.
InParanoid	Q9NXK6.
OMA	TSCVYPL.
OrthoDB	EOG4GHZPV.
PhylomeDB	Q9NXK6.
Gene expression databases
ArrayExpress	Q9NXK6.
Bgee	Q9NXK6.
CleanEx	HS_PAQR5.
Genevestigator	Q9NXK6.
GermOnline	ENSG00000137819. Homo sapiens.
Family and domain databases
InterPro	IPR004254. HlyIII-related. [Graphical view]
PANTHER	PTHR20855. PTHR20855. 1 hit.
Pfam	PF03006. HlyIII. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	54852.
NextBio	57704.
SOURCE	Search...

Entry information

Entry name

MPRG_HUMAN

Accession

Primary (citable) accession number: Q9NXK6
Secondary accession number(s): Q8IXU2

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 16, 2004
Last sequence update:	April 3, 2007
Last modified:	April 3, 2013
This is version 87 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.