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Q9NXK6

- MPRG_HUMAN

UniProt

Q9NXK6 - MPRG_HUMAN

Protein

Membrane progestin receptor gamma

Gene

PAQR5

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 96 (01 Oct 2014)
      Sequence version 2 (03 Apr 2007)
      Previous versions | rss
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    Functioni

    Steroid membrane receptor. Binds progesterone. May be involved in oocyte maturation.1 Publication

    GO - Molecular functioni

    1. receptor activity Source: RefGenome
    2. steroid binding Source: UniProtKB-KW

    GO - Biological processi

    1. multicellular organismal development Source: UniProtKB-KW
    2. oogenesis Source: UniProtKB-KW

    Keywords - Molecular functioni

    Developmental protein, Receptor

    Keywords - Biological processi

    Differentiation, Oogenesis

    Keywords - Ligandi

    Lipid-binding, Steroid-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Membrane progestin receptor gamma
    Short name:
    mPR gamma
    Alternative name(s):
    Progestin and adipoQ receptor family member 5
    Progestin and adipoQ receptor family member V
    Gene namesi
    Name:PAQR5
    Synonyms:MPRG
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 15

    Organism-specific databases

    HGNCiHGNC:29645. PAQR5.

    Subcellular locationi

    Membrane By similarity; Multi-pass membrane protein By similarity

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA142671199.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 330330Membrane progestin receptor gammaPRO_0000218843Add
    BLAST

    Proteomic databases

    MaxQBiQ9NXK6.
    PRIDEiQ9NXK6.

    PTM databases

    PhosphoSiteiQ9NXK6.

    Expressioni

    Tissue specificityi

    Expressed in the brain, lung, kidney, colon, adrenal and lung.2 Publications

    Gene expression databases

    ArrayExpressiQ9NXK6.
    BgeeiQ9NXK6.
    CleanExiHS_PAQR5.
    GenevestigatoriQ9NXK6.

    Organism-specific databases

    HPAiHPA016507.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9NXK6.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 5151CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini73 – 808ExtracellularSequence Analysis
    Topological domaini102 – 11312CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini135 – 1417ExtracellularSequence Analysis
    Topological domaini163 – 18624CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini208 – 25346ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini275 – 29420CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini316 – 33015ExtracellularSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei52 – 7221Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei81 – 10121Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei114 – 13421Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei142 – 16221Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei187 – 20721Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei254 – 27421Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei295 – 31521Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ADIPOR family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1272.
    HOGENOMiHOG000067790.
    HOVERGENiHBG052505.
    InParanoidiQ9NXK6.
    OMAiPYTWDSL.
    OrthoDBiEOG7D59NW.
    PhylomeDBiQ9NXK6.
    TreeFamiTF319738.

    Family and domain databases

    InterProiIPR004254. HlyIII-related.
    [Graphical view]
    PANTHERiPTHR20855. PTHR20855. 1 hit.
    PfamiPF03006. HlyIII. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9NXK6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLSLKLPRLF SIDQIPQVFH EQGILFGYRH PQSSATACIL SLFQMTNETL    50
    NIWTHLLPFW FFAWRFVTAL YMTDIKNDSY SWPMLVYMCT SCVYPLVSSC 100
    AHTFSSMSKN ARHICYFLDY GAVNLFSLGS AIAYSAYTFP DALMCTTFHD 150
    YYVALAVLNT ILSTGLSCYS RFLEIQKPRL CKVIRVLAFA YPYTWDSLPI 200
    FYRLFLFPGE SAQNEATSYH QKHMIMTLLA SFLYSAHLPE RLAPGRFDYI 250
    GHSHQLFHVC VILATHMQME AILLDKTLRK EWLLATSKPF SFSQIAGAIL 300
    LCIIFSLSNI IYFSAALYRI PKPELHKKET 330
    Length:330
    Mass (Da):38,014
    Last modified:April 3, 2007 - v2
    Checksum:iFA0AF2785EAAFFE8
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti175 – 1751I → V in AAR08371. (PubMed:16044242)Curated
    Sequence conflicti175 – 1751I → V in BAA91004. (PubMed:14702039)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti24 – 241I → T.1 Publication
    Corresponds to variant rs17853893 [ dbSNP | Ensembl ].
    VAR_031436

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY424283 mRNA. Translation: AAR08371.1.
    AK000197 mRNA. Translation: BAA91004.1.
    BC039234 mRNA. Translation: AAH39234.1.
    CCDSiCCDS10232.1.
    RefSeqiNP_001098024.1. NM_001104554.1.
    NP_060175.3. NM_017705.3.
    XP_005254551.1. XM_005254494.2.
    XP_006720646.1. XM_006720583.1.
    UniGeneiHs.591096.

    Genome annotation databases

    EnsembliENST00000340965; ENSP00000343877; ENSG00000137819.
    ENST00000395407; ENSP00000378803; ENSG00000137819.
    ENST00000561153; ENSP00000453526; ENSG00000137819.
    GeneIDi54852.
    KEGGihsa:54852.
    UCSCiuc002arz.2. human.

    Polymorphism databases

    DMDMi143811422.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY424283 mRNA. Translation: AAR08371.1 .
    AK000197 mRNA. Translation: BAA91004.1 .
    BC039234 mRNA. Translation: AAH39234.1 .
    CCDSi CCDS10232.1.
    RefSeqi NP_001098024.1. NM_001104554.1.
    NP_060175.3. NM_017705.3.
    XP_005254551.1. XM_005254494.2.
    XP_006720646.1. XM_006720583.1.
    UniGenei Hs.591096.

    3D structure databases

    ProteinModelPortali Q9NXK6.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q9NXK6.

    Polymorphism databases

    DMDMi 143811422.

    Proteomic databases

    MaxQBi Q9NXK6.
    PRIDEi Q9NXK6.

    Protocols and materials databases

    DNASUi 54852.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000340965 ; ENSP00000343877 ; ENSG00000137819 .
    ENST00000395407 ; ENSP00000378803 ; ENSG00000137819 .
    ENST00000561153 ; ENSP00000453526 ; ENSG00000137819 .
    GeneIDi 54852.
    KEGGi hsa:54852.
    UCSCi uc002arz.2. human.

    Organism-specific databases

    CTDi 54852.
    GeneCardsi GC15P069591.
    H-InvDB HIX0012388.
    HGNCi HGNC:29645. PAQR5.
    HPAi HPA016507.
    MIMi 607781. gene.
    neXtProti NX_Q9NXK6.
    PharmGKBi PA142671199.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG1272.
    HOGENOMi HOG000067790.
    HOVERGENi HBG052505.
    InParanoidi Q9NXK6.
    OMAi PYTWDSL.
    OrthoDBi EOG7D59NW.
    PhylomeDBi Q9NXK6.
    TreeFami TF319738.

    Miscellaneous databases

    GenomeRNAii 54852.
    NextBioi 57704.
    PROi Q9NXK6.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9NXK6.
    Bgeei Q9NXK6.
    CleanExi HS_PAQR5.
    Genevestigatori Q9NXK6.

    Family and domain databases

    InterProi IPR004254. HlyIII-related.
    [Graphical view ]
    PANTHERi PTHR20855. PTHR20855. 1 hit.
    Pfami PF03006. HlyIII. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "PAQR proteins: a novel membrane receptor family defined by an ancient 7-transmembrane pass motif."
      Tang Y.T., Hu T., Arterburn M., Boyle B., Bright J.M., Emtage P.C., Funk W.D.
      J. Mol. Evol. 61:372-380(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Colon mucosa.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT THR-24.
      Tissue: Kidney.
    4. "Identification, classification, and partial characterization of genes in humans and other vertebrates homologous to a fish membrane progestin receptor."
      Zhu Y., Bond J., Thomas P.
      Proc. Natl. Acad. Sci. U.S.A. 100:2237-2242(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, TISSUE SPECIFICITY.
    5. "The further redefining of steroid-mediated signaling."
      Hammes S.R.
      Proc. Natl. Acad. Sci. U.S.A. 100:2168-2170(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: REVIEW.

    Entry informationi

    Entry nameiMPRG_HUMAN
    AccessioniPrimary (citable) accession number: Q9NXK6
    Secondary accession number(s): Q8IXU2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 16, 2004
    Last sequence update: April 3, 2007
    Last modified: October 1, 2014
    This is version 96 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 15
      Human chromosome 15: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3