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Protein

Membrane progestin receptor gamma

Gene

PAQR5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plasma membrane progesterone (P4) receptor coupled to G proteins (PubMed:23763432). Seems to act through a G(i) mediated pathway (PubMed:23763432). May be involved in oocyte maturation (PubMed:12601167).1 Publication1 Publication

Miscellaneous

Non-classical progesterone receptors involved in extranuclear signaling are classified in 2 groups: the class II progestin and adipoQ receptor (PAQR) family (also called mPRs) (PAQR5, PAQR6, PAQR7, PAQR8 and PAQR9) and the b5-like heme/steroid-binding protein family (also called MAPRs) (PGRMC1, PGRMC2, NENF and CYB5D2).1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, Receptor
Biological processDifferentiation, Oogenesis
LigandLipid-binding, Steroid-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Membrane progestin receptor gamma1 Publication
Short name:
mPR gamma1 Publication
Alternative name(s):
Membrane progesterone P4 receptor gamma1 Publication
Membrane progesterone receptor gamma1 Publication
Progesterone and adipoQ receptor family member 5
Progestin and adipoQ receptor family member 51 Publication
Progestin and adipoQ receptor family member V
Gene namesi
Name:PAQR5Imported
Synonyms:MPRG
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

EuPathDBiHostDB:ENSG00000137819.13
HGNCiHGNC:29645 PAQR5
MIMi607781 gene
neXtProtiNX_Q9NXK6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 51CytoplasmicSequence analysisAdd BLAST51
Transmembranei52 – 72Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini73 – 80ExtracellularSequence analysis8
Transmembranei81 – 101Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini102 – 113CytoplasmicSequence analysisAdd BLAST12
Transmembranei114 – 134Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini135 – 141ExtracellularSequence analysis7
Transmembranei142 – 162Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini163 – 186CytoplasmicSequence analysisAdd BLAST24
Transmembranei187 – 207Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini208 – 253ExtracellularSequence analysisAdd BLAST46
Transmembranei254 – 274Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini275 – 294CytoplasmicSequence analysisAdd BLAST20
Transmembranei295 – 315Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini316 – 330ExtracellularSequence analysisAdd BLAST15

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi54852
OpenTargetsiENSG00000137819
PharmGKBiPA142671199

Polymorphism and mutation databases

BioMutaiPAQR5
DMDMi143811422

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002188431 – 330Membrane progestin receptor gammaAdd BLAST330

Proteomic databases

MaxQBiQ9NXK6
PaxDbiQ9NXK6
PeptideAtlasiQ9NXK6
PRIDEiQ9NXK6

PTM databases

iPTMnetiQ9NXK6
PhosphoSitePlusiQ9NXK6

Expressioni

Tissue specificityi

Expressed in the brain, lung, kidney, colon, adrenal and lung.2 Publications

Gene expression databases

BgeeiENSG00000137819
CleanExiHS_PAQR5
ExpressionAtlasiQ9NXK6 baseline and differential
GenevisibleiQ9NXK6 HS

Organism-specific databases

HPAiHPA076729

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
SYNE4Q8N2053EBI-10316423,EBI-7131783

Protein-protein interaction databases

BioGridi120202, 3 interactors
IntActiQ9NXK6, 1 interactor
STRINGi9606.ENSP00000343877

Structurei

3D structure databases

ProteinModelPortaliQ9NXK6
SMRiQ9NXK6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ADIPOR family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0748 Eukaryota
COG1272 LUCA
GeneTreeiENSGT00530000062965
HOGENOMiHOG000067790
HOVERGENiHBG052505
InParanoidiQ9NXK6
OMAiKNARHIC
OrthoDBiEOG091G0NO8
PhylomeDBiQ9NXK6
TreeFamiTF319738

Family and domain databases

InterProiView protein in InterPro
IPR004254 AdipoR/HlyIII-related
PANTHERiPTHR20855 PTHR20855, 1 hit
PfamiView protein in Pfam
PF03006 HlyIII, 1 hit

Sequencei

Sequence statusi: Complete.

Q9NXK6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLSLKLPRLF SIDQIPQVFH EQGILFGYRH PQSSATACIL SLFQMTNETL
60 70 80 90 100
NIWTHLLPFW FFAWRFVTAL YMTDIKNDSY SWPMLVYMCT SCVYPLVSSC
110 120 130 140 150
AHTFSSMSKN ARHICYFLDY GAVNLFSLGS AIAYSAYTFP DALMCTTFHD
160 170 180 190 200
YYVALAVLNT ILSTGLSCYS RFLEIQKPRL CKVIRVLAFA YPYTWDSLPI
210 220 230 240 250
FYRLFLFPGE SAQNEATSYH QKHMIMTLLA SFLYSAHLPE RLAPGRFDYI
260 270 280 290 300
GHSHQLFHVC VILATHMQME AILLDKTLRK EWLLATSKPF SFSQIAGAIL
310 320 330
LCIIFSLSNI IYFSAALYRI PKPELHKKET
Length:330
Mass (Da):38,014
Last modified:April 3, 2007 - v2
Checksum:iFA0AF2785EAAFFE8
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti175I → V in AAR08371 (PubMed:16044242).Curated1
Sequence conflicti175I → V in BAA91004 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03143624I → T1 PublicationCorresponds to variant dbSNP:rs17853893Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY424283 mRNA Translation: AAR08371.1
AK000197 mRNA Translation: BAA91004.1
BC039234 mRNA Translation: AAH39234.1
CCDSiCCDS10232.1
RefSeqiNP_001098024.1, NM_001104554.1
NP_060175.3, NM_017705.3
XP_011520022.1, XM_011521720.2
XP_011520024.1, XM_011521722.2
XP_016877849.1, XM_017022360.1
XP_016877850.1, XM_017022361.1
XP_016877851.1, XM_017022362.1
XP_016877852.1, XM_017022363.1
XP_016877853.1, XM_017022364.1
UniGeneiHs.591096

Genome annotation databases

EnsembliENST00000340965; ENSP00000343877; ENSG00000137819
ENST00000395407; ENSP00000378803; ENSG00000137819
ENST00000561153; ENSP00000453526; ENSG00000137819
GeneIDi54852
KEGGihsa:54852
UCSCiuc002arz.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiPAQR5_HUMAN
AccessioniPrimary (citable) accession number: Q9NXK6
Secondary accession number(s): Q8IXU2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: April 3, 2007
Last modified: April 25, 2018
This is version 119 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

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