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Protein

Pyroglutamyl-peptidase 1

Gene

PGPEP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Removes 5-oxoproline from various penultimate amino acid residues except L-proline.1 Publication

Catalytic activityi

Release of an N-terminal pyroglutamyl group from a polypeptide, the second amino acid generally not being Pro.PROSITE-ProRule annotation1 Publication

Enzyme regulationi

Inhibited by transition metal ions including Ni2+, Zn2+, and Cu2+ and by sulfhydryl-blocking agents.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei85 – 851By similarity
Active sitei149 – 1491By similarity
Active sitei168 – 1681By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol protease

Enzyme and pathway databases

BRENDAi3.4.19.3. 2681.

Protein family/group databases

MEROPSiC15.010.

Names & Taxonomyi

Protein namesi
Recommended name:
Pyroglutamyl-peptidase 1 (EC:3.4.19.3)
Alternative name(s):
5-oxoprolyl-peptidase
Pyroglutamyl aminopeptidase I
Short name:
PAP-I
Pyroglutamyl-peptidase I
Short name:
PGP-I
Pyrrolidone-carboxylate peptidase
Gene namesi
Name:PGPEP1
Synonyms:PGPI
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:13568. PGPEP1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA33247.

Polymorphism and mutation databases

BioMutaiPGPEP1.
DMDMi14548183.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 209209Pyroglutamyl-peptidase 1PRO_0000184761Add
BLAST

Proteomic databases

EPDiQ9NXJ5.
MaxQBiQ9NXJ5.
PaxDbiQ9NXJ5.
PeptideAtlasiQ9NXJ5.
PRIDEiQ9NXJ5.

PTM databases

iPTMnetiQ9NXJ5.
PhosphoSiteiQ9NXJ5.

Expressioni

Gene expression databases

BgeeiENSG00000130517.
CleanExiHS_PGPEP1.
ExpressionAtlasiQ9NXJ5. baseline and differential.
GenevisibleiQ9NXJ5. HS.

Organism-specific databases

HPAiHPA035368.

Interactioni

Subunit structurei

Monomer.1 Publication

Protein-protein interaction databases

BioGridi120208. 7 interactions.
STRINGi9606.ENSP00000269919.

Structurei

3D structure databases

ProteinModelPortaliQ9NXJ5.
SMRiQ9NXJ5. Positions 3-172.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase C15 family.Curated

Phylogenomic databases

eggNOGiKOG4755. Eukaryota.
COG2039. LUCA.
GeneTreeiENSGT00390000015368.
HOGENOMiHOG000007775.
HOVERGENiHBG019147.
InParanoidiQ9NXJ5.
KOiK01304.
OMAiCGYIYLK.
OrthoDBiEOG091G0LSD.
PhylomeDBiQ9NXJ5.
TreeFamiTF313278.

Family and domain databases

CDDicd00501. Peptidase_C15. 1 hit.
Gene3Di3.40.630.20. 1 hit.
InterProiIPR000816. Peptidase_C15.
IPR016125. Peptidase_C15-like.
IPR029761. PGP-I_metazoa.
IPR033694. PGPEP1_Cys_AS.
IPR033693. PGPEP1_Glu_AS.
[Graphical view]
PANTHERiPTHR23402. PTHR23402. 1 hit.
PTHR23402:SF16. PTHR23402:SF16. 1 hit.
PfamiPF01470. Peptidase_C15. 1 hit.
[Graphical view]
PIRSFiPIRSF015592. Prld-crbxl_pptds. 1 hit.
PRINTSiPR00706. PYROGLUPTASE.
PROSITEiPS01334. PYRASE_CYS. 1 hit.
PS01333. PYRASE_GLU. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9NXJ5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEQPRKAVVV TGFGPFGEHT VNASWIAVQE LEKLGLGDSV DLHVYEIPVE
60 70 80 90 100
YQTVQRLIPA LWEKHSPQLV VHVGVSGMAT TVTLEKCGHN KGYKGLDNCR
110 120 130 140 150
FCPGSQCCVE DGPESIDSII DMDAVCKRVT TLGLDVSVTI SQDAGRYLCD
160 170 180 190 200
FTYYTSLYQS HGRSAFVHVP PLGKPYNADQ LGRALRAIIE EMLDLLEQSE

GKINYCHKH
Length:209
Mass (Da):23,138
Last modified:October 1, 2000 - v1
Checksum:i91456CB1D52B04AB
GO
Isoform 2 (identifier: Q9NXJ5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-77: Missing.

Show »
Length:132
Mass (Da):14,639
Checksum:i165ADCBDC74D323E
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 7777Missing in isoform 2. 2 PublicationsVSP_056472Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ278828 mRNA. Translation: CAC03610.1.
AK000215 mRNA. Translation: BAA91015.1.
AK289968 mRNA. Translation: BAF82657.1.
AK294497 mRNA. Translation: BAG57716.1.
AC008397 Genomic DNA. No translation available.
CH471106 Genomic DNA. Translation: EAW84691.1.
CH471106 Genomic DNA. Translation: EAW84692.1.
BC042138 mRNA. Translation: AAH42138.1.
CCDSiCCDS12375.1. [Q9NXJ5-1]
RefSeqiNP_001287856.1. NM_001300927.1.
NP_001295295.1. NM_001308366.1.
NP_060182.1. NM_017712.3. [Q9NXJ5-1]
XP_011526417.1. XM_011528115.1. [Q9NXJ5-2]
UniGeneiHs.131776.

Genome annotation databases

EnsembliENST00000252813; ENSP00000252813; ENSG00000130517. [Q9NXJ5-2]
ENST00000269919; ENSP00000269919; ENSG00000130517. [Q9NXJ5-1]
GeneIDi54858.
KEGGihsa:54858.
UCSCiuc002nis.2. human. [Q9NXJ5-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ278828 mRNA. Translation: CAC03610.1.
AK000215 mRNA. Translation: BAA91015.1.
AK289968 mRNA. Translation: BAF82657.1.
AK294497 mRNA. Translation: BAG57716.1.
AC008397 Genomic DNA. No translation available.
CH471106 Genomic DNA. Translation: EAW84691.1.
CH471106 Genomic DNA. Translation: EAW84692.1.
BC042138 mRNA. Translation: AAH42138.1.
CCDSiCCDS12375.1. [Q9NXJ5-1]
RefSeqiNP_001287856.1. NM_001300927.1.
NP_001295295.1. NM_001308366.1.
NP_060182.1. NM_017712.3. [Q9NXJ5-1]
XP_011526417.1. XM_011528115.1. [Q9NXJ5-2]
UniGeneiHs.131776.

3D structure databases

ProteinModelPortaliQ9NXJ5.
SMRiQ9NXJ5. Positions 3-172.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120208. 7 interactions.
STRINGi9606.ENSP00000269919.

Protein family/group databases

MEROPSiC15.010.

PTM databases

iPTMnetiQ9NXJ5.
PhosphoSiteiQ9NXJ5.

Polymorphism and mutation databases

BioMutaiPGPEP1.
DMDMi14548183.

Proteomic databases

EPDiQ9NXJ5.
MaxQBiQ9NXJ5.
PaxDbiQ9NXJ5.
PeptideAtlasiQ9NXJ5.
PRIDEiQ9NXJ5.

Protocols and materials databases

DNASUi54858.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000252813; ENSP00000252813; ENSG00000130517. [Q9NXJ5-2]
ENST00000269919; ENSP00000269919; ENSG00000130517. [Q9NXJ5-1]
GeneIDi54858.
KEGGihsa:54858.
UCSCiuc002nis.2. human. [Q9NXJ5-1]

Organism-specific databases

CTDi54858.
GeneCardsiPGPEP1.
HGNCiHGNC:13568. PGPEP1.
HPAiHPA035368.
MIMi610694. gene.
neXtProtiNX_Q9NXJ5.
PharmGKBiPA33247.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4755. Eukaryota.
COG2039. LUCA.
GeneTreeiENSGT00390000015368.
HOGENOMiHOG000007775.
HOVERGENiHBG019147.
InParanoidiQ9NXJ5.
KOiK01304.
OMAiCGYIYLK.
OrthoDBiEOG091G0LSD.
PhylomeDBiQ9NXJ5.
TreeFamiTF313278.

Enzyme and pathway databases

BRENDAi3.4.19.3. 2681.

Miscellaneous databases

ChiTaRSiPGPEP1. human.
GeneWikiiPGPEP1.
GenomeRNAii54858.
PROiQ9NXJ5.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000130517.
CleanExiHS_PGPEP1.
ExpressionAtlasiQ9NXJ5. baseline and differential.
GenevisibleiQ9NXJ5. HS.

Family and domain databases

CDDicd00501. Peptidase_C15. 1 hit.
Gene3Di3.40.630.20. 1 hit.
InterProiIPR000816. Peptidase_C15.
IPR016125. Peptidase_C15-like.
IPR029761. PGP-I_metazoa.
IPR033694. PGPEP1_Cys_AS.
IPR033693. PGPEP1_Glu_AS.
[Graphical view]
PANTHERiPTHR23402. PTHR23402. 1 hit.
PTHR23402:SF16. PTHR23402:SF16. 1 hit.
PfamiPF01470. Peptidase_C15. 1 hit.
[Graphical view]
PIRSFiPIRSF015592. Prld-crbxl_pptds. 1 hit.
PRINTSiPR00706. PYROGLUPTASE.
PROSITEiPS01334. PYRASE_CYS. 1 hit.
PS01333. PYRASE_GLU. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPGPI_HUMAN
AccessioniPrimary (citable) accession number: Q9NXJ5
Secondary accession number(s): A8K1Q3, Q8IVT1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: October 1, 2000
Last modified: September 7, 2016
This is version 134 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Peptidase families
    Classification of peptidase families and list of entries
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.