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Q9NXH8

- TOR4A_HUMAN

UniProt

Q9NXH8 - TOR4A_HUMAN

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Protein
Torsin-4A
Gene
TOR4A, C9orf167
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi194 – 2018ATP Reviewed prediction

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. nucleoside-triphosphatase activity Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. chaperone mediated protein folding requiring cofactor Source: InterPro
Complete GO annotation...

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Torsin-4A
Alternative name(s):
Torsin family 4 member A
Gene namesi
Name:TOR4A
Synonyms:C9orf167
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 9

Organism-specific databases

HGNCiHGNC:25981. TOR4A.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei122 – 13817Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162380839.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 423423Torsin-4A
PRO_0000287489Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei81 – 811Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9NXH8.
PaxDbiQ9NXH8.
PRIDEiQ9NXH8.

PTM databases

PhosphoSiteiQ9NXH8.

Expressioni

Gene expression databases

BgeeiQ9NXH8.
CleanExiHS_C9orf167.
GenevestigatoriQ9NXH8.

Organism-specific databases

HPAiHPA044913.

Interactioni

Protein-protein interaction databases

BioGridi120213. 5 interactions.
STRINGi9606.ENSP00000350102.

Structurei

3D structure databases

ProteinModelPortaliQ9NXH8.
SMRiQ9NXH8. Positions 157-213.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG264969.
HOGENOMiHOG000043098.
HOVERGENiHBG054429.
InParanoidiQ9NXH8.
OMAiRAQRCLL.
OrthoDBiEOG715Q4K.
PhylomeDBiQ9NXH8.
TreeFamiTF314941.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR027417. P-loop_NTPase.
IPR010448. Torsin.
[Graphical view]
PANTHERiPTHR10760. PTHR10760. 1 hit.
PfamiPF06309. Torsin. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9NXH8-1 [UniParc]FASTAAdd to Basket

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MDRGQPSLEP AAAAPRASGR CVIAPVRAVL RLRRRVCVLR KRRLLQPGGG    50
PDVGTGAPRP GCSPRAPRAD LDQPKFFTFD SPAELPSRTP RKKRRRSRLV 100
LYPETSRKYR PRVEHRSRAQ RCLLLLVAIV GFQVLNAIEN LDDNAQRYDL 150
DGLEKALQRA VFGQPAAVSR IVALMRDYLA THVHSRPLLL ALHGPSGVGK 200
SHVGRLLARH FRSVLEDSAL VLQYHARHHC PEARAAQDCR EELARRVADV 250
VARAEAEEKT PLLVLDDVEL MPRPLLDELH GFLQPQRSHH FHNAIYVLLS 300
GAGGAEVTRF VLQNASRALP LRPDGFRSAE AAAAQAEEDL RASLLAVLSR 350
EHPLWQAAAI VPFLLLDKRD VVSCFRDEMA GEGFFPDQAR AENLAAQLSF 400
YRVAGREFAV TGCKQVVATV NLL 423
Length:423
Mass (Da):46,914
Last modified:May 15, 2007 - v2
Checksum:i5CF52BC28A1AD7CC
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti356 – 3561Q → R in BAA91032. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK000252 mRNA. Translation: BAA91032.1.
BX255925 Genomic DNA. Translation: CAM24150.1.
CCDSiCCDS7041.1.
RefSeqiNP_060193.2. NM_017723.2.
UniGeneiHs.495541.

Genome annotation databases

EnsembliENST00000357503; ENSP00000350102; ENSG00000198113.
GeneIDi54863.
KEGGihsa:54863.
UCSCiuc004cmn.3. human.

Polymorphism databases

DMDMi147638588.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK000252 mRNA. Translation: BAA91032.1 .
BX255925 Genomic DNA. Translation: CAM24150.1 .
CCDSi CCDS7041.1.
RefSeqi NP_060193.2. NM_017723.2.
UniGenei Hs.495541.

3D structure databases

ProteinModelPortali Q9NXH8.
SMRi Q9NXH8. Positions 157-213.
ModBasei Search...

Protein-protein interaction databases

BioGridi 120213. 5 interactions.
STRINGi 9606.ENSP00000350102.

PTM databases

PhosphoSitei Q9NXH8.

Polymorphism databases

DMDMi 147638588.

Proteomic databases

MaxQBi Q9NXH8.
PaxDbi Q9NXH8.
PRIDEi Q9NXH8.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000357503 ; ENSP00000350102 ; ENSG00000198113 .
GeneIDi 54863.
KEGGi hsa:54863.
UCSCi uc004cmn.3. human.

Organism-specific databases

CTDi 54863.
GeneCardsi GC09P140173.
H-InvDB HIX0020701.
HGNCi HGNC:25981. TOR4A.
HPAi HPA044913.
neXtProti NX_Q9NXH8.
PharmGKBi PA162380839.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG264969.
HOGENOMi HOG000043098.
HOVERGENi HBG054429.
InParanoidi Q9NXH8.
OMAi RAQRCLL.
OrthoDBi EOG715Q4K.
PhylomeDBi Q9NXH8.
TreeFami TF314941.

Miscellaneous databases

GenomeRNAii 54863.
NextBioi 57754.
PROi Q9NXH8.

Gene expression databases

Bgeei Q9NXH8.
CleanExi HS_C9orf167.
Genevestigatori Q9NXH8.

Family and domain databases

Gene3Di 3.40.50.300. 1 hit.
InterProi IPR003593. AAA+_ATPase.
IPR027417. P-loop_NTPase.
IPR010448. Torsin.
[Graphical view ]
PANTHERi PTHR10760. PTHR10760. 1 hit.
Pfami PF06309. Torsin. 1 hit.
[Graphical view ]
SMARTi SM00382. AAA. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Colon mucosa.
  2. "DNA sequence and analysis of human chromosome 9."
    Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
    , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
    Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-81, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.

Entry informationi

Entry nameiTOR4A_HUMAN
AccessioniPrimary (citable) accession number: Q9NXH8
Secondary accession number(s): A2BFA4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: May 15, 2007
Last modified: September 3, 2014
This is version 98 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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