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Protein

Torsin-4A

Gene

TOR4A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi194 – 2018ATPSequence Analysis

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Torsin-4A
Alternative name(s):
Torsin family 4 member A
Gene namesi
Name:TOR4A
Synonyms:C9orf167
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 9

Organism-specific databases

HGNCiHGNC:25981. TOR4A.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei122 – 13817HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162380839.

Polymorphism and mutation databases

BioMutaiTOR4A.
DMDMi147638588.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 423423Torsin-4APRO_0000287489Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei81 – 811Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9NXH8.
PaxDbiQ9NXH8.
PRIDEiQ9NXH8.

PTM databases

PhosphoSiteiQ9NXH8.

Expressioni

Gene expression databases

BgeeiQ9NXH8.
CleanExiHS_C9orf167.
GenevisibleiQ9NXH8. HS.

Organism-specific databases

HPAiHPA044913.

Interactioni

Protein-protein interaction databases

BioGridi120213. 2 interactions.
STRINGi9606.ENSP00000350102.

Structurei

3D structure databases

ProteinModelPortaliQ9NXH8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ClpA/ClpB family. Torsin subfamily.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG264969.
GeneTreeiENSGT00390000001920.
HOGENOMiHOG000043098.
HOVERGENiHBG054429.
InParanoidiQ9NXH8.
OMAiCFRDEMA.
OrthoDBiEOG715Q4K.
PhylomeDBiQ9NXH8.
TreeFamiTF314941.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR027417. P-loop_NTPase.
IPR010448. Torsin.
IPR030551. Torsin-4A.
[Graphical view]
PANTHERiPTHR10760. PTHR10760. 1 hit.
PTHR10760:SF1. PTHR10760:SF1. 1 hit.
PfamiPF06309. Torsin. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9NXH8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDRGQPSLEP AAAAPRASGR CVIAPVRAVL RLRRRVCVLR KRRLLQPGGG
60 70 80 90 100
PDVGTGAPRP GCSPRAPRAD LDQPKFFTFD SPAELPSRTP RKKRRRSRLV
110 120 130 140 150
LYPETSRKYR PRVEHRSRAQ RCLLLLVAIV GFQVLNAIEN LDDNAQRYDL
160 170 180 190 200
DGLEKALQRA VFGQPAAVSR IVALMRDYLA THVHSRPLLL ALHGPSGVGK
210 220 230 240 250
SHVGRLLARH FRSVLEDSAL VLQYHARHHC PEARAAQDCR EELARRVADV
260 270 280 290 300
VARAEAEEKT PLLVLDDVEL MPRPLLDELH GFLQPQRSHH FHNAIYVLLS
310 320 330 340 350
GAGGAEVTRF VLQNASRALP LRPDGFRSAE AAAAQAEEDL RASLLAVLSR
360 370 380 390 400
EHPLWQAAAI VPFLLLDKRD VVSCFRDEMA GEGFFPDQAR AENLAAQLSF
410 420
YRVAGREFAV TGCKQVVATV NLL
Length:423
Mass (Da):46,914
Last modified:May 15, 2007 - v2
Checksum:i5CF52BC28A1AD7CC
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti356 – 3561Q → R in BAA91032 (PubMed:14702039).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK000252 mRNA. Translation: BAA91032.1.
BX255925 Genomic DNA. Translation: CAM24150.1.
CCDSiCCDS7041.1.
RefSeqiNP_060193.2. NM_017723.2.
UniGeneiHs.495541.

Genome annotation databases

EnsembliENST00000357503; ENSP00000350102; ENSG00000198113.
GeneIDi54863.
KEGGihsa:54863.
UCSCiuc004cmn.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK000252 mRNA. Translation: BAA91032.1.
BX255925 Genomic DNA. Translation: CAM24150.1.
CCDSiCCDS7041.1.
RefSeqiNP_060193.2. NM_017723.2.
UniGeneiHs.495541.

3D structure databases

ProteinModelPortaliQ9NXH8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120213. 2 interactions.
STRINGi9606.ENSP00000350102.

PTM databases

PhosphoSiteiQ9NXH8.

Polymorphism and mutation databases

BioMutaiTOR4A.
DMDMi147638588.

Proteomic databases

MaxQBiQ9NXH8.
PaxDbiQ9NXH8.
PRIDEiQ9NXH8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000357503; ENSP00000350102; ENSG00000198113.
GeneIDi54863.
KEGGihsa:54863.
UCSCiuc004cmn.3. human.

Organism-specific databases

CTDi54863.
GeneCardsiGC09P140173.
H-InvDBHIX0020701.
HGNCiHGNC:25981. TOR4A.
HPAiHPA044913.
neXtProtiNX_Q9NXH8.
PharmGKBiPA162380839.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG264969.
GeneTreeiENSGT00390000001920.
HOGENOMiHOG000043098.
HOVERGENiHBG054429.
InParanoidiQ9NXH8.
OMAiCFRDEMA.
OrthoDBiEOG715Q4K.
PhylomeDBiQ9NXH8.
TreeFamiTF314941.

Miscellaneous databases

GenomeRNAii54863.
NextBioi57754.
PROiQ9NXH8.

Gene expression databases

BgeeiQ9NXH8.
CleanExiHS_C9orf167.
GenevisibleiQ9NXH8. HS.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR027417. P-loop_NTPase.
IPR010448. Torsin.
IPR030551. Torsin-4A.
[Graphical view]
PANTHERiPTHR10760. PTHR10760. 1 hit.
PTHR10760:SF1. PTHR10760:SF1. 1 hit.
PfamiPF06309. Torsin. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Colon mucosa.
  2. "DNA sequence and analysis of human chromosome 9."
    Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
    , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
    Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-81, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.

Entry informationi

Entry nameiTOR4A_HUMAN
AccessioniPrimary (citable) accession number: Q9NXH8
Secondary accession number(s): A2BFA4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: May 15, 2007
Last modified: July 22, 2015
This is version 107 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.