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Protein

Protein phosphatase 1 regulatory subunit 14D

Gene

PPP1R14D

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Inhibitor of PPP1CA. Has inhibitory activity only when phosphorylated, creating a molecular switch for regulating the phosphorylation status of PPP1CA substrates and smooth muscle contraction.1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionProtein phosphatase inhibitor

Names & Taxonomyi

Protein namesi
Recommended name:
Protein phosphatase 1 regulatory subunit 14D
Alternative name(s):
Gastrointestinal and brain-specific PP1-inhibitory protein 1
Short name:
GBPI-1
Gene namesi
Name:PPP1R14D
Synonyms:GBPI
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

HGNCiHGNC:14953. PPP1R14D.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi21 – 22KK → EE: Reduces inhibitory activity by 57%. 1 Publication2
Mutagenesisi25W → A: Reduces inhibitory activity by 13%. 1 Publication1
Mutagenesisi58T → E: Reduces inhibitory activity by 16%. Reduces phosphorylation. 1 Publication1

Organism-specific databases

OpenTargetsiENSG00000166143.
PharmGKBiPA33631.

Polymorphism and mutation databases

BioMutaiPPP1R14D.
DMDMi55583999.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000714971 – 145Protein phosphatase 1 regulatory subunit 14DAdd BLAST145

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei58Phosphothreonine1 Publication1

Post-translational modificationi

Phosphorylated on several residues.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ9NXH3.
PeptideAtlasiQ9NXH3.
PRIDEiQ9NXH3.

PTM databases

iPTMnetiQ9NXH3.
PhosphoSitePlusiQ9NXH3.

Expressioni

Tissue specificityi

Detected in colon, intestine, kidney and brain cortex.1 Publication

Gene expression databases

BgeeiENSG00000166143.
CleanExiHS_PPP1R14D.
ExpressionAtlasiQ9NXH3. baseline and differential.
GenevisibleiQ9NXH3. HS.

Organism-specific databases

HPAiHPA041846.

Interactioni

Protein-protein interaction databases

BioGridi120215. 5 interactors.
STRINGi9606.ENSP00000398342.

Structurei

3D structure databases

ProteinModelPortaliQ9NXH3.
SMRiQ9NXH3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni21 – 25Interaction with protein phosphatase 15

Sequence similaritiesi

Belongs to the PP1 inhibitor family.Curated

Phylogenomic databases

eggNOGiENOG410J01A. Eukaryota.
ENOG41115QK. LUCA.
GeneTreeiENSGT00390000003608.
HOGENOMiHOG000231993.
HOVERGENiHBG054419.
InParanoidiQ9NXH3.
KOiK17557.
PhylomeDBiQ9NXH3.

Family and domain databases

Gene3Di1.10.150.220. 1 hit.
InterProiView protein in InterPro
IPR008025. PP1_inhibitor.
PANTHERiPTHR16188. PTHR16188. 1 hit.
PfamiView protein in Pfam
PF05361. PP1_inhibitor. 1 hit.
SUPFAMiSSF81790. SSF81790. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9NXH3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLSSSPASCT SPSPDGENPC KKVHWASGRR RTSSTDSESK SHPDSSKIPR
60 70 80 90 100
SRRPSRLTVK YDRGQLQRWL EMEQWVDAQV QELFQDQATP SEPEIDLEAL
110 120 130 140
MDLSTEEQKT QLEAILGNCP RPTEAFISEL LSQLKKLRRL SRPQK
Length:145
Mass (Da):16,508
Last modified:October 1, 2000 - v1
Checksum:i012899C72C5760A4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY050671 mRNA. Translation: AAL25829.1.
AK000258 mRNA. Translation: BAA91037.1.
BC096716 mRNA. Translation: AAH96716.1.
BC098124 mRNA. Translation: AAH98124.1.
CCDSiCCDS10066.1.
RefSeqiNP_060196.1. NM_017726.7.
UniGeneiHs.192927.

Genome annotation databases

EnsembliENST00000299174; ENSP00000299174; ENSG00000166143.
GeneIDi54866.
KEGGihsa:54866.
UCSCiuc001zmy.3. human.

Similar proteinsi

Entry informationi

Entry nameiPP14D_HUMAN
AccessioniPrimary (citable) accession number: Q9NXH3
Secondary accession number(s): Q4V773
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 9, 2004
Last sequence update: October 1, 2000
Last modified: August 30, 2017
This is version 114 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families