Q9NXG2 (THUM1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
THUMP domain-containing protein 1

Gene names

Name:

THUMPD1

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	353 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Sequence similarities

Belongs to the THUMPD1 family. Contains 1 THUMP domain.

Ontologies

Keywords
Coding sequence diversity	Polymorphism
PTM	Acetylation Phosphoprotein
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Initiator methionine

1

1

Removed

Chain

2 – 353

352

THUMP domain-containing protein 1

PRO_0000072530

Regions

Domain

147 – 254

108

THUMP

Amino acid modifications

Modified residue

2

1

N-acetylalanine Ref.8

Modified residue

86

1

Phosphoserine Ref.3 Ref.4 Ref.6 Ref.7 Ref.8 Ref.9

Modified residue

88

1

Phosphoserine Ref.3 Ref.4 Ref.5 Ref.6 Ref.7 Ref.8 Ref.9

Natural variations

Natural variant

311

1

E → D.
Corresponds to variant rs11074471 [ dbSNP | Ensembl ].

VAR_037645

Experimental info

Sequence conflict

84

1

Q → R in BAA91050. Ref.1

Sequence conflict

285

1

K → E in BAA91050. Ref.1

Sequence conflict

352

1

F → S in BAA91050. Ref.1

Secondary structure

1

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

353

Helix Strand Turn

Details...

Helix

171 – 188

18

Beta strand

196 – 201

6

Helix

210 – 217

8

Helix

221 – 224

4

Beta strand

232 – 234

3

Beta strand

236 – 244

9

Beta strand

247 – 254

8

Sequences

	Sequence		Length	Mass (Da)
	Q9NXG2 [UniParc]. Last modified July 5, 2004. Version 2. Checksum: 7F0BBD91D204AA1B	FASTA	353	39,315
	10 20 30 40 50 60 MAAPAQQTTQ PGGGKRKGKA QYVLAKRARR CDAGGPRQLE PGLQGILITC NMNERKCVEE 70 80 90 100 110 120 AYSLLNEYGD DMYGPEKFTD KDQQPSGSEG EDDDAEAALK KEVGDIKAST EMRLRRFQSV 130 140 150 160 170 180 ESGANNVVFI RTLGIEPEKL VHHILQDMYK TKKKKTRVIL RMLPISGTCK AFLEDMKKYA 190 200 210 220 230 240 ETFLEPWFKA PNKGTFQIVY KSRNNSHVNR EEVIRELAGI VCTLNSENKV DLTNPQYTVV 250 260 270 280 290 300 VEIIKAVCCL SVVKDYMLFR KYNLQEVVKS PKDPSQLNSK QGNGKEAKLE SADKSDQNNT 310 320 330 340 350 AEGKNNQQVP ENTEELGQTK PTSNPQVVNE GGAKPELASQ ATEGSKSNEN DFS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Lung.
[3]	"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M. Cell 127:635-648(2006) [PubMed: 17081983] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-86 AND SER-88, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[4]	"Global proteomic profiling of phosphopeptides using electron transfer dissociation tandem mass spectrometry." Molina H., Horn D.M., Tang N., Mathivanan S., Pandey A. Proc. Natl. Acad. Sci. U.S.A. 104:2199-2204(2007) [PubMed: 17287340] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-86 AND SER-88, MASS SPECTROMETRY. Tissue: Embryonic kidney.
[5]	"Phosphorylation analysis of primary human T lymphocytes using sequential IMAC and titanium oxide enrichment." Carrascal M., Ovelleiro D., Casas V., Gay M., Abian J. J. Proteome Res. 7:5167-5176(2008) [PubMed: 19367720] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-88, MASS SPECTROMETRY. Tissue: T-cell.
[6]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed: 18669648] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-86 AND SER-88, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[7]	"Large-scale phosphoproteome analysis of human liver tissue by enrichment and fractionation of phosphopeptides with strong anion exchange chromatography." Han G., Ye M., Zhou H., Jiang X., Feng S., Jiang X., Tian R., Wan D., Zou H., Gu J. Proteomics 8:1346-1361(2008) [PubMed: 18318008] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-86 AND SER-88, MASS SPECTROMETRY. Tissue: Liver.
[8]	"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach." Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S. Anal. Chem. 81:4493-4501(2009) [PubMed: 19413330] [Abstract] Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-86 AND SER-88, MASS SPECTROMETRY. Tissue: Embryonic kidney.
[9]	"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions." Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K. Sci. Signal. 2:RA46-RA46(2009) [PubMed: 19690332] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-86 AND SER-88, MASS SPECTROMETRY. Tissue: Leukemic T-cell.
[10]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed: 21269460] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[11]	"Solution structure of the THUMP domain of THUMP domain-containing protein 1." RIKEN structural genomics initiative (RSGI) Submitted (SEP-2006) to the PDB data bank Cited for: STRUCTURE BY NMR OF 170-254.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AK000281 mRNA. Translation: BAA91050.1.
BC000448 mRNA. Translation: AAH00448.1.

IPI

IPI00550243.

RefSeq

NP_060206.2. NM_017736.3.

UniGene

Hs.460232.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2DIR	NMR	-	A	170-254	[»]

ProteinModelPortal

Q9NXG2.

SMR

Q9NXG2. Positions 170-254.

ModBase

Search...

Protein-protein interaction databases

STRING

Q9NXG2.

PTM databases

PhosphoSite

Q9NXG2.

Polymorphism databases

DMDM

61248576.

Proteomic databases

PRIDE

Q9NXG2.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000381337; ENSP00000370741; ENSG00000066654.
ENST00000396083; ENSP00000379392; ENSG00000066654.
ENST00000431224; ENSP00000392282; ENSG00000066654.

GeneID

55623.

KEGG

hsa:55623.

NMPDR

fig|9606.3.peg.11828.

UCSC

uc002dho.1. human.

Organism-specific databases

CTD

55623.

GeneCards

GC16M020744.

H-InvDB

HIX0019394.

HGNC

HGNC:23807. THUMPD1.

HPA

HPA027851.

neXtProt

NX_Q9NXG2.

GenAtlas

Search...

Phylogenomic databases

GeneTree

ENSGT00390000002365.

HOVERGEN

HBG053030.

InParanoid

Q9NXG2.

OrthoDB

EOG4P8FJT.

PhylomeDB

Q9NXG2.

Gene expression databases

ArrayExpress

Q9NXG2.

Bgee

Q9NXG2.

CleanEx

HS_THUMPD1.

Genevestigator

Q9NXG2.

GermOnline

ENSG00000066654. Homo sapiens.

Family and domain databases

InterPro

IPR004114. THUMP.
[Graphical view]

KO

K06963.

Pfam

PF02926. THUMP. 1 hit.
[Graphical view]

SMART

SM00981. THUMP. 1 hit.
[Graphical view]

PROSITE

PS51165. THUMP. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

NextBio

60236.

Entry information

Entry name

THUM1_HUMAN

Accession

Primary (citable) accession number: Q9NXG2
Secondary accession number(s): Q9BWC3

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 5, 2004
Last sequence update:	July 5, 2004
Last modified:	January 25, 2012
This is version 70 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.