Q9NXG0 (CNTLN_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Centlein

Alternative name(s):
Centrosomal protein

Gene names

Name:	CNTLN
Synonyms:	C9orf101, C9orf39

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	1405 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Subcellular location	Cytoplasm › cytoskeleton › centrosome › centriole. Note: Colocalizes with gamma-tubulin during interphase and mitosis. Appears to associated with the mother centriole during G1 phase and with daughter centrioles towards G1/S phase By similarity.
Sequence caution	The sequence BAA91052.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended. The sequence BAB13850.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Ontologies

Keywords
Cellular component	Cytoplasm Cytoskeleton
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Coiled coil
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	phosphorelay signal transduction system Inferred from electronic annotation. Source: GOC signal transduction by phosphorylation Inferred from electronic annotation. Source: GOC
Cellular_component	centriole Inferred from electronic annotation. Source: UniProtKB-SubCell centrosome Inferred from direct assay. Source: HPA membrane Inferred from electronic annotation. Source: InterPro mitochondrion Inferred from direct assay. Source: HPA
Molecular_function	phosphorelay sensor kinase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q9NXG0-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Note: No experimental confirmation available.

Isoform 2 (identifier: Q9NXG0-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1374-1405: SLTLSPRLKCNGAIMAHQNLRLPDSSSSASAS → LPFASYLLEAVLEKINEKKKLVEGYFTIMKDIR

Note: No experimental confirmation available.

Isoform 3 (identifier: Q9NXG0-3)

The sequence of this isoform differs from the canonical sequence as follows:
     383-391: LYNELHICF → VCFYSVIKM
     392-1405: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1405	1405	Centlein		PRO_0000227567
Regions
	Coiled coil	95 – 126	32	Potential
	Coiled coil	613 – 655	43	Potential
	Coiled coil	681 – 793	113	Potential
	Coiled coil	980 – 1311	332	Potential
	Compositional bias	1398 – 1405	8	Poly-Ser
Amino acid modifications
	Modified residue	5	1	Phosphoserine By similarity
Natural variations
	Alternative sequence	383 – 391	9	LYNELHICF → VCFYSVIKM in isoform 3.		VSP_032864
	Alternative sequence	392 – 1405	1014	Missing in isoform 3.		VSP_032865
	Alternative sequence	1374 – 1405	32	SLTLS…SASAS → LPFASYLLEAVLEKINEKKK LVEGYFTIMKDIR in isoform 2.		VSP_017558
	Natural variant	284	1	T → A. Corresponds to variant rs3808795 [ dbSNP | Ensembl ].		VAR_056840
	Natural variant	291	1	E → D. Corresponds to variant rs3808794 [ dbSNP | Ensembl ].		VAR_056841
	Natural variant	562	1	R → C. Corresponds to variant rs3808782 [ dbSNP | Ensembl ].		VAR_025608
	Natural variant	695	1	T → I. Ref.1 Corresponds to variant rs7035276 [ dbSNP | Ensembl ].		VAR_025609
	Natural variant	1376	1	T → A. Corresponds to variant rs2499057 [ dbSNP | Ensembl ].		VAR_025610
Experimental info
	Sequence conflict	700	1	R → Q in BAB13850. Ref.1
	Sequence conflict	871	1	Missing in BAB13850. Ref.1
	Sequence conflict	1004	1	T → A in BAB13850. Ref.1
	Sequence conflict	1240	1	A → V in BAB13850. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified January 11, 2011. Version 5. Checksum: 6161171F6995E843	FASTA	1,405	161,603
	10 20 30 40 50 60 MAARSPPSPH PSPPARQLGP RSPRVGRGAE VHAMRSEASG FAGAAREVVA DESDKIWVGE 70 80 90 100 110 120 EGSGGRRGPG GAAPAHAPLL SAPMGSRRLE GISVEEAMVT RTQLLEEELS SLKEELALCQ 130 140 150 160 170 180 ADKEFVWSLW KRLQVTNPDL TQVVSLVVER EKQKSEAKDR KVLEILQVKD AKIQEFEQRE 190 200 210 220 230 240 SVLKQEINDL VKRKIAVDEE NAFLRKEFSD LEKKFKDKSQ EIKDTKECVQ NKEEQNRLVI 250 260 270 280 290 300 KNLEEENKKL STRCTDLLND LEKLRKQEAH LRKEKYSTDA KIKTFEDNLI EARKEVEVSQ 310 320 330 340 350 360 SKYNALSLQL SNKQTELIQK DMDITLVRKE LQELQNLYKQ NSTHTAQQAE LIQQLQVLNM 370 380 390 400 410 420 DTQKVLRNQE DVHTAESISY QKLYNELHIC FETTKSNEAM LRQSVTNLQD QLLQKEQENA 430 440 450 460 470 480 KLKEKLQESQ GAPLPLPQES DPDYSAQVPH RPSLSSLETL MVSQKSEIEY LQEKLKIANE 490 500 510 520 530 540 KLSENISANK GFSRKSIMTS AEGKHKEPPV KRSRSLSPKS SFTDSEELQK LRKAERKIEN 550 560 570 580 590 600 LEKALQLKSQ ENDELRDAHE KRKERLQMLQ TNYRAVKEQL KQWEEGSGMT EIRKIKRADP 610 620 630 640 650 660 QQLRQEDSDA VWNELAYFKR ENQELMIQKM NLEEELDELK VHISIDKAAI QELNRCVAER 670 680 690 700 710 720 REEQLFRSGE DDEVKRSTPE KNGKEMLEQT LQKVTELENR LKSFEKRSRK LKEGNKKLMK 730 740 750 760 770 780 ENDFLKSLLK QQQEDTETRE KELEQIIKGS KDVEKENTEL QVKISELETE VTSLRRQVAE 790 800 810 820 830 840 ANALRNENEE LINPMEKSHQ SADRAKSEMA TMKVRSGRYD CKTTMTKVKF KAAKKNCSVG 850 860 870 880 890 900 RHHTVLNHSI KVMSNVFENL SKDGWEDVSE SSSDSEAQTS QTLGTIIVET SQKISPTEDG 910 920 930 940 950 960 KDQKESDPTE DSQTQGKEIV QTYLNIDGKT PKDYFHDKNA KKPTFQKKNC KMQKSSHTAV 970 980 990 1000 1010 1020 PTRVNREKYK NITAQKSSSN IILLRERIIS LQQQNSVLQN AKKTAELSVK EYKEVNEKLL 1030 1040 1050 1060 1070 1080 HQQQVSDQRF QTSRQTIKKL NLDLAGLRKE KEDLLKKLES SSEITSLAEE NSQVTFPRIQ 1090 1100 1110 1120 1130 1140 VTSLSPSRSM DLEMKQLQYK LKNATNELTK QSSNVKTLKF ELLAKEEHIK EMHEKISRME 1150 1160 1170 1180 1190 1200 RDITMKRHLI EDLKFRQKVN LESNKSFSEM LQNLDKKVKT LTEECSNKKV SIDSLKQRLN 1210 1220 1230 1240 1250 1260 VAVKEKSQYE QMYQKSKEEL EKKDLKLTLL VSRISETESA MAEIETAASK QLQELALQSE 1270 1280 1290 1300 1310 1320 QVLEGAQKTL LLANEKVEEF TTFVKALAKE LQNDVHVVRR QIRELKKMKK NRDACKTSTH 1330 1340 1350 1360 1370 1380 KAQTLAASIL NISRSDLEEI LDTEDQVEIE KTKIDAENDK EWMLYIQKLL EGQSLTLSPR 1390 1400 LKCNGAIMAH QNLRLPDSSS SASAS
	Isoform 2 [UniParc]. Checksum: 6F6D3FAA60C90837	FASTA	1,406	162,190
	10 20 30 40 50 60 MAARSPPSPH PSPPARQLGP RSPRVGRGAE VHAMRSEASG FAGAAREVVA DESDKIWVGE 70 80 90 100 110 120 EGSGGRRGPG GAAPAHAPLL SAPMGSRRLE GISVEEAMVT RTQLLEEELS SLKEELALCQ 130 140 150 160 170 180 ADKEFVWSLW KRLQVTNPDL TQVVSLVVER EKQKSEAKDR KVLEILQVKD AKIQEFEQRE 190 200 210 220 230 240 SVLKQEINDL VKRKIAVDEE NAFLRKEFSD LEKKFKDKSQ EIKDTKECVQ NKEEQNRLVI 250 260 270 280 290 300 KNLEEENKKL STRCTDLLND LEKLRKQEAH LRKEKYSTDA KIKTFEDNLI EARKEVEVSQ 310 320 330 340 350 360 SKYNALSLQL SNKQTELIQK DMDITLVRKE LQELQNLYKQ NSTHTAQQAE LIQQLQVLNM 370 380 390 400 410 420 DTQKVLRNQE DVHTAESISY QKLYNELHIC FETTKSNEAM LRQSVTNLQD QLLQKEQENA 430 440 450 460 470 480 KLKEKLQESQ GAPLPLPQES DPDYSAQVPH RPSLSSLETL MVSQKSEIEY LQEKLKIANE 490 500 510 520 530 540 KLSENISANK GFSRKSIMTS AEGKHKEPPV KRSRSLSPKS SFTDSEELQK LRKAERKIEN 550 560 570 580 590 600 LEKALQLKSQ ENDELRDAHE KRKERLQMLQ TNYRAVKEQL KQWEEGSGMT EIRKIKRADP 610 620 630 640 650 660 QQLRQEDSDA VWNELAYFKR ENQELMIQKM NLEEELDELK VHISIDKAAI QELNRCVAER 670 680 690 700 710 720 REEQLFRSGE DDEVKRSTPE KNGKEMLEQT LQKVTELENR LKSFEKRSRK LKEGNKKLMK 730 740 750 760 770 780 ENDFLKSLLK QQQEDTETRE KELEQIIKGS KDVEKENTEL QVKISELETE VTSLRRQVAE 790 800 810 820 830 840 ANALRNENEE LINPMEKSHQ SADRAKSEMA TMKVRSGRYD CKTTMTKVKF KAAKKNCSVG 850 860 870 880 890 900 RHHTVLNHSI KVMSNVFENL SKDGWEDVSE SSSDSEAQTS QTLGTIIVET SQKISPTEDG 910 920 930 940 950 960 KDQKESDPTE DSQTQGKEIV QTYLNIDGKT PKDYFHDKNA KKPTFQKKNC KMQKSSHTAV 970 980 990 1000 1010 1020 PTRVNREKYK NITAQKSSSN IILLRERIIS LQQQNSVLQN AKKTAELSVK EYKEVNEKLL 1030 1040 1050 1060 1070 1080 HQQQVSDQRF QTSRQTIKKL NLDLAGLRKE KEDLLKKLES SSEITSLAEE NSQVTFPRIQ 1090 1100 1110 1120 1130 1140 VTSLSPSRSM DLEMKQLQYK LKNATNELTK QSSNVKTLKF ELLAKEEHIK EMHEKISRME 1150 1160 1170 1180 1190 1200 RDITMKRHLI EDLKFRQKVN LESNKSFSEM LQNLDKKVKT LTEECSNKKV SIDSLKQRLN 1210 1220 1230 1240 1250 1260 VAVKEKSQYE QMYQKSKEEL EKKDLKLTLL VSRISETESA MAEIETAASK QLQELALQSE 1270 1280 1290 1300 1310 1320 QVLEGAQKTL LLANEKVEEF TTFVKALAKE LQNDVHVVRR QIRELKKMKK NRDACKTSTH 1330 1340 1350 1360 1370 1380 KAQTLAASIL NISRSDLEEI LDTEDQVEIE KTKIDAENDK EWMLYIQKLL EGQLPFASYL 1390 1400 LEAVLEKINE KKKLVEGYFT IMKDIR
	Isoform 3 [UniParc]. Checksum: 2D42ACFC8A710C21	FASTA	391	44,587
	10 20 30 40 50 60 MAARSPPSPH PSPPARQLGP RSPRVGRGAE VHAMRSEASG FAGAAREVVA DESDKIWVGE 70 80 90 100 110 120 EGSGGRRGPG GAAPAHAPLL SAPMGSRRLE GISVEEAMVT RTQLLEEELS SLKEELALCQ 130 140 150 160 170 180 ADKEFVWSLW KRLQVTNPDL TQVVSLVVER EKQKSEAKDR KVLEILQVKD AKIQEFEQRE 190 200 210 220 230 240 SVLKQEINDL VKRKIAVDEE NAFLRKEFSD LEKKFKDKSQ EIKDTKECVQ NKEEQNRLVI 250 260 270 280 290 300 KNLEEENKKL STRCTDLLND LEKLRKQEAH LRKEKYSTDA KIKTFEDNLI EARKEVEVSQ 310 320 330 340 350 360 SKYNALSLQL SNKQTELIQK DMDITLVRKE LQELQNLYKQ NSTHTAQQAE LIQQLQVLNM 370 380 390 DTQKVLRNQE DVHTAESISY QKVCFYSVIK M

References

[1]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 278-1405 (ISOFORM 1), VARIANT ILE-695. Tissue: Embryo and Gastric mucosa.
[2]	"DNA sequence and analysis of human chromosome 9." Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L. , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I. Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK000283 mRNA. Translation: BAA91052.1. Different initiation. AK021596 mRNA. Translation: BAB13850.1. Different initiation. AK098502 mRNA. Translation: BAC05319.1. AL133214 , AL162725, AL354711, AL354738, AL590377 Genomic DNA. Translation: CAH70743.2. AL162725 , AL133214, AL354711, AL354738, AL590377 Genomic DNA. Translation: CAH70424.1. AL162725, AL354711 Genomic DNA. Translation: CAH70425.1. AL354711 , AL133214, AL162725, AL354738, AL590377 Genomic DNA. Translation: CAH72682.2. AL354711, AL162725 Genomic DNA. Translation: CAH72684.1. AL354738 , AL133214, AL162725, AL354711, AL590377 Genomic DNA. Translation: CAI16195.2. AL590377 , AL133214, AL162725, AL354711, AL354738 Genomic DNA. Translation: CAI14630.2.
IPI	IPI00657839. IPI00815832. IPI00889646.
RefSeq	NP_001107867.1. NM_001114395.1. NP_060208.2. NM_017738.2.
UniGene	Hs.435381.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-47295N.
STRING	9606.ENSP00000370021.
PTM databases
PhosphoSite	Q9NXG0.
Polymorphism databases
DMDM	160419146.
Proteomic databases
PaxDb	Q9NXG0.
PRIDE	Q9NXG0.
Protocols and materials databases
DNASU	54875.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000380641; ENSP00000370015; ENSG00000044459. ENST00000380647; ENSP00000370021; ENSG00000044459.
GeneID	54875.
KEGG	hsa:54875.
UCSC	uc003zmx.4. human. uc003zmy.3. human. uc003zmz.2. human.
Organism-specific databases
CTD	54875.
GeneCards	GC09P017124.
HGNC	HGNC:23432. CNTLN.
HPA	HPA036728. HPA036729.
MIM	611870. gene.
neXtProt	NX_Q9NXG0.
PharmGKB	PA162382646.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG129417.
HOGENOM	HOG000111849.
HOVERGEN	HBG107737.
KO	K16467.
OMA	MDLEMKQ.
Gene expression databases
ArrayExpress	Q9NXG0.
Bgee	Q9NXG0.
CleanEx	HS_CNTLN.
Genevestigator	Q9NXG0.
GermOnline	ENSG00000044459. Homo sapiens.
Family and domain databases
InterPro	IPR003661. Sig_transdc_His_kin_sub1_dim/P. [Graphical view]
SMART	SM00388. HisKA. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	54875.
NextBio	57805.
SOURCE	Search...

Entry information

Entry name

CNTLN_HUMAN

Accession

Primary (citable) accession number: Q9NXG0
Secondary accession number(s): A5Z2X6 , Q5VYJ0, Q8N1G9, Q9HAJ5

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 21, 2006
Last sequence update:	January 11, 2011
Last modified:	April 3, 2013
This is version 83 of the entry and version 5 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.