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Protein

Palmitoyltransferase ZDHHC7

Gene

ZDHHC7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Palmitoyltransferase with broad specificity. Palmitoylates SNAP25 and DLG4/PSD95. May palmitoylate GABA receptors on their gamma subunit (GABRG1, GABRG2 and GABRG3) and thereby regulate their synaptic clustering and/or cell surface stability (By similarity). Palmitoylates sex steroid hormone receptors, including ESR1, PGR and AR, thereby regulating their targeting to the plasma membrane. This affects rapid intracellular signaling by sex hormones via ERK and AKT kinases and the generation of cAMP, but does not affect that mediated by their nuclear receptors.By similarity1 Publication

Catalytic activityi

Palmitoyl-CoA + [protein]-L-cysteine = [protein]-S-palmitoyl-L-cysteine + CoA.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri130 – 18051DHHC-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. palmitoyltransferase activity Source: UniProtKB
  2. protein-cysteine S-palmitoyltransferase activity Source: UniProtKB-EC
  3. zinc ion binding Source: InterPro

GO - Biological processi

  1. peptidyl-L-cysteine S-palmitoylation Source: UniProtKB
  2. protein palmitoylation Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Palmitoyltransferase ZDHHC7 (EC:2.3.1.225)
Alternative name(s):
Zinc finger DHHC domain-containing protein 7
Short name:
DHHC-7
Zinc finger protein 370
Gene namesi
Name:ZDHHC7
Synonyms:ZNF370
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 16

Organism-specific databases

HGNCiHGNC:18459. ZDHHC7.

Subcellular locationi

Membrane Curated; Multi-pass membrane protein Curated. Golgi apparatus 1 Publication

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei51 – 7121HelicalSequence AnalysisAdd
BLAST
Transmembranei76 – 9621HelicalSequence AnalysisAdd
BLAST
Transmembranei175 – 19521HelicalSequence AnalysisAdd
BLAST
Transmembranei218 – 23821HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. Golgi apparatus Source: UniProtKB
  2. integral component of membrane Source: UniProtKB-KW
  3. intracellular membrane-bounded organelle Source: HPA
  4. nucleolus Source: HPA
  5. nucleoplasm Source: HPA
  6. nucleus Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA38335.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 308308Palmitoyltransferase ZDHHC7PRO_0000212874Add
BLAST

Proteomic databases

MaxQBiQ9NXF8.
PaxDbiQ9NXF8.
PRIDEiQ9NXF8.

PTM databases

PhosphoSiteiQ9NXF8.

Expressioni

Gene expression databases

BgeeiQ9NXF8.
CleanExiHS_ZDHHC7.
ExpressionAtlasiQ9NXF8. baseline and differential.
GenevestigatoriQ9NXF8.

Organism-specific databases

HPAiHPA019215.
HPA059642.

Interactioni

Protein-protein interaction databases

BioGridi120764. 9 interactions.
IntActiQ9NXF8. 2 interactions.
MINTiMINT-1036602.
STRINGi9606.ENSP00000341681.

Structurei

3D structure databases

ProteinModelPortaliQ9NXF8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

The DHHC domain is required for palmitoyltransferase activity.By similarity

Sequence similaritiesi

Belongs to the DHHC palmitoyltransferase family.Curated
Contains 1 DHHC-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri130 – 18051DHHC-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Transmembrane, Transmembrane helix, Zinc-finger

Phylogenomic databases

eggNOGiCOG5273.
GeneTreeiENSGT00760000119247.
HOGENOMiHOG000234755.
HOVERGENiHBG056583.
InParanoidiQ9NXF8.
OMAiNGVLFNC.
OrthoDBiEOG7QK0CG.
PhylomeDBiQ9NXF8.
TreeFamiTF319798.

Family and domain databases

InterProiIPR001594. Znf_DHHC_palmitoyltrfase.
[Graphical view]
PfamiPF01529. zf-DHHC. 1 hit.
[Graphical view]
PROSITEiPS50216. ZF_DHHC. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9NXF8-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MQPSGHRLRD VEHHPLLAEN DNYDSSSSSS SEADVADRVW FIRDGCGMIC
60 70 80 90 100
AVMTWLLVAY ADFVVTFVML LPSKDFWYSV VNGVIFNCLA VLALSSHLRT
110 120 130 140 150
MLTDPGAVPK GNATKEYMES LQLKPGEVIY KCPKCCCIKP ERAHHCSICK
160 170 180 190 200
RCIRKMDHHC PWVNNCVGEK NQRFFVLFTM YIALSSVHAL ILCGFQFISC
210 220 230 240 250
VRGQWTECSD FSPPITVILL IFLCLEGLLF FTFTAVMFGT QIHSICNDET
260 270 280 290 300
EIERLKSEKP TWERRLRWEG MKSVFGGPPS LLWMNPFVGF RFRRLPTRPR

KGGPEFSV
Length:308
Mass (Da):35,140
Last modified:October 17, 2006 - v2
Checksum:i0E4F2E69A62C90C3
GO
Isoform 2 (identifier: Q9NXF8-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     105-105: P → PEKSSDCRPSACTVKTGLDPTLVGICGEGTESVQSLLL

Show »
Length:345
Mass (Da):38,917
Checksum:i70448128ABCF6626
GO

Sequence cautioni

The sequence AAH17702.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAA91814.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti22 – 221N → D in BAA91055. (PubMed:14702039)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti44 – 441D → N in a colorectal cancer sample; somatic mutation. 1 Publication
VAR_036261
Natural varianti201 – 2011V → I.
Corresponds to variant rs13334011 [ dbSNP | Ensembl ].
VAR_028360

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei105 – 1051P → PEKSSDCRPSACTVKTGLDP TLVGICGEGTESVQSLLL in isoform 2. 1 PublicationVSP_006942

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK000286 mRNA. Translation: BAA91055.1.
AK001654 mRNA. Translation: BAA91814.1. Different initiation.
CH471114 Genomic DNA. Translation: EAW95464.1.
CH471114 Genomic DNA. Translation: EAW95465.1.
BC017702 mRNA. Translation: AAH17702.1. Different initiation.
BC018772 mRNA. Translation: AAH18772.1.
CCDSiCCDS10950.1. [Q9NXF8-1]
CCDS45538.1. [Q9NXF8-2]
RefSeqiNP_001139020.1. NM_001145548.1. [Q9NXF8-2]
NP_060210.2. NM_017740.2. [Q9NXF8-1]
UniGeneiHs.461610.
Hs.723447.

Genome annotation databases

EnsembliENST00000313732; ENSP00000315604; ENSG00000153786. [Q9NXF8-1]
ENST00000344861; ENSP00000341681; ENSG00000153786. [Q9NXF8-2]
ENST00000564466; ENSP00000456782; ENSG00000153786. [Q9NXF8-2]
GeneIDi55625.
KEGGihsa:55625.
UCSCiuc002fiq.2. human. [Q9NXF8-1]
uc010voi.1. human. [Q9NXF8-2]

Polymorphism databases

DMDMi116242853.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK000286 mRNA. Translation: BAA91055.1.
AK001654 mRNA. Translation: BAA91814.1. Different initiation.
CH471114 Genomic DNA. Translation: EAW95464.1.
CH471114 Genomic DNA. Translation: EAW95465.1.
BC017702 mRNA. Translation: AAH17702.1. Different initiation.
BC018772 mRNA. Translation: AAH18772.1.
CCDSiCCDS10950.1. [Q9NXF8-1]
CCDS45538.1. [Q9NXF8-2]
RefSeqiNP_001139020.1. NM_001145548.1. [Q9NXF8-2]
NP_060210.2. NM_017740.2. [Q9NXF8-1]
UniGeneiHs.461610.
Hs.723447.

3D structure databases

ProteinModelPortaliQ9NXF8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120764. 9 interactions.
IntActiQ9NXF8. 2 interactions.
MINTiMINT-1036602.
STRINGi9606.ENSP00000341681.

PTM databases

PhosphoSiteiQ9NXF8.

Polymorphism databases

DMDMi116242853.

Proteomic databases

MaxQBiQ9NXF8.
PaxDbiQ9NXF8.
PRIDEiQ9NXF8.

Protocols and materials databases

DNASUi55625.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000313732; ENSP00000315604; ENSG00000153786. [Q9NXF8-1]
ENST00000344861; ENSP00000341681; ENSG00000153786. [Q9NXF8-2]
ENST00000564466; ENSP00000456782; ENSG00000153786. [Q9NXF8-2]
GeneIDi55625.
KEGGihsa:55625.
UCSCiuc002fiq.2. human. [Q9NXF8-1]
uc010voi.1. human. [Q9NXF8-2]

Organism-specific databases

CTDi55625.
GeneCardsiGC16M085007.
HGNCiHGNC:18459. ZDHHC7.
HPAiHPA019215.
HPA059642.
MIMi614604. gene.
neXtProtiNX_Q9NXF8.
PharmGKBiPA38335.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG5273.
GeneTreeiENSGT00760000119247.
HOGENOMiHOG000234755.
HOVERGENiHBG056583.
InParanoidiQ9NXF8.
OMAiNGVLFNC.
OrthoDBiEOG7QK0CG.
PhylomeDBiQ9NXF8.
TreeFamiTF319798.

Miscellaneous databases

ChiTaRSiZDHHC7. human.
GenomeRNAii55625.
NextBioi60244.
PROiQ9NXF8.
SOURCEiSearch...

Gene expression databases

BgeeiQ9NXF8.
CleanExiHS_ZDHHC7.
ExpressionAtlasiQ9NXF8. baseline and differential.
GenevestigatoriQ9NXF8.

Family and domain databases

InterProiIPR001594. Znf_DHHC_palmitoyltrfase.
[Graphical view]
PfamiPF01529. zf-DHHC. 1 hit.
[Graphical view]
PROSITEiPS50216. ZF_DHHC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Hepatoma and Teratocarcinoma.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 97-308 (ISOFORM 1).
    Tissue: Duodenal mucosa and Skin.
  4. "DHHC-7 and -21 are palmitoylacyltransferases for sex steroid receptors."
    Pedram A., Razandi M., Deschenes R.J., Levin E.R.
    Mol. Biol. Cell 23:188-199(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION.
  5. Cited for: VARIANT [LARGE SCALE ANALYSIS] ASN-44.

Entry informationi

Entry nameiZDHC7_HUMAN
AccessioniPrimary (citable) accession number: Q9NXF8
Secondary accession number(s): D3DUM1, Q8WV42, Q9NVD8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 2003
Last sequence update: October 17, 2006
Last modified: February 4, 2015
This is version 112 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.