Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q9NXF8 (ZDHC7_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 108. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Palmitoyltransferase ZDHHC7

EC=2.3.1.225
Alternative name(s):
Zinc finger DHHC domain-containing protein 7
Short name=DHHC-7
Zinc finger protein 370
Gene names
Name:ZDHHC7
Synonyms:ZNF370
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length308 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Palmitoyltransferase with broad specificity. Palmitoylates SNAP25 and DLG4/PSD95. May palmitoylate GABA receptors on their gamma subunit (GABRG1, GABRG2 and GABRG3) and thereby regulate their synaptic clustering and/or cell surface stability By similarity. Palmitoylates sex steroid hormone receptors, including ESR1, PGR and AR, thereby regulating their targeting to the plasma membrane. This affects rapid intracellular signaling by sex hormones via ERK and AKT kinases and the generation of cAMP, but does not affect that mediated by their nuclear receptors. Ref.4

Catalytic activity

Palmitoyl-CoA + [protein]-L-cysteine = [protein]-S-palmitoyl-L-cysteine + CoA.

Subcellular location

Membrane; Multi-pass membrane protein Potential. Golgi apparatus Ref.4.

Domain

The DHHC domain is required for palmitoyltransferase activity By similarity.

Sequence similarities

Belongs to the DHHC palmitoyltransferase family.

Contains 1 DHHC-type zinc finger.

Sequence caution

The sequence AAH17702.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

The sequence BAA91814.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q9NXF8-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q9NXF8-2)

The sequence of this isoform differs from the canonical sequence as follows:
     105-105: P → PEKSSDCRPSACTVKTGLDPTLVGICGEGTESVQSLLL

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 308308Palmitoyltransferase ZDHHC7
PRO_0000212874

Regions

Transmembrane51 – 7121Helical; Potential
Transmembrane76 – 9621Helical; Potential
Transmembrane175 – 19521Helical; Potential
Transmembrane218 – 23821Helical; Potential
Zinc finger130 – 18051DHHC-type

Natural variations

Alternative sequence1051P → PEKSSDCRPSACTVKTGLDP TLVGICGEGTESVQSLLL in isoform 2.
VSP_006942
Natural variant441D → N in a colorectal cancer sample; somatic mutation. Ref.5
VAR_036261
Natural variant2011V → I.
Corresponds to variant rs13334011 [ dbSNP | Ensembl ].
VAR_028360

Experimental info

Sequence conflict221N → D in BAA91055. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified October 17, 2006. Version 2.
Checksum: 0E4F2E69A62C90C3

FASTA30835,140
        10         20         30         40         50         60 
MQPSGHRLRD VEHHPLLAEN DNYDSSSSSS SEADVADRVW FIRDGCGMIC AVMTWLLVAY 

        70         80         90        100        110        120 
ADFVVTFVML LPSKDFWYSV VNGVIFNCLA VLALSSHLRT MLTDPGAVPK GNATKEYMES 

       130        140        150        160        170        180 
LQLKPGEVIY KCPKCCCIKP ERAHHCSICK RCIRKMDHHC PWVNNCVGEK NQRFFVLFTM 

       190        200        210        220        230        240 
YIALSSVHAL ILCGFQFISC VRGQWTECSD FSPPITVILL IFLCLEGLLF FTFTAVMFGT 

       250        260        270        280        290        300 
QIHSICNDET EIERLKSEKP TWERRLRWEG MKSVFGGPPS LLWMNPFVGF RFRRLPTRPR 


KGGPEFSV 

« Hide

Isoform 2 [UniParc].

Checksum: 70448128ABCF6626
Show »

FASTA34538,917

References

« Hide 'large scale' references
[1]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Hepatoma and Teratocarcinoma.
[2]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 97-308 (ISOFORM 1).
Tissue: Duodenal mucosa and Skin.
[4]"DHHC-7 and -21 are palmitoylacyltransferases for sex steroid receptors."
Pedram A., Razandi M., Deschenes R.J., Levin E.R.
Mol. Biol. Cell 23:188-199(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, SUBCELLULAR LOCATION.
[5]"The consensus coding sequences of human breast and colorectal cancers."
Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V. expand/collapse author list , Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E.
Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANT [LARGE SCALE ANALYSIS] ASN-44.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK000286 mRNA. Translation: BAA91055.1.
AK001654 mRNA. Translation: BAA91814.1. Different initiation.
CH471114 Genomic DNA. Translation: EAW95464.1.
CH471114 Genomic DNA. Translation: EAW95465.1.
BC017702 mRNA. Translation: AAH17702.1. Different initiation.
BC018772 mRNA. Translation: AAH18772.1.
CCDSCCDS10950.1. [Q9NXF8-1]
CCDS45538.1. [Q9NXF8-2]
RefSeqNP_001139020.1. NM_001145548.1. [Q9NXF8-2]
NP_060210.2. NM_017740.2. [Q9NXF8-1]
UniGeneHs.461610.
Hs.723447.

3D structure databases

ProteinModelPortalQ9NXF8.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid120764. 3 interactions.
IntActQ9NXF8. 2 interactions.
MINTMINT-1036602.
STRING9606.ENSP00000341681.

PTM databases

PhosphoSiteQ9NXF8.

Polymorphism databases

DMDM116242853.

Proteomic databases

MaxQBQ9NXF8.
PaxDbQ9NXF8.
PRIDEQ9NXF8.

Protocols and materials databases

DNASU55625.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000313732; ENSP00000315604; ENSG00000153786. [Q9NXF8-1]
ENST00000344861; ENSP00000341681; ENSG00000153786. [Q9NXF8-2]
ENST00000564466; ENSP00000456782; ENSG00000153786. [Q9NXF8-2]
GeneID55625.
KEGGhsa:55625.
UCSCuc002fiq.2. human. [Q9NXF8-1]
uc010voi.1. human. [Q9NXF8-2]

Organism-specific databases

CTD55625.
GeneCardsGC16M085007.
HGNCHGNC:18459. ZDHHC7.
HPAHPA019215.
HPA059642.
MIM614604. gene.
neXtProtNX_Q9NXF8.
PharmGKBPA38335.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG5273.
HOGENOMHOG000234755.
HOVERGENHBG056583.
OMANGVLFNC.
OrthoDBEOG7QK0CG.
PhylomeDBQ9NXF8.
TreeFamTF319798.

Gene expression databases

ArrayExpressQ9NXF8.
BgeeQ9NXF8.
CleanExHS_ZDHHC7.
GenevestigatorQ9NXF8.

Family and domain databases

InterProIPR001594. Znf_DHHC_palmitoyltrfase.
[Graphical view]
PfamPF01529. zf-DHHC. 1 hit.
[Graphical view]
PROSITEPS50216. ZF_DHHC. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSZDHHC7. human.
GenomeRNAi55625.
NextBio60244.
PROQ9NXF8.
SOURCESearch...

Entry information

Entry nameZDHC7_HUMAN
AccessionPrimary (citable) accession number: Q9NXF8
Secondary accession number(s): D3DUM1, Q8WV42, Q9NVD8
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 2003
Last sequence update: October 17, 2006
Last modified: July 9, 2014
This is version 108 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 16

Human chromosome 16: entries, gene names and cross-references to MIM