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Q9NXF8

- ZDHC7_HUMAN

UniProt

Q9NXF8 - ZDHC7_HUMAN

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Protein

Palmitoyltransferase ZDHHC7

Gene
ZDHHC7, ZNF370
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Palmitoyltransferase with broad specificity. Palmitoylates SNAP25 and DLG4/PSD95. May palmitoylate GABA receptors on their gamma subunit (GABRG1, GABRG2 and GABRG3) and thereby regulate their synaptic clustering and/or cell surface stability By similarity. Palmitoylates sex steroid hormone receptors, including ESR1, PGR and AR, thereby regulating their targeting to the plasma membrane. This affects rapid intracellular signaling by sex hormones via ERK and AKT kinases and the generation of cAMP, but does not affect that mediated by their nuclear receptors.1 Publication

Catalytic activityi

Palmitoyl-CoA + [protein]-L-cysteine = [protein]-S-palmitoyl-L-cysteine + CoA.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri130 – 18051DHHC-typeAdd
BLAST

GO - Molecular functioni

  1. palmitoyltransferase activity Source: UniProt
  2. protein-cysteine S-palmitoyltransferase activity Source: UniProtKB-EC
  3. zinc ion binding Source: InterPro

GO - Biological processi

  1. peptidyl-L-cysteine S-palmitoylation Source: UniProtKB
  2. protein palmitoylation Source: UniProt
Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Palmitoyltransferase ZDHHC7 (EC:2.3.1.225)
Alternative name(s):
Zinc finger DHHC domain-containing protein 7
Short name:
DHHC-7
Zinc finger protein 370
Gene namesi
Name:ZDHHC7
Synonyms:ZNF370
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 16

Organism-specific databases

HGNCiHGNC:18459. ZDHHC7.

Subcellular locationi

Membrane; Multi-pass membrane protein Reviewed prediction. Golgi apparatus 1 Publication

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei51 – 7121Helical; Reviewed predictionAdd
BLAST
Transmembranei76 – 9621Helical; Reviewed predictionAdd
BLAST
Transmembranei175 – 19521Helical; Reviewed predictionAdd
BLAST
Transmembranei218 – 23821Helical; Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. Golgi apparatus Source: UniProtKB
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA38335.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 308308Palmitoyltransferase ZDHHC7PRO_0000212874Add
BLAST

Proteomic databases

MaxQBiQ9NXF8.
PaxDbiQ9NXF8.
PRIDEiQ9NXF8.

PTM databases

PhosphoSiteiQ9NXF8.

Expressioni

Gene expression databases

ArrayExpressiQ9NXF8.
BgeeiQ9NXF8.
CleanExiHS_ZDHHC7.
GenevestigatoriQ9NXF8.

Organism-specific databases

HPAiHPA019215.
HPA059642.

Interactioni

Protein-protein interaction databases

BioGridi120764. 3 interactions.
IntActiQ9NXF8. 2 interactions.
MINTiMINT-1036602.
STRINGi9606.ENSP00000341681.

Structurei

3D structure databases

ProteinModelPortaliQ9NXF8.

Family & Domainsi

Domaini

The DHHC domain is required for palmitoyltransferase activity By similarity.

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri130 – 18051DHHC-typeAdd
BLAST

Keywords - Domaini

Transmembrane, Transmembrane helix, Zinc-finger

Phylogenomic databases

eggNOGiCOG5273.
HOGENOMiHOG000234755.
HOVERGENiHBG056583.
OMAiNGVLFNC.
OrthoDBiEOG7QK0CG.
PhylomeDBiQ9NXF8.
TreeFamiTF319798.

Family and domain databases

InterProiIPR001594. Znf_DHHC_palmitoyltrfase.
[Graphical view]
PfamiPF01529. zf-DHHC. 1 hit.
[Graphical view]
PROSITEiPS50216. ZF_DHHC. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9NXF8-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MQPSGHRLRD VEHHPLLAEN DNYDSSSSSS SEADVADRVW FIRDGCGMIC    50
AVMTWLLVAY ADFVVTFVML LPSKDFWYSV VNGVIFNCLA VLALSSHLRT 100
MLTDPGAVPK GNATKEYMES LQLKPGEVIY KCPKCCCIKP ERAHHCSICK 150
RCIRKMDHHC PWVNNCVGEK NQRFFVLFTM YIALSSVHAL ILCGFQFISC 200
VRGQWTECSD FSPPITVILL IFLCLEGLLF FTFTAVMFGT QIHSICNDET 250
EIERLKSEKP TWERRLRWEG MKSVFGGPPS LLWMNPFVGF RFRRLPTRPR 300
KGGPEFSV 308
Length:308
Mass (Da):35,140
Last modified:October 17, 2006 - v2
Checksum:i0E4F2E69A62C90C3
GO
Isoform 2 (identifier: Q9NXF8-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     105-105: P → PEKSSDCRPSACTVKTGLDPTLVGICGEGTESVQSLLL

Show »
Length:345
Mass (Da):38,917
Checksum:i70448128ABCF6626
GO

Sequence cautioni

The sequence AAH17702.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
The sequence BAA91814.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti44 – 441D → N in a colorectal cancer sample; somatic mutation. 1 Publication
VAR_036261
Natural varianti201 – 2011V → I.
Corresponds to variant rs13334011 [ dbSNP | Ensembl ].
VAR_028360

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei105 – 1051P → PEKSSDCRPSACTVKTGLDP TLVGICGEGTESVQSLLL in isoform 2. VSP_006942

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti22 – 221N → D in BAA91055. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK000286 mRNA. Translation: BAA91055.1.
AK001654 mRNA. Translation: BAA91814.1. Different initiation.
CH471114 Genomic DNA. Translation: EAW95464.1.
CH471114 Genomic DNA. Translation: EAW95465.1.
BC017702 mRNA. Translation: AAH17702.1. Different initiation.
BC018772 mRNA. Translation: AAH18772.1.
CCDSiCCDS10950.1. [Q9NXF8-1]
CCDS45538.1. [Q9NXF8-2]
RefSeqiNP_001139020.1. NM_001145548.1. [Q9NXF8-2]
NP_060210.2. NM_017740.2. [Q9NXF8-1]
UniGeneiHs.461610.
Hs.723447.

Genome annotation databases

EnsembliENST00000313732; ENSP00000315604; ENSG00000153786. [Q9NXF8-1]
ENST00000344861; ENSP00000341681; ENSG00000153786. [Q9NXF8-2]
ENST00000564466; ENSP00000456782; ENSG00000153786. [Q9NXF8-2]
GeneIDi55625.
KEGGihsa:55625.
UCSCiuc002fiq.2. human. [Q9NXF8-1]
uc010voi.1. human. [Q9NXF8-2]

Polymorphism databases

DMDMi116242853.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK000286 mRNA. Translation: BAA91055.1 .
AK001654 mRNA. Translation: BAA91814.1 . Different initiation.
CH471114 Genomic DNA. Translation: EAW95464.1 .
CH471114 Genomic DNA. Translation: EAW95465.1 .
BC017702 mRNA. Translation: AAH17702.1 . Different initiation.
BC018772 mRNA. Translation: AAH18772.1 .
CCDSi CCDS10950.1. [Q9NXF8-1 ]
CCDS45538.1. [Q9NXF8-2 ]
RefSeqi NP_001139020.1. NM_001145548.1. [Q9NXF8-2 ]
NP_060210.2. NM_017740.2. [Q9NXF8-1 ]
UniGenei Hs.461610.
Hs.723447.

3D structure databases

ProteinModelPortali Q9NXF8.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 120764. 3 interactions.
IntActi Q9NXF8. 2 interactions.
MINTi MINT-1036602.
STRINGi 9606.ENSP00000341681.

PTM databases

PhosphoSitei Q9NXF8.

Polymorphism databases

DMDMi 116242853.

Proteomic databases

MaxQBi Q9NXF8.
PaxDbi Q9NXF8.
PRIDEi Q9NXF8.

Protocols and materials databases

DNASUi 55625.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000313732 ; ENSP00000315604 ; ENSG00000153786 . [Q9NXF8-1 ]
ENST00000344861 ; ENSP00000341681 ; ENSG00000153786 . [Q9NXF8-2 ]
ENST00000564466 ; ENSP00000456782 ; ENSG00000153786 . [Q9NXF8-2 ]
GeneIDi 55625.
KEGGi hsa:55625.
UCSCi uc002fiq.2. human. [Q9NXF8-1 ]
uc010voi.1. human. [Q9NXF8-2 ]

Organism-specific databases

CTDi 55625.
GeneCardsi GC16M085007.
HGNCi HGNC:18459. ZDHHC7.
HPAi HPA019215.
HPA059642.
MIMi 614604. gene.
neXtProti NX_Q9NXF8.
PharmGKBi PA38335.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5273.
HOGENOMi HOG000234755.
HOVERGENi HBG056583.
OMAi NGVLFNC.
OrthoDBi EOG7QK0CG.
PhylomeDBi Q9NXF8.
TreeFami TF319798.

Miscellaneous databases

ChiTaRSi ZDHHC7. human.
GenomeRNAii 55625.
NextBioi 60244.
PROi Q9NXF8.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q9NXF8.
Bgeei Q9NXF8.
CleanExi HS_ZDHHC7.
Genevestigatori Q9NXF8.

Family and domain databases

InterProi IPR001594. Znf_DHHC_palmitoyltrfase.
[Graphical view ]
Pfami PF01529. zf-DHHC. 1 hit.
[Graphical view ]
PROSITEi PS50216. ZF_DHHC. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Hepatoma and Teratocarcinoma.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 97-308 (ISOFORM 1).
    Tissue: Duodenal mucosa and Skin.
  4. "DHHC-7 and -21 are palmitoylacyltransferases for sex steroid receptors."
    Pedram A., Razandi M., Deschenes R.J., Levin E.R.
    Mol. Biol. Cell 23:188-199(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION.
  5. Cited for: VARIANT [LARGE SCALE ANALYSIS] ASN-44.

Entry informationi

Entry nameiZDHC7_HUMAN
AccessioniPrimary (citable) accession number: Q9NXF8
Secondary accession number(s): D3DUM1, Q8WV42, Q9NVD8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 2003
Last sequence update: October 17, 2006
Last modified: July 9, 2014
This is version 108 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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