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Q9NXF8

- ZDHC7_HUMAN

UniProt

Q9NXF8 - ZDHC7_HUMAN

Protein

Palmitoyltransferase ZDHHC7

Gene

ZDHHC7

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 109 (01 Oct 2014)
      Sequence version 2 (17 Oct 2006)
      Previous versions | rss
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    Functioni

    Palmitoyltransferase with broad specificity. Palmitoylates SNAP25 and DLG4/PSD95. May palmitoylate GABA receptors on their gamma subunit (GABRG1, GABRG2 and GABRG3) and thereby regulate their synaptic clustering and/or cell surface stability By similarity. Palmitoylates sex steroid hormone receptors, including ESR1, PGR and AR, thereby regulating their targeting to the plasma membrane. This affects rapid intracellular signaling by sex hormones via ERK and AKT kinases and the generation of cAMP, but does not affect that mediated by their nuclear receptors.By similarity1 Publication

    Catalytic activityi

    Palmitoyl-CoA + [protein]-L-cysteine = [protein]-S-palmitoyl-L-cysteine + CoA.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri130 – 18051DHHC-typePROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. palmitoyltransferase activity Source: UniProt
    2. protein-cysteine S-palmitoyltransferase activity Source: UniProtKB-EC
    3. zinc ion binding Source: InterPro

    GO - Biological processi

    1. peptidyl-L-cysteine S-palmitoylation Source: UniProtKB
    2. protein palmitoylation Source: UniProt

    Keywords - Molecular functioni

    Acyltransferase, Transferase

    Keywords - Ligandi

    Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Palmitoyltransferase ZDHHC7 (EC:2.3.1.225)
    Alternative name(s):
    Zinc finger DHHC domain-containing protein 7
    Short name:
    DHHC-7
    Zinc finger protein 370
    Gene namesi
    Name:ZDHHC7
    Synonyms:ZNF370
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 16

    Organism-specific databases

    HGNCiHGNC:18459. ZDHHC7.

    Subcellular locationi

    Membrane Curated; Multi-pass membrane protein Curated. Golgi apparatus 1 Publication

    GO - Cellular componenti

    1. Golgi apparatus Source: UniProtKB
    2. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Golgi apparatus, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA38335.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 308308Palmitoyltransferase ZDHHC7PRO_0000212874Add
    BLAST

    Proteomic databases

    MaxQBiQ9NXF8.
    PaxDbiQ9NXF8.
    PRIDEiQ9NXF8.

    PTM databases

    PhosphoSiteiQ9NXF8.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9NXF8.
    BgeeiQ9NXF8.
    CleanExiHS_ZDHHC7.
    GenevestigatoriQ9NXF8.

    Organism-specific databases

    HPAiHPA019215.
    HPA059642.

    Interactioni

    Protein-protein interaction databases

    BioGridi120764. 3 interactions.
    IntActiQ9NXF8. 2 interactions.
    MINTiMINT-1036602.
    STRINGi9606.ENSP00000341681.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9NXF8.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei51 – 7121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei76 – 9621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei175 – 19521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei218 – 23821HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domaini

    The DHHC domain is required for palmitoyltransferase activity.By similarity

    Sequence similaritiesi

    Belongs to the DHHC palmitoyltransferase family.Curated
    Contains 1 DHHC-type zinc finger.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri130 – 18051DHHC-typePROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Transmembrane, Transmembrane helix, Zinc-finger

    Phylogenomic databases

    eggNOGiCOG5273.
    HOGENOMiHOG000234755.
    HOVERGENiHBG056583.
    OMAiNGVLFNC.
    OrthoDBiEOG7QK0CG.
    PhylomeDBiQ9NXF8.
    TreeFamiTF319798.

    Family and domain databases

    InterProiIPR001594. Znf_DHHC_palmitoyltrfase.
    [Graphical view]
    PfamiPF01529. zf-DHHC. 1 hit.
    [Graphical view]
    PROSITEiPS50216. ZF_DHHC. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9NXF8-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MQPSGHRLRD VEHHPLLAEN DNYDSSSSSS SEADVADRVW FIRDGCGMIC    50
    AVMTWLLVAY ADFVVTFVML LPSKDFWYSV VNGVIFNCLA VLALSSHLRT 100
    MLTDPGAVPK GNATKEYMES LQLKPGEVIY KCPKCCCIKP ERAHHCSICK 150
    RCIRKMDHHC PWVNNCVGEK NQRFFVLFTM YIALSSVHAL ILCGFQFISC 200
    VRGQWTECSD FSPPITVILL IFLCLEGLLF FTFTAVMFGT QIHSICNDET 250
    EIERLKSEKP TWERRLRWEG MKSVFGGPPS LLWMNPFVGF RFRRLPTRPR 300
    KGGPEFSV 308
    Length:308
    Mass (Da):35,140
    Last modified:October 17, 2006 - v2
    Checksum:i0E4F2E69A62C90C3
    GO
    Isoform 2 (identifier: Q9NXF8-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         105-105: P → PEKSSDCRPSACTVKTGLDPTLVGICGEGTESVQSLLL

    Show »
    Length:345
    Mass (Da):38,917
    Checksum:i70448128ABCF6626
    GO

    Sequence cautioni

    The sequence AAH17702.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
    The sequence BAA91814.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti22 – 221N → D in BAA91055. (PubMed:14702039)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti44 – 441D → N in a colorectal cancer sample; somatic mutation. 1 Publication
    VAR_036261
    Natural varianti201 – 2011V → I.
    Corresponds to variant rs13334011 [ dbSNP | Ensembl ].
    VAR_028360

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei105 – 1051P → PEKSSDCRPSACTVKTGLDP TLVGICGEGTESVQSLLL in isoform 2. 1 PublicationVSP_006942

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK000286 mRNA. Translation: BAA91055.1.
    AK001654 mRNA. Translation: BAA91814.1. Different initiation.
    CH471114 Genomic DNA. Translation: EAW95464.1.
    CH471114 Genomic DNA. Translation: EAW95465.1.
    BC017702 mRNA. Translation: AAH17702.1. Different initiation.
    BC018772 mRNA. Translation: AAH18772.1.
    CCDSiCCDS10950.1. [Q9NXF8-1]
    CCDS45538.1. [Q9NXF8-2]
    RefSeqiNP_001139020.1. NM_001145548.1. [Q9NXF8-2]
    NP_060210.2. NM_017740.2. [Q9NXF8-1]
    UniGeneiHs.461610.
    Hs.723447.

    Genome annotation databases

    EnsembliENST00000313732; ENSP00000315604; ENSG00000153786. [Q9NXF8-1]
    ENST00000344861; ENSP00000341681; ENSG00000153786. [Q9NXF8-2]
    ENST00000564466; ENSP00000456782; ENSG00000153786. [Q9NXF8-2]
    GeneIDi55625.
    KEGGihsa:55625.
    UCSCiuc002fiq.2. human. [Q9NXF8-1]
    uc010voi.1. human. [Q9NXF8-2]

    Polymorphism databases

    DMDMi116242853.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK000286 mRNA. Translation: BAA91055.1 .
    AK001654 mRNA. Translation: BAA91814.1 . Different initiation.
    CH471114 Genomic DNA. Translation: EAW95464.1 .
    CH471114 Genomic DNA. Translation: EAW95465.1 .
    BC017702 mRNA. Translation: AAH17702.1 . Different initiation.
    BC018772 mRNA. Translation: AAH18772.1 .
    CCDSi CCDS10950.1. [Q9NXF8-1 ]
    CCDS45538.1. [Q9NXF8-2 ]
    RefSeqi NP_001139020.1. NM_001145548.1. [Q9NXF8-2 ]
    NP_060210.2. NM_017740.2. [Q9NXF8-1 ]
    UniGenei Hs.461610.
    Hs.723447.

    3D structure databases

    ProteinModelPortali Q9NXF8.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 120764. 3 interactions.
    IntActi Q9NXF8. 2 interactions.
    MINTi MINT-1036602.
    STRINGi 9606.ENSP00000341681.

    PTM databases

    PhosphoSitei Q9NXF8.

    Polymorphism databases

    DMDMi 116242853.

    Proteomic databases

    MaxQBi Q9NXF8.
    PaxDbi Q9NXF8.
    PRIDEi Q9NXF8.

    Protocols and materials databases

    DNASUi 55625.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000313732 ; ENSP00000315604 ; ENSG00000153786 . [Q9NXF8-1 ]
    ENST00000344861 ; ENSP00000341681 ; ENSG00000153786 . [Q9NXF8-2 ]
    ENST00000564466 ; ENSP00000456782 ; ENSG00000153786 . [Q9NXF8-2 ]
    GeneIDi 55625.
    KEGGi hsa:55625.
    UCSCi uc002fiq.2. human. [Q9NXF8-1 ]
    uc010voi.1. human. [Q9NXF8-2 ]

    Organism-specific databases

    CTDi 55625.
    GeneCardsi GC16M085007.
    HGNCi HGNC:18459. ZDHHC7.
    HPAi HPA019215.
    HPA059642.
    MIMi 614604. gene.
    neXtProti NX_Q9NXF8.
    PharmGKBi PA38335.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5273.
    HOGENOMi HOG000234755.
    HOVERGENi HBG056583.
    OMAi NGVLFNC.
    OrthoDBi EOG7QK0CG.
    PhylomeDBi Q9NXF8.
    TreeFami TF319798.

    Miscellaneous databases

    ChiTaRSi ZDHHC7. human.
    GenomeRNAii 55625.
    NextBioi 60244.
    PROi Q9NXF8.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9NXF8.
    Bgeei Q9NXF8.
    CleanExi HS_ZDHHC7.
    Genevestigatori Q9NXF8.

    Family and domain databases

    InterProi IPR001594. Znf_DHHC_palmitoyltrfase.
    [Graphical view ]
    Pfami PF01529. zf-DHHC. 1 hit.
    [Graphical view ]
    PROSITEi PS50216. ZF_DHHC. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Hepatoma and Teratocarcinoma.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 97-308 (ISOFORM 1).
      Tissue: Duodenal mucosa and Skin.
    4. "DHHC-7 and -21 are palmitoylacyltransferases for sex steroid receptors."
      Pedram A., Razandi M., Deschenes R.J., Levin E.R.
      Mol. Biol. Cell 23:188-199(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION.
    5. Cited for: VARIANT [LARGE SCALE ANALYSIS] ASN-44.

    Entry informationi

    Entry nameiZDHC7_HUMAN
    AccessioniPrimary (citable) accession number: Q9NXF8
    Secondary accession number(s): D3DUM1, Q8WV42, Q9NVD8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 2003
    Last sequence update: October 17, 2006
    Last modified: October 1, 2014
    This is version 109 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 16
      Human chromosome 16: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3