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Q9NXF7

- DCA16_HUMAN

UniProt

Q9NXF7 - DCA16_HUMAN

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Protein

DDB1- and CUL4-associated factor 16

Gene

DCAF16

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex.1 Publication

Pathwayi

GO - Biological processi

  1. protein ubiquitination Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Ubl conjugation pathway

Enzyme and pathway databases

UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
DDB1- and CUL4-associated factor 16
Gene namesi
Name:DCAF16
Synonyms:C4orf30
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 4

Organism-specific databases

HGNCiHGNC:25987. DCAF16.

Subcellular locationi

GO - Cellular componenti

  1. Cul4-RING E3 ubiquitin ligase complex Source: UniProtKB
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA165663579.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 216216DDB1- and CUL4-associated factor 16PRO_0000301964Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei61 – 611N6-acetyllysine1 Publication

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiQ9NXF7.
PaxDbiQ9NXF7.
PRIDEiQ9NXF7.

PTM databases

PhosphoSiteiQ9NXF7.

Expressioni

Gene expression databases

BgeeiQ9NXF7.
CleanExiHS_C4orf30.
GenevestigatoriQ9NXF7.

Organism-specific databases

HPAiHPA042487.

Interactioni

Subunit structurei

Interacts with DDB1 and CUL4A.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
tatP046082EBI-2559096,EBI-6164389From a different organism.

Protein-protein interaction databases

BioGridi120224. 19 interactions.
IntActiQ9NXF7. 5 interactions.
MINTiMINT-8417635.
STRINGi9606.ENSP00000371682.

Structurei

3D structure databases

ProteinModelPortaliQ9NXF7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi13 – 208Poly-Glu

Phylogenomic databases

eggNOGiNOG70631.
GeneTreeiENSGT00390000012430.
HOGENOMiHOG000111466.
HOVERGENiHBG101583.
InParanoidiQ9NXF7.
OMAiEDPVVPN.
OrthoDBiEOG7SR4NJ.
PhylomeDBiQ9NXF7.
TreeFamiTF341783.

Family and domain databases

InterProiIPR028216. DCAF16.
[Graphical view]
PANTHERiPTHR16194:SF0. PTHR16194:SF0. 1 hit.
PfamiPF15349. DCA16. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9NXF7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGPRNPSPDH LSESESEEEE NISYLNESSG EEWDSSEEED SMVPNLSPLE
60 70 80 90 100
SLAWQVKCLL KYSTTWKPLN PNSWLYHAKL LDPSTPVHIL REIGLRLSHC
110 120 130 140 150
SHCVPKLEPI PEWPPLASCG VPPFQKPLTS PSRLSRDHAT LNGALQFATK
160 170 180 190 200
QLSRTLSRAT PIPEYLKQIP NSCVSGCCCG WLTKTVKETT RTEPINTTYS
210
YTDFQKAVNK LLTASL
Length:216
Mass (Da):24,193
Last modified:October 1, 2000 - v1
Checksum:iD34295DCBC579986
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti181 – 1811W → R in BAG51629. (PubMed:14702039)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti45 – 451N → S.
Corresponds to variant rs34085539 [ dbSNP | Ensembl ].
VAR_034917
Natural varianti129 – 1291T → I.
Corresponds to variant rs7690457 [ dbSNP | Ensembl ].
VAR_034918

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK000287 mRNA. Translation: BAA91056.1.
AK056116 mRNA. Translation: BAG51629.1.
CH471069 Genomic DNA. Translation: EAW92784.1.
BC050697 mRNA. Translation: AAH50697.1.
BC068025 mRNA. Translation: AAH68025.1.
BC101716 mRNA. Translation: AAI01717.1.
BC101718 mRNA. Translation: AAI01719.1.
CCDSiCCDS3423.1.
RefSeqiNP_060211.3. NM_017741.3.
XP_005248226.1. XM_005248169.1.
XP_005248227.1. XM_005248170.1.
XP_005248228.1. XM_005248171.1.
XP_006714029.1. XM_006713966.1.
UniGeneiHs.614787.

Genome annotation databases

EnsembliENST00000382247; ENSP00000371682; ENSG00000163257.
GeneIDi54876.
KEGGihsa:54876.
UCSCiuc003gpn.3. human.

Polymorphism databases

DMDMi74719452.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK000287 mRNA. Translation: BAA91056.1 .
AK056116 mRNA. Translation: BAG51629.1 .
CH471069 Genomic DNA. Translation: EAW92784.1 .
BC050697 mRNA. Translation: AAH50697.1 .
BC068025 mRNA. Translation: AAH68025.1 .
BC101716 mRNA. Translation: AAI01717.1 .
BC101718 mRNA. Translation: AAI01719.1 .
CCDSi CCDS3423.1.
RefSeqi NP_060211.3. NM_017741.3.
XP_005248226.1. XM_005248169.1.
XP_005248227.1. XM_005248170.1.
XP_005248228.1. XM_005248171.1.
XP_006714029.1. XM_006713966.1.
UniGenei Hs.614787.

3D structure databases

ProteinModelPortali Q9NXF7.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 120224. 19 interactions.
IntActi Q9NXF7. 5 interactions.
MINTi MINT-8417635.
STRINGi 9606.ENSP00000371682.

PTM databases

PhosphoSitei Q9NXF7.

Polymorphism databases

DMDMi 74719452.

Proteomic databases

MaxQBi Q9NXF7.
PaxDbi Q9NXF7.
PRIDEi Q9NXF7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000382247 ; ENSP00000371682 ; ENSG00000163257 .
GeneIDi 54876.
KEGGi hsa:54876.
UCSCi uc003gpn.3. human.

Organism-specific databases

CTDi 54876.
GeneCardsi GC04M017802.
HGNCi HGNC:25987. DCAF16.
HPAi HPA042487.
neXtProti NX_Q9NXF7.
PharmGKBi PA165663579.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG70631.
GeneTreei ENSGT00390000012430.
HOGENOMi HOG000111466.
HOVERGENi HBG101583.
InParanoidi Q9NXF7.
OMAi EDPVVPN.
OrthoDBi EOG7SR4NJ.
PhylomeDBi Q9NXF7.
TreeFami TF341783.

Enzyme and pathway databases

UniPathwayi UPA00143 .

Miscellaneous databases

ChiTaRSi DCAF16. human.
GenomeRNAii 54876.
NextBioi 35469191.
PROi Q9NXF7.

Gene expression databases

Bgeei Q9NXF7.
CleanExi HS_C4orf30.
Genevestigatori Q9NXF7.

Family and domain databases

InterProi IPR028216. DCAF16.
[Graphical view ]
PANTHERi PTHR16194:SF0. PTHR16194:SF0. 1 hit.
Pfami PF15349. DCA16. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Heart, Kidney, Lung and Testis.
  4. "A family of diverse Cul4-Ddb1-interacting proteins includes Cdt2, which is required for S phase destruction of the replication factor Cdt1."
    Jin J., Arias E.E., Chen J., Harper J.W., Walter J.C.
    Mol. Cell 23:709-721(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH DDB1 AND CUL4A, IDENTIFICATION BY MASS SPECTROMETRY.
  5. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
    Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
    Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-61, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiDCA16_HUMAN
AccessioniPrimary (citable) accession number: Q9NXF7
Secondary accession number(s): B3KPB7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: October 1, 2000
Last modified: October 29, 2014
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. PATHWAY comments
    Index of metabolic and biosynthesis pathways

External Data

Dasty 3