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Protein

DDB1- and CUL4-associated factor 16

Gene

DCAF16

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex.1 Publication

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

GO - Biological processi

  • protein ubiquitination Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Ubl conjugation pathway

Enzyme and pathway databases

BioCyciZFISH:ENSG00000163257-MONOMER.
UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
DDB1- and CUL4-associated factor 16
Gene namesi
Name:DCAF16
Synonyms:C4orf30
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

HGNCiHGNC:25987. DCAF16.

Subcellular locationi

GO - Cellular componenti

  • Cul4-RING E3 ubiquitin ligase complex Source: UniProtKB
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000163257.
PharmGKBiPA165663579.

Polymorphism and mutation databases

BioMutaiDCAF16.
DMDMi74719452.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003019641 – 216DDB1- and CUL4-associated factor 16Add BLAST216

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei61N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ9NXF7.
MaxQBiQ9NXF7.
PaxDbiQ9NXF7.
PeptideAtlasiQ9NXF7.
PRIDEiQ9NXF7.

PTM databases

iPTMnetiQ9NXF7.
PhosphoSitePlusiQ9NXF7.

Expressioni

Gene expression databases

BgeeiENSG00000163257.
CleanExiHS_C4orf30.
GenevisibleiQ9NXF7. HS.

Organism-specific databases

HPAiHPA042487.

Interactioni

Subunit structurei

Interacts with DDB1 and CUL4A.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
tatP046082EBI-2559096,EBI-6164389From a different organism.

Protein-protein interaction databases

BioGridi120224. 28 interactors.
IntActiQ9NXF7. 5 interactors.
MINTiMINT-8417635.
STRINGi9606.ENSP00000371682.

Structurei

3D structure databases

ProteinModelPortaliQ9NXF7.
SMRiQ9NXF7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi13 – 20Poly-Glu8

Phylogenomic databases

eggNOGiENOG410J90R. Eukaryota.
ENOG4111BF0. LUCA.
GeneTreeiENSGT00390000012430.
HOGENOMiHOG000111466.
HOVERGENiHBG101583.
InParanoidiQ9NXF7.
OMAiNANYLNE.
OrthoDBiEOG091G0KFC.
PhylomeDBiQ9NXF7.
TreeFamiTF341783.

Family and domain databases

InterProiIPR028216. DCAF16.
[Graphical view]
PANTHERiPTHR16194:SF0. PTHR16194:SF0. 1 hit.
PfamiPF15349. DCA16. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9NXF7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGPRNPSPDH LSESESEEEE NISYLNESSG EEWDSSEEED SMVPNLSPLE
60 70 80 90 100
SLAWQVKCLL KYSTTWKPLN PNSWLYHAKL LDPSTPVHIL REIGLRLSHC
110 120 130 140 150
SHCVPKLEPI PEWPPLASCG VPPFQKPLTS PSRLSRDHAT LNGALQFATK
160 170 180 190 200
QLSRTLSRAT PIPEYLKQIP NSCVSGCCCG WLTKTVKETT RTEPINTTYS
210
YTDFQKAVNK LLTASL
Length:216
Mass (Da):24,193
Last modified:October 1, 2000 - v1
Checksum:iD34295DCBC579986
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti181W → R in BAG51629 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03491745N → S.Corresponds to variant rs34085539dbSNPEnsembl.1
Natural variantiVAR_034918129T → I.Corresponds to variant rs7690457dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK000287 mRNA. Translation: BAA91056.1.
AK056116 mRNA. Translation: BAG51629.1.
CH471069 Genomic DNA. Translation: EAW92784.1.
BC050697 mRNA. Translation: AAH50697.1.
BC068025 mRNA. Translation: AAH68025.1.
BC101716 mRNA. Translation: AAI01717.1.
BC101718 mRNA. Translation: AAI01719.1.
CCDSiCCDS3423.1.
RefSeqiNP_060211.3. NM_017741.3.
XP_016863816.1. XM_017008327.1.
XP_016863817.1. XM_017008328.1.
UniGeneiHs.614787.

Genome annotation databases

EnsembliENST00000382247; ENSP00000371682; ENSG00000163257.
GeneIDi54876.
KEGGihsa:54876.
UCSCiuc003gpn.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK000287 mRNA. Translation: BAA91056.1.
AK056116 mRNA. Translation: BAG51629.1.
CH471069 Genomic DNA. Translation: EAW92784.1.
BC050697 mRNA. Translation: AAH50697.1.
BC068025 mRNA. Translation: AAH68025.1.
BC101716 mRNA. Translation: AAI01717.1.
BC101718 mRNA. Translation: AAI01719.1.
CCDSiCCDS3423.1.
RefSeqiNP_060211.3. NM_017741.3.
XP_016863816.1. XM_017008327.1.
XP_016863817.1. XM_017008328.1.
UniGeneiHs.614787.

3D structure databases

ProteinModelPortaliQ9NXF7.
SMRiQ9NXF7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120224. 28 interactors.
IntActiQ9NXF7. 5 interactors.
MINTiMINT-8417635.
STRINGi9606.ENSP00000371682.

PTM databases

iPTMnetiQ9NXF7.
PhosphoSitePlusiQ9NXF7.

Polymorphism and mutation databases

BioMutaiDCAF16.
DMDMi74719452.

Proteomic databases

EPDiQ9NXF7.
MaxQBiQ9NXF7.
PaxDbiQ9NXF7.
PeptideAtlasiQ9NXF7.
PRIDEiQ9NXF7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000382247; ENSP00000371682; ENSG00000163257.
GeneIDi54876.
KEGGihsa:54876.
UCSCiuc003gpn.3. human.

Organism-specific databases

CTDi54876.
GeneCardsiDCAF16.
HGNCiHGNC:25987. DCAF16.
HPAiHPA042487.
neXtProtiNX_Q9NXF7.
OpenTargetsiENSG00000163257.
PharmGKBiPA165663579.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J90R. Eukaryota.
ENOG4111BF0. LUCA.
GeneTreeiENSGT00390000012430.
HOGENOMiHOG000111466.
HOVERGENiHBG101583.
InParanoidiQ9NXF7.
OMAiNANYLNE.
OrthoDBiEOG091G0KFC.
PhylomeDBiQ9NXF7.
TreeFamiTF341783.

Enzyme and pathway databases

UniPathwayiUPA00143.
BioCyciZFISH:ENSG00000163257-MONOMER.

Miscellaneous databases

ChiTaRSiDCAF16. human.
GenomeRNAii54876.
PROiQ9NXF7.

Gene expression databases

BgeeiENSG00000163257.
CleanExiHS_C4orf30.
GenevisibleiQ9NXF7. HS.

Family and domain databases

InterProiIPR028216. DCAF16.
[Graphical view]
PANTHERiPTHR16194:SF0. PTHR16194:SF0. 1 hit.
PfamiPF15349. DCA16. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDCA16_HUMAN
AccessioniPrimary (citable) accession number: Q9NXF7
Secondary accession number(s): B3KPB7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: October 1, 2000
Last modified: November 30, 2016
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. PATHWAY comments
    Index of metabolic and biosynthesis pathways

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.