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Protein

Testis-expressed protein 10

Gene

TEX10

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Functions as a component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes (PubMed:22872859). Component of the PELP1 complex involved in the nucleolar steps of 28S rRNA maturation and the subsequent nucleoplasmic transit of the pre-60S ribosomal subunit (PubMed:21326211).2 Publications

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-HSA-6791226. Major pathway of rRNA processing in the nucleolus and cytosol.

Names & Taxonomyi

Protein namesi
Recommended name:
Testis-expressed protein 10
Gene namesi
Name:TEX10
ORF Names:L18, Nbla10363
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

EuPathDBiHostDB:ENSG00000136891.13.
HGNCiHGNC:25988. TEX10.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000136891.
PharmGKBiPA134991964.

Polymorphism and mutation databases

BioMutaiTEX10.
DMDMi71153593.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000724911 – 929Testis-expressed protein 10Add BLAST929

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei29PhosphothreonineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9NXF1.
MaxQBiQ9NXF1.
PaxDbiQ9NXF1.
PeptideAtlasiQ9NXF1.
PRIDEiQ9NXF1.

2D gel databases

SWISS-2DPAGEiQ9NXF1.

PTM databases

iPTMnetiQ9NXF1.
PhosphoSitePlusiQ9NXF1.
SwissPalmiQ9NXF1.

Expressioni

Gene expression databases

BgeeiENSG00000136891.
CleanExiHS_TEX10.
ExpressionAtlasiQ9NXF1. baseline and differential.
GenevisibleiQ9NXF1. HS.

Interactioni

Subunit structurei

Component of some MLL1/MLL complex, at least composed of the core components KMT2A/MLL1, ASH2L, HCFC1/HCF1, WDR5 and RBBP5, as well as the facultative components BAP18, CHD8, E2F6, HSP70, INO80C, KANSL1, LAS1L, MAX, MCRS1, MGA, KAT8/MOF, PELP1, PHF20, PRP31, RING2, RUVB1/TIP49A, RUVB2/TIP49B, SENP3, TAF1, TAF4, TAF6, TAF7, TAF9 and TEX10. Component of the 5FMC complex, at least composed of PELP1, LAS1L, TEX10, WDR18 and SENP3; the complex interacts with methylated CHTOP and ZNF148. Component of the PELP1 complex, composed of at least PELP1, TEX10 and WDR18. The complex interacts with pre-60S ribosome particles (PubMed:21326211).3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
SENP3Q9H4L42EBI-2371062,EBI-2880236

Protein-protein interaction databases

BioGridi120229. 52 interactors.
CORUMiQ9NXF1.
IntActiQ9NXF1. 25 interactors.
MINTiMINT-1182702.
STRINGi9606.ENSP00000364037.

Structurei

3D structure databases

ProteinModelPortaliQ9NXF1.
SMRiQ9NXF1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati99 – 137HEATAdd BLAST39

Sequence similaritiesi

Belongs to the IPI1/TEX10 family.Curated

Phylogenomic databases

eggNOGiKOG2149. Eukaryota.
ENOG410YR7T. LUCA.
GeneTreeiENSGT00390000012654.
HOGENOMiHOG000133040.
HOVERGENiHBG083741.
InParanoidiQ9NXF1.
KOiK14827.
OMAiPLLIECW.
OrthoDBiEOG091G0EBA.
PhylomeDBiQ9NXF1.
TreeFamiTF318197.

Family and domain databases

Gene3Di1.25.10.10. 1 hit.
InterProiView protein in InterPro
IPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR021133. HEAT_type_2.
IPR024679. IPI1/TEX10.
PfamiView protein in Pfam
PF12333. Ipi1_N. 1 hit.
SUPFAMiSSF48371. SSF48371. 2 hits.
PROSITEiView protein in PROSITE
PS50077. HEAT_REPEAT. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9NXF1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTKKRKRQHD FQKVKLKVGK KKPKLQNATP TNFKTKTIHL PEQLKEDGTL
60 70 80 90 100
PTNNRKLNIK DLLSQMHHYN AGVKQSALLG LKDLLSQYPF IIDAHLSNIL
110 120 130 140 150
SEVTAVFTDK DANVRLAAVQ LLQFLAPKIR AEQISPFFPL VSAHLSSAMT
160 170 180 190 200
HITEGIQEDS LKVLDILLEQ YPALITGRSS ILLKNFVELI SHQQLSKGLI
210 220 230 240 250
NRDRSQSWIL SVNPNRRLTS QQWRLKVLVR LSKFLQALAD GSSRLRESEG
260 270 280 290 300
LQEQKENPHA TSNSIFINWK EHANDQQHIQ VYENGGSQPN VSSQFRLRYL
310 320 330 340 350
VGGLSGVDEG LSSTENLKGF IEIIIPLLIE CWVEAVPPQL ATPVGNGIER
360 370 380 390 400
EPLQVMQQVL NIISLLWKLS KQQDETHKLE SWLRKNYLID FKHHFMSRFP
410 420 430 440 450
YVLKEITKHK RKEPNKSIKH CTVLSNNIDH LLLNLTLSDI MVSLANASTL
460 470 480 490 500
QKDCSWIEMI RKFVTETLED GSRLNSKQLN RLLGVSWRLM QIQPNREDTE
510 520 530 540 550
TLIKAVYTLY QQRGLILPVR TLLLKFFSKI YQTEELRSCR FRYRSKVLSR
560 570 580 590 600
WLAGLPLQLA HLGSRNPELS TQLIDIIHTA AARANKELLK SLQATALRIY
610 620 630 640 650
DPQEGAVVVL PADSQQRLVQ LVYFLPSLPA DLLSRLSRCC IMGRLSSSLA
660 670 680 690 700
AMLIGILHMR SSFSGWKYSA KDWLMSDVDY FSFLFSTLTG FSKEELTWLQ
710 720 730 740 750
SLRGVPHVIQ TQLSPVLLYL TDLDQFLHHW DVTEAVFHSL LVIPARSQNF
760 770 780 790 800
DILQSAISKH LVGLTVIPDS TAGCVFGVIC KLLDHTCVVS ETLLPFLASC
810 820 830 840 850
CYSLLYFLLT IEKGEAEHLR KRDKLWGVCV SILALLPRVL RLMLQSLRVN
860 870 880 890 900
RVGPEELPVV GQLLRLLLQH APLRTHMLTN AILVQQIIKN ITTLKSGSVQ
910 920
EQWLTDLHYC FNVYITGHPQ GPSALATVY
Length:929
Mass (Da):105,674
Last modified:July 19, 2005 - v2
Checksum:i2E0F8062989415BA
GO
Isoform 2 (identifier: Q9NXF1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MSRM
     822-840: Missing.

Note: No experimental confirmation available.
Show »
Length:913
Mass (Da):103,915
Checksum:iB1C70A0807B527C7
GO

Sequence cautioni

The sequence CAI12537 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAI39742 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti411R → G in AAH30652 (PubMed:15489334).Curated1
Sequence conflicti430H → R in AAT06748 (PubMed:15334068).Curated1
Sequence conflicti430H → R in BAA91062 (PubMed:14702039).Curated1
Sequence conflicti526F → L in AAH30652 (PubMed:15489334).Curated1
Sequence conflicti731D → E in BAB87845 (PubMed:12880961).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0437041M → MSRM in isoform 2. 1 Publication1
Alternative sequenceiVSP_043705822 – 840Missing in isoform 2. 1 PublicationAdd BLAST19

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY598337 mRNA. Translation: AAT06748.1.
AB060968 mRNA. Translation: BAB87845.1.
AK000294 mRNA. Translation: BAA91062.1.
AK302619 mRNA. Translation: BAG63864.1.
AL353805, AL445214 Genomic DNA. Translation: CAI12537.1. Sequence problems.
AL353805, AL445214 Genomic DNA. Translation: CAI12538.1.
AL445214, AL353805 Genomic DNA. Translation: CAI39742.1. Sequence problems.
AL445214, AL353805 Genomic DNA. Translation: CAI39743.1.
BC030652 mRNA. Translation: AAH30652.1.
CCDSiCCDS55330.1. [Q9NXF1-2]
CCDS6748.1. [Q9NXF1-1]
RefSeqiNP_001155056.1. NM_001161584.1. [Q9NXF1-2]
NP_060216.2. NM_017746.3. [Q9NXF1-1]
UniGeneiHs.494648.

Genome annotation databases

EnsembliENST00000374902; ENSP00000364037; ENSG00000136891. [Q9NXF1-1]
ENST00000535814; ENSP00000444555; ENSG00000136891. [Q9NXF1-2]
GeneIDi54881.
KEGGihsa:54881.
UCSCiuc004bas.4. human. [Q9NXF1-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiTEX10_HUMAN
AccessioniPrimary (citable) accession number: Q9NXF1
Secondary accession number(s): B4DYV2
, Q5T722, Q5T723, Q8NCN8, Q8TDY0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: July 19, 2005
Last modified: November 22, 2017
This is version 147 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families