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Protein

Pre-mRNA-splicing factor CWC25 homolog

Gene

CWC25

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-HSA-72163. mRNA Splicing - Major Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Pre-mRNA-splicing factor CWC25 homolog
Alternative name(s):
Coiled-coil domain-containing protein 49
Spliceosome-associated protein homolog CWC25
Gene namesi
Name:CWC25
Synonyms:CCDC49
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000273559.4.
HGNCiHGNC:25989. CWC25.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000273559.
PharmGKBiPA165431769.

Polymorphism and mutation databases

DMDMi74734693.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002888651 – 425Pre-mRNA-splicing factor CWC25 homologAdd BLAST425

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei170PhosphoserineCombined sources1
Modified residuei218PhosphoserineCombined sources1
Modified residuei222PhosphoserineCombined sources1
Cross-linki391Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ9NXE8.
MaxQBiQ9NXE8.
PaxDbiQ9NXE8.
PeptideAtlasiQ9NXE8.
PRIDEiQ9NXE8.

PTM databases

iPTMnetiQ9NXE8.
PhosphoSitePlusiQ9NXE8.

Expressioni

Gene expression databases

BgeeiENSG00000273559.
CleanExiHS_CCDC49.
ExpressionAtlasiQ9NXE8. baseline and differential.
GenevisibleiQ9NXE8. HS.

Organism-specific databases

HPAiCAB014874.
HPA062997.

Interactioni

Protein-protein interaction databases

BioGridi120231. 15 interactors.
IntActiQ9NXE8. 6 interactors.
MINTiMINT-1440092.
STRINGi9606.ENSP00000225428.

Structurei

3D structure databases

ProteinModelPortaliQ9NXE8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili20 – 70Sequence analysisAdd BLAST51
Coiled coili333 – 377Sequence analysisAdd BLAST45

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi144 – 190Lys-richAdd BLAST47

Sequence similaritiesi

Belongs to the CWC25 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG3869. Eukaryota.
ENOG410XSTA. LUCA.
GeneTreeiENSGT00440000039055.
HOGENOMiHOG000006950.
HOVERGENiHBG061012.
InParanoidiQ9NXE8.
OMAiEKLEWMY.
OrthoDBiEOG091G0Z7J.
PhylomeDBiQ9NXE8.
TreeFamiTF320801.

Family and domain databases

InterProiView protein in InterPro
IPR019339. CIR_N_dom.
IPR022209. CWC25.
PfamiView protein in Pfam
PF10197. Cir_N. 1 hit.
PF12542. CWC25. 1 hit.
SMARTiView protein in SMART
SM01083. Cir_N. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9NXE8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGGGDLNLKK SWHPQTLRNV EKVWKAEQKH EAERKKIEEL QRELREERAR
60 70 80 90 100
EEMQRYAEDV GAVKKKEEKL DWMYQGPGGM VNRDEYLLGR PIDKYVFEKM
110 120 130 140 150
EEKEAGCSSE TGLLPGSIFA PSGANSLLDM ASKIREDPLF IIRKKEEEKK
160 170 180 190 200
REVLNNPVKM KKIKELLQMS LEKKEKKKKK EKKKKHKKHK HRSSSSDRSS
210 220 230 240 250
SEDEHSAGRS QKKMANSSPV LSKVPGYGLQ VRNSDRNQGL QGPLTAEQKR
260 270 280 290 300
GHGMKNHSRS RSSSHSPPRH ASKKSTREAG SRDRRSRSLG RRSRSPRPSK
310 320 330 340 350
LHNSKVNRRE TGQTRSPSPK KEVYQRRHAP GYTRKLSAEE LERKRQEMME
360 370 380 390 400
NAKWREEERL NILKRHAKDE EREQRLEKLD SRDGKFIHRM KLESASTSSL
410 420
EDRVKRNIYS LQRTSVALEK NFMKR
Length:425
Mass (Da):49,647
Last modified:October 1, 2000 - v1
Checksum:iF8288E143A3FF764
GO
Isoform 2 (identifier: Q9NXE8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-347: Missing.

Show »
Length:78
Mass (Da):9,522
Checksum:iAF7DB596F46C98C4
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0257971 – 347Missing in isoform 2. 1 PublicationAdd BLAST347

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK000298 mRNA. Translation: BAA91065.1.
CR749362 mRNA. Translation: CAH18215.1.
BC003085 mRNA. Translation: AAH03085.1. Different termination.
BC008833 mRNA. Translation: AAH08833.1.
CCDSiCCDS45663.1. [Q9NXE8-1]
RefSeqiNP_060218.1. NM_017748.4. [Q9NXE8-1]
UniGeneiHs.406223.

Genome annotation databases

EnsembliENST00000614790; ENSP00000478070; ENSG00000273559. [Q9NXE8-1]
ENST00000614868; ENSP00000477799; ENSG00000276761. [Q9NXE8-1]
GeneIDi54883.
KEGGihsa:54883.
UCSCiuc002hqu.5. human. [Q9NXE8-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiCWC25_HUMAN
AccessioniPrimary (citable) accession number: Q9NXE8
Secondary accession number(s): A0JLM3, Q68DK5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: October 1, 2000
Last modified: October 25, 2017
This is version 110 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families