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Q9NXE8

- CWC25_HUMAN

UniProt

Q9NXE8 - CWC25_HUMAN

Protein

Pre-mRNA-splicing factor CWC25 homolog

Gene

CWC25

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 85 (01 Oct 2014)
      Sequence version 1 (01 Oct 2000)
      Previous versions | rss
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    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Pre-mRNA-splicing factor CWC25 homolog
    Alternative name(s):
    Coiled-coil domain-containing protein 49
    Spliceosome-associated protein homolog CWC25
    Gene namesi
    Name:CWC25
    Synonyms:CCDC49
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 17

    Organism-specific databases

    HGNCiHGNC:25989. CWC25.

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA165431769.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 425425Pre-mRNA-splicing factor CWC25 homologPRO_0000288865Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei218 – 2181Phosphoserine2 Publications
    Modified residuei222 – 2221Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ9NXE8.
    PaxDbiQ9NXE8.
    PRIDEiQ9NXE8.

    PTM databases

    PhosphoSiteiQ9NXE8.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9NXE8.
    BgeeiQ9NXE8.
    CleanExiHS_CCDC49.
    GenevestigatoriQ9NXE8.

    Organism-specific databases

    HPAiCAB014874.
    HPA044334.

    Interactioni

    Protein-protein interaction databases

    BioGridi120231. 4 interactions.
    IntActiQ9NXE8. 3 interactions.
    MINTiMINT-1440092.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9NXE8.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili20 – 7051Sequence AnalysisAdd
    BLAST
    Coiled coili333 – 37745Sequence AnalysisAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi144 – 19047Lys-richAdd
    BLAST

    Sequence similaritiesi

    Belongs to the CWC25 family.Curated

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiNOG296370.
    HOGENOMiHOG000006950.
    HOVERGENiHBG061012.
    InParanoidiQ9NXE8.
    OMAiDRNQGLQ.
    OrthoDBiEOG7TTQ83.
    PhylomeDBiQ9NXE8.
    TreeFamiTF320801.

    Family and domain databases

    InterProiIPR019339. CIR_N_dom.
    IPR022209. CWC25.
    [Graphical view]
    PfamiPF10197. Cir_N. 1 hit.
    PF12542. CWC25. 1 hit.
    [Graphical view]
    SMARTiSM01083. Cir_N. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9NXE8-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MGGGDLNLKK SWHPQTLRNV EKVWKAEQKH EAERKKIEEL QRELREERAR    50
    EEMQRYAEDV GAVKKKEEKL DWMYQGPGGM VNRDEYLLGR PIDKYVFEKM 100
    EEKEAGCSSE TGLLPGSIFA PSGANSLLDM ASKIREDPLF IIRKKEEEKK 150
    REVLNNPVKM KKIKELLQMS LEKKEKKKKK EKKKKHKKHK HRSSSSDRSS 200
    SEDEHSAGRS QKKMANSSPV LSKVPGYGLQ VRNSDRNQGL QGPLTAEQKR 250
    GHGMKNHSRS RSSSHSPPRH ASKKSTREAG SRDRRSRSLG RRSRSPRPSK 300
    LHNSKVNRRE TGQTRSPSPK KEVYQRRHAP GYTRKLSAEE LERKRQEMME 350
    NAKWREEERL NILKRHAKDE EREQRLEKLD SRDGKFIHRM KLESASTSSL 400
    EDRVKRNIYS LQRTSVALEK NFMKR 425
    Length:425
    Mass (Da):49,647
    Last modified:October 1, 2000 - v1
    Checksum:iF8288E143A3FF764
    GO
    Isoform 2 (identifier: Q9NXE8-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-347: Missing.

    Show »
    Length:78
    Mass (Da):9,522
    Checksum:iAF7DB596F46C98C4
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 347347Missing in isoform 2. 1 PublicationVSP_025797Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK000298 mRNA. Translation: BAA91065.1.
    CR749362 mRNA. Translation: CAH18215.1.
    BC003085 mRNA. Translation: AAH03085.1. Different termination.
    BC008833 mRNA. Translation: AAH08833.1.
    CCDSiCCDS45663.1. [Q9NXE8-1]
    RefSeqiNP_060218.1. NM_017748.4. [Q9NXE8-1]
    UniGeneiHs.406223.

    Genome annotation databases

    GeneIDi54883.
    KEGGihsa:54883.
    UCSCiuc002hqu.4. human. [Q9NXE8-1]

    Polymorphism databases

    DMDMi74734693.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK000298 mRNA. Translation: BAA91065.1 .
    CR749362 mRNA. Translation: CAH18215.1 .
    BC003085 mRNA. Translation: AAH03085.1 . Different termination.
    BC008833 mRNA. Translation: AAH08833.1 .
    CCDSi CCDS45663.1. [Q9NXE8-1 ]
    RefSeqi NP_060218.1. NM_017748.4. [Q9NXE8-1 ]
    UniGenei Hs.406223.

    3D structure databases

    ProteinModelPortali Q9NXE8.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 120231. 4 interactions.
    IntActi Q9NXE8. 3 interactions.
    MINTi MINT-1440092.

    PTM databases

    PhosphoSitei Q9NXE8.

    Polymorphism databases

    DMDMi 74734693.

    Proteomic databases

    MaxQBi Q9NXE8.
    PaxDbi Q9NXE8.
    PRIDEi Q9NXE8.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 54883.
    KEGGi hsa:54883.
    UCSCi uc002hqu.4. human. [Q9NXE8-1 ]

    Organism-specific databases

    CTDi 54883.
    GeneCardsi GC17M036957.
    HGNCi HGNC:25989. CWC25.
    HPAi CAB014874.
    HPA044334.
    neXtProti NX_Q9NXE8.
    PharmGKBi PA165431769.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG296370.
    HOGENOMi HOG000006950.
    HOVERGENi HBG061012.
    InParanoidi Q9NXE8.
    OMAi DRNQGLQ.
    OrthoDBi EOG7TTQ83.
    PhylomeDBi Q9NXE8.
    TreeFami TF320801.

    Miscellaneous databases

    GenomeRNAii 54883.
    NextBioi 57855.
    PROi Q9NXE8.

    Gene expression databases

    ArrayExpressi Q9NXE8.
    Bgeei Q9NXE8.
    CleanExi HS_CCDC49.
    Genevestigatori Q9NXE8.

    Family and domain databases

    InterProi IPR019339. CIR_N_dom.
    IPR022209. CWC25.
    [Graphical view ]
    Pfami PF10197. Cir_N. 1 hit.
    PF12542. CWC25. 1 hit.
    [Graphical view ]
    SMARTi SM01083. Cir_N. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Hepatoma.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Liver.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Eye and Uterus.
    4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    5. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-218 AND SER-222, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    6. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-218, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiCWC25_HUMAN
    AccessioniPrimary (citable) accession number: Q9NXE8
    Secondary accession number(s): A0JLM3, Q68DK5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 29, 2007
    Last sequence update: October 1, 2000
    Last modified: October 1, 2014
    This is version 85 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 17
      Human chromosome 17: entries, gene names and cross-references to MIM
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3