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Q9NXE8

- CWC25_HUMAN

UniProt

Q9NXE8 - CWC25_HUMAN

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Protein
Pre-mRNA-splicing factor CWC25 homolog
Gene
CWC25, CCDC49
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Pre-mRNA-splicing factor CWC25 homolog
Alternative name(s):
Coiled-coil domain-containing protein 49
Spliceosome-associated protein homolog CWC25
Gene namesi
Name:CWC25
Synonyms:CCDC49
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 17

Organism-specific databases

HGNCiHGNC:25989. CWC25.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA165431769.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 425425Pre-mRNA-splicing factor CWC25 homolog
PRO_0000288865Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei218 – 2181Phosphoserine2 Publications
Modified residuei222 – 2221Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9NXE8.
PaxDbiQ9NXE8.
PRIDEiQ9NXE8.

PTM databases

PhosphoSiteiQ9NXE8.

Expressioni

Gene expression databases

ArrayExpressiQ9NXE8.
BgeeiQ9NXE8.
CleanExiHS_CCDC49.
GenevestigatoriQ9NXE8.

Organism-specific databases

HPAiCAB014874.
HPA044334.

Interactioni

Protein-protein interaction databases

BioGridi120231. 4 interactions.
IntActiQ9NXE8. 3 interactions.
MINTiMINT-1440092.

Structurei

3D structure databases

ProteinModelPortaliQ9NXE8.

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili20 – 7051 Reviewed prediction
Add
BLAST
Coiled coili333 – 37745 Reviewed prediction
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi144 – 19047Lys-rich
Add
BLAST

Sequence similaritiesi

Belongs to the CWC25 family.

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG296370.
HOGENOMiHOG000006950.
HOVERGENiHBG061012.
InParanoidiQ9NXE8.
OMAiDRNQGLQ.
OrthoDBiEOG7TTQ83.
PhylomeDBiQ9NXE8.
TreeFamiTF320801.

Family and domain databases

InterProiIPR019339. CIR_N_dom.
IPR022209. CWC25.
[Graphical view]
PfamiPF10197. Cir_N. 1 hit.
PF12542. CWC25. 1 hit.
[Graphical view]
SMARTiSM01083. Cir_N. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9NXE8-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MGGGDLNLKK SWHPQTLRNV EKVWKAEQKH EAERKKIEEL QRELREERAR    50
EEMQRYAEDV GAVKKKEEKL DWMYQGPGGM VNRDEYLLGR PIDKYVFEKM 100
EEKEAGCSSE TGLLPGSIFA PSGANSLLDM ASKIREDPLF IIRKKEEEKK 150
REVLNNPVKM KKIKELLQMS LEKKEKKKKK EKKKKHKKHK HRSSSSDRSS 200
SEDEHSAGRS QKKMANSSPV LSKVPGYGLQ VRNSDRNQGL QGPLTAEQKR 250
GHGMKNHSRS RSSSHSPPRH ASKKSTREAG SRDRRSRSLG RRSRSPRPSK 300
LHNSKVNRRE TGQTRSPSPK KEVYQRRHAP GYTRKLSAEE LERKRQEMME 350
NAKWREEERL NILKRHAKDE EREQRLEKLD SRDGKFIHRM KLESASTSSL 400
EDRVKRNIYS LQRTSVALEK NFMKR 425
Length:425
Mass (Da):49,647
Last modified:October 1, 2000 - v1
Checksum:iF8288E143A3FF764
GO
Isoform 2 (identifier: Q9NXE8-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-347: Missing.

Show »
Length:78
Mass (Da):9,522
Checksum:iAF7DB596F46C98C4
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 347347Missing in isoform 2.
VSP_025797Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK000298 mRNA. Translation: BAA91065.1.
CR749362 mRNA. Translation: CAH18215.1.
BC003085 mRNA. Translation: AAH03085.1. Different termination.
BC008833 mRNA. Translation: AAH08833.1.
CCDSiCCDS45663.1. [Q9NXE8-1]
RefSeqiNP_060218.1. NM_017748.4. [Q9NXE8-1]
UniGeneiHs.406223.

Genome annotation databases

EnsembliENST00000225428; ENSP00000225428; ENSG00000108296. [Q9NXE8-1]
GeneIDi54883.
KEGGihsa:54883.
UCSCiuc002hqu.4. human. [Q9NXE8-1]

Polymorphism databases

DMDMi74734693.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK000298 mRNA. Translation: BAA91065.1 .
CR749362 mRNA. Translation: CAH18215.1 .
BC003085 mRNA. Translation: AAH03085.1 . Different termination.
BC008833 mRNA. Translation: AAH08833.1 .
CCDSi CCDS45663.1. [Q9NXE8-1 ]
RefSeqi NP_060218.1. NM_017748.4. [Q9NXE8-1 ]
UniGenei Hs.406223.

3D structure databases

ProteinModelPortali Q9NXE8.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 120231. 4 interactions.
IntActi Q9NXE8. 3 interactions.
MINTi MINT-1440092.

PTM databases

PhosphoSitei Q9NXE8.

Polymorphism databases

DMDMi 74734693.

Proteomic databases

MaxQBi Q9NXE8.
PaxDbi Q9NXE8.
PRIDEi Q9NXE8.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000225428 ; ENSP00000225428 ; ENSG00000108296 . [Q9NXE8-1 ]
GeneIDi 54883.
KEGGi hsa:54883.
UCSCi uc002hqu.4. human. [Q9NXE8-1 ]

Organism-specific databases

CTDi 54883.
GeneCardsi GC17M036957.
HGNCi HGNC:25989. CWC25.
HPAi CAB014874.
HPA044334.
neXtProti NX_Q9NXE8.
PharmGKBi PA165431769.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG296370.
HOGENOMi HOG000006950.
HOVERGENi HBG061012.
InParanoidi Q9NXE8.
OMAi DRNQGLQ.
OrthoDBi EOG7TTQ83.
PhylomeDBi Q9NXE8.
TreeFami TF320801.

Miscellaneous databases

GenomeRNAii 54883.
NextBioi 57855.
PROi Q9NXE8.

Gene expression databases

ArrayExpressi Q9NXE8.
Bgeei Q9NXE8.
CleanExi HS_CCDC49.
Genevestigatori Q9NXE8.

Family and domain databases

InterProi IPR019339. CIR_N_dom.
IPR022209. CWC25.
[Graphical view ]
Pfami PF10197. Cir_N. 1 hit.
PF12542. CWC25. 1 hit.
[Graphical view ]
SMARTi SM01083. Cir_N. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Hepatoma.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Liver.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Eye and Uterus.
  4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  5. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-218 AND SER-222, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  6. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-218, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiCWC25_HUMAN
AccessioniPrimary (citable) accession number: Q9NXE8
Secondary accession number(s): A0JLM3, Q68DK5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: October 1, 2000
Last modified: July 9, 2014
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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