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Protein

Pre-mRNA-splicing factor CWC25 homolog

Gene

CWC25

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-HSA-72163 mRNA Splicing - Major Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Pre-mRNA-splicing factor CWC25 homolog
Alternative name(s):
Coiled-coil domain-containing protein 49
Spliceosome-associated protein homolog CWC25
Gene namesi
Name:CWC25
Synonyms:CCDC49
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000273559.4
HGNCiHGNC:25989 CWC25
neXtProtiNX_Q9NXE8

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000273559
PharmGKBiPA165431769

Polymorphism and mutation databases

DMDMi74734693

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002888651 – 425Pre-mRNA-splicing factor CWC25 homologAdd BLAST425

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei170PhosphoserineCombined sources1
Modified residuei218PhosphoserineCombined sources1
Modified residuei222PhosphoserineCombined sources1
Cross-linki391Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ9NXE8
MaxQBiQ9NXE8
PaxDbiQ9NXE8
PeptideAtlasiQ9NXE8
PRIDEiQ9NXE8

PTM databases

iPTMnetiQ9NXE8
PhosphoSitePlusiQ9NXE8

Expressioni

Gene expression databases

BgeeiENSG00000273559
CleanExiHS_CCDC49
ExpressionAtlasiQ9NXE8 baseline and differential
GenevisibleiQ9NXE8 HS

Organism-specific databases

HPAiCAB014874
HPA062997

Interactioni

Protein-protein interaction databases

BioGridi120231, 15 interactors
IntActiQ9NXE8, 15 interactors
STRINGi9606.ENSP00000225428

Structurei

3D structure databases

ProteinModelPortaliQ9NXE8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili20 – 70Sequence analysisAdd BLAST51
Coiled coili333 – 377Sequence analysisAdd BLAST45

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi144 – 190Lys-richAdd BLAST47

Sequence similaritiesi

Belongs to the CWC25 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG3869 Eukaryota
ENOG410XSTA LUCA
GeneTreeiENSGT00440000039055
HOGENOMiHOG000006950
HOVERGENiHBG061012
InParanoidiQ9NXE8
OMAiEKLEWMY
OrthoDBiEOG091G0Z7J
PhylomeDBiQ9NXE8
TreeFamiTF320801

Family and domain databases

InterProiView protein in InterPro
IPR019339 CIR_N_dom
IPR022209 CWC25
PfamiView protein in Pfam
PF10197 Cir_N, 1 hit
PF12542 CWC25, 1 hit
SMARTiView protein in SMART
SM01083 Cir_N, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9NXE8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGGGDLNLKK SWHPQTLRNV EKVWKAEQKH EAERKKIEEL QRELREERAR
60 70 80 90 100
EEMQRYAEDV GAVKKKEEKL DWMYQGPGGM VNRDEYLLGR PIDKYVFEKM
110 120 130 140 150
EEKEAGCSSE TGLLPGSIFA PSGANSLLDM ASKIREDPLF IIRKKEEEKK
160 170 180 190 200
REVLNNPVKM KKIKELLQMS LEKKEKKKKK EKKKKHKKHK HRSSSSDRSS
210 220 230 240 250
SEDEHSAGRS QKKMANSSPV LSKVPGYGLQ VRNSDRNQGL QGPLTAEQKR
260 270 280 290 300
GHGMKNHSRS RSSSHSPPRH ASKKSTREAG SRDRRSRSLG RRSRSPRPSK
310 320 330 340 350
LHNSKVNRRE TGQTRSPSPK KEVYQRRHAP GYTRKLSAEE LERKRQEMME
360 370 380 390 400
NAKWREEERL NILKRHAKDE EREQRLEKLD SRDGKFIHRM KLESASTSSL
410 420
EDRVKRNIYS LQRTSVALEK NFMKR
Length:425
Mass (Da):49,647
Last modified:October 1, 2000 - v1
Checksum:iF8288E143A3FF764
GO
Isoform 2 (identifier: Q9NXE8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-347: Missing.

Show »
Length:78
Mass (Da):9,522
Checksum:iAF7DB596F46C98C4
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0257971 – 347Missing in isoform 2. 1 PublicationAdd BLAST347

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK000298 mRNA Translation: BAA91065.1
CR749362 mRNA Translation: CAH18215.1
BC003085 mRNA Translation: AAH03085.1 Different termination.
BC008833 mRNA Translation: AAH08833.1
CCDSiCCDS45663.1 [Q9NXE8-1]
RefSeqiNP_060218.1, NM_017748.4 [Q9NXE8-1]
UniGeneiHs.406223

Genome annotation databases

EnsembliENST00000614790; ENSP00000478070; ENSG00000273559 [Q9NXE8-1]
ENST00000614868; ENSP00000477799; ENSG00000276761 [Q9NXE8-1]
GeneIDi54883
KEGGihsa:54883
UCSCiuc002hqu.5 human [Q9NXE8-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiCWC25_HUMAN
AccessioniPrimary (citable) accession number: Q9NXE8
Secondary accession number(s): A0JLM3, Q68DK5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: October 1, 2000
Last modified: March 28, 2018
This is version 112 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health