Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Glucose-fructose oxidoreductase domain-containing protein 1

Gene

GFOD1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-fructose oxidoreductase domain-containing protein 1 (EC:1.-.-.-)
Gene namesi
Name:GFOD1
Synonyms:C6orf114
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:21096. GFOD1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA128394667.
PA134917499.

Polymorphism and mutation databases

BioMutaiGFOD1.
DMDMi74753042.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121Sequence analysisAdd
BLAST
Chaini22 – 390369Glucose-fructose oxidoreductase domain-containing protein 1PRO_0000282968Add
BLAST

Proteomic databases

EPDiQ9NXC2.
MaxQBiQ9NXC2.
PaxDbiQ9NXC2.
PeptideAtlasiQ9NXC2.
PRIDEiQ9NXC2.

PTM databases

iPTMnetiQ9NXC2.
PhosphoSiteiQ9NXC2.

Expressioni

Gene expression databases

BgeeiENSG00000145990.
CleanExiHS_C6orf114.
HS_GFOD1.
ExpressionAtlasiQ9NXC2. baseline and differential.
GenevisibleiQ9NXC2. HS.

Organism-specific databases

HPAiHPA029096.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
FAM9BQ8IZU03EBI-8799578,EBI-10175124
KRT31Q153233EBI-8799578,EBI-948001
KRT40Q6A1623EBI-8799578,EBI-10171697
KRTAP10-8P604103EBI-8799578,EBI-10171774
MAGEA6P433603EBI-8799578,EBI-1045155
NOTCH2NLQ7Z3S93EBI-8799578,EBI-945833

Protein-protein interaction databases

BioGridi119954. 41 interactions.
IntActiQ9NXC2. 7 interactions.
STRINGi9606.ENSP00000368589.

Structurei

3D structure databases

ProteinModelPortaliQ9NXC2.
SMRiQ9NXC2. Positions 5-258.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Gfo/Idh/MocA family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG2742. Eukaryota.
COG0673. LUCA.
GeneTreeiENSGT00390000001507.
HOGENOMiHOG000010274.
HOVERGENiHBG054911.
InParanoidiQ9NXC2.
OMAiLLVCEVQ.
OrthoDBiEOG091G0FOZ.
PhylomeDBiQ9NXC2.
TreeFamiTF323246.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR016040. NAD(P)-bd_dom.
IPR000683. Oxidoreductase_N.
IPR004104. OxRdtase_C.
[Graphical view]
PfamiPF01408. GFO_IDH_MocA. 1 hit.
PF02894. GFO_IDH_MocA_C. 1 hit.
[Graphical view]
SUPFAMiSSF51735. SSF51735. 1 hit.

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9NXC2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLPGVGVFGT SLTARVIIPL LKDEGFAVKA LWGRTQEEAE ELAKEMSVPF
60 70 80 90 100
YTSRIDEVLL HQDVDLVCIN LPPPLTRQIA VKTLGIGKNV ICDRTATPLD
110 120 130 140 150
AFRMTSAAHY YPKLMSIMGN VLRFLPAFVR MKQLIEEGYV GEPLVCEVQV
160 170 180 190 200
HGGSLLGKKY NWSCDDLMGG GGLHSVGTYI IDLLTFLTGQ KAVKVHGLLK
210 220 230 240 250
TFVKQTDHIK GIRQITSDDF CTFQMVLEGG VCCTVTLNFN VPGEFKQDVT
260 270 280 290 300
VVGSAGRLLA VGTDLYGQRN SAPEQELLVQ DATPVSNSLL PEKAFSDIPS
310 320 330 340 350
PYLRGTIKMM QAVRQAFQDQ DDRRTWDGRP LTMAATFDDC LYALCVVDTI
360 370 380 390
KRSSQTGEWQ NIAIMTEEPE LSPAYLISEA MRRSRMSLYC
Length:390
Mass (Da):43,158
Last modified:October 1, 2000 - v1
Checksum:i59C3FA2D6D837C8A
GO
Isoform 2 (identifier: Q9NXC2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-103: Missing.

Note: No experimental confirmation available.
Show »
Length:287
Mass (Da):31,857
Checksum:i5F6D60830CBDE567
GO
Isoform 3 (identifier: Q9NXC2-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-390: MLPGVGVFGT...MRRSRMSLYC → MGDSRRDVLH...LTMCQIWCET

Note: No experimental confirmation available. Dubious isoform.
Show »
Length:136
Mass (Da):15,988
Checksum:iA2157A9F55BA144C
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Isoform 3 (identifier: Q9NXC2-3)
Natural varianti134 – 1341C → S.
Corresponds to variant rs766773 [ dbSNP | Ensembl ].

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 390390MLPGV…MSLYC → MGDSRRDVLHEPAIALLSSP QTQSRLQIDAFIARRCWGSQ WDITGYIHQQDFPTAVFIGF SNEFNICIPHPFTEWLQCVR KYSQSWGVRKGQRHIRYGMC SERTHHLSRTYSSLLEREEK LAFYGVLTMCQIWCET in isoform 3. 2 PublicationsVSP_041468Add
BLAST
Alternative sequencei1 – 103103Missing in isoform 2. 1 PublicationVSP_024261Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK000337 mRNA. Translation: BAA91093.1.
AF264036 mRNA. Translation: AAK58533.1.
AK027010 mRNA. Translation: BAB15624.1.
AL583828, AL589984 Genomic DNA. Translation: CAI14822.1.
AL589984, AL583828 Genomic DNA. Translation: CAI21577.1.
AL589984 Genomic DNA. Translation: CAI21578.1.
AL583828 Genomic DNA. Translation: CAI14821.1.
CH471087 Genomic DNA. Translation: EAW55331.1.
BC066553 mRNA. Translation: AAH66553.1.
BC119005 mRNA. Translation: AAI19006.1.
BC124557 mRNA. Translation: AAI24558.1.
BC148295 mRNA. Translation: AAI48296.1.
CCDSiCCDS4524.1. [Q9NXC2-1]
CCDS56397.1. [Q9NXC2-2]
RefSeqiNP_001229557.1. NM_001242628.1. [Q9NXC2-2]
NP_001229558.1. NM_001242629.1.
NP_001229559.1. NM_001242630.1. [Q9NXC2-2]
NP_061861.1. NM_018988.3. [Q9NXC2-1]
XP_011513001.1. XM_011514699.2. [Q9NXC2-2]
UniGeneiHs.484686.
Hs.593631.

Genome annotation databases

EnsembliENST00000379284; ENSP00000368586; ENSG00000145990. [Q9NXC2-2]
ENST00000379287; ENSP00000368589; ENSG00000145990. [Q9NXC2-1]
ENST00000612338; ENSP00000479493; ENSG00000145990. [Q9NXC2-2]
GeneIDi54438.
KEGGihsa:54438.
UCSCiuc003nar.4. human. [Q9NXC2-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK000337 mRNA. Translation: BAA91093.1.
AF264036 mRNA. Translation: AAK58533.1.
AK027010 mRNA. Translation: BAB15624.1.
AL583828, AL589984 Genomic DNA. Translation: CAI14822.1.
AL589984, AL583828 Genomic DNA. Translation: CAI21577.1.
AL589984 Genomic DNA. Translation: CAI21578.1.
AL583828 Genomic DNA. Translation: CAI14821.1.
CH471087 Genomic DNA. Translation: EAW55331.1.
BC066553 mRNA. Translation: AAH66553.1.
BC119005 mRNA. Translation: AAI19006.1.
BC124557 mRNA. Translation: AAI24558.1.
BC148295 mRNA. Translation: AAI48296.1.
CCDSiCCDS4524.1. [Q9NXC2-1]
CCDS56397.1. [Q9NXC2-2]
RefSeqiNP_001229557.1. NM_001242628.1. [Q9NXC2-2]
NP_001229558.1. NM_001242629.1.
NP_001229559.1. NM_001242630.1. [Q9NXC2-2]
NP_061861.1. NM_018988.3. [Q9NXC2-1]
XP_011513001.1. XM_011514699.2. [Q9NXC2-2]
UniGeneiHs.484686.
Hs.593631.

3D structure databases

ProteinModelPortaliQ9NXC2.
SMRiQ9NXC2. Positions 5-258.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119954. 41 interactions.
IntActiQ9NXC2. 7 interactions.
STRINGi9606.ENSP00000368589.

PTM databases

iPTMnetiQ9NXC2.
PhosphoSiteiQ9NXC2.

Polymorphism and mutation databases

BioMutaiGFOD1.
DMDMi74753042.

Proteomic databases

EPDiQ9NXC2.
MaxQBiQ9NXC2.
PaxDbiQ9NXC2.
PeptideAtlasiQ9NXC2.
PRIDEiQ9NXC2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000379284; ENSP00000368586; ENSG00000145990. [Q9NXC2-2]
ENST00000379287; ENSP00000368589; ENSG00000145990. [Q9NXC2-1]
ENST00000612338; ENSP00000479493; ENSG00000145990. [Q9NXC2-2]
GeneIDi54438.
KEGGihsa:54438.
UCSCiuc003nar.4. human. [Q9NXC2-1]

Organism-specific databases

CTDi54438.
GeneCardsiGFOD1.
HGNCiHGNC:21096. GFOD1.
HPAiHPA029096.
neXtProtiNX_Q9NXC2.
PharmGKBiPA128394667.
PA134917499.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2742. Eukaryota.
COG0673. LUCA.
GeneTreeiENSGT00390000001507.
HOGENOMiHOG000010274.
HOVERGENiHBG054911.
InParanoidiQ9NXC2.
OMAiLLVCEVQ.
OrthoDBiEOG091G0FOZ.
PhylomeDBiQ9NXC2.
TreeFamiTF323246.

Miscellaneous databases

GenomeRNAii54438.
PROiQ9NXC2.

Gene expression databases

BgeeiENSG00000145990.
CleanExiHS_C6orf114.
HS_GFOD1.
ExpressionAtlasiQ9NXC2. baseline and differential.
GenevisibleiQ9NXC2. HS.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR016040. NAD(P)-bd_dom.
IPR000683. Oxidoreductase_N.
IPR004104. OxRdtase_C.
[Graphical view]
PfamiPF01408. GFO_IDH_MocA. 1 hit.
PF02894. GFO_IDH_MocA_C. 1 hit.
[Graphical view]
SUPFAMiSSF51735. SSF51735. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiGFOD1_HUMAN
AccessioniPrimary (citable) accession number: Q9NXC2
Secondary accession number(s): A8E4L6
, Q5T058, Q96JD4, Q9H5K2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: October 1, 2000
Last modified: September 7, 2016
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.