ID   SYBU_HUMAN              Reviewed;         663 AA.
AC   Q9NX95; A8K354; B3KQX3; B3KU61; Q5R1T1; Q5R1T2; Q5R1T3; Q5Y2M6; Q8ND49;
AC   Q8TCR6; Q96D80; Q9P256;
DT   21-FEB-2001, integrated into UniProtKB/Swiss-Prot.
DT   11-JUL-2006, sequence version 2.
DT   27-MAR-2024, entry version 160.
DE   RecName: Full=Syntabulin;
DE   AltName: Full=Golgi-localized syntaphilin-related protein;
DE   AltName: Full=Syntaxin-1-binding protein;
GN   Name=SYBU; Synonyms=GOLSYN, KIAA1472;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, INTERACTION WITH KIF5B
RP   AND STX1A, AND SUBCELLULAR LOCATION.
RC   TISSUE=Brain;
RX   PubMed=15459722; DOI=10.1038/ncb1169;
RA   Su Q., Cai Q., Gerwin C., Smith C.L., Sheng Z.-H.;
RT   "Syntabulin is a microtubule-associated protein implicated in syntaxin
RT   transport in neurons.";
RL   Nat. Cell Biol. 6:941-953(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 3; 4 AND 5), SUBCELLULAR LOCATION, AND
RP   TISSUE SPECIFICITY.
RC   TISSUE=Fetal brain;
RX   PubMed=15656992; DOI=10.1016/j.gene.2004.10.024;
RA   Funakoshi E., Nakagawa K.-Y., Hamano A., Hori T., Shimizu A., Asakawa S.,
RA   Shimizu N., Ito F.;
RT   "Molecular cloning and characterization of gene for Golgi-localized
RT   syntaphilin-related protein on human chromosome 8q23.";
RL   Gene 344:259-271(2005).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 5).
RC   TISSUE=Fetal brain, and Hepatoma;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA   Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA   Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA   Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA   Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA   Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA   Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA   Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA   Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA   Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA   Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA   Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND NUCLEOTIDE SEQUENCE
RP   [LARGE SCALE MRNA] OF 191-663.
RC   TISSUE=Amygdala, and Brain;
RX   PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA   Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA   Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA   Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA   Wiemann S., Schupp I.;
RT   "The full-ORF clone resource of the German cDNA consortium.";
RL   BMC Genomics 8:399-399(2007).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA   Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA   Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA   Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA   Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA   Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA   Hunkapiller M.W., Myers E.W., Venter J.C.;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN   [6]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 5).
RC   TISSUE=Colon;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [7]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 63-663.
RC   TISSUE=Brain;
RX   PubMed=10819331; DOI=10.1093/dnares/7.2.143;
RA   Nagase T., Kikuno R., Ishikawa K., Hirosawa M., Ohara O.;
RT   "Prediction of the coding sequences of unidentified human genes. XVII. The
RT   complete sequences of 100 new cDNA clones from brain which code for large
RT   proteins in vitro.";
RL   DNA Res. 7:143-150(2000).
RN   [8]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-50, AND IDENTIFICATION BY
RP   MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Cervix carcinoma;
RX   PubMed=23186163; DOI=10.1021/pr300630k;
RA   Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA   Mohammed S.;
RT   "Toward a comprehensive characterization of a human cancer cell
RT   phosphoproteome.";
RL   J. Proteome Res. 12:260-271(2013).
RN   [9]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-396, AND IDENTIFICATION BY
RP   MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Liver;
RX   PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014;
RA   Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L.,
RA   Ye M., Zou H.;
RT   "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver
RT   phosphoproteome.";
RL   J. Proteomics 96:253-262(2014).
CC   -!- FUNCTION: Part of a kinesin motor-adapter complex that is critical for
CC       the anterograde axonal transport of active zone components and
CC       contributes to activity-dependent presynaptic assembly during neuronal
CC       development. {ECO:0000250, ECO:0000269|PubMed:15459722}.
CC   -!- SUBUNIT: Interacts with STX1A and KIF5B. {ECO:0000269|PubMed:15459722}.
CC   -!- INTERACTION:
CC       Q9NX95; P54253: ATXN1; NbExp=3; IntAct=EBI-948293, EBI-930964;
CC       Q9NX95-5; O15145: ARPC3; NbExp=3; IntAct=EBI-12816095, EBI-351829;
CC       Q9NX95-5; P54253: ATXN1; NbExp=6; IntAct=EBI-12816095, EBI-930964;
CC       Q9NX95-5; Q7Z460-2: CLASP1; NbExp=3; IntAct=EBI-12816095, EBI-10967515;
CC   -!- SUBCELLULAR LOCATION: [Isoform 1]: Cytoplasm, cytoskeleton. Cytoplasmic
CC       vesicle. Note=Colocalizes with syntaxin vesicles along microtubules in
CC       neuronal processes.
CC   -!- SUBCELLULAR LOCATION: [Isoform 3]: Golgi apparatus membrane; Single-
CC       pass membrane protein.
CC   -!- SUBCELLULAR LOCATION: [Isoform 4]: Golgi apparatus membrane; Single-
CC       pass membrane protein.
CC   -!- SUBCELLULAR LOCATION: [Isoform 5]: Golgi apparatus membrane; Single-
CC       pass membrane protein.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=5;
CC       Name=1;
CC         IsoId=Q9NX95-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q9NX95-2; Sequence=VSP_019719, VSP_019722;
CC       Name=3; Synonyms=GOLSYN A;
CC         IsoId=Q9NX95-3; Sequence=VSP_019721;
CC       Name=4; Synonyms=GOLSYN C;
CC         IsoId=Q9NX95-4; Sequence=VSP_019720;
CC       Name=5; Synonyms=GOLSYN B;
CC         IsoId=Q9NX95-5; Sequence=VSP_019718;
CC   -!- TISSUE SPECIFICITY: Isoform 3, isoform 4 and isoform 5 are expressed in
CC       HeLa cell line (at protein level). Isoform 3 is expressed in fetal and
CC       adult brain. Isoform 4 is expressed in numerous fetal tissues (brain,
CC       kidney, liver, lung, and thymus) and in adult brain, kidney, liver,
CC       lung, pancreas, colon, prostate, small intestine, testis and thymus.
CC       Isoform 5 is expressed in fetal brain, brain and small intestine.
CC       {ECO:0000269|PubMed:15656992}.
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DR   EMBL; AY705385; AAU93914.1; -; mRNA.
DR   EMBL; AB195676; BAD72976.1; -; mRNA.
DR   EMBL; AB195677; BAD72977.1; -; mRNA.
DR   EMBL; AB195678; BAD72978.1; -; mRNA.
DR   EMBL; AB195679; BAD72979.1; -; mRNA.
DR   EMBL; AK000373; BAA91121.1; -; mRNA.
DR   EMBL; AK090559; BAG52185.1; -; mRNA.
DR   EMBL; AK096558; BAG53323.1; -; mRNA.
DR   EMBL; AK290469; BAF83158.1; -; mRNA.
DR   EMBL; AL713645; CAD28457.2; -; mRNA.
DR   EMBL; AL834406; CAD39068.1; -; mRNA.
DR   EMBL; CH471060; EAW91937.1; -; Genomic_DNA.
DR   EMBL; BC012082; AAH12082.2; -; mRNA.
DR   EMBL; AB040905; BAA95996.1; -; mRNA.
DR   CCDS; CCDS43763.1; -. [Q9NX95-3]
DR   CCDS; CCDS43764.1; -. [Q9NX95-4]
DR   CCDS; CCDS47912.1; -. [Q9NX95-1]
DR   CCDS; CCDS55271.1; -. [Q9NX95-5]
DR   RefSeq; NP_001093213.1; NM_001099743.1. [Q9NX95-3]
DR   RefSeq; NP_001093214.1; NM_001099744.1. [Q9NX95-1]
DR   RefSeq; NP_001093215.1; NM_001099745.1. [Q9NX95-1]
DR   RefSeq; NP_001093216.1; NM_001099746.1. [Q9NX95-5]
DR   RefSeq; NP_001093217.1; NM_001099747.1. [Q9NX95-3]
DR   RefSeq; NP_001093218.1; NM_001099748.1. [Q9NX95-1]
DR   RefSeq; NP_001093219.1; NM_001099749.1. [Q9NX95-5]
DR   RefSeq; NP_001093220.1; NM_001099750.1. [Q9NX95-1]
DR   RefSeq; NP_001093221.1; NM_001099751.1. [Q9NX95-3]
DR   RefSeq; NP_001093222.1; NM_001099752.1. [Q9NX95-1]
DR   RefSeq; NP_001093223.1; NM_001099753.1. [Q9NX95-3]
DR   RefSeq; NP_001093224.1; NM_001099754.1. [Q9NX95-1]
DR   RefSeq; NP_001093225.1; NM_001099755.1. [Q9NX95-5]
DR   RefSeq; NP_001093226.1; NM_001099756.1. [Q9NX95-4]
DR   RefSeq; NP_001317525.1; NM_001330596.1.
DR   RefSeq; NP_060256.3; NM_017786.5. [Q9NX95-3]
DR   RefSeq; XP_016869103.1; XM_017013614.1.
DR   RefSeq; XP_016869104.1; XM_017013615.1.
DR   AlphaFoldDB; Q9NX95; -.
DR   SMR; Q9NX95; -.
DR   BioGRID; 120776; 31.
DR   IntAct; Q9NX95; 22.
DR   MINT; Q9NX95; -.
DR   STRING; 9606.ENSP00000407118; -.
DR   GlyGen; Q9NX95; 1 site, 1 O-linked glycan (1 site).
DR   iPTMnet; Q9NX95; -.
DR   PhosphoSitePlus; Q9NX95; -.
DR   BioMuta; SYBU; -.
DR   DMDM; 110283010; -.
DR   EPD; Q9NX95; -.
DR   jPOST; Q9NX95; -.
DR   MassIVE; Q9NX95; -.
DR   MaxQB; Q9NX95; -.
DR   PaxDb; 9606-ENSP00000407118; -.
DR   PeptideAtlas; Q9NX95; -.
DR   ProteomicsDB; 83059; -. [Q9NX95-1]
DR   ProteomicsDB; 83060; -. [Q9NX95-2]
DR   ProteomicsDB; 83061; -. [Q9NX95-3]
DR   ProteomicsDB; 83062; -. [Q9NX95-4]
DR   ProteomicsDB; 83063; -. [Q9NX95-5]
DR   Antibodypedia; 42935; 26 antibodies from 14 providers.
DR   DNASU; 55638; -.
DR   Ensembl; ENST00000276646.14; ENSP00000276646.9; ENSG00000147642.17. [Q9NX95-1]
DR   Ensembl; ENST00000399066.7; ENSP00000382019.3; ENSG00000147642.17. [Q9NX95-4]
DR   Ensembl; ENST00000408889.7; ENSP00000386196.3; ENSG00000147642.17. [Q9NX95-5]
DR   Ensembl; ENST00000408908.6; ENSP00000386154.2; ENSG00000147642.17. [Q9NX95-1]
DR   Ensembl; ENST00000422135.5; ENSP00000407118.1; ENSG00000147642.17. [Q9NX95-1]
DR   Ensembl; ENST00000433638.1; ENSP00000403544.1; ENSG00000147642.17. [Q9NX95-1]
DR   Ensembl; ENST00000440310.5; ENSP00000404369.1; ENSG00000147642.17. [Q9NX95-1]
DR   Ensembl; ENST00000446070.6; ENSP00000414748.2; ENSG00000147642.17. [Q9NX95-3]
DR   Ensembl; ENST00000528331.5; ENSP00000436041.1; ENSG00000147642.17. [Q9NX95-5]
DR   Ensembl; ENST00000528647.5; ENSP00000432501.1; ENSG00000147642.17. [Q9NX95-3]
DR   Ensembl; ENST00000532779.5; ENSP00000436266.1; ENSG00000147642.17. [Q9NX95-2]
DR   Ensembl; ENST00000533065.5; ENSP00000432962.1; ENSG00000147642.17. [Q9NX95-5]
DR   Ensembl; ENST00000533171.5; ENSP00000434679.1; ENSG00000147642.17. [Q9NX95-1]
DR   Ensembl; ENST00000533895.5; ENSP00000433446.1; ENSG00000147642.17. [Q9NX95-3]
DR   GeneID; 55638; -.
DR   KEGG; hsa:55638; -.
DR   MANE-Select; ENST00000276646.14; ENSP00000276646.9; NM_001099754.2; NP_001093224.1.
DR   UCSC; uc003yni.5; human. [Q9NX95-1]
DR   AGR; HGNC:26011; -.
DR   CTD; 55638; -.
DR   DisGeNET; 55638; -.
DR   GeneCards; SYBU; -.
DR   HGNC; HGNC:26011; SYBU.
DR   HPA; ENSG00000147642; Tissue enhanced (brain, pancreas).
DR   MIM; 611568; gene.
DR   neXtProt; NX_Q9NX95; -.
DR   OpenTargets; ENSG00000147642; -.
DR   PharmGKB; PA165586000; -.
DR   VEuPathDB; HostDB:ENSG00000147642; -.
DR   eggNOG; ENOG502QQZ1; Eukaryota.
DR   GeneTree; ENSGT00520000055634; -.
DR   HOGENOM; CLU_019458_0_0_1; -.
DR   InParanoid; Q9NX95; -.
DR   OMA; EHSKRTI; -.
DR   OrthoDB; 4211662at2759; -.
DR   PhylomeDB; Q9NX95; -.
DR   TreeFam; TF332407; -.
DR   PathwayCommons; Q9NX95; -.
DR   SignaLink; Q9NX95; -.
DR   SIGNOR; Q9NX95; -.
DR   BioGRID-ORCS; 55638; 25 hits in 1159 CRISPR screens.
DR   ChiTaRS; SYBU; human.
DR   GeneWiki; GOLSYN; -.
DR   GenomeRNAi; 55638; -.
DR   Pharos; Q9NX95; Tbio.
DR   PRO; PR:Q9NX95; -.
DR   Proteomes; UP000005640; Chromosome 8.
DR   RNAct; Q9NX95; Protein.
DR   Bgee; ENSG00000147642; Expressed in cerebellar vermis and 179 other cell types or tissues.
DR   ExpressionAtlas; Q9NX95; baseline and differential.
DR   GO; GO:1904115; C:axon cytoplasm; IEA:GOC.
DR   GO; GO:0005881; C:cytoplasmic microtubule; IBA:GO_Central.
DR   GO; GO:0031410; C:cytoplasmic vesicle; IEA:UniProtKB-KW.
DR   GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0043231; C:intracellular membrane-bounded organelle; IDA:HPA.
DR   GO; GO:1990048; P:anterograde neuronal dense core vesicle transport; IEA:Ensembl.
DR   GO; GO:0019896; P:axonal transport of mitochondrion; IBA:GO_Central.
DR   GO; GO:0035774; P:positive regulation of insulin secretion involved in cellular response to glucose stimulus; IEA:Ensembl.
DR   GO; GO:0060025; P:regulation of synaptic activity; IEA:Ensembl.
DR   GO; GO:0060074; P:synapse maturation; IBA:GO_Central.
DR   InterPro; IPR028197; Syntaphilin/Syntabulin.
DR   PANTHER; PTHR16208; MICROTUBULE-ASSOCIATED PROTEIN/SYNTAPHILIN; 1.
DR   PANTHER; PTHR16208:SF4; SYNTABULIN; 1.
DR   Pfam; PF15290; Syntaphilin; 1.
DR   Genevisible; Q9NX95; HS.
PE   1: Evidence at protein level;
KW   Alternative splicing; Coiled coil; Cytoplasm; Cytoplasmic vesicle;
KW   Cytoskeleton; Golgi apparatus; Membrane; Phosphoprotein;
KW   Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..663
FT                   /note="Syntabulin"
FT                   /id="PRO_0000050798"
FT   TRANSMEM        606..626
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          1..202
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          2..417
FT                   /note="Sufficient for interaction with KIF5B"
FT                   /evidence="ECO:0000269|PubMed:15459722"
FT   REGION          216..267
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          310..417
FT                   /note="Sufficient for interaction with STX1A"
FT                   /evidence="ECO:0000269|PubMed:15459722"
FT   COILED          271..353
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        1..26
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        38..95
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        144..201
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        216..238
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         50
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0007744|PubMed:23186163"
FT   MOD_RES         107
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q8BHS8"
FT   MOD_RES         396
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0007744|PubMed:24275569"
FT   MOD_RES         555
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q8BHS8"
FT   VAR_SEQ         1..119
FT                   /note="Missing (in isoform 5)"
FT                   /evidence="ECO:0000303|PubMed:14702039,
FT                   ECO:0000303|PubMed:15489334, ECO:0000303|PubMed:15656992"
FT                   /id="VSP_019718"
FT   VAR_SEQ         1..68
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:14702039"
FT                   /id="VSP_019719"
FT   VAR_SEQ         1..8
FT                   /note="MGPLRESK -> MSNFE (in isoform 4)"
FT                   /evidence="ECO:0000303|PubMed:15656992"
FT                   /id="VSP_019720"
FT   VAR_SEQ         8
FT                   /note="Missing (in isoform 3)"
FT                   /evidence="ECO:0000303|PubMed:15656992"
FT                   /id="VSP_019721"
FT   VAR_SEQ         69..76
FT                   /note="VSSNSFCS -> MGPFWARK (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:14702039"
FT                   /id="VSP_019722"
FT   CONFLICT        8
FT                   /note="K -> KMSNFE (in Ref. 4; CAD28457)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        331
FT                   /note="R -> G (in Ref. 3; BAG53323)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        440
FT                   /note="D -> G (in Ref. 3; BAA91121)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   663 AA;  72388 MW;  41521DBD4AAE733B CRC64;
     MGPLRESKKE HRVQHHDKEI SRSRIPRLIL RPHMPQQQHK VSPASESPFS EEESREFNPS
     SSGRSARTVS SNSFCSDDTG CPSSQSVSPV KTPSDAGNSP IGFCPGSDEG FTRKKCTIGM
     VGEGSIQSSR YKKESKSGLV KPGSEADFSS SSSTGSISAP EVHMSTAGSK RSSSSRNRGP
     HGRSNGASSH KPGSSPSSPR EKDLLSMLCR NQLSPVNIHP SYAPSSPSSS NSGSYKGSDC
     SPIMRRSGRY MSCGENHGVR PPNPEQYLTP LQQKEVTVRH LKTKLKESER RLHERESEIV
     ELKSQLARMR EDWIEEECHR VEAQLALKEA RKEIKQLKQV IETMRSSLAD KDKGIQKYFV
     DINIQNKKLE SLLQSMEMAH SGSLRDELCL DFPCDSPEKS LTLNPPLDTM ADGLSLEEQV
     TGEGADRELL VGDSIANSTD LFDEIVTATT TESGDLELVH STPGANVLEL LPIVMGQEEG
     SVVVERAVQT DVVPYSPAIS ELIQSVLQKL QDPCPSSLAS PDESEPDSME SFPESLSALV
     VDLTPRNPNS AILLSPVETP YANVDAEVHA NRLMRELDFA ACVEERLDGV IPLARGGVVR
     QYWSSSFLVD LLAVAAPVVP TVLWAFSTQR GGTDPVYNIG ALLRGCCVVA LHSLRRTAFR
     IKT
//