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Protein

Syntabulin

Gene

SYBU

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Part of a kinesin motor-adapter complex that is critical for the anterograde axonal transport of active zone components and contributes to activity-dependent presynaptic assembly during neuronal development.By similarity1 Publication

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:ENSG00000147642-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Syntabulin
Alternative name(s):
Golgi-localized syntaphilin-related protein
Syntaxin-1-binding protein
Gene namesi
Name:SYBU
Synonyms:GOLSYN, KIAA1472
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

HGNCiHGNC:26011. SYBU.

Subcellular locationi

Isoform 1 :

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei606 – 626HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoplasmic vesicle, Cytoskeleton, Golgi apparatus, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi55638.
OpenTargetsiENSG00000147642.
PharmGKBiPA165586000.

Polymorphism and mutation databases

BioMutaiSYBU.
DMDMi110283010.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000507981 – 663SyntabulinAdd BLAST663

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei50PhosphoserineCombined sources1
Modified residuei107PhosphoserineBy similarity1
Modified residuei396PhosphoserineCombined sources1
Modified residuei555PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9NX95.
MaxQBiQ9NX95.
PaxDbiQ9NX95.
PeptideAtlasiQ9NX95.
PRIDEiQ9NX95.

PTM databases

iPTMnetiQ9NX95.
PhosphoSitePlusiQ9NX95.

Expressioni

Tissue specificityi

Isoform 3, isoform 4 and isoform 5 are expressed in HeLa cell line (at protein level). Isoform 3 is expressed in fetal and adult brain. Isoform 4 is expressed in numerous fetal tissues (brain, kidney, liver, lung, and thymus) and in adult brain, kidney, liver, lung, pancreas, colon, prostate, small intestine, testis and thymus. Isoform 5 is expressed in fetal brain, brain and small intestine.1 Publication

Gene expression databases

BgeeiENSG00000147642.
ExpressionAtlasiQ9NX95. baseline and differential.
GenevisibleiQ9NX95. HS.

Organism-specific databases

HPAiHPA053057.

Interactioni

Subunit structurei

Interacts with STX1A and KIF5B.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
ATXN1P542533EBI-948293,EBI-930964

Protein-protein interaction databases

BioGridi120776. 19 interactors.
IntActiQ9NX95. 7 interactors.
MINTiMINT-1432603.
STRINGi9606.ENSP00000276646.

Structurei

3D structure databases

ProteinModelPortaliQ9NX95.
SMRiQ9NX95.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni2 – 417Sufficient for interaction with KIF5B1 PublicationAdd BLAST416
Regioni310 – 417Sufficient for interaction with STX1A1 PublicationAdd BLAST108

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili271 – 353Sequence analysisAdd BLAST83

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi42 – 241Ser-richAdd BLAST200

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IGP3. Eukaryota.
ENOG410XQEB. LUCA.
GeneTreeiENSGT00520000055634.
HOVERGENiHBG006785.
InParanoidiQ9NX95.
PhylomeDBiQ9NX95.
TreeFamiTF332407.

Family and domain databases

InterProiIPR026198. Syntabulin.
IPR028197. Syntaphilin/Syntabulin.
[Graphical view]
PANTHERiPTHR16208. PTHR16208. 1 hit.
PTHR16208:SF4. PTHR16208:SF4. 1 hit.
PfamiPF15290. Syntaphilin. 1 hit.
[Graphical view]

Sequences (5)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9NX95-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGPLRESKKE HRVQHHDKEI SRSRIPRLIL RPHMPQQQHK VSPASESPFS
60 70 80 90 100
EEESREFNPS SSGRSARTVS SNSFCSDDTG CPSSQSVSPV KTPSDAGNSP
110 120 130 140 150
IGFCPGSDEG FTRKKCTIGM VGEGSIQSSR YKKESKSGLV KPGSEADFSS
160 170 180 190 200
SSSTGSISAP EVHMSTAGSK RSSSSRNRGP HGRSNGASSH KPGSSPSSPR
210 220 230 240 250
EKDLLSMLCR NQLSPVNIHP SYAPSSPSSS NSGSYKGSDC SPIMRRSGRY
260 270 280 290 300
MSCGENHGVR PPNPEQYLTP LQQKEVTVRH LKTKLKESER RLHERESEIV
310 320 330 340 350
ELKSQLARMR EDWIEEECHR VEAQLALKEA RKEIKQLKQV IETMRSSLAD
360 370 380 390 400
KDKGIQKYFV DINIQNKKLE SLLQSMEMAH SGSLRDELCL DFPCDSPEKS
410 420 430 440 450
LTLNPPLDTM ADGLSLEEQV TGEGADRELL VGDSIANSTD LFDEIVTATT
460 470 480 490 500
TESGDLELVH STPGANVLEL LPIVMGQEEG SVVVERAVQT DVVPYSPAIS
510 520 530 540 550
ELIQSVLQKL QDPCPSSLAS PDESEPDSME SFPESLSALV VDLTPRNPNS
560 570 580 590 600
AILLSPVETP YANVDAEVHA NRLMRELDFA ACVEERLDGV IPLARGGVVR
610 620 630 640 650
QYWSSSFLVD LLAVAAPVVP TVLWAFSTQR GGTDPVYNIG ALLRGCCVVA
660
LHSLRRTAFR IKT
Length:663
Mass (Da):72,388
Last modified:July 11, 2006 - v2
Checksum:i41521DBD4AAE733B
GO
Isoform 2 (identifier: Q9NX95-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-68: Missing.
     69-76: VSSNSFCS → MGPFWARK

Show »
Length:595
Mass (Da):64,656
Checksum:i56C948ABD34736C7
GO
Isoform 3 (identifier: Q9NX95-3) [UniParc]FASTAAdd to basket
Also known as: GOLSYN A

The sequence of this isoform differs from the canonical sequence as follows:
     8-8: Missing.

Show »
Length:662
Mass (Da):72,260
Checksum:iC3699D85C7D07058
GO
Isoform 4 (identifier: Q9NX95-4) [UniParc]FASTAAdd to basket
Also known as: GOLSYN C

The sequence of this isoform differs from the canonical sequence as follows:
     1-8: MGPLRESK → MSNFE

Show »
Length:660
Mass (Da):72,098
Checksum:iB323D1F909837394
GO
Isoform 5 (identifier: Q9NX95-5) [UniParc]FASTAAdd to basket
Also known as: GOLSYN B

The sequence of this isoform differs from the canonical sequence as follows:
     1-119: Missing.

Show »
Length:544
Mass (Da):59,368
Checksum:i6FD961B15A290747
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti8K → KMSNFE in CAD28457 (PubMed:17974005).Curated1
Sequence conflicti331R → G in BAG53323 (PubMed:14702039).Curated1
Sequence conflicti440D → G in BAA91121 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0197181 – 119Missing in isoform 5. 3 PublicationsAdd BLAST119
Alternative sequenceiVSP_0197191 – 68Missing in isoform 2. 1 PublicationAdd BLAST68
Alternative sequenceiVSP_0197201 – 8MGPLRESK → MSNFE in isoform 4. 1 Publication8
Alternative sequenceiVSP_0197218Missing in isoform 3. 1 Publication1
Alternative sequenceiVSP_01972269 – 76VSSNSFCS → MGPFWARK in isoform 2. 1 Publication8

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY705385 mRNA. Translation: AAU93914.1.
AB195676 mRNA. Translation: BAD72976.1.
AB195677 mRNA. Translation: BAD72977.1.
AB195678 mRNA. Translation: BAD72978.1.
AB195679 mRNA. Translation: BAD72979.1.
AK000373 mRNA. Translation: BAA91121.1.
AK090559 mRNA. Translation: BAG52185.1.
AK096558 mRNA. Translation: BAG53323.1.
AK290469 mRNA. Translation: BAF83158.1.
AL713645 mRNA. Translation: CAD28457.2.
AL834406 mRNA. Translation: CAD39068.1.
CH471060 Genomic DNA. Translation: EAW91937.1.
BC012082 mRNA. Translation: AAH12082.2.
AB040905 mRNA. Translation: BAA95996.1.
CCDSiCCDS43763.1. [Q9NX95-3]
CCDS43764.1. [Q9NX95-4]
CCDS47912.1. [Q9NX95-1]
CCDS55271.1. [Q9NX95-5]
RefSeqiNP_001093213.1. NM_001099743.1. [Q9NX95-3]
NP_001093214.1. NM_001099744.1. [Q9NX95-1]
NP_001093215.1. NM_001099745.1. [Q9NX95-1]
NP_001093216.1. NM_001099746.1. [Q9NX95-5]
NP_001093217.1. NM_001099747.1. [Q9NX95-3]
NP_001093218.1. NM_001099748.1. [Q9NX95-1]
NP_001093219.1. NM_001099749.1. [Q9NX95-5]
NP_001093220.1. NM_001099750.1. [Q9NX95-1]
NP_001093221.1. NM_001099751.1. [Q9NX95-3]
NP_001093222.1. NM_001099752.1. [Q9NX95-1]
NP_001093223.1. NM_001099753.1. [Q9NX95-3]
NP_001093224.1. NM_001099754.1. [Q9NX95-1]
NP_001093225.1. NM_001099755.1. [Q9NX95-5]
NP_001093226.1. NM_001099756.1. [Q9NX95-4]
NP_001317525.1. NM_001330596.1.
NP_060256.3. NM_017786.5. [Q9NX95-3]
XP_016869103.1. XM_017013614.1. [Q9NX95-5]
XP_016869104.1. XM_017013615.1. [Q9NX95-5]
UniGeneiHs.390738.

Genome annotation databases

EnsembliENST00000276646; ENSP00000276646; ENSG00000147642. [Q9NX95-1]
ENST00000399066; ENSP00000382019; ENSG00000147642. [Q9NX95-4]
ENST00000408889; ENSP00000386196; ENSG00000147642. [Q9NX95-5]
ENST00000408908; ENSP00000386154; ENSG00000147642. [Q9NX95-1]
ENST00000422135; ENSP00000407118; ENSG00000147642. [Q9NX95-1]
ENST00000433638; ENSP00000403544; ENSG00000147642. [Q9NX95-1]
ENST00000440310; ENSP00000404369; ENSG00000147642. [Q9NX95-1]
ENST00000446070; ENSP00000414748; ENSG00000147642. [Q9NX95-3]
ENST00000528331; ENSP00000436041; ENSG00000147642. [Q9NX95-5]
ENST00000528647; ENSP00000432501; ENSG00000147642. [Q9NX95-3]
ENST00000532779; ENSP00000436266; ENSG00000147642. [Q9NX95-2]
ENST00000533065; ENSP00000432962; ENSG00000147642. [Q9NX95-5]
ENST00000533171; ENSP00000434679; ENSG00000147642. [Q9NX95-1]
ENST00000533895; ENSP00000433446; ENSG00000147642. [Q9NX95-3]
GeneIDi55638.
KEGGihsa:55638.
UCSCiuc003yni.5. human. [Q9NX95-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY705385 mRNA. Translation: AAU93914.1.
AB195676 mRNA. Translation: BAD72976.1.
AB195677 mRNA. Translation: BAD72977.1.
AB195678 mRNA. Translation: BAD72978.1.
AB195679 mRNA. Translation: BAD72979.1.
AK000373 mRNA. Translation: BAA91121.1.
AK090559 mRNA. Translation: BAG52185.1.
AK096558 mRNA. Translation: BAG53323.1.
AK290469 mRNA. Translation: BAF83158.1.
AL713645 mRNA. Translation: CAD28457.2.
AL834406 mRNA. Translation: CAD39068.1.
CH471060 Genomic DNA. Translation: EAW91937.1.
BC012082 mRNA. Translation: AAH12082.2.
AB040905 mRNA. Translation: BAA95996.1.
CCDSiCCDS43763.1. [Q9NX95-3]
CCDS43764.1. [Q9NX95-4]
CCDS47912.1. [Q9NX95-1]
CCDS55271.1. [Q9NX95-5]
RefSeqiNP_001093213.1. NM_001099743.1. [Q9NX95-3]
NP_001093214.1. NM_001099744.1. [Q9NX95-1]
NP_001093215.1. NM_001099745.1. [Q9NX95-1]
NP_001093216.1. NM_001099746.1. [Q9NX95-5]
NP_001093217.1. NM_001099747.1. [Q9NX95-3]
NP_001093218.1. NM_001099748.1. [Q9NX95-1]
NP_001093219.1. NM_001099749.1. [Q9NX95-5]
NP_001093220.1. NM_001099750.1. [Q9NX95-1]
NP_001093221.1. NM_001099751.1. [Q9NX95-3]
NP_001093222.1. NM_001099752.1. [Q9NX95-1]
NP_001093223.1. NM_001099753.1. [Q9NX95-3]
NP_001093224.1. NM_001099754.1. [Q9NX95-1]
NP_001093225.1. NM_001099755.1. [Q9NX95-5]
NP_001093226.1. NM_001099756.1. [Q9NX95-4]
NP_001317525.1. NM_001330596.1.
NP_060256.3. NM_017786.5. [Q9NX95-3]
XP_016869103.1. XM_017013614.1. [Q9NX95-5]
XP_016869104.1. XM_017013615.1. [Q9NX95-5]
UniGeneiHs.390738.

3D structure databases

ProteinModelPortaliQ9NX95.
SMRiQ9NX95.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120776. 19 interactors.
IntActiQ9NX95. 7 interactors.
MINTiMINT-1432603.
STRINGi9606.ENSP00000276646.

PTM databases

iPTMnetiQ9NX95.
PhosphoSitePlusiQ9NX95.

Polymorphism and mutation databases

BioMutaiSYBU.
DMDMi110283010.

Proteomic databases

EPDiQ9NX95.
MaxQBiQ9NX95.
PaxDbiQ9NX95.
PeptideAtlasiQ9NX95.
PRIDEiQ9NX95.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000276646; ENSP00000276646; ENSG00000147642. [Q9NX95-1]
ENST00000399066; ENSP00000382019; ENSG00000147642. [Q9NX95-4]
ENST00000408889; ENSP00000386196; ENSG00000147642. [Q9NX95-5]
ENST00000408908; ENSP00000386154; ENSG00000147642. [Q9NX95-1]
ENST00000422135; ENSP00000407118; ENSG00000147642. [Q9NX95-1]
ENST00000433638; ENSP00000403544; ENSG00000147642. [Q9NX95-1]
ENST00000440310; ENSP00000404369; ENSG00000147642. [Q9NX95-1]
ENST00000446070; ENSP00000414748; ENSG00000147642. [Q9NX95-3]
ENST00000528331; ENSP00000436041; ENSG00000147642. [Q9NX95-5]
ENST00000528647; ENSP00000432501; ENSG00000147642. [Q9NX95-3]
ENST00000532779; ENSP00000436266; ENSG00000147642. [Q9NX95-2]
ENST00000533065; ENSP00000432962; ENSG00000147642. [Q9NX95-5]
ENST00000533171; ENSP00000434679; ENSG00000147642. [Q9NX95-1]
ENST00000533895; ENSP00000433446; ENSG00000147642. [Q9NX95-3]
GeneIDi55638.
KEGGihsa:55638.
UCSCiuc003yni.5. human. [Q9NX95-1]

Organism-specific databases

CTDi55638.
DisGeNETi55638.
GeneCardsiSYBU.
HGNCiHGNC:26011. SYBU.
HPAiHPA053057.
MIMi611568. gene.
neXtProtiNX_Q9NX95.
OpenTargetsiENSG00000147642.
PharmGKBiPA165586000.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IGP3. Eukaryota.
ENOG410XQEB. LUCA.
GeneTreeiENSGT00520000055634.
HOVERGENiHBG006785.
InParanoidiQ9NX95.
PhylomeDBiQ9NX95.
TreeFamiTF332407.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000147642-MONOMER.

Miscellaneous databases

ChiTaRSiSYBU. human.
GeneWikiiGOLSYN.
GenomeRNAii55638.
PROiQ9NX95.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000147642.
ExpressionAtlasiQ9NX95. baseline and differential.
GenevisibleiQ9NX95. HS.

Family and domain databases

InterProiIPR026198. Syntabulin.
IPR028197. Syntaphilin/Syntabulin.
[Graphical view]
PANTHERiPTHR16208. PTHR16208. 1 hit.
PTHR16208:SF4. PTHR16208:SF4. 1 hit.
PfamiPF15290. Syntaphilin. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSYBU_HUMAN
AccessioniPrimary (citable) accession number: Q9NX95
Secondary accession number(s): A8K354
, B3KQX3, B3KU61, Q5R1T1, Q5R1T2, Q5R1T3, Q5Y2M6, Q8ND49, Q8TCR6, Q96D80, Q9P256
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: July 11, 2006
Last modified: November 30, 2016
This is version 119 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.