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Q9NX95 (SYBU_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 95. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Syntabulin
Alternative name(s):
Golgi-localized syntaphilin-related protein
Syntaxin-1-binding protein
Gene names
Name:SYBU
Synonyms:GOLSYN, KIAA1472
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length663 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Part of a kinesin motor-adapter complex that is critical for the anterograde axonal transport of active zone components and contributes to activity-dependent presynaptic assembly during neuronal development By similarity. Ref.1

Subunit structure

Interacts with STX1A and KIF5B. Ref.1

Subcellular location

Isoform 1: Cytoplasmcytoskeleton. Cytoplasmic vesicle. Note: Colocalizes with syntaxin vesicles along microtubules in neuronal processes. Ref.1 Ref.2

Isoform 3: Golgi apparatus membrane; Single-pass membrane protein Ref.1 Ref.2.

Isoform 4: Golgi apparatus membrane; Single-pass membrane protein Ref.1 Ref.2.

Isoform 5: Golgi apparatus membrane; Single-pass membrane protein Ref.1 Ref.2.

Tissue specificity

Isoform 3, isoform 4 and isoform 5 are expressed in HeLa cell line (at protein level). Isoform 3 is expressed in fetal and adult brain. Isoform 4 is expressed in numerous fetal tissues (brain, kidney, liver, lung, and thymus) and in adult brain, kidney, liver, lung, pancreas, colon, prostate, small intestine, testis and thymus. Isoform 5 is expressed in fetal brain, brain and small intestine. Ref.2

Binary interactions

With

Entry

#Exp.

IntAct

Notes

ATXN1P542533EBI-948293,EBI-930964

Alternative products

This entry describes 5 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q9NX95-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q9NX95-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-68: Missing.
     69-76: VSSNSFCS → MGPFWARK
Isoform 3 (identifier: Q9NX95-3)

Also known as: GOLSYN A;

The sequence of this isoform differs from the canonical sequence as follows:
     8-8: Missing.
Isoform 4 (identifier: Q9NX95-4)

Also known as: GOLSYN C;

The sequence of this isoform differs from the canonical sequence as follows:
     1-8: MGPLRESK → MSNFE
Isoform 5 (identifier: Q9NX95-5)

Also known as: GOLSYN B;

The sequence of this isoform differs from the canonical sequence as follows:
     1-119: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 663663Syntabulin
PRO_0000050798

Regions

Transmembrane606 – 62621Helical; Potential
Region2 – 417416Sufficient for interaction with KIF5B
Region310 – 417108Sufficient for interaction with STX1A
Coiled coil271 – 35383 Potential
Compositional bias42 – 241200Ser-rich

Amino acid modifications

Modified residue5551Phosphoserine By similarity

Natural variations

Alternative sequence1 – 119119Missing in isoform 5.
VSP_019718
Alternative sequence1 – 6868Missing in isoform 2.
VSP_019719
Alternative sequence1 – 88MGPLRESK → MSNFE in isoform 4.
VSP_019720
Alternative sequence81Missing in isoform 3.
VSP_019721
Alternative sequence69 – 768VSSNSFCS → MGPFWARK in isoform 2.
VSP_019722

Experimental info

Sequence conflict81K → KMSNFE in CAD28457. Ref.4
Sequence conflict3311R → G in BAG53323. Ref.3
Sequence conflict4401D → G in BAA91121. Ref.3

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified July 11, 2006. Version 2.
Checksum: 41521DBD4AAE733B

FASTA66372,388
        10         20         30         40         50         60 
MGPLRESKKE HRVQHHDKEI SRSRIPRLIL RPHMPQQQHK VSPASESPFS EEESREFNPS 

        70         80         90        100        110        120 
SSGRSARTVS SNSFCSDDTG CPSSQSVSPV KTPSDAGNSP IGFCPGSDEG FTRKKCTIGM 

       130        140        150        160        170        180 
VGEGSIQSSR YKKESKSGLV KPGSEADFSS SSSTGSISAP EVHMSTAGSK RSSSSRNRGP 

       190        200        210        220        230        240 
HGRSNGASSH KPGSSPSSPR EKDLLSMLCR NQLSPVNIHP SYAPSSPSSS NSGSYKGSDC 

       250        260        270        280        290        300 
SPIMRRSGRY MSCGENHGVR PPNPEQYLTP LQQKEVTVRH LKTKLKESER RLHERESEIV 

       310        320        330        340        350        360 
ELKSQLARMR EDWIEEECHR VEAQLALKEA RKEIKQLKQV IETMRSSLAD KDKGIQKYFV 

       370        380        390        400        410        420 
DINIQNKKLE SLLQSMEMAH SGSLRDELCL DFPCDSPEKS LTLNPPLDTM ADGLSLEEQV 

       430        440        450        460        470        480 
TGEGADRELL VGDSIANSTD LFDEIVTATT TESGDLELVH STPGANVLEL LPIVMGQEEG 

       490        500        510        520        530        540 
SVVVERAVQT DVVPYSPAIS ELIQSVLQKL QDPCPSSLAS PDESEPDSME SFPESLSALV 

       550        560        570        580        590        600 
VDLTPRNPNS AILLSPVETP YANVDAEVHA NRLMRELDFA ACVEERLDGV IPLARGGVVR 

       610        620        630        640        650        660 
QYWSSSFLVD LLAVAAPVVP TVLWAFSTQR GGTDPVYNIG ALLRGCCVVA LHSLRRTAFR 


IKT 

« Hide

Isoform 2 [UniParc].

Checksum: 56C948ABD34736C7
Show »

FASTA59564,656
Isoform 3 (GOLSYN A) [UniParc].

Checksum: C3699D85C7D07058
Show »

FASTA66272,260
Isoform 4 (GOLSYN C) [UniParc].

Checksum: B323D1F909837394
Show »

FASTA66072,098
Isoform 5 (GOLSYN B) [UniParc].

Checksum: 6FD961B15A290747
Show »

FASTA54459,368

References

« Hide 'large scale' references
[1]"Syntabulin is a microtubule-associated protein implicated in syntaxin transport in neurons."
Su Q., Cai Q., Gerwin C., Smith C.L., Sheng Z.-H.
Nat. Cell Biol. 6:941-953(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, INTERACTION WITH KIF5B AND STX1A, SUBCELLULAR LOCATION.
Tissue: Brain.
[2]"Molecular cloning and characterization of gene for Golgi-localized syntaphilin-related protein on human chromosome 8q23."
Funakoshi E., Nakagawa K.-Y., Hamano A., Hori T., Shimizu A., Asakawa S., Shimizu N., Ito F.
Gene 344:259-271(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 3; 4 AND 5), SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
Tissue: Fetal brain.
[3]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 5).
Tissue: Fetal brain and Hepatoma.
[4]"The full-ORF clone resource of the German cDNA consortium."
Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I.
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 191-663.
Tissue: Amygdala and Brain.
[5]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 5).
Tissue: Colon.
[7]"Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
Nagase T., Kikuno R., Ishikawa K., Hirosawa M., Ohara O.
DNA Res. 7:143-150(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 63-663.
Tissue: Brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY705385 mRNA. Translation: AAU93914.1.
AB195676 mRNA. Translation: BAD72976.1.
AB195677 mRNA. Translation: BAD72977.1.
AB195678 mRNA. Translation: BAD72978.1.
AB195679 mRNA. Translation: BAD72979.1.
AK000373 mRNA. Translation: BAA91121.1.
AK090559 mRNA. Translation: BAG52185.1.
AK096558 mRNA. Translation: BAG53323.1.
AK290469 mRNA. Translation: BAF83158.1.
AL713645 mRNA. Translation: CAD28457.2.
AL834406 mRNA. Translation: CAD39068.1.
CH471060 Genomic DNA. Translation: EAW91937.1.
BC012082 mRNA. Translation: AAH12082.2.
AB040905 mRNA. Translation: BAA95996.1.
RefSeqNP_001093213.1. NM_001099743.1.
NP_001093214.1. NM_001099744.1.
NP_001093215.1. NM_001099745.1.
NP_001093216.1. NM_001099746.1.
NP_001093217.1. NM_001099747.1.
NP_001093218.1. NM_001099748.1.
NP_001093219.1. NM_001099749.1.
NP_001093220.1. NM_001099750.1.
NP_001093221.1. NM_001099751.1.
NP_001093222.1. NM_001099752.1.
NP_001093223.1. NM_001099753.1.
NP_001093224.1. NM_001099754.1.
NP_001093225.1. NM_001099755.1.
NP_001093226.1. NM_001099756.1.
NP_060256.3. NM_017786.5.
UniGeneHs.390738.

3D structure databases

ProteinModelPortalQ9NX95.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid120776. 5 interactions.
IntActQ9NX95. 4 interactions.
MINTMINT-1432603.

PTM databases

PhosphoSiteQ9NX95.

Polymorphism databases

DMDM110283010.

Proteomic databases

PaxDbQ9NX95.
PRIDEQ9NX95.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000276646; ENSP00000276646; ENSG00000147642. [Q9NX95-1]
ENST00000399066; ENSP00000382019; ENSG00000147642. [Q9NX95-4]
ENST00000408889; ENSP00000386196; ENSG00000147642. [Q9NX95-5]
ENST00000408908; ENSP00000386154; ENSG00000147642. [Q9NX95-1]
ENST00000419099; ENSP00000402652; ENSG00000147642. [Q9NX95-3]
ENST00000422135; ENSP00000407118; ENSG00000147642. [Q9NX95-1]
ENST00000424158; ENSP00000415654; ENSG00000147642.
ENST00000433638; ENSP00000403544; ENSG00000147642. [Q9NX95-1]
ENST00000440310; ENSP00000404369; ENSG00000147642. [Q9NX95-1]
ENST00000446070; ENSP00000414748; ENSG00000147642. [Q9NX95-3]
ENST00000528331; ENSP00000436041; ENSG00000147642. [Q9NX95-5]
ENST00000528647; ENSP00000432501; ENSG00000147642. [Q9NX95-3]
ENST00000532779; ENSP00000436266; ENSG00000147642. [Q9NX95-2]
ENST00000533065; ENSP00000432962; ENSG00000147642. [Q9NX95-5]
ENST00000533171; ENSP00000434679; ENSG00000147642. [Q9NX95-1]
ENST00000533895; ENSP00000433446; ENSG00000147642. [Q9NX95-3]
GeneID55638.
KEGGhsa:55638.
UCSCuc003ynh.4. human. [Q9NX95-1]
uc003yni.4. human. [Q9NX95-4]
uc003ynl.4. human. [Q9NX95-3]
uc003ynp.4. human. [Q9NX95-2]

Organism-specific databases

CTD55638.
GeneCardsGC08M110586.
HGNCHGNC:26011. SYBU.
HPAHPA053057.
MIM611568. gene.
neXtProtNX_Q9NX95.
PharmGKBPA165586000.
HUGESearch...
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG79825.
HOVERGENHBG006785.
InParanoidQ9NX95.
OrthoDBEOG7WQ7SF.
PhylomeDBQ9NX95.
TreeFamTF332407.

Gene expression databases

ArrayExpressQ9NX95.
BgeeQ9NX95.
GenevestigatorQ9NX95.

Family and domain databases

InterProIPR026198. Syntabulin.
IPR028197. Syntaphilin/Syntabulin.
[Graphical view]
PANTHERPTHR16208. PTHR16208. 1 hit.
PTHR16208:SF4. PTHR16208:SF4. 1 hit.
PfamPF15290. Syntaphilin. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSSYBU. human.
GeneWikiGOLSYN.
GenomeRNAi55638.
NextBio60295.
PROQ9NX95.
SOURCESearch...

Entry information

Entry nameSYBU_HUMAN
AccessionPrimary (citable) accession number: Q9NX95
Secondary accession number(s): A8K354 expand/collapse secondary AC list , B3KQX3, B3KU61, Q5R1T1, Q5R1T2, Q5R1T3, Q5Y2M6, Q8ND49, Q8TCR6, Q96D80, Q9P256
Entry history
Integrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: July 11, 2006
Last modified: April 16, 2014
This is version 95 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 8

Human chromosome 8: entries, gene names and cross-references to MIM